Article
Microbiology
Eun-Ji Song, Na Rae Shin, Songhee Jeon, Young-Do Nam, Hojun Kim
Summary: This study aimed to explore the effects of lorcaserin (LS) and phentermine (PT) on obesity and gut microbiota. The results showed that LS and PT can modulate the composition of gut microbiota and restore gut microbial dysbiosis, which is strongly correlated with obesity-related markers. Additionally, LS and PT increased the mRNA level of G protein-coupled receptor 120 (GPR120) and correlated with obesity-related markers.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Kyungha Min, Bumjo Oh, Hye Yeon Koo, Yang-Hyun Kim, Ji-Won Lee, Sangsub Lee, Youngah Kim, Hyuktae Kwon
Summary: Glaceum Inc. plans to conduct a randomized, double-blind, placebo-controlled clinical trial to evaluate the safety and efficacy of HSG4112 in overweight and obese patients.
FRONTIERS IN PHARMACOLOGY
(2023)
Editorial Material
Multidisciplinary Sciences
McKenzie Prillaman
Summary: Drugs that suppress appetite have demonstrated remarkable results in trials and real-world use. However, it remains uncertain whether they can assist all individuals with obesity and address weight stigma.
Review
Polymer Science
Balzhima Shagdarova, Mariya Konovalova, Valery Varlamov, Elena Svirshchevskaya
Summary: The number of obese people in the world is increasing, leading to a higher prevalence of type 2 diabetes and other metabolic disorders. The use of chitosan and its derivatives, such as short-chain oligosaccharides (COS), has shown potential for treating obesity and its associated conditions. Chitosan can improve gut microbiota, restore intestinal barrier dysfunction, and regulate thermogenesis and lipid metabolism. However, its effects are mild and mostly independent of its physical characteristics. The anti-obesity effect of chitosan may be due to its ability to collect food remnants in the gastrointestinal tract.
Review
Medicine, Research & Experimental
Julien Gouju, Samuel Legeay
Summary: Obesity is a pathological condition defined by a body mass index greater than 30 kg/m2, characterized by the accumulation of adipose tissue and leading to significant weight gain. It is associated with comorbidities such as cardiovascular disease, type 2 diabetes, and cancer, making it the fifth leading cause of death worldwide. Obesity affects the pharmacokinetics of drugs, particularly in terms of absorption and distribution, and may require dosage adjustments. Understanding these necessary adjustments is essential for the therapeutic management of obese patients.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Kyeong-dae Kim, Jeong Min Choe, Soomin Myoung, Seung Hyun Lee, Minkyu Kim, Jae-Hoon Choi, Hyun Tae Park
Summary: This study aimed to investigate the cellular and molecular changes in ATM in ovariectomized obese mice. The results showed that E2 treatment can decrease M1-like ATMs and increase M2-like ATMs, along with upregulation of anti-inflammatory genes and downregulation of pro-inflammatory genes. Additionally, E2 treatment induced M2-like phenotype in human macrophages.
ANIMAL CELLS AND SYSTEMS
(2022)
Article
Multidisciplinary Sciences
Ali Abdelati, Michele M. Burns, Michael Chary
Summary: Fatigue, increased body temperature, and paresthesias from DNP are reported more frequently at doses greater than 150 mg each day than at doses less than 150 mg each day. Online discussions of DNP frequently mention androgenic anabolic steroids and other weight loss agents.
