Hypoxia-inducible factor 1-alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl-4-hydroxylase 2

Conditional Deletion of Prolyl Hydroxylase Domain-Containing Protein 2 (Phd2) Gene Reveals Its Essential Role in Chondrocyte Function and Endochondral Bone Formation

(2016) Shaohong Cheng et al.   ENDOCRINOLOGY

Prolyl hydroxylase domain proteins regulate bone mass through their expression in osteoblasts

(2016) Ke Zhu et al.   GENE

Energy metabolism in osteoclast formation and activity

(2016) Silvia Lemma et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Increased EPO Levels Are Associated With Bone Loss in Mice Lacking PHD2 in EPO-Producing Cells

(2016) Martina Rauner et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Oxygen-sensing PHDs regulate bone homeostasis through the modulation of osteoprotegerin

(2015) Colleen Wu et al.   GENES & DEVELOPMENT

Reactive oxygen species and oxidative stress in osteoclastogenesis, skeletal aging and bone diseases

(2015) Danielle A. Callaway et al.   JOURNAL OF BONE AND MINERAL METABOLISM

New therapeutic targets for cancer bone metastasis

(2015) Jing Y. Krzeszinski et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Reperfusion injury and reactive oxygen species: The evolution of a concept

(2015) D. Neil Granger et al.   Redox Biology

Prolyl hydroxylase domain 2 deficiency promotes skeletal muscle fiber-type transition via a calcineurin/NFATc1-dependent pathway

(2015) Junchul Shin et al.   Skeletal Muscle

Mitochondrial Complex I Activity Suppresses Inflammation and Enhances Bone Resorption by Shifting Macrophage-Osteoclast Polