Identification of Novel Structural Determinants in MW965 Env That Regulate the Neutralization Phenotype and Conformational Masking Potential of Primary HIV-1 Isolates
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Identification of Novel Structural Determinants in MW965 Env That Regulate the Neutralization Phenotype and Conformational Masking Potential of Primary HIV-1 Isolates
Authors
Keywords
-
Journal
JOURNAL OF VIROLOGY
Volume 92, Issue 5, Pages -
Publisher
American Society for Microbiology
Online
2017-12-14
DOI
10.1128/jvi.01779-17
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Broadly Neutralizing Antibodies to HIV and Their Role in Vaccine Design
- (2016) Dennis R. Burton et al. Annual Review of Immunology
- Cryo-EM structure of a CD4-bound open HIV-1 envelope trimer reveals structural rearrangements of the gp120 V1V2 loop
- (2016) Haoqing Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Broadly Neutralizing Antibody Responses in a Large Longitudinal Sub-Saharan HIV Primary Infection Cohort
- (2016) Elise Landais et al. PLoS Pathogens
- Broadly Neutralizing Human Immunodeficiency Virus Type 1 Antibody Gene Transfer Protects Nonhuman Primates from Mucosal Simian-Human Immunodeficiency Virus Infection
- (2015) Kevin O. Saunders et al. JOURNAL OF VIROLOGY
- New Member of the V1V2-Directed CAP256-VRC26 Lineage That Shows Increased Breadth and Exceptional Potency
- (2015) Nicole A. Doria-Rose et al. JOURNAL OF VIROLOGY
- Murine Antibody Responses to Cleaved Soluble HIV-1 Envelope Trimers Are Highly Restricted in Specificity
- (2015) Joyce K. Hu et al. JOURNAL OF VIROLOGY
- A broad range of mutations in HIV-1 neutralizing human monoclonal antibodies specific for V2, V3, and the CD4 binding site
- (2015) Liuzhe Li et al. MOLECULAR IMMUNOLOGY
- Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design
- (2015) Jason Gorman et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- CATNAP: a tool to compile, analyze and tally neutralizing antibody panels
- (2015) Hyejin Yoon et al. NUCLEIC ACIDS RESEARCH
- Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design
- (2015) Jason Gorman et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Structural Delineation of a Quaternary, Cleavage-Dependent Epitope at the gp41-gp120 Interface on Intact HIV-1 Env Trimers
- (2014) Claudia Blattner et al. IMMUNITY
- Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies
- (2014) Nicole A. Doria-Rose et al. NATURE
- Passive Immunization against HIV/AIDS by Antibody Gene Transfer
- (2014) Lili Yang et al. Viruses-Basel
- Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization
- (2013) Florian Klein et al. CELL
- Isolation of human monoclonal antibodies from peripheral blood B cells
- (2013) Jinghe Huang et al. Nature Protocols
- Prefusion structure of trimeric HIV-1 envelope glycoprotein determined by cryo-electron microscopy
- (2013) Alberto Bartesaghi et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Pre-Clinical Development of a Recombinant, Replication-Competent Adenovirus Serotype 4 Vector Vaccine Expressing HIV-1 Envelope 1086 Clade C
- (2013) Jeff Alexander et al. PLoS One
- Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer
- (2013) J.-P. Julien et al. SCIENCE
- Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer
- (2013) D. Lyumkis et al. SCIENCE
- Specific sequences commonly found in the V3 domain of HIV-1 subtype C isolates affect the overall conformation of native Env and induce a neutralization-resistant phenotype independent of V1/V2 masking
- (2013) Aidy Salomon et al. VIROLOGY
- A Mechanistic Understanding of Allosteric Immune Escape Pathways in the HIV-1 Envelope Glycoprotein
- (2013) Anurag Sethi et al. PLoS Computational Biology
- Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans
- (2013) Jean-Philippe Julien et al. PLoS Pathogens
- The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies
- (2013) Devin Sok et al. PLoS Pathogens
- A Next-Generation Cleaved, Soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, Expresses Multiple Epitopes for Broadly Neutralizing but Not Non-Neutralizing Antibodies
- (2013) Rogier W. Sanders et al. PLoS Pathogens
- Neutralizing Antibody Escape during HIV-1 Mother-to-Child Transmission Involves Conformational Masking of Distal Epitopes in Envelope
- (2012) Leslie Goo et al. JOURNAL OF VIROLOGY
- Sequences in Glycoprotein gp41, the CD4 Binding Site, and the V2 Domain Regulate Sensitivity and Resistance of HIV-1 to Broadly Neutralizing Antibodies