Review
Food Science & Technology
Haitao Jiang, Wanli Zhang, Xiangxin Li, Yan Xu, Jiankang Cao, Weibo Jiang
Summary: This article summarizes the main strategies for managing obesity and discusses the potential of berry fruits in combating obesity. It also explores the bioaccessibility of phenolic compounds in berry fruits and highlights the challenges that need to be addressed in the future.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Chemistry, Analytical
Jinpeng Liu, Mashooq Khan, Yong Wei, Anna Liu, Tao Wang, Qiongzheng Hu, Li Yu
Summary: A robust and versatile sensing platform based on liquid crystal-infused porous surfaces (LCIPS) is developed for high-throughput screening of lipase inhibitors. The sliding time of droplets on LCIPS is found to be extended due to the adsorption of oleate at the solution/liquid crystal (LC) interface. However, the presence of lipase inhibitors inhibits the enzymatic hydrolysis of glycerol trioleate (GT), resulting in a shortened sliding time. The study demonstrates the screening of three popular anti-obesity drugs, orlistat, cetilistat, and epigallocatechin gallate (EGCG), with respective IC50 values of 17.45 +/- 3.15 nM, 72.15 +/- 6.32 nM, and 2.19 +/- 0.24 mu M. This research provides a simple, inexpensive, portable, user-friendly, and instrument-free method for rapid, accurate, and high-throughput screening of lipase inhibitors. The LCIPS-based sensing platform shows great potential in developing advanced bioanalytical sensors.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Review
Pharmacology & Pharmacy
Hiroaki Ueno, Weidong Zhang, Masamitsu Nakazato
Summary: Obesity and obesity-related diseases are global pandemics. Peptide chemistry and molecular biology have identified peptides that regulate appetite and energy metabolism. Peptide-related drugs have powerful anti-obesity effects with fewer adverse effects. Liraglutide and other candidates have been developed as anti-obesity drugs, and hybrid peptides have been designed to enhance appetite suppression.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Pharmacology & Pharmacy
Jing Li, Hongli Duan, Yan Liu, Lu Wang, Xing Zhou
Summary: Obesity is a global public health issue, and there is an urgent need for alternative treatment strategies. Only a handful of drugs are currently approved for clinical obesity treatment. Biomaterials have promising applications in obesity treatment.
Article
Chemistry, Medicinal
Nicola Gambacorta, Fulvio Ciriaco, Nicola Amoroso, Cosimo Damiano Altomare, Ju''rgen Bajorath, Orazio Nicolotti
Summary: In this study, a CIRCE compound prediction platform was developed based on explainable machine learning to support the design of selective CB1R and CB2R ligands. The platform achieved about 80% accuracy in test calculations and provided rationalized explanations for the predictions. CIRCE is freely available as a web-based prediction platform.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Review
Food Science & Technology
Anne Karoline de Souza Oliveira, Ana Mara de Oliveira e Silva, Raquel Oliveira Pereira, Andreza Santana Santos, Erivan Vieira Barbosa Junior, Mikaella Tuanny Bezerra, Rosana S. S. Barreto, Lucindo J. Quintans-Junior, Jullyana S. S. Quintans
Summary: Flavonoids, a group of natural substances, have shown promising anti-obesity effects by modulating various biological activities that decrease lipogenesis, increase lipolysis, expend energy, stimulate fatty acids B-oxidation, as well as digestion and metabolism of carbohydrates. Additionally, flavonoids can mitigate inflammatory responses and suppress oxidative stress, making them potential compounds for treating obesity and its associated comorbidities.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Zhiguo Li, Xuexun Fang, Dahai Yu
Summary: Transdermal drug delivery (TDD) has emerged as an effective alternative to traditional oral and injection administration, with potential for enhanced anti-obesity drug delivery. Obesity is a global epidemic with significant health threats, requiring more effective drug delivery strategies. Despite most studies being in the animal stage, the application of TDD in anti-obesity drugs could bring safe and effective therapies to obese patients in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Prakash Raj Pandeya, Ramakanta Lamichhane, Gopal Lamichhane, Kyung-Hee Lee, Hyeong Kyu Lee, Su-jin Rhee, Hyun-Ju Jung
