A principal mechanism for the cancer chemopreventive activity of phenethyl isothiocyanate is modulation of carcinogen metabolism

Phenethyl isothiocyanate: A comprehensive review of anti-cancer mechanisms

(2014) Parul Gupta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Molecular targets of isothiocyanates in cancer: Recent advances

(2014) Parul Gupta et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Induction of Epoxide Hydrolase, Glucuronosyl Transferase, and Sulfotransferase by Phenethyl Isothiocyanate in Male Wistar Albino Rats

(2014) Ahmad Faizal Abdull Razis et al.   Biomed Research International

Differential hepatic GSTA2 expression of arylalkyl isothiocyanates in vivo and in vitro: The molecular mechanism of gene induction by phenethyl isothiocyanate

(2013) Sang Il Gum et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Chemopreventive and anti-angiogenic effects of dietary phenethyl isothiocyanate in anN-methyl nitrosourea-induced breast cancer animal model

(2012) Urvi Aras et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Contributions of Human Enzymes in Carcinogen Metabolism

(2012) Slobodan Rendic et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Structural influence of isothiocyanates on expression of cytochrome P450, phase II enzymes, and activation of Nrf2 in primary rat hepatocytes

(2012) M. La Marca et al.   FOOD AND CHEMICAL TOXICOLOGY

The potential to intensify sulforaphane formation in cooked broccoli (Brassica oleracea var. italica) using mustard seeds (Sinapis alba)

(2012) Sameer Khalil Ghawi et al.   FOOD CHEMISTRY

Characterization of the Temporal Induction of Hepatic Xenobiotic-Metabolizing Enzymes by Glucosinolates and Isothiocyanates: Requirement for at Least a 6 h Exposure To Elicit Complete Induction Profile

(2012) Ahmad F. Abdull Razis et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Characterization of Products from the Reaction of Glucosinolate-Derived Isothiocyanates with Cysteine and Lysine Derivatives Formed in Either Model Systems or Broccoli Sprouts

(2012) Franziska S. Hanschen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Biomarkers of Phenethyl Isothiocyanate-Mediated Mammary Cancer Chemoprevention in a Clinically Relevant Mouse Model

(2012) S. V. Singh et al.   JNCI-Journal of the National Cancer Institute

Evaluation of the metabolism and hepatotoxicity of xenobiotics utilizing precision-cut slices

(2012) Brian G. Lake et al.   XENOBIOTICA

Up-regulation of cytochrome P450 and phase II enzymes by xenobiotics in precision-cut tissue slices

(2012) Costas Ioannides   XENOBIOTICA

Enhancing sulforaphane absorption and excretion in healthy men through the combined consumption of fresh broccoli sprouts and a glucoraphanin-rich powder

(2011) Jenna M. Cramer et al.   BRITISH JOURNAL OF NUTRITION

The molecular basis that unifies the metabolism, cellular uptake and chemopreventive activities of dietary isothiocyanates

(2011) Y. Zhang   CARCINOGENESIS

Chemopreventative Potential of the Cruciferous Vegetable Constituent Phenethyl Isothiocyanate in a Mouse Model of Prostate Cancer

(2011) Anna A. Powolny et al.   JNCI-Journal of the National Cancer Institute

Identification of glucosinolate congeners able to form DNA adducts and to induce mutations upon activation by myrosinase

(2011) Chimgee Baasanjav-Gerber et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Exposure to Isothiocyanates Suppresses Urinary Mutagenicity in Rats Treated With Heterocyclic Amine IQ: Lack of Association With CYP1 Activity

(2011) Natalya Hanlon et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Modulation of Carcinogen Metabolizing Cytochromes P450 in Rat Liver and Kidney by Cabbage and Sauerkraut Juices: Comparison with the Effects of Indole-3-carbinol and Phenethyl Isothiocyanate

(2011) Hanna Szaefer et al.   PHYTOTHERAPY RESEARCH

Phenethyl isocyanate is not the metabolite of phenethyl isothiocyanate responsible for mechanism-based inhibition of cytochrome P450

(2010) Nattaya Konsue et al.   ARCHIVES OF TOXICOLOGY

Induction of epoxide hydrolase and glucuronosyl transferase by isothiocyanates and intact glucosinolates in precision-cut rat liver slices: importance of side-chain substituent and chirality

(2010) Ahmad Faizal Abdull Razis et al.   ARCHIVES OF TOXICOLOGY

Formation and Distribution of NNK Metabolites in an Isolated Perfused Rat Lung

(2010) L. A. Maertens et al.   DRUG METABOLISM AND DISPOSITION

Prostate cancer chemopreventive activity of phenethyl isothiocyanate through epigenetic regulation (Review)

(2010) Wang   INTERNATIONAL JOURNAL OF ONCOLOGY

Differential response of four human livers to modulation of phase II enzyme systems by the chemopreventive phytochemical phenethyl isothiocyanate

(2010) Nattaya Konsue et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Sulforaphane- and Phenethyl Isothiocyanate–Induced Inhibition of Aflatoxin B1–Mediated Genotoxicity in Human Hepatocytes: Role of GSTM1 Genotype and CYP3A4 Gene Expression

(2010) Kerstin Gross-Steinmeyer et al.   TOXICOLOGICAL SCIENCES

Dietary Intake of Individual Glucosinolates in Participants of the EPIC-Heidelberg Cohort Study

(2009) Astrid Steinbrecher et al.   ANNALS OF NUTRITION AND METABOLISM

ABC transporters and isothiocyanates: potential for pharmacokinetic diet-drug interactions

(2009) Urvi Telang et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Urinary Isothiocyanates; Glutathione S-Transferase M1, T1, and P1 Polymorphisms; and Risk of Colorectal Cancer: The Multiethnic Cohort Study

(2009) M. Epplein et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Cruciferous Vegetable Consumption and Lung Cancer Risk: A Systematic Review

(2009) T. K. Lam et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Differential in vivo mechanism of chemoprevention of tumor formation in azoxymethane/dextran sodium sulfate mice by PEITC and DBM

(2009) K. L. Cheung et al.   CARCINOGENESIS

Modulation of detoxification enzymes by watercress: in vitro and in vivo investigations in human peripheral blood cells

(2009) Thomas Hofmann et al.   EUROPEAN JOURNAL OF NUTRITION

Dietary glucosinolate intake and risk of prostate cancer in the EPIC-Heidelberg cohort study

(2009) Astrid Steinbrecher et al.   INTERNATIONAL JOURNAL OF CANCER

The aliphatic isothiocyanates erucin and sulforaphane do not effectively up-regulate NAD(P)H:quinone oxidoreductase (NQO1) in human liver compared with rat

(2009) Natalya Hanlon et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Repeated oral administration modulates the pharmacokinetic behavior of the chemopreventive agent phenethyl isothiocyanate in rats

(2009) Nattaya Konsue et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Modulation of carcinogen-metabolising cytochromes P450 in human liver by the chemopreventive phytochemical phenethyl isothiocyanate, a constituent of cruciferous vegetables

(2009) Nattaya Konsue et al.   TOXICOLOGY

The cancer chemopreventive actions of phytochemicals derived from glucosinolates

(2008) John D. Hayes et al.   EUROPEAN JOURNAL OF NUTRITION

Tissue differences in the modulation of rat cytochromes P450 and phase II conjugation systems by dietary doses of phenethyl isothiocyanate

(2008) N. Konsue et al.   FOOD AND CHEMICAL TOXICOLOGY

Modulation of Rat Hepatic and Pulmonary Cytochromes P450 and Phase II Enzyme Systems by Erucin, an Isothiocyanate Structurally Related to Sulforaphane

(2008) Natalya Hanlon et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Murine Prostate Cancer Inhibition by Dietary Phytochemicals—Curcumin and Phenyethylisothiocyanate

(2008) Avantika Barve et al.   PHARMACEUTICAL RESEARCH

Up-regulation of the CYP1 family in rat and human liver by the aliphatic isothiocyanates erucin and sulforaphane

(2008) Natalya Hanlon et al.   TOXICOLOGY

Chemoprevention of familial adenomatous polyposis inApcMin/+ mice by phenethyl isothiocyanate (PEITC)

(2007) Tin Oo Khor et al.   MOLECULAR CARCINOGENESIS