Article
Dermatology
Alexander Salava, Ville Salo, Anita Remitz
Summary: Keratosis pilaris (KP) is associated with atopic dermatitis (AD) but its role in disease severity and concomitant atopic diseases varies between populations. A study on Finnish AD patients found that KP was not linked to disease severity, asthma, or atopic sensitization. However, it was significantly associated with palmar hyperlinearity and a specific filaggrin loss-of-function mutation. The prevalence of KP in the cohort was low, which may be due to the rarity of the tested gene mutations in the Finnish population.
JOURNAL OF DERMATOLOGY
(2022)
Article
Dermatology
Jason Thomson, Findlay Bewicke-Copley, Chinedu Anthony Anene, Abha Gulati, Ai Nagano, Karin Purdie, Gareth J. Inman, Charlotte M. Proby, Irene M. Leigh, Catherine A. Harwood, Jun Wang
Summary: This study conducted the largest AK whole exome sequencing study to date and found significant similarities between AK and cSCC in terms of genetic mutations, copy number alterations, driver gene mutations, and mutational signatures. The research identified 44 significantly mutated AK driver genes and suggested that dysregulated TGFf3 signaling may play an important role in AK-cSCC progression.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Allergy
Chih-Yung Chiu, Gigin Lin, Chia-Jung Wang, Shuen-Iu Hung, Wen-Hung Chung
Summary: This study identified a correlation between metabolomic profiles in AD patients with FLG mutations and allergic responses, revealing metabolic pathways associated with AD such as nitrogen and amino acid metabolism, microbe-related methane and propanoate metabolism. FLG mutations were positively correlated with total serum IgE levels, with microbial-derived metabolites like dimethylamine and isopropanol strongly associated with methane and propanoate metabolism in AD.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Verena Moosbrugger-Martinz, Corinne Leprince, Marie-Claire Mechin, Michel Simon, Stefan Blunder, Robert Gruber, Sandrine Dubrac
Summary: The discovery of loss-of-function mutations in the filaggrin gene has shed new light on the understanding of skin conditions such as ichthyosis vulgaris and atopic dermatitis. However, there is still much to learn about how filaggrin deficiency contributes to atopic dermatitis and the factors that lead to reduced filaggrin levels. This review re-evaluates the roles of filaggrin in the epidermis and atopic dermatitis, providing insights into its importance for keratinocyte alignment, maintenance of epidermal texture, and cellular abnormalities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chunying Xiao, Zhongbin Sun, Jixin Gao, Yaxing Bai, Chen Zhang, Bingyu Pang, Hongjiang Qiao, Meng Fu, Erle Dang, Gang Wang
Summary: This study demonstrated the critical role of skin barrier protein FLG in the pathogenesis of atopic dermatitis, with CPT-induced dermatitis being more severe in Flg(-/-) mice compared to wild-type mice. Additionally, emollients MPS and ceramide partially restored epidermal function and alleviated skin inflammation in the Flg(-/-) mouse model of AD induced by CPT.
Article
Medicine, General & Internal
Annalisa Astolfi, Francesca Cipriani, Daria Messelodi, Matilde De Luca, Valentina Indio, Costanza Di Chiara, Arianna Giannetti, Lorenza Ricci, Iria Neri, Annalisa Patrizi, Giampaolo Ricci, Andrea Pession
Summary: This study revealed that children with atopic dermatitis carrying FLG mutations are at higher risk of developing severe food allergies, such as anaphylaxis. Peanut and hazelnut were identified as high-risk foods for patients with FLG mutations.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Kjell Lussmann, Kerry Montgomery, Andrew Thompson, Uwe Gieler, Christoph Zick, Joerg Kupfer, Christina Schut
Summary: Itch intensity is positively correlated with itch catastrophizing, while mindfulness is negatively correlated with itch catastrophizing. Increasing acting with awareness may buffer itch catastrophizing and lead to lower itch intensity in patients with AD.
