Article
Engineering, Chemical
Ulas Baysan, Asli Zungur Bastioglu, Necmiye Oznur Coskun, Dilara Konuk Takma, Eda Ulkeryildiz Balcuk, Hilal Sahin-Nadeem, Mehmet Koc
Summary: This study investigated the effects of coating materials on encapsulated propolis using spray and freeze drying methods. The emulsion properties influenced the physical and chemical properties of the final product, which varied depending on the encapsulation method and coating materials used. The freeze drying method showed higher product yield compared to spray drying, with encapsulation efficiency consistently above 95% in both drying methods, indicating effective encapsulation processes.
Article
Pharmacology & Pharmacy
Jason C. K. Lo, Harry W. Pan, Jenny K. W. Lam
Summary: The study evaluated the conditions and formulation of inhalable dry powders containing biological medicines produced by spray-freeze-drying (SFD), with atomization gas flow rate identified as a significant factor influencing the powder formulations and protein aggregation. High atomization gas flow rate induced aggregation, highlighting the need for further optimization.
Article
Acoustics
Hualin Dong, Peng Wang, Zongyun Yang, Ru Li, Xinglian Xu, Juan Shen
Summary: Ultrasound treatment can improve protein solubility and curcumin encapsulation rate, but excessive exposure can lead to sample aggregation. After freeze drying and redispersion, the sample treated with ultrasound for 12 minutes showed minimal aggregation and curcumin loss. This study has practical significance for developing the delivery of hydrophobic active substances.
ULTRASONICS SONOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Jianqing Su, Xinyu Zhang, Shengliang Cao, Cheng Liu, Xiang Fu, Rui Zhang, Xiaoli Li, Jiaojiao Xue, Ying Li, Xueyan Wang, Yi Ding, Yubao Li, Xiuling Chu
Summary: An inclusion complex formed with cyclodextrin can improve the bioavailability of water-insoluble drugs. The pharmacokinetic characteristics of Hyperoside-2-hydroxypropyl-beta-cyclodextrin inclusion complex were evaluated in rats, showing increased plasma concentration and AUC0-t indexes, prolonged half-life time, and decreased apparent clearance. In addition, the Hyperoside inclusion complex demonstrated a superior therapeutic effect in a colitis mice model, increasing body weight, improving disease activity index, alleviating colon shortening, and showing a protective effect. This may be attributed to the complex's anti-inflammatory effect by balancing the colon's microbiota.
BIOSCIENCE REPORTS
(2023)
Article
Pharmacology & Pharmacy
Marija Banozic, Malgorzata Krzywonos, Krunoslav Aladic, Hanna Pinkowska, Igor Mucha, Adrianna Zlocinska, Stela Jokic
Summary: This study evaluated the encapsulation of hesperidin using freeze drying and spray drying techniques with maltodextrin and gum arabic. The results showed that these encapsulation techniques significantly improved the solubility and stability of hesperidin, while also enhancing its flow properties.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Santiago Lopez-Miranda, Daniel Berdejo, Elisa Pagan, Diego Garcia-Gonzalo, Rafael Pagan
Summary: The study demonstrated that HP-alpha- and HP-gamma-CD are suitable alternatives for encapsulating carvacrol and thymol to preserve their antimicrobial activities.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Biochemistry & Molecular Biology
Aleksandra A. Jovanovic, Steva M. Levic, Vladimir B. Pavlovic, Smilja B. Markovic, Rada V. Pjanovic, Verica B. Dordevic, Viktor Nedovic, Branko M. Bugarski
Summary: The study compared freeze drying and spray drying for processing wild thyme drugs, finding that freeze drying was more effective in terms of total powder yield and polyphenol content. Gelatin as a coating agent improved TPC recovery and reduced material deposition on the drying chamber wall, leading to differences in polyphenol content in the resulting powders.