- (2012) S. M. O'Rourke et al. JOURNAL OF VIROLOGY
- Gene-based passive antibody protection from HIV
- (2012) Margaret A Liu NATURE BIOTECHNOLOGY
- Evolution of an HIV glycan–dependent broadly neutralizing antibody epitope through immune escape
- (2012) Penny L Moore et al. NATURE MEDICINE
- NIH Image to ImageJ: 25 years of image analysis
- (2012) Caroline A Schneider et al. NATURE METHODS
- Elicitation of Neutralizing Antibodies Directed against CD4-Induced Epitope(s) Using a CD4 Mimetic Cross-Linked to a HIV-1 Envelope Glycoprotein
- (2012) Antu K. Dey et al. PLoS One
- Functional and immunochemical cross-reactivity of V2-specific monoclonal antibodies from HIV-1-infected individuals
- (2012) Miroslaw K. Gorny et al. VIROLOGY
- Characterization of Structural Features and Diversity of Variable-Region Determinants of Related Quaternary Epitopes Recognized by Human and Rhesus Macaque Monoclonal Antibodies Possessing Unusually Potent Neutralizing Activities
- (2011) C. Krachmarov et al. JOURNAL OF VIROLOGY
- Analysis of a Clonal Lineage of HIV-1 Envelope V2/V3 Conformational Epitope-Specific Broadly Neutralizing Antibodies and Their Inferred Unmutated Common Ancestors
- (2011) M. Bonsignori et al. JOURNAL OF VIROLOGY
- Potent and Broad Neutralization of HIV-1 Subtype C by Plasma Antibodies Targeting a Quaternary Epitope Including Residues in the V2 Loop
- (2011) P. L. Moore et al. JOURNAL OF VIROLOGY
- Antibody-based protection against HIV infection by vectored immunoprophylaxis
- (2011) Alejandro B. Balazs et al. NATURE
- Broad neutralization coverage of HIV by multiple highly potent antibodies
- (2011) Laura M. Walker et al. NATURE
- Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding
- (2011) J. F. Scheid et al. SCIENCE
- Quaternary Epitope Specificities of Anti-HIV-1 Neutralizing Antibodies Generated in Rhesus Macaques Infected by the Simian/Human Immunodeficiency Virus SHIVSF162P4
- (2010) J. E. Robinson et al. JOURNAL OF VIROLOGY
- Crystal Structure of PG16 and Chimeric Dissection with Somatically Related PG9: Structure-Function Analysis of Two Quaternary-Specific Antibodies That Effectively Neutralize HIV-1
- (2010) M. Pancera et al. JOURNAL OF VIROLOGY
- Conserved structural elements in the V3 crown of HIV-1 gp120
- (2010) Xunqing Jiang et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1
- (2010) R. Pejchal et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- HIV-1 subtype distribution in the Gambia and the significant presence of CRF49_cpx, a novel circulating recombinant form
- (2010) Thushan I de Silva et al. Retrovirology
- Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01
- (2010) T. Zhou et al. SCIENCE
- Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1
- (2010) X. Wu et al. SCIENCE
- Structure-guided design and immunological characterization of immunogens presenting the HIV-1 gp120 V3 loop on a CTB scaffold
- (2010) Maxim Totrov et al. VIROLOGY
- Tiered Categorization of a Diverse Panel of HIV-1 Env Pseudoviruses for Assessment of Neutralizing Antibodies
- (2009) M. S. Seaman et al. JOURNAL OF VIROLOGY
- Structural Basis of Immune Evasion at the Site of CD4 Attachment on HIV-1 gp120
- (2009) L. Chen et al. SCIENCE
- Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target
- (2009) L. M. Walker et al. SCIENCE
- High titer HIV-1 V3-specific antibodies with broad reactivity but low neutralizing potency in acute infection and following vaccination
- (2009) Katie L. Davis et al. VIROLOGY
- Role of the HIV gp120 Conserved Domain 5 in Processing and Viral Entry†
- (2008) Jayita Sen et al. BIOCHEMISTRY
- Engineering human hematopoietic stem/progenitor cells to produce a broadly neutralizing anti-HIV antibody after in vitro maturation to human B lymphocytes.
- (2008) X. M. Luo et al. BLOOD
- Role of the HIV gp120 Conserved Domain 1 in Processing and Viral Entry
- (2008) Jizhen Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Optimization of Human Immunodeficiency Virus Type 1 Envelope Glycoproteins with V1/V2 Deleted, Using Virus Evolution
- (2008) I. Bontjer et al. JOURNAL OF VIROLOGY
- Only Five of 10 Strictly Conserved Disulfide Bonds Are Essential for Folding and Eight for Function of the HIV-1 Envelope Glycoprotein
- (2008) Eelco van Anken et al. MOLECULAR BIOLOGY OF THE CELL
- Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning
- (2007) Thomas Tiller et al. JOURNAL OF IMMUNOLOGICAL METHODS
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now