FRONTIERS IN MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Petra Pavel, Stefan Blunder, Verena Moosbrugger-Martinz, Peter M. Elias, Sandrine Dubrac
Summary: Atopic dermatitis is a chronic inflammatory skin disease influenced by both genetic and environmental factors. Alterations of the epidermal barrier and lipid abnormalities play crucial roles in the development and inflammation of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Allergy
Haengdueng Jeong, Nakyum Lee, Chanyang Uhm, Kyungrae Cho, Heeju Oh, Yeseul Oh, KeLun Zhang, Hye Li Kim, James R. Goldenring, Kyung-Min Lim, Chang Ook Park, Ki Taek Nam
Summary: Rab-25 plays an important role in maintaining skin barrier function and keratinization in atopic dermatitis (AD).
Article
Dermatology
Sahana M. Srinivas, Sandipan Dhar, Aruna Gowdra, Abhijit Saha, Lakshmi Sundararajan, Thenral S. Geetha, Raghubir Banerjee, Rajib Malakar, Amrita Sil, Arakali Lakshminarayana Shyam Prasad
Summary: This study explores the FLG gene polymorphisms in Indian children and finds a significant correlation between these variants and an early onset of atopic dermatitis and elevated serum IgE levels.
INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY
(2023)
Article
Allergy
Anna Maria Andersson, Julie Solberg, Anders Koch, Lone Skov, Ivone Jakasa, Sanja Kezic, Jacob Pontoppidan Thyssen
Summary: This study analyzed biomarkers in children with atopic dermatitis using tape strips and skin biopsies, finding that cytokine profiles in lesional skin were associated with disease severity, food allergy, and filaggrin gene mutations. Levels of TARC, CTACK, IL-8, and IL-18 in tape strips correlated significantly with AD severity, while skin biopsy data did not show significant correlations. Sampling the stratum corneum with non-invasive tape strips may be useful for identifying biomarkers associated with disease severity, food allergy, and filaggrin mutations.
Article
Dermatology
Hila Emmert, Hansjoerg Baurecht, Frederieke Thielking, Dora Stoelzl, Elke Rodriguez, Inken Harder, Ehrhardt Proksch, Stephan Weidinger
Summary: This study revealed significant differences in lipid composition between body sites and between AD patients and healthy individuals, as well as correlations between skin microbiome and skin lipid alterations in AD.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Medicine, General & Internal
Michael Constantin Kirchberger, Michael Gfesser, Michael Erdmann, Stefan Schliep, Carola Berking, Markus Vincent Heppt
Summary: The study found that tirbanibulin 1% ointment significantly and rapidly reduced the AKASI score in a real-world setting, achieving similar clearance rates as observed in the pivotal trials.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Allergy
Jessica W. Hui-Beckman, Elena Goleva, Evgeny Berdyshev, Donald Y. M. Leung
Summary: Atopic dermatitis (AD) and food allergy (FA) are closely related and one-third of AD children develop concomitant FA. Epithelial barrier dysfunction is important in both diseases. Genetic factors such as filaggrin mutations and IL-4 receptor alpha chain polymorphisms are associated with increased risk. In addition, several environmental exposures lead to reduced filaggrin and contribute to skin barrier dysfunction. Staphylococcus aureus colonization appears to contribute to AD and FA as well as activating the type 2 immune response. Comprehensive multiomic studies have identified distinct atopic endotypes with unique characteristics, providing an opportunity for improved diagnosis and prevention of atopy.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Allergy
Tammy Gonzalez, Mariana L. Stevens, Asel Baatyrbek Kyzy, Rosario Alarcon, Hua He, John W. Kroner, Daniel Spagna, Brittany Grashel, Elaine Sidler, Lisa J. Martin, Jocelyn M. Biagini Myers, Gurjit K. Khurana Hershey, Andrew B. Herr
Summary: In the first US early-life cohort of children with atopic dermatitis, the presence of staphylococcal biofilms on skin lesions was found to be associated with increased disease severity, suggesting a pathogenic role forS aureus biofilms in atopic dermatitis development. Additionally, the balance between S epidermidis and S aureus, as well as their biofilm propensity, may have important implications for atopic dermatitis.