Summary: The study developed a multi-herbal formulation, 18KHT01, with synergistic antioxidant, anti-adipogenic, and anti-obesity activities.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Behavioral Sciences
Simon R. O. Nilsson, Johan Alsio, Elizabeth M. Somerville, Peter G. Clifton
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2015)
Editorial Material
Clinical Neurology
Colin T. Dourish, Peter G. Clifton
JOURNAL OF PSYCHOPHARMACOLOGY
(2017)
Review
Clinical Neurology
Peter G. Clifton
JOURNAL OF PSYCHOPHARMACOLOGY
(2017)
Article
Behavioral Sciences
H. V. Morris, S. Nilsson, C. I. Dixon, D. N. Stephens, P. G. Clifton
Article
Behavioral Sciences
Nima Davoodi, Mikhail Kalinichev, Peter G. Clifton
BEHAVIOURAL PHARMACOLOGY
(2008)
Review
Neurosciences
Steven P. Vickers, Peter G. Clifton
Article
Behavioral Sciences
Clare E. Greenhalgh, Janice W. Smith, Peter G. Clifton
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2008)
Editorial Material
Behavioral Sciences
Pete Clifton, Suzanne Higgs, Michelle Lee
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2010)
Article
Behavioral Sciences
K. G. T. Pulman, E. M. Somerville, P. G. Clifton
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2010)
Article
Multidisciplinary Sciences
Kim G. T. Pulman, Elizabeth M. Somerville, Peter G. Clifton
Article
Multidisciplinary Sciences
Simon R. O. Nilsson, Elizabeth M. Somerville, Peter G. Clifton
Article
Neurosciences
Nima Davoodi, Mikhail Kalinichev, Sergei A. Korneev, Peter G. Clifton
PSYCHOPHARMACOLOGY
(2009)
Article
Neurosciences
S. R. O. Nilsson, T. L. Ripley, E. M. Somerville, P. G. Clifton
PSYCHOPHARMACOLOGY
(2012)
Article
Cell Biology
Ligang Zhou, Gregory M. Sutton, Justin J. Rochford, Robert K. Semple, Daniel D. Lam, Laura J. Oksanen, Zoe D. Thornton-Jones, Peter G. Clifton, Chen-Yu Yueh, Mark L. Evans, Rory J. McCrimmon, Joel K. Elmquist, Andrew A. Butler, Lora K. Heisler
Article
Behavioral Sciences
Amine Bahi
Summary: Gestational environmental enrichment (EE) has protective effects on social stress-induced anxiety-like behaviors and excessive ethanol consumption through increasing BDNF levels.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Sarabesh Natarajan, Grant Abass, Lucas Kim, Corinne Wells, Amir H. Rezvani, Edward D. Levin
Summary: Multiple neural systems, including dopamine D1 receptors and glutamate NMDA receptors, are involved in nicotine reinforcement. Acute blockade of D1 receptors decreases nicotine self-administration, while acute blockade of NMDA receptors increases it. Chronic blockade of NMDA receptors decreases nicotine self-administration. Memantine attenuates the decrease in nicotine self-administration caused by chronic D1 antagonist SCH-23390.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
David R. Maguire
Summary: The study found that Lorcaserin alone reduces ventilation and enhances the ventilatory-depressant effects of opioids. This suggests that combining a 5-HT2C receptor agonist with opioids may increase the risk of ventilatory depression without reducing abuse.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Fen Liu, Qing Tian, Hui-Ling Tang, Xiang Cheng, Wei Zou, Ping Zhang
Summary: This study demonstrates the attenuating effect of H2S on PD-associated depression by improving hippocampal synaptic plasticity.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Mehrsa Rahimi-Danesh, Mohammad-Ali Samizadeh, Amir-Ehsan Sajadi, Tara Rezvankhah, Salar Vaseghi
Summary: This study investigated the effects of lithium on freezing behavior and pain perception in a fear-conditioning model in rats. The results showed that lithium had no effect on freezing behavior and pain subthreshold in all rats. Extinction training decreased freezing behavior, with more efficacy in females. Gender differences were also observed in the effects of extinction training.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)