Pharmacogenetics of Drug-Induced QT Interval Prolongation: An Update

An Enhancer Polymorphism at the Cardiomyocyte Intercalated Disc Protein NOS1AP Locus Is a Major Regulator of the QT Interval

(2014) Ashish Kapoor et al.   AMERICAN JOURNAL OF HUMAN GENETICS

KCNH2 polymorphism and methadone dosage interact to enhance QT duration

(2014) Aline Hajj et al.   DRUG AND ALCOHOL DEPENDENCE

Short-term QT variability markers for the prediction of ventricular arrhythmias and sudden cardiac death: a systematic review

(2014) Maartje N Niemeijer et al.   HEART

Normal values of the electrocardiogram for ages 16–90years

(2014) Peter R. Rijnbeek et al.   JOURNAL OF ELECTROCARDIOLOGY

Exome Sequencing Implicates an Increased Burden of Rare Potassium Channel Variants in the Risk of Drug-Induced Long QT Interval Syndrome

(2014) Peter Weeke et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Effect of risperidone metabolism and P-glycoprotein gene polymorphism on QT interval in patients with schizophrenia

(2014) Y Suzuki et al.   PHARMACOGENOMICS JOURNAL

Clinical Evidence Supporting Pharmacogenomic Biomarker Testing Provided in US Food and Drug Administration Drug Labels

(2014) Bo Wang et al.   JAMA Internal Medicine

Associations between NOS1AP Single Nucleotide Polymorphisms (SNPs) and QT Interval Duration in Four Racial/Ethnic Groups in the Multi-Ethnic Study of Atherosclerosis (MESA)

(2013) Sidharth A. Shah et al.   ANNALS OF NONINVASIVE ELECTROCARDIOLOGY

Pharmacogenetics of Risperidone: A Systematic Review of the Clinical Effects of CYP2D6 Polymorphisms

(2013) Andrea L Cartwright et al.   ANNALS OF PHARMACOTHERAPY

Thorough QT study of the effect of oral moxifloxacin on QTcinterval in the fed and fasted state in healthy Japanese and Caucasian subjects

(2013) Jorg Taubel et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Racial susceptibility for QT prolongation in acute drug overdoses

(2013) Alex F. Manini et al.   JOURNAL OF ELECTROCARDIOLOGY

Molecular analysis of potassium ion channel genes in sudden death cases among patients administered psychotropic drug therapy: are polymorphisms in LQT genes a potential risk factor?

(2013) Sayako Kamei et al.   JOURNAL OF HUMAN GENETICS

Genetics of congenital and drug-induced long QT syndromes: current evidence and future research perspectives

(2013) Saagar Mahida et al.   JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY

Drug–gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval

(2013) C L Avery et al.   PHARMACOGENOMICS JOURNAL

Genome Wide Analysis of Drug-Induced Torsades de Pointes: Lack of Common Variants with Large Effect Sizes

(2013) Elijah R. Behr et al.   PLoS One

Drug-induced QT interval prolongation: does ethnicity of the thorough QT study population matter?

(2012) Rashmi R. Shah   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Impact of Ancestry and Common Genetic Variants on QT Interval in African Americans

(2012) J. Gustav Smith et al.   Circulation-Cardiovascular Genetics

A Thorough QTc Study of 3 Doses of Iloperidone Including Metabolic Inhibition Via CYP2D6 and/or CYP3A4 and a Comparison to Quetiapine and Ziprasidone

(2012) Steven G. Potkin et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Common Variation in the NOS1AP Gene Is Associated With Drug-Induced QT Prolongation and Ventricular Arrhythmia

(2012) Yalda Jamshidi et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

An integrated map of genetic variation from 1,092 human genomes

(2012)   NATURE

Exome sequencing and the genetic basis of complex traits

(2012) Adam Kiezun et al.   NATURE GENETICS

The Molecular Autopsy: Should the Evaluation Continue After the Funeral?

(2012) David J. Tester et al.   PEDIATRIC CARDIOLOGY

Novel rare variants in congenital cardiac arrhythmia genes are frequent in drug-induced torsades de pointes

(2012) A H Ramirez et al.   PHARMACOGENOMICS JOURNAL

hERG K+ Channels: Structure, Function, and Clinical Significance

(2012) Jamie I. Vandenberg et al.   PHYSIOLOGICAL REVIEWS

Fine-Mapping and Initial Characterization of QT Interval Loci in African Americans

(2012) Christy L. Avery et al.   PLoS Genetics

Comparison of the effects of levofloxacin on QT/QTc interval assessed in both healthy Japanese and Caucasian subjects

(2011) Atsushi Sugiyama et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

A Large Candidate Gene Survey Identifies the KCNE1 D85N Polymorphism as a Possible Modulator of Drug-Induced Torsades de Pointes

(2011) Stefan Kääb et al.   Circulation-Cardiovascular Genetics

Pharmacogenomics: Application to the Management of Cardiovascular Disease

(2011) J A Johnson et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Factors affecting the degree of QT prolongation with drug challenge in a large cohort of normal volunteers

(2011) Prince J. Kannankeril et al.   HEART RHYTHM

5 HT3-receptor antagonists and cardiac repolarization time in patients expressing a novel genetic target associated with baseline QTc interval abnormalities

(2011) Sadeq A. Quraishi et al.   JOURNAL OF CLINICAL ANESTHESIA

Population Pharmacokinetic and Concentration-QTc Models for Moxifloxacin: Pooled Analysis of 20 Thorough QT Studies

(2011) Jeffry A. Florian et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Long QT Syndrome in African-Americans

(2010) Thomas Fugate II et al.   ANNALS OF NONINVASIVE ELECTROCARDIOLOGY

Impact of ABCB1 Allelic Variants on QTc Interval Prolongation

(2010) T. M. Sissung et al.   CLINICAL CANCER RESEARCH

A map of human genome variation from population-scale sequencing

(2010) Richard M. Durbin et al.   NATURE

Genome-wide association studies in pharmacogenomics

(2010) Ann K. Daly   NATURE REVIEWS GENETICS

Genome-wide association study of antipsychotic-induced QTc interval prolongation

(2010) K Åberg et al.   PHARMACOGENOMICS JOURNAL

Drug-Induced Long QT Syndrome

(2010) P. Kannankeril et al.   PHARMACOLOGICAL REVIEWS

Latent Genetic Backgrounds and Molecular Pathogenesis in Drug-Induced Long-QT Syndrome

(2009) Hideki Itoh et al.   Circulation-Arrhythmia and Electrophysiology

Effects of Standard and Supratherapeutic Doses of Nelfinavir on Cardiac Repolarization: A Thorough QT Study

(2009) Bharat Damle et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Electrocardiographic QTc Changes Due to Moxifloxacin Infusion

(2009) Marek Malik et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Common variants at ten loci modulate the QT interval duration in the QTSCD Study

(2009) Arne Pfeufer et al.   NATURE GENETICS

Common variants at ten loci influence QT interval duration in the QTGEN Study

(2009) Christopher Newton-Cheh et al.   NATURE GENETICS

Common ATP-binding cassette B1 variants are associated with increased digoxin serum concentration

(2009) Albert-Jan L.H.J. Aarnoudse et al.   Pharmacogenetics and Genomics

Calcium channel blockers, NOS1AP, and heart-rate-corrected QT prolongation

(2009) Charlotte van Noord et al.   Pharmacogenetics and Genomics

Multiple Independent Genetic Factors at NOS1AP Modulate the QT Interval in a Multi-Ethnic Population

(2009) Dan E. Arking et al.   PLoS One

Association of NOS1AP Genetic Variants With QT Interval Duration in Families From the Diabetes Heart Study

(2008) A. B. Lehtinen et al.   DIABETES

Understanding drug-induced torsades de pointes: a genetic stance

(2008) Prince J Kannankeril   Expert Opinion On Drug Safety

Identification of a common variant at the NOS1AP locus strongly associated to QT-interval duration

(2008) M. Eijgelsheim et al.   HUMAN MOLECULAR GENETICS

Gender and effects of a common genetic variant in the NOS1 regulator NOS1AP on cardiac repolarization in 3761 individuals from two independent populations

(2008) Martin D Tobin et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

The QT syndromes: long and short

(2008) Hiroshi Morita et al.   LANCET

Whole genome association study identifies polymorphisms associated with QT prolongation during iloperidone treatment of schizophrenia

(2008) S Volpi et al.   MOLECULAR PSYCHIATRY