Role of impulsivity and reward in the anti-obesity actions of 5-HT2C receptor agonists

The 5-HT2C receptor agonist meta-chlorophenylpiperazine (mCPP) reduces palatable food consumption and BOLD fMRI responses to food images in healthy female volunteers

(2017) Jason M. Thomas et al.   PSYCHOPHARMACOLOGY

Choice between delayed food and immediate opioids in rats: treatment effects and individual differences

(2017) Leigh V. Panlilio et al.   PSYCHOPHARMACOLOGY

Effects of 5-HT1A, 5-HT2A and 5-HT2C receptor agonists and antagonists on responding for a conditioned reinforcer and its enhancement by methylphenidate

(2017) Paul J. Fletcher et al.   PSYCHOPHARMACOLOGY

Lorcaserin Administration Decreases Activation of Brain Centers in Response to Food Cues and These Emotion- and Salience-Related Changes Correlate With Weight Loss Effects: A 4-Week-Long Randomized, Placebo-Controlled, Double-Blind Clinical Trial

(2016) Olivia M. Farr et al.   DIABETES

The 5-HT 2C receptor agonist lorcaserin reduces cocaine self-administration, reinstatement of cocaine-seeking and cocaine induced locomotor activity

(2016) Colin Harvey-Lewis et al.   NEUROPHARMACOLOGY

Activation of Ventral Tegmental Area 5-HT2C Receptors Reduces Incentive Motivation

(2016) Lourdes Valencia-Torres et al.   NEUROPSYCHOPHARMACOLOGY

Repeated 7-Day Treatment with the 5-HT2C Agonist Lorcaserin or the 5-HT2A Antagonist Pimavanserin Alone or in Combination Fails to Reduce Cocaine vs Food Choice in Male Rhesus Monkeys

(2016) Matthew L Banks et al.   NEUROPSYCHOPHARMACOLOGY

Effects of lorcaserin on pre-existing valvulopathy: A pooled analysis of phase 3 trials

(2016) Neil J. Weissman et al.   Obesity

Lorcaserin and CP-809101 reduce motor impulsivity and reinstatement of food seeking behavior in male rats: Implications for understanding the anti-obesity property of 5-HT2C receptor agonists

(2016) Guy A. Higgins et al.   PSYCHOPHARMACOLOGY

The Serotonin 2C Receptor Agonist Lorcaserin Attenuates Intracranial Self-Stimulation and Blocks the Reward-Enhancing Effects of Nicotine

(2015) Fiona D. Zeeb et al.   ACS Chemical Neuroscience

Therapeutic Potential of 5-HT2C Receptor Agonists for Addictive Disorders

(2015) Guy A. Higgins et al.   ACS Chemical Neuroscience

Satiation attenuates BOLD activity in brain regions involved in reward and increases activity in dorsolateral prefrontal cortex: an fMRI study in healthy volunteers

(2015) Jason M Thomas et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Lorcaserin Hcl for the treatment of obesity

(2015) Alpana P Shukla et al.   EXPERT OPINION ON PHARMACOTHERAPY

5-Hydroxytryptamine Medications for the Treatment of Obesity

(2015) L. K. Burke et al.   JOURNAL OF NEUROENDOCRINOLOGY

Effects of lisdexamfetamine in a rat model of binge-eating

(2015) Steven P Vickers et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Serotonin-2C and -2a receptor co-expression on cells in the rat medial prefrontal cortex

(2015) C. Nocjar et al.   NEUROSCIENCE

The 5-HT2C receptor agonist, lorcaserin, and the 5-HT6 receptor antagonist, SB-742457, promote satiety; a microstructural analysis of feeding behaviour

(2015) Suzanne Higgs et al.   PSYCHOPHARMACOLOGY

Attenuation of cocaine-induced reinstatement of drug seeking in squirrel monkeys by direct and indirect activation of 5-HT2C receptors

(2015) Daniela Rüedi-Bettschen et al.   PSYCHOPHARMACOLOGY

Neuroimaging and neuromodulation approaches to study eating behavior and prevent and treat eating disorders and obesity