Article
Allergy
Maria Rasmussen Rinnov, Anne-Sofie Halling, Trine Gerner, Nina Haarup Ravn, Mette Hjorslev Knudgaard, Simon Trautner, Susan M. Goorden, Karen J. M. Ghauharali-van der Vlugt, Femke S. Stet, Lone Skov, Simon Francis Thomsen, Alexander Egeberg, Aske L. L. Rosted, Troels Petersen, Ivone Jakasa, Christoph Riethmuller, Sanja Kezic, Jacob P. Thyssen
Summary: This study found that levels and chain length of certain lipids were altered in infants who later developed AD, and that TARC/CCL17 levels were higher in these infants.
Article
Cardiac & Cardiovascular Systems
Flemming Javier Olsen, Caroline Lokke Bjerregaard, Kristoffer Grundtvig Skaarup, Mats Christian Hojbjerg Lassen, Niklas Dyrby Johansen, Daniel Modin, Gorm Boje Jensen, Peter Schnohr, Peter Sogaard, Gunnar Gislason, Jesper Hastrup Svendsen, Rasmus Mogelvang, Tor Biering-Sorensen
Summary: Different event timing modalities have an impact on myocardial work indices, with visual assessment yielding lower global work index (GWI) values compared with Doppler-based methods.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Sidsel Marie Bernt Jorgensen, Thomas Alexander Gerds, Nina Fons Johnsen, Gunnar Gislason, Mohamad El-Chouli, Stig Brondum, Thomas Maribo, Maria Kristiansen
Summary: Returning to work and maintaining employment after cardiovascular disease is crucial for working-age individuals. Individuals with heart failure have the highest probability of not returning to work, highlighting the need for effective vocational rehabilitation strategies in comprehensive cardiac rehabilitation programs.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Substance Abuse
Alan Manivannan, Morten Schou, Kevin M. Monahan, Robert Helm, Darae Ko, Emil Fosbol, Lars Kober, Finn Gustafsson, Gunnar H. Gislason, Christian Torp-Pedersen, Charlotte Andersson
Summary: Alcoholic cardiomyopathy (ACM) is associated with poor outcomes, but the high mortality is not driven by atrial fibrillation. Oral anticoagulation in ACM has similar stroke and bleeding risks as in dilated cardiomyopathy.
ALCOHOL AND ALCOHOLISM
(2023)
Article
Allergy
Malin Glindvad Ahlstrom, Lone Skov, Steffen Heegaard, Claus Zachariae, Lene Heise Garvey, Jeanne Duus Johansen
Summary: A retrospective study in a Danish tertiary dermatology department found that allergic contact dermatitis (ACD) in the eye region caused by topical eye medications is difficult to diagnose and may be overlooked. The study identified phenylephrine, timolol, and ketotifen as the main culprits of contact allergy to topical eye allergens/medications. Patients often had previous diagnoses of cataract or glaucoma and reported multiple previous reactions, with symptoms including edema, erythema, and dermatitis in the eye region.
CONTACT DERMATITIS
(2023)
Article
Cardiac & Cardiovascular Systems
Betul Toprak, Stephanie Brandt, Jan Brederecke, Francesco Gianfagna, Julie K. K. Vishram-Nielsen, Francisco M. Ojeda, Simona Costanzo, Christin S. Borschel, Stefan Soderberg, Ioannis Katsoularis, Stephan Camen, Erkki Vartiainen, Maria Benedetta Donati, Jukka Kontto, Martin Bobak, Ellisiv B. Mathiesen, Allan Linneberg, Wolfgang Koenig, Maja-Lisa Lochen, Augusto Di Castelnuovo, Stefan Blankenberg, Giovanni de Gaetano, Kari Kuulasmaa, Veikko Salomaa, Licia Iacoviello, Teemu Niiranen, Tanja Zeller, Renate B. Schnabel
Summary: The study aims to find reliable circulating predictors for incident atrial fibrillation (AF) using classical regressions and machine learning techniques. Fourteen routinely available biomarkers reflecting different pathophysiological pathways were examined in relation to incident AF. NT-proBNP was identified as the strongest blood-based predictor of incident AF.
