R4496C RyR2 mutation impairs atrial and ventricular contractility

Clinical Management of Catecholaminergic Polymorphic Ventricular Tachycardia: The Role of Left Cardiac Sympathetic Denervation

(2015) G. M. De Ferrari et al.   CIRCULATION

Clinical and molecular characterization of a cardiac ryanodine receptor founder mutation causing catecholaminergic polymorphic ventricular tachycardia

(2015) Fernando Wangüemert et al.   HEART RHYTHM

Roles of the NH2-terminal Domains of Cardiac Ryanodine Receptor in Ca2+Release Activation and Termination

(2015) Yingjie Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impact of detubulation on force and kinetics of cardiac muscle contraction

(2014) Cecilia Ferrantini et al.   JOURNAL OF GENERAL PHYSIOLOGY

The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias

(2014) Wenqian Chen et al.   NATURE MEDICINE

The CPVT-associated RyR2 mutation G230C enhances store overloadinduced Ca2+release and destabilizes the N-terminal domains

(2013) Yingjie Liu et al.   BIOCHEMICAL JOURNAL

Ca 2+ /Calmodulin-Dependent Protein Kinase II and Protein Kinase A Differentially Regulate Sarcoplasmic Reticulum Ca 2+ Leak in Human Cardiac Pathology

(2013) Thomas H. Fischer et al.   CIRCULATION

Decreased RyR2 refractoriness determines myocardial synchronization of aberrant Ca2+ release in a genetic model of arrhythmia

(2013) L. Brunello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Paradoxical Effect of Increased Diastolic Ca 2+ Release and Decreased Sinoatrial Node Activity in a Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia

(2012) Patricia Neco et al.   CIRCULATION

Late Sodium Current Inhibition Reverses Electromechanical Dysfunction in Human Hypertrophic Cardiomyopathy

(2012) Raffaele Coppini et al.   CIRCULATION

Shortened Ca 2+ Signaling Refractoriness Underlies Cellular Arrhythmogenesis in a Postinfarction Model of Sudden Cardiac Death

(2012) Andriy E. Belevych et al.   CIRCULATION RESEARCH

In Situ Confocal Imaging in Intact Heart Reveals Stress-Induced Ca 2+ Release Variability in a Murine Catecholaminergic Polymorphic Ventricular Tachycardia Model of Type 2 Ryanodine Receptor R4496C+/− Mutation

(2012) Biyi Chen et al.   Circulation-Arrhythmia and Electrophysiology

Familial Evaluation in Catecholaminergic Polymorphic Ventricular Tachycardia

(2012) Christian van der Werf et al.   Circulation-Arrhythmia and Electrophysiology

Expression of SERCA and phospholamban in rainbow trout (Oncorhynchus mykiss) heart: comparison of atrial and ventricular tissue and effects of thermal acclimation

(2012) H. Korajoki et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

The relationship between arrhythmogenesis and impaired contractility in heart failure: role of altered ryanodine receptor function

(2011) Andriy E. Belevych et al.   CARDIOVASCULAR RESEARCH

Recovery of cardiac calcium release is controlled by sarcoplasmic reticulum refilling and ryanodine receptor sensitivity

(2011) Hena R. Ramay et al.   CARDIOVASCULAR RESEARCH

Therapeutic approach for patients with catecholaminergic polymorphic ventricular tachycardia: state of the art and future developments

(2011) C. van der Werf et al.   EUROPACE

Calsequestrin 2 deletion shortens the refractoriness of Ca2+ release and reduces rate-dependent Ca2+-alternans in intact mouse hearts

(2011) Dmytro Kornyeyev et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Overexpression of CaMKIIδc in RyR2R4496C+/− Knock-In Mice Leads to Altered Intracellular Ca2+ Handling and Increased Mortality

(2011) Nataliya Dybkova et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Flecainide Therapy Reduces Exercise-Induced Ventricular Arrhythmias in Patients With Catecholaminergic Polymorphic Ventricular Tachycardia

(2011) Christian van der Werf et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Na+-dependent SR Ca2+ overload induces arrhythmogenic events in mouse cardiomyocytes with a human CPVT mutation

(2010) Simon Sedej et al.   CARDIOVASCULAR RESEARCH

In the RyR2 R4496C Mouse Model of CPVT, β-Adrenergic Stimulation Induces Ca Waves by Increasing SR Ca Content and Not by Decreasing the Threshold for Ca Waves

(2010) Takeshi Kashimura et al.   CIRCULATION RESEARCH

Accelerated Development of Pressure Overload–Induced Cardiac Hypertrophy and Dysfunction in an RyR2-R176Q Knockin Mouse Model

(2010) Ralph J. van Oort et al.   HYPERTENSION

Ryanodine Receptors: Structure, Expression, Molecular Details, and Function in Calcium Release

(2010) J. T. Lanner et al.   Cold Spring Harbor Perspectives in Biology

Incidence and Risk Factors of Arrhythmic Events in Catecholaminergic Polymorphic Ventricular Tachycardia

(2009) Meiso Hayashi et al.   CIRCULATION

CELLULAR OPEN RESOURCE (COR): current status and future directions

(2009) A. Garny et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Unexpected Structural and Functional Consequences of the R33Q Homozygous Mutation in Cardiac Calsequestrin

(2008) Nicoletta Rizzi et al.   CIRCULATION RESEARCH

Increased Ca 2+ Sensitivity of the Ryanodine Receptor Mutant RyR2 R4496C Underlies Catecholaminergic Polymorphic Ventricular Tachycardia

(2008) María Fernández-Velasco et al.   CIRCULATION RESEARCH

U-waves and T-wave peak to T-wave end intervals in patients with catecholaminergic polymorphic ventricular tachycardia, effects of beta-blockers

(2008) Matti Viitasalo et al.   HEART RHYTHM

What role does modulation of the ryanodine receptor play in cardiac inotropy and arrhythmogenesis?

(2008) D.A. Eisner et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY