Melatonin delays photoreceptor degeneration in a mouse model of autosomal recessive retinitis pigmentosa

Microglial phagocytosis and activation underlying photoreceptor degeneration is regulated by CX3CL1-CX3CR1 signaling in a mouse model of retinitis pigmentosa

(2016) Matthew K. Zabel et al.   GLIA

Neuroprotective effect of melatonin in experimental optic neuritis in rats

(2016) Marcos L. Aranda et al.   JOURNAL OF PINEAL RESEARCH

Cancer metastasis: Mechanisms of inhibition by melatonin

(2016) Shih-Chi Su et al.   JOURNAL OF PINEAL RESEARCH

Melatonin as an antioxidant: under promises but over delivers

(2016) Russel J. Reiter et al.   JOURNAL OF PINEAL RESEARCH

Safety and durability of effect of contralateral-eye administration of AAV2 gene therapy in patients with childhood-onset blindness caused by RPE65 mutations: a follow-on phase 1 trial

(2016) Jean Bennett et al.   LANCET

Protective Effects of Melatonin on Retinal Inflammation and Oxidative Stress in Experimental Diabetic Retinopathy

(2016) Tingting Jiang et al.   Oxidative Medicine and Cellular Longevity

Activation of the molecular chaperone, sigma 1 receptor, preserves cone function in a murine model of inherited retinal degeneration

(2016) Jing Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glia–neuron interactions in the mammalian retina

(2016) Elena Vecino et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Programmed necrosis in inflammation: Toward identification of the effector molecules

(2016) D. Wallach et al.   SCIENCE

Carnosic acid slows photoreceptor degeneration in the Pde6b rd10 mouse model of retinitis pigmentosa

(2016) Kai Kang et al.   Scientific Reports

Persistent inflammatory state after photoreceptor loss in an animal model of retinal degeneration

(2016) Agustina Noailles et al.   Scientific Reports

The Safety of Melatonin in Humans

(2015) Lars Peter Holst Andersen et al.   CLINICAL DRUG INVESTIGATION

Melatonin Redox Activity. Its Potential Clinical Applications in Neurodegenerative Disorders

(2015) Elzbieta Miller et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Müller glia as an important source of cytokines and inflammatory factors present in the gliotic retina during proliferative vitreoretinopathy

(2015) K. Eastlake et al.   GLIA

Pyroptotic cell death defends against intracellular pathogens

(2015) Ine Jorgensen et al.   IMMUNOLOGICAL REVIEWS

Halting progressive neurodegeneration in advanced retinitis pigmentosa

(2015) Susanne F. Koch et al.   JOURNAL OF CLINICAL INVESTIGATION

Chemokine-mediated inflammation in the degenerating retina is coordinated by Müller cells, activated microglia, and retinal pigment epithelium

(2015) Matt Rutar et al.   Journal of Neuroinflammation

Melatonin and endoplasmic reticulum stress: relation to autophagy and apoptosis

(2015) Anna Fernández et al.   JOURNAL OF PINEAL RESEARCH

Melatonin: an ancient molecule that makes oxygen metabolically tolerable

(2015) Lucien C. Manchester et al.   JOURNAL OF PINEAL RESEARCH

Long-Term Effects of Retinal Gene Therapy in Childhood Blindness

(2015) Alan F. Wright   NEW ENGLAND JOURNAL OF MEDICINE

Long-Term Effect of Gene Therapy on Leber’s Congenital Amaurosis

(2015) James W.B. Bainbridge et al.   NEW ENGLAND JOURNAL OF MEDICINE

Improvement and Decline in Vision with Gene Therapy in Childhood Blindness

(2015) Samuel G. Jacobson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Successful arrest of photoreceptor and vision loss expands the therapeutic window of retinal gene therapy to later stages of disease

(2015) William A. Beltran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retinal microglia: Just bystander or target for therapy?

(2015) Marcus Karlstetter et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Adalimumab Reduces Photoreceptor Cell Death in A Mouse Model of Retinal Degeneration

(2015) Cristina Martínez-Fernández de la Cámara et al.   Scientific Reports

Treatment with melatonin after onset of experimental uveitis attenuates ocular inflammation

(2014) P H Sande et al.   BRITISH JOURNAL OF PHARMACOLOGY

Lysosomal membrane permeabilization and autophagy blockade contribute to photoreceptor cell death in a mouse model of retinitis pigmentosa

(2014) N Rodríguez-Muela et al.   CELL DEATH AND DIFFERENTIATION

Viral-mediated RdCVF and RdCVFL expression protects cone and rod photoreceptors in retinal degeneration

(2014) Leah C. Byrne et al.   JOURNAL OF CLINICAL INVESTIGATION

Suppression of Microglial Activation Is Neuroprotective in a Mouse Model of Human Retinitis Pigmentosa

(2014) B. Peng et al.   JOURNAL OF NEUROSCIENCE

Cellular responses following retinal injuries and therapeutic approaches for neurodegenerative diseases

(2014) Nicolás Cuenca et al.   PROGRESS IN RETINAL AND EYE RESEARCH

The golden era of ocular disease gene discovery: Race to the finish

(2013) A Swaroop et al.   CLINICAL GENETICS

The Human Gene Mutation Database: building a comprehensive mutation repository for clinical and molecular genetics, diagnostic testing and personalized genomic medicine

(2013) Peter D. Stenson et al.   HUMAN GENETICS

Small interfering RNA-mediated suppression of Ccl2 in Müller cells attenuates microglial recruitment and photoreceptor death following retinal degeneration

(2013) Matt Rutar et al.   Journal of Neuroinflammation

Therapeutic efficacy of melatonin in reducing retinal damage in an experimental model of early type 2 diabetes in rats

(2012) Ezequiel M. Salido et al.   JOURNAL OF PINEAL RESEARCH

Neuroprotective effect of melatonin against hypoxia-induced retinal ganglion cell death in neonatal rats

(2012) Charanjit Kaur et al.   JOURNAL OF PINEAL RESEARCH

Laboratory Evidence of Sustained Chronic Inflammatory Reaction in Retinitis Pigmentosa

(2012) Noriko Yoshida et al.   OPHTHALMOLOGY

Clinical Evidence of Sustained Chronic Inflammatory Reaction in Retinitis Pigmentosa

(2012) Noriko Yoshida et al.   OPHTHALMOLOGY

Receptor interacting protein kinase mediates necrotic cone but not rod cell death in a mouse model of inherited degeneration

(2012) Y. Murakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuromodulatory role of melatonin in retinal information processing

(2012) Hai Huang et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Therapeutic benefit of melatonin in experimental feline uveitis

(2011) María José Del Sole et al.   JOURNAL OF PINEAL RESEARCH

Alzheimer’s disease: pathological mechanisms and the beneficial role of melatonin

(2011) Sergio A. Rosales-Corral et al.   JOURNAL OF PINEAL RESEARCH

Reactive glial cells: increased stiffness correlates with increased intermediate filament expression

(2010) Yun-Bi Lu et al.   FASEB JOURNAL

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Melatonin: Action as antioxidant and potential applications in human disease and aging

(2010) Dominique Bonnefont-Rousselot et al.   TOXICOLOGY

Excessive HDAC activation is critical for neurodegeneration in the rd1 mouse

(2010) J Sancho-Pelluz et al.   Cell Death & Disease

Retinitis pigmentosa and allied conditions today: a paradigm of translational research

(2010) Carmen Ayuso et al.   Genome Medicine