Article
Food Science & Technology
Kutlu Cevik, Mehmet Horzum, Hamza Alasalvar, Hasan Yalcin, Mahmut Dogan
Summary: This study investigated the effect of different surfactants on the properties of hazelnut oil emulsion and powder. The results showed that certain surfactants significantly increased the emulsion activity index and viscosity, as well as the encapsulation efficiency and oxidation stability of the powder. In particular, diacetyl tartaric acid ester of mono- and diglycerides, sodium stearoyl-2-lactylate, and glycerol monostearate demonstrated superior performance in capsule formation.
FOOD AND BIOPROCESS TECHNOLOGY
(2023)
Article
Food Science & Technology
Delal Meryem Yaman, Derya Kocak Yanik, Aysel Elik Demir, Hicran Uzun Karka, Gamze Guclu, Serkan Selli, Hasim Kelebek, Fahrettin Gogus
Summary: This study aimed to evaluate the effects of different ratios of gum arabic to maltodextrin and various encapsulation techniques on the properties of powdered substance and the retention of terebinth fruit oil aroma. The emulsion stability was highest at a gum arabic to maltodextrin ratio of 75:25, showing minimal creaming and even dispersion. Spray drying with an ultrasonic nozzle and a two-fluidized nozzle achieved the highest encapsulation efficiency (>90%), particularly for retaining volatiles.
Article
Pharmacology & Pharmacy
Ljubisa Nikolic, Maja Urosevic, Vesna Nikolic, Ivana Gajic, Ana Dinic, Vojkan Miljkovic, Srdan Rakic, Sanja Dokic, Jelena Kesic, Snezana Ilic-Stojanovic, Goran Nikolic
Summary: This paper presents the formulation of a complex of curcumin with 2-hydroxypropyl-beta-cyclodextrin in a thermosensitive hydrogel, characterized by various techniques. The release rate of curcumin from the gel complex formulation is constant over time, and a formulation that can release curcumin for more than 60 days can be designed. The Korsmeyer-Peppas model best describes the release of curcumin from the gel formulation, with diffusion as the mechanism of release.
Article
Biochemistry & Molecular Biology
Vanja Seregelj, Lorenzo Estivi, Andrea Brandolini, Gordana Cetkovic, Vesna Tumbas Saponjac, Alyssa Hidalgo
Summary: The encapsulation of carrot waste oil extract improved the antioxidant properties of durum wheat pasta. Freeze-drying was more effective in protecting carotenoids from degradation compared to spray-drying. The activation energies tended to be higher in freeze-dried encapsulates.
Article
Food Science & Technology
Jiseon Lee, Yu Ra Ji, Youngjae Cho, Mi -Jung Choi
Summary: The aim of this study was to improve the shelf-life of Lactobacillus acidophilus KBL409 by optimizing its encapsulated formulation and freeze-drying conditions. The optimal freeze-drying conditions were determined to be 8% sucrose as a lyoprotectant at -30°C. Various encapsulated forms of L. acidophilus KBL409, including free, alginate-encapsulated (Al-), and alginate/chitosan-encapsulated (Al/Chi-), with or without sucrose, were prepared and evaluated for simulated gastrointestinal (SGI) tract, moisture characteristics, and storage stability. The results showed that the freeze-dried Al/Chi-cells with sucrose had the highest survival rate in the SGI tract and exhibited favorable moisture content and stability during storage.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Review
Food Science & Technology
Di Zhang, Ngouana Moffo A. Ivane, Suleiman A. Haruna, Marcillinus Zekrumah, Fopa Kue Romeo Elyse, Haroon Elrasheid Tahir, Guicai Wang, Chengtao Wang, Xiaobo Zou
Summary: This article discusses the necessity of using plant-derived antioxidants to protect meat from microbial growth and extend its shelf life. However, limitations of plant bioactive compounds restrict their use in the meat system; encapsulation technology is a promising approach to overcome these limitations.