(2015) D. Val-Laillet et al.   NeuroImage-Clinical

Update on obesity pharmacotherapy

(2014) George A. Bray et al.   Annals of the New York Academy of Sciences

Examination of the effects of varenicline, bupropion, lorcaserin, or naltrexone on responding for conditioned reinforcement in nicotine-exposed rats

(2014) Elizabeth G. Guy et al.   BEHAVIOURAL PHARMACOLOGY

High Trait Impulsivity Predicts Food Addiction-Like Behavior in the Rat

(2014) Clara Velázquez-Sánchez et al.   NEUROPSYCHOPHARMACOLOGY

Early weight loss while on lorcaserin, diet and exercise as a predictor of week 52 weight-loss outcomes

(2014) Steven R. Smith et al.   Obesity

Beyond BMI - Phenotyping the Obesities

(2014) John E. Blundell et al.   Obesity Facts

Responding for a conditioned reinforcer, and its enhancement by nicotine, is blocked by dopamine receptor antagonists and a 5-HT 2C receptor agonist but not by a 5-HT 2A receptor antagonist

(2014) Elizabeth Glenn Guy et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Lorcaserin, a selective 5-HT 2C receptor agonist, decreases alcohol intake in female alcohol preferring rats

(2014) Amir H. Rezvani et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Safety and Efficacy of Lorcaserin: A Combined Analysis of the BLOOM and BLOSSOM Trials

(2014) Louis Aronne et al.   POSTGRADUATE MEDICINE

Evidence for a role of 5-HT2C receptors in the motor aspects of performance, but not the efficacy of food reinforcers, in a progressive ratio schedule

(2014) G. Bezzina et al.   PSYCHOPHARMACOLOGY

The Prevalence and Correlates of Binge Eating Disorder in the World Health Organization World Mental Health Surveys

(2013) Ronald C. Kessler et al.   BIOLOGICAL PSYCHIATRY

Parallel, Redundant Circuit Organization for Homeostatic Control of Feeding Behavior

(2013) J. Nicholas Betley et al.   CELL

The role of impulsivity in relapse vulnerability

(2013) Tommy Pattij et al.   CURRENT OPINION IN NEUROBIOLOGY

Central nervous system biomarkers for antiobesity drug development

(2013) Hisham Ziauddeen et al.   DRUG DISCOVERY TODAY

The Merits of Subtyping Obesity

(2013) Alison E. Field et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The use of the reinstatement model to study relapse to palatable food seeking during dieting

(2013) Donna J. Calu et al.   NEUROPHARMACOLOGY

Food-related impulsivity in obesity and Binge Eating Disorder - a systematic review

(2013) K. Schag et al.   Obesity Reviews

Impulsivity in Binge Eating Disorder: Food Cues Elicit Increased Reward Responses and Disinhibition

(2013) Kathrin Schag et al.   PLoS One

The reinstatement model of drug relapse: recent neurobiological findings, emerging research topics, and translational research

(2013) Jennifer M. Bossert et al.   PSYCHOPHARMACOLOGY

From obesity to substance abuse: therapeutic opportunities for 5-HT2C receptor agonists

(2013) Guy A. Higgins et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Serotonin (2C) receptor regulation of cocaine-induced conditioned place preference and locomotor sensitization

(2012) Caryne P. Craige et al.   BEHAVIOURAL BRAIN RESEARCH

Neural and Behavioral Effects of a Novel Mu Opioid Receptor Antagonist in Binge-Eating Obese People

(2012) Victoria C. Cambridge et al.   BIOLOGICAL PSYCHIATRY

The Neurobiological Underpinnings of Obesity and Binge Eating: A Rationale for Adopting the Food Addiction Model

(2012) Dana G. Smith et al.   BIOLOGICAL PSYCHIATRY

Current pharmacotherapy options for bulimia nervosa and binge eating disorder

(2012) Susan L McElroy et al.   EXPERT OPINION ON PHARMACOTHERAPY

Effects of the mu-opioid receptor antagonist GSK1521498 on hedonic and consummatory eating behaviour: a proof of mechanism study in binge-eating obese subjects

(2012) H Ziauddeen et al.   MOLECULAR PSYCHIATRY

Reward circuit function in high BMI individuals with compulsive overeating: Similarities with addiction

(2012) Francesca M. Filbey et al.   NEUROIMAGE

Animal models to explore the effects of CNS drugs on food intake and energy expenditure

(2012) Steven P. Vickers et al.   NEUROPHARMACOLOGY

What is the prognosis for new centrally-acting anti-obesity drugs?

