Thrombin contributes to protective immunity in pneumonia-derived sepsis via fibrin polymerization and platelet-neutrophil interactions

Mice expressing a mutant form of fibrinogen that cannot support fibrin formation exhibit compromised antimicrobial host defense

(2015) J. M. Prasad et al.   BLOOD

Fibrin activates GPVI in human and mouse platelets

(2015) O. M. Alshehri et al.   BLOOD

PAD4-deficiency does not affect bacteremia in polymicrobial sepsis and ameliorates endotoxemic shock

(2015) K. Martinod et al.   BLOOD

Regulation of Neutrophilic Inflammation by Proteinase-Activated Receptor 1 during Bacterial Pulmonary Infection

(2015) Ricardo J. José et al.   JOURNAL OF IMMUNOLOGY

Endothelial barrier dysfunction in septic shock

(2015) S. M. Opal et al.   JOURNAL OF INTERNAL MEDICINE

Plateletandendothelial cell P-selectin are required for host defense againstKlebsiella pneumoniae-induced pneumosepsis

(2015) S. F. de Stoppelaar et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Thrombin-dependent intravascular leukocyte trafficking regulated by fibrin and the platelet receptors GPIb and PAR4

(2015) Zane S. Kaplan et al.   Nature Communications

Thrombocytopenia impairs host defense in gram-negative pneumonia-derived sepsis in mice

(2014) S. F. de Stoppelaar et al.   BLOOD

Differential contribution of FXa and thrombin to vascular inflammation in a mouse model of sickle cell disease

(2014) E. M. Sparkenbaugh et al.   BLOOD

Genetic elimination of the binding motif on fibrinogen for the S. aureus virulence factor ClfA improves host survival in septicemia

(2013) M. J. Flick et al.   BLOOD

Deficiency of protease-activated receptor-1 limits bacterial dissemination during severe Gram-negative sepsis (melioidosis)

(2013) Liesbeth M. Kager et al.   MICROBES AND INFECTION

Severe Sepsis and Septic Shock

(2013) Derek C. Angus et al.   NEW ENGLAND JOURNAL OF MEDICINE

Protease activated receptor 4 limits bacterial growth and lung pathology during late stage Streptococcus pneumoniae induced pneumonia in mice

(2013) Cornelis van ’t Veer et al.   THROMBOSIS AND HAEMOSTASIS

Intravascular Neutrophil Extracellular Traps Capture Bacteria from the Bloodstream during Sepsis

(2012) Braedon McDonald et al.   Cell Host & Microbe

Bacterial Plasminogen Receptors Utilize Host Plasminogen System for Effective Invasion and Dissemination

(2012) Sarbani Bhattacharya et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Fibrin formation by staphylothrombin facilitates Staphylococcus aureus-induced platelet aggregation

(2012) Alexandre Kauskot et al.   THROMBOSIS AND HAEMOSTASIS

Inhibition of staphylothrombin by dabigatran reduces Staphylococcus aureus virulence

(2011) T. VANASSCHE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Neutrophil extracellular traps promote deep vein thrombosis in mice

(2011) A. BRILL et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Systemic versus localized coagulation activation contributing to organ failure in critically ill patients

(2011) Marcel Levi et al.   Seminars in Immunopathology

The roles of thrombin and protease-activated receptors in inflammation

(2011) Liang Ma et al.   Seminars in Immunopathology

Thrombin as a multi-functional enzyme

(2011) Michael Schwameis et al.   THROMBOSIS AND HAEMOSTASIS

Preventing Staphylococcus aureus Sepsis through the Inhibition of Its Agglutination in Blood

(2011) Molly McAdow et al.   PLoS Pathogens

Inflammation and coagulation

(2010) Marcel Levi et al.   CRITICAL CARE MEDICINE

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

(2010) Pingxin Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Risk factors and pathogenic significance of severe sepsis and septic shock in 2286 patients with gram-negative bacteremia

(2010) Cheol-In Kang et al.   JOURNAL OF INFECTION

Recombinant human tissue factor pathway inhibitor exerts anticoagulant, anti-inflammatory and antimicrobial effects in murine pneumococcal pneumonia

(2010) F. E. VAN DEN BOOGAARD et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

(2010) Steffen Massberg et al.   NATURE MEDICINE

Unfractioned heparin for treatment of sepsis: A randomized clinical trial (The HETRASE Study)*

(2009) Fabián Jaimes et al.   CRITICAL CARE MEDICINE

Reduced thrombin generation increases host susceptibility to group A streptococcal infection

(2008) H. Sun et al.   BLOOD

Discovery of a Novel, Orally Active Himbacine-Based Thrombin Receptor Antagonist (SCH 530348) with Potent Antiplatelet Activity

(2008) Samuel Chackalamannil et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dendritic cell PAR1–S1P3 signalling couples coagulation and inflammation

(2008) Frank Niessen et al.   NATURE