Article
Cardiac & Cardiovascular Systems
Hanna Ratcovich, Golnaz Sadjadieh, Jesper J. Linde, Francis R. Joshi, Henning Kelbaek, Klaus F. Kofoed, Lars Kober, Peter Riis Hansen, Christian Torp-Pedersen, Hanne Elming, Gunnar Hilmar Gislason, Dan Eik Hofsten, Thomas Engstrom, Lene Holmvang
Summary: This study investigated the diagnostic accuracy of cCTA and the impact of early ICA on long-term clinical outcomes in elderly patients with NSTEACS. The study found that cCTA had a high accuracy in ruling out significant CAD in patients aged ≥75 years, but early ICA did not significantly improve long-term clinical outcomes.
Article
Cardiac & Cardiovascular Systems
Hannah K. Wood-Kurland, Matthew Phelps, Jens Jakob Thune, Berit Philbert, Charlotte Ellen Larroude, Morten Schou, Morten Lock Hansen, Gunnar H. Gislason, Casper N. Bang
Summary: This study aimed to determine the impact of two nationwide lockdowns in Denmark on the implantation rate of cardiac implantable electronic devices (CIEDs). The study found that there were modest changes in CIED implantations during the lockdowns, with a decrease of 15.5% during the first lockdown and 5.1% during the second lockdown.
HEART LUNG AND CIRCULATION
(2023)
Article
Allergy
Anne-Sofie Halling, Maria Rasmussen Rinnov, Iben Frier Ruge, Trine Gerner, Nina Haarup Ravn, Mette Hjorslev Knudgaard, Simon Trautner, Nikolai Loft, Lone Skov, Simon F. Thomsen, Alexander Egeberg, Emma Guttman-Yassky, Aske L. L. Rosted, Troels Petersen, Ivone Jakasa, Sanja Kezic, Jacob P. Thyssen
Summary: This study aimed to investigate whether skin biomarkers collected in infancy can predict the onset of atopic dermatitis (AD) and be used in future prevention trials. The results showed that skin biomarkers collected at birth did not predict the onset of AD. However, elevated levels of certain immune and barrier biomarkers collected at 2 months of age increased the risk of AD.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Dermatology
Julie B. K. Solberg, Anna S. Quaade, Lylia Drici, Karolina Sulek, Nina H. Ulrich, Marianne B. Lovendorf, Jacob P. Thyssen, Matthias Mann, Beatrice Dyring-Andersen, Jeanne D. Johansen
Summary: The noninvasive tape strip method in combination with liquid chromatography-mass spectrometry proteomics can be used to analyze skin protein expression in patients with hand eczema (HE), and has potential for subtype differentiation and biomarker discovery. HE lesional samples exhibit increased expression of immune-related markers and decreased expression of structural barrier proteins compared to healthy skin. The subtype differences in HE are restricted to the lesional areas and include increased expression of skin barrier-related proteins independently of concurrent atopic dermatitis.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Dermatology
David Thein, Nana A. L. Roseno, Julia-Tatjana Maul, Jashin J. Wu, Lone Skov, Lars Erik Bryld, Mads K. Rasmussen, Kawa Khaled Ajgeiy, Simon Francis Thomsen, Jacob P. Thyssen, Alexander Egeberg
Summary: The real-world effectiveness of biologics in treating psoriasis was examined using a nationwide registry. The results showed that the risk of discontinuation or off-label dose escalation was lower for secukinumab compared to ustekinumab, but higher for adalimumab. However, the risk of discontinuation was higher for both secukinumab and adalimumab. For patients who were bio-naive, the risk of discontinuation was comparable between secukinumab and ustekinumab.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Health Care Sciences & Services
Mette Gyldenlove, Howraman Meteran, Jennifer A. Sorensen, Simon Fage, Yiqiu Yao, Jesper Lindhardsen, Christoffer V. Nissen, Tanja Todberg, Simon F. Thomsen, Lone Skov, Claus Zachariae, Lars Iversen, Mia -Louise Nielsen, Alexander Egeberg
Summary: This study demonstrates the efficacy and safety of oral roflumilast in treating moderate-to-severe psoriasis, suggesting that it may serve as a cost-effective and convenient alternative treatment option.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Dermatology
Maria Rasmussen Rinnov, Trine Gerner, Anne-Sofie Halling, Mie Sylow Liljendahl, Nina Haarup Ravn, Mette Hjorslev Knudgaard, Simon Trautner, Lone Skov, Simon Francis Thomsen, Alexander Egeberg, Ivone Jakasa, Sanja Kezic, Andreas Petersen, Anders Rhod Larsen, Casper Dam-Nielsen, Jens Otto Jarlov, Jacob P. Thyssen
Summary: This study found that colonization of Staphylococcus aureus was more common at 2 months of age in children who later developed atopic dermatitis (AD). However, there was no association between S. aureus colonization and the severity or age at onset of AD.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Daniel Molager Christensen, Jarl Emanuel Strange, Mohamad El-Chouli, Alexander Christian Falkentoft, Morten Malmborg, Nina Nouhravesh, Gunnar Gislason, Morten Schou, Christian Torp-Pedersen, Thomas S. G. Sehested
Summary: The study found that noncardiovascular morbidity and mortality increased among MI patients, highlighting the need for further attention to noncardiovascular outcomes.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Christina Magnussen, Francisco M. Ojeda, Darryl P. Leong, Jesus Alegre-Diaz, Philippe Amouyel, Larissa Aviles-Santa, Dirk De Bacquer, Christie M. Ballantyne, Antonio Bernabe-Ortiz, Martin Bobak, Hermann Brenner, Rodrigo M. Carrillo-Larco, James de Lemos, Annette Dobson, Marcus Dorr, Chiara Donfrancesco, Wojciech Drygas, Robin P. Dullaart, Gunnar Engstrom, Marco M. Ferrario, Jean Ferrieres, Giovanni de Gaetano, Uri Goldbourt, Clicerio Gonzalez, Guido Grassi, Allison M. Hodge, Kristian Hveem, Licia Iacoviello, M. Kamran Ikram, Vilma Irazola, Modou Jobe, Pekka Jousilahti, Pontiano Kaleebu, Maryam Kavousi, Frank Kee, Davood Khalili, Wolfgang Koenig, Anna Kontsevaya, Kari Kuulasmaa, Karl J. Lackner, David M. Leistner, Lars Lind, Allan Linneberg, Thiess Lorenz, Magnus Nakrem Lyngbakken, Reza Malekzadeh, Sofia Malyutina, Ellisiv B. Mathiesen, Olle Melander, Andres Metspalu, J. Jaime Miranda, Marie Moitry, Joseph Mugisha, Mahdi Nalini, Vijay Nambi, Toshiharu Ninomiya, Karen Oppermann, Eleonora d'Orsi, Andrzej Pajak, Luigi Palmieri, Demosthenes Panagiotakos, Arokiasamy Perianayagam, Annette Peters, Hossein Poustchi, Andrew M. Prentice, Eva Prescott, Ulf Riserus, Veikko Salomaa, Susana Sans, Satoko Sakata, Ben Schottker, Aletta E. Schutte, Sadaf G. Sepanlou, Sanjib Kumar Sharma, Jonathan E. Shaw, Leon A. Simons, Stefan Soderberg, Abdonas Tamosiunas, Barbara Thorand, Hugh Tunstall-Pedoe, Raphael Twerenbold, Diego Vanuzzo, Giovanni Veronesi, Julia Waibel, S. Goya Wannamethee, Masafumi Watanabe, Philipp S. Wild, Yao Yao, Yi Zeng, Andreas Ziegler, Stefan Blankenberg
Summary: This study provides evidence that five modifiable risk factors are associated with cardiovascular disease and death, and their prevalence varies by geographic region and sex.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