(2012) David J. Heal et al.   NEUROPHARMACOLOGY

Effects of the 5-HT2C receptor agonist Ro60-0175 and the 5-HT2A receptor antagonist M100907 on nicotine self-administration and reinstatement

(2012) Paul J. Fletcher et al.   NEUROPHARMACOLOGY

The FDA's Assessment of Two Drugs for Chronic Weight Management

(2012) Eric Colman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Randomized Placebo-Controlled Clinical Trial of Lorcaserin for Weight Loss in Type 2 Diabetes Mellitus: The BLOOM-DM Study

(2012) Patrick M. O'Neil et al.   Obesity

Evaluation of chemically diverse 5-HT2C receptor agonists on behaviours motivated by food and nicotine and on side effect profiles

(2012) G. A. Higgins et al.   PSYCHOPHARMACOLOGY

A theory of behaviour on progressive ratio schedules, with applications in behavioural pharmacology

(2012) C. M. Bradshaw et al.   PSYCHOPHARMACOLOGY

Neural Correlates of Food Addiction

(2011) Ashley N. Gearhardt   ARCHIVES OF GENERAL PSYCHIATRY

Evaluation of the Abuse Potential of Lorcaserin, a Serotonin 2C (5-HT2C) Receptor Agonist, in Recreational Polydrug Users

(2011) M J Shram et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

New Drug Targets for the Treatment of Obesity

(2011) A G Powell et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

A One-Year Randomized Trial of Lorcaserin for Weight Loss in Obese and Overweight Adults: The BLOSSOM Trial

(2011) Meredith C. Fidler et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Lorcaserin, a 5-HT2C Agonist, Decreases Nicotine Self-Administration in Female Rats

(2011) E. D. Levin et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Impulsivity, Compulsivity, and Top-Down Cognitive Control

(2011) Jeffrey W. Dalley et al.   NEURON

Impulsive action induced by amphetamine, cocaine and MK801 is reduced by 5-HT2C receptor stimulation and 5-HT2A receptor blockade

(2011) Paul J. Fletcher et al.   NEUROPHARMACOLOGY

Selective serotonin 5-HT2C receptor activation suppresses the reinforcing efficacy of cocaine and sucrose but differentially affects the incentive-salience value of cocaine- vs. sucrose-associated cues

(2011) Kathryn A. Cunningham et al.   NEUROPHARMACOLOGY

The 5-HT2C Receptor Agonist Lorcaserin Reduces Nicotine Self-Administration, Discrimination and Reinstatement: Relationship to Feeding Behavior and Impulse Control

(2011) Guy A Higgins et al.   NEUROPSYCHOPHARMACOLOGY

Serotonin receptors and heart valve disease—It was meant 2B

(2011) Joshua D. Hutcheson et al.   PHARMACOLOGY & THERAPEUTICS

Feeding and reward: Perspectives from three rat models of binge eating

(2011) Rebecca L. Corwin et al.   PHYSIOLOGY & BEHAVIOR

5-HT2C Receptors Localize to Dopamine and GABA Neurons in the Rat Mesoaccumbens Pathway

(2011) Marcy J. Bubar et al.   PLoS One

The study of food addiction using animal models of binge eating

(2010) Nicole M. Avena   APPETITE

5-HT2C receptor modulators: a patent survey

(2010) Junwon Lee et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Lorcaserin, A 5-HT2CReceptor Agonist, Reduces Body Weight by Decreasing Energy Intake without Influencing Energy Expenditure

(2010) Corby K. Martin et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The role of nucleus accumbens shell GABA receptors on ventral tegmental area intracranial self-stimulation and a potential role for the 5-HT2C receptor

(2010) Dave J Hayes et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Pharmacological management of appetite expression in obesity

(2010) Jason C. G. Halford et al.   Nature Reviews Endocrinology

Body mass correlates inversely with inhibitory control in response to food among adolescent girls: An fMRI study

(2010) Laura Batterink et al.   NEUROIMAGE

Stimulation of Medial Prefrontal Cortex Serotonin 2C (5-HT2C) Receptors Attenuates Cocaine-Seeking Behavior

(2010) Nathan S Pentkowski et al.   NEUROPSYCHOPHARMACOLOGY

Multicenter, Placebo-Controlled Trial of Lorcaserin for Weight Management

(2010) Steven R. Smith et al.   NEW ENGLAND JOURNAL OF MEDICINE

Obesity and the four facets of impulsivity

(2010) Olivia Mobbs et al.   PATIENT EDUCATION AND COUNSELING

Genetic and pharmacological evidence that 5-HT2C receptor activation, but not inhibition, affects motivation to feed under a progressive ratio schedule of reinforcement

(2010) Paul J. Fletcher et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

New approaches to the pharmacological treatment of obesity: Can they break through the efficacy barrier?

(2010) G.A. Kennett et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Behavioural satiety sequence (BSS): Separating wheat from chaff in the behavioural pharmacology of appetite

(2010) R.J. Rodgers et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Role of serotonin 5-HT2A and 5-HT2C receptors on brain stimulation reward and the reward-facilitating effect of cocaine

(2010) Vicky Katsidoni et al.   PSYCHOPHARMACOLOGY

The neuropharmacology of relapse to food seeking: Methodology, main findings, and comparison with relapse to drug seeking

(2009) Sunila G. Nair et al.   PROGRESS IN NEUROBIOLOGY

Should Binge Eating Disorder Be Included in the DSM-V? A Critical Review of the State of the Evidence

(2008) Ruth H. Striegel-Moore et al.   Annual Review of Clinical Psychology

Differential effects of 5-HT2C receptor activation by WAY 161503 on nicotine-induced place conditioning and locomotor activity in rats

(2008) Dave J. Hayes et al.   BEHAVIOURAL BRAIN RESEARCH

Lorcaserin, a Novel Selective Human 5-Hydroxytryptamine2C Agonist: in Vitro and in Vivo Pharmacological Characterization

(2008) W. J. Thomsen et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

5-HT2CRs Expressed by Pro-Opiomelanocortin Neurons Regulate Energy Homeostasis

(2008) Yong Xu et al.   NEURON

Lorcaserin (APD356), a Selective 5-HT2CAgonist, Reduces Body Weight in Obese Men and Women

(2008) Steven R. Smith et al.   Obesity

Effect of (−)-trans-PAT, a novel 5-HT2C receptor agonist, on intake of palatable food in mice

(2008) N ROWLAND et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Effects of systemic and intra-nucleus accumbens 5-HT2C receptor compounds on ventral tegmental area self-stimulation thresholds in rats

(2008) Dave J. Hayes et al.   PSYCHOPHARMACOLOGY

The role of impulsive behavior in drug abuse

(2008) Jennifer L. Perry et al.   PSYCHOPHARMACOLOGY

Brain circuits regulating energy homeostasis

(2008) Alfonso Abizaid et al.   REGULATORY PEPTIDES

The neuropharmacology of impulsive behaviour

(2008) T PATTIJ et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The 5-HT2C receptor agonist WAY-163909 decreases impulsivity in the 5-choice serial reaction time test

(2007) R NAVARRA   BEHAVIOURAL BRAIN RESEARCH

Impulsive Choice and Impulsive Action Predict Vulnerability to Distinct Stages of Nicotine Seeking in Rats

(2007) Leontien Diergaarde et al.   BIOLOGICAL PSYCHIATRY

Discovery and Structure−Activity Relationship of (1R)-8-Chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a Selective Serotonin 5-HT2CReceptor Agonist for the Treatment of Obesity

(2007) Brian M. Smith et al.   JOURNAL OF MEDICINAL CHEMISTRY