Authorization of Animal Experiments Is Based on Confidence Rather than Evidence of Scientific Rigor

Reproducibility Crisis: Are We Ignoring Reaction Norms?

(2016) Bernhard Voelkl et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Researchers’ View of Scientific Rigor—Survey on the Conduct and Reporting of In Vivo Research

(2016) Thomas S. Reichlin et al.   PLoS One

Promoting an open research culture

(2015) B. A. Nosek et al.   SCIENCE

Methodological Quality of Experimental Stroke Studies Published in theStrokeJournal

(2015) Jens Minnerup et al.   STROKE

Risk of Bias in Reports of In Vivo Research: A Focus for Improvement

(2015) Malcolm R. Macleod et al.   PLOS BIOLOGY

The Extent and Consequences of P-Hacking in Science

(2015) Megan L. Head et al.   PLOS BIOLOGY

The Economics of Reproducibility in Preclinical Research

(2015) Leonard P. Freedman et al.   PLOS BIOLOGY

A meta-analysis of threats to valid clinical inference in preclinical research of sunitinib

(2015) Valerie C Henderson et al.   eLife

All preclinical trials should be registered in advance in an online registry

(2014) Sanne J. Jansen of Lorkeers et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Refinement of Experimental Design and Conduct in Laboratory Animal Research

(2014) J. D. Bailoo et al.   ILAR JOURNAL

Reducing waste from incomplete or unusable reports of biomedical research

(2014) Paul Glasziou et al.   LANCET

Preclinical research: Make mouse studies work

(2014) Steve Perrin   NATURE

Systematic Reviews of Animal Studies; Missing Link in Translational Research?

(2014) Judith van Luijk et al.   PLoS One

Journals unite for reproducibility

(2014) M. McNutt   SCIENCE

Efficacy of Antidepressants in Animal Models of Ischemic Stroke

(2014) Sarah K. McCann et al.   STROKE

Some Salt with Your Statin, Professor?

(2014) Malcolm Macleod   PLOS BIOLOGY

Nonindustry-Sponsored Preclinical Studies on Statins Yield Greater Efficacy Estimates Than Industry-Sponsored Studies: A Meta-Analysis

(2014) David Krauth et al.   PLOS BIOLOGY

Two Years Later: Journals Are Not Yet Enforcing the ARRIVE Guidelines on Reporting Standards for Pre-Clinical Animal Studies

(2014) David Baker et al.   PLOS BIOLOGY

Threats to Validity in the Design and Conduct of Preclinical Efficacy Studies: A Systematic Review of Guidelines for In Vivo Animal Experiments

(2013) Valerie C. Henderson et al.   PLOS MEDICINE

A call for transparent reporting to optimize the predictive value of preclinical research

(2012) Story C. Landis et al.   NATURE

Raise standards for preclinical cancer research

(2012) C. Glenn Begley et al.   NATURE

Why animal research needs to improve

(2011) Malcolm Macleod   NATURE

Phase II failures: 2008–2010

(2011) John Arrowsmith   NATURE REVIEWS DRUG DISCOVERY

Believe it or not: how much can we rely on published data on potential drug targets?

(2011) Florian Prinz et al.   NATURE REVIEWS DRUG DISCOVERY

Dopamine agonists in animal models of Parkinson’s disease: A systematic review and meta-analysis

(2011) Evelien D.M. Rooke et al.   PARKINSONISM & RELATED DISORDERS

Effect of Population Heterogenization on the Reproducibility of Mouse Behavior: A Multi-Laboratory Study

(2011) S. Helene Richter et al.   PLoS One

Improving the translational hit of experimental treatments in multiple sclerosis

(2010) Hanna M Vesterinen et al.   Multiple Sclerosis Journal

Systematic variation improves reproducibility of animal experiments

(2010) S Helene Richter et al.   NATURE METHODS

Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy

(2010) Emily S. Sena et al.   PLOS BIOLOGY

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

Can Animal Models of Disease Reliably Inform Human Studies?

(2010) H. Bart van der Worp et al.   PLOS MEDICINE

REPRINT: Good Laboratory Practice: Preventing Introduction of Bias at the Bench

(2009) Malcolm R. Macleod et al.   International Journal of Stroke

Repeatability of published microarray gene expression analyses

(2009) John P A Ioannidis et al.   NATURE GENETICS

Environmental standardization: cure or cause of poor reproducibility in animal experiments?

(2009) S Helene Richter et al.   NATURE METHODS

Survey of the Quality of Experimental Design, Statistical Analysis and Reporting of Research Using Animals

(2009) Carol Kilkenny et al.   PLoS One

Evidence for the Efficacy of NXY-059 in Experimental Focal Cerebral Ischaemia Is Confounded by Study Quality

(2008) Malcolm R. Macleod et al.   STROKE