Article
Food Science & Technology
Xin Ying, Jiaxing Gao, Jing Lu, Changlu Ma, Jiaping Lv, Benu Adhikari, Bo Wang
Summary: In this study, soy peptide solution was successfully encapsulated in a W-1/O/W-2 double emulsion using PGPR as an effective inner emulsifier. The droplet size and encapsulation efficiency of the peptide solution depended on various factors including the ratio and concentration of phases. The freeze-dried microcapsule powder showed higher encapsulation efficiency compared to spray-dried one, indicating the potential of this double emulsion as a delivery matrix for hydrophilic ingredients.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Sangita Bhattacharyya, Hindole Ghosh, Obdulia Covarrubias-Zambrano, Krishan Jain, K. Venkateswara Swamy, Anup Kasi, Ameer Hamza, Shrikant Anant, Michael VanSaun, Scott J. Weir, Stefan H. Bossmann, Subhash B. Padhye, Prasad Dandawate
Summary: Pancreatic ductal adenocarcinoma (PDAC) is the leading cause of cancer-related deaths in the US. The development of novel drugs with improved delivery is crucial due to factors such as genetic mutations, drug resistance, multiple signaling pathways, cancer stem cells (CSCs), and desmoplastic stroma. Curcumin shows promise in inhibiting PDAC, but its clinical applicability is limited by poor solubility and metabolic instability. A difluorinated curcumin analog (CDF) has been developed, which selectively accumulates in the pancreas and inhibits PDAC growth. Its inclusion complex with 2-hydroxy-propyl-beta-cyclodextrin (HCD) increases water solubility and hydrolytic stability, leading to improved therapeutic efficacy against PDAC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Madhusmita Nayak, Avinash Pradhan, Shiba Shankar Giri, Mrinal Samanta, V. Badireenath Konkimalla, Ashis Saha
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2018)
Article
Computer Science, Artificial Intelligence
Ramamani Tripathy, Debahuti Mishra, V. Badireenath Konkimalla, Rudra Kalyan Nayak
JOURNAL OF INTELLIGENT & FUZZY SYSTEMS
(2018)
Article
Materials Science, Biomaterials
Diptendu Patra, Saikat Mukherjee, Ipsita Chakraborty, Tapan K. Dash, Shantibhusan Senapati, Rangeet Bhattacharyya, Raja Shunmugam
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2018)
Article
Materials Science, Biomaterials
Diptendu Patra, Saikat Mukherjee, Ipsita Chakraborty, Tapan K. Dash, Shantibhusan Senapati, Rangeet Bhattacharyya, Raja Shunmugam
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2018)
Article
Chemistry, Multidisciplinary
Sangeeta Mohanty, Ashish Kumar Sahoo, V. Badireenath Konkimalla, Abhisek Pal, Sudam Chandra Si
Correction
Chemistry, Multidisciplinary
Sangeeta Mohanty, Ashish Kumar Sahoo, V. Badireenath Konkimalla, Abhisek Pal, Sudam Chandra Si
Article
Materials Science, Biomaterials
Shounak Roy, Monika Kumari, Prakash Haloi, Saurabh Chawla, V. Badireenath Konkimalla, Ajith Kumar, Hemant K. Kashyap, Amit Jaiswal
Summary: The study demonstrates the bacterial killing activity of a pullulan derivative without toxicity to mammalian cells, as it disrupts membrane integrity through a novel non-pore forming pathway. This polysaccharide shows potential as a next-generation antimicrobial material for biomedical applications.
BIOMATERIALS SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Sangeeta Mohanty, V. Badireenath Konkimalla, Abhisek Pal, Tripti Sharma, Sudam Chandra Si
Summary: The study introduces polymeric nanoparticles of Naringin (NAR) to enhance its oral efficiency, with improved absorption and bioavailability. Physicochemical properties were evaluated, in vitro and ex vivo studies were conducted to show potential anti-arthritic effects, and the optimized nanoformulation demonstrated sustained action and reduced arthritic inflammation compared to free NAR.
Article
Materials Science, Multidisciplinary
Diptendu Patra, Pawan Kumar, Tapan Kumar Dash, Ipsita Chakraborty, Rangeet Bhattacharyya, Raja Shunmugam
Summary: A theranostic polymer capable of sequentially targeting folate receptors on cancer cells and inhibiting cancer cell growth through multiple mechanisms has been developed. The polymer can track the release of chemotherapeutic drugs through MRI and has the potential for precise multidrug codelivery in clinical applications.
ACS APPLIED POLYMER MATERIALS
(2022)
Review
Chemistry, Inorganic & Nuclear
Manisha Gaikwad, V. Badireenath Konkimalla, Sunita Salunke-Gawali
Summary: The topoisomerase family plays a crucial role in maintaining DNA topology during cellular processes. Inhibition of these enzymes can be achieved through the use of metal complexes, which provide a three-dimensional framework for increased selectivity. This review focuses on the metal complexes that exhibit topoisomerase inhibition activity and their IC50 values.
INORGANICA CHIMICA ACTA
(2022)
Article
Pharmacology & Pharmacy
B. Siva Lokesh, Prakash Haloi, V. Badireenath Konkimalla
Summary: In this study, PEITC-loaded biocompatible nanoparticles were successfully developed using BSA and PEG as biodegradable polymers. The optimized nanoparticles exhibited smaller particle size, good stability, higher drug encapsulation efficiency and drug loading. The nanoparticles showed sustained release of PEITC and demonstrated enhanced antibacterial activity compared to free PEITC. In a mice infection model, PEITC nanoparticles significantly reduced the area of infection and bacterial viability.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Shounak Roy, Prakash Haloi, Rajat Choudhary, Saurabh Chawla, Monika Kumari, V. Badireenath Konkimalla, Amit Jaiswal
Summary: The rapid emergence of multidrug-resistant bacterial strains poses a global threat to public health. Hospital-acquired infections in diabetic and burn patients impede wound healing and result in high mortality. Researchers have developed a new biomaterial, MCP glycosheets, that synergistically destroys pathogenic strains and promotes wound healing. These glycosheets efficiently eradicate both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus within a short period of time, leading to rapid and highly efficient in vivo wound disinfection and healing.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Pharmacology & Pharmacy
Prakash Haloi, B. Siva Lokesh, Saurabh Chawla, V. Badireenath Konkimalla
Summary: A study reported a method to treat rheumatoid arthritis (RA) by co-delivering methotrexate (MTX) and phenethyl isothiocyanate (PEITC) using a sodium alginate-pluronic F127 in situ hydrogel formulation. The co-delivery of MTX and PEITC in nanoparticulate form enhanced stability and solubility, and facilitated greater penetration into arthritic tissues. The method significantly reduced chronic inflammation, delayed bone erosion, and improved joint morphology in RA rats.
Article
Nanoscience & Nanotechnology
Prem Singh, Prakash Haloi, Khushal Singh, Shounak Roy, Ankita Sarkar, B. Siva Lokesh, Rajat Choudhary, Chandrasen Mohite, Saurabh Chawla, V. Badireenath Konkimalla, Pallab Sanpui, Amit Jaiswal
Summary: Recent developments in nanomaterials have led to the application of plasmonic photothermal therapy (PPTT) for the treatment of cancer. However, the limitations of low penetration depth of NIR-I lights and high laser power density have restricted its clinical translation. To overcome these shortcomings, the researchers have developed a bimetallic palladium nanocapsule (Pd Ncap) that can be used for PPTT in both NIR-I and NIR-II regions. The Pd Ncap exhibits excellent photothermal stability and killing efficiency, with the potential to protect cells from reactive oxygen species (ROS) produced during PPTT.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Tapan Kumar Dash, Diptendu Patra, Parvathy Venu, Biswajit Das, Rangeet Bhattacharyya, Raja Shunmugam
Summary: Designing multifunctional linkers is crucial for the development of tricomponent theranostic targeted nanomedicine. In this study, a hetero-trifunctional linker was synthesized to optimize self-assembly and enhance targeted drug delivery. Combining physical chemistry methods and biological experiments validated the effectiveness of the designed molecule in targeted theranostic development.
ACS APPLIED BIO MATERIALS
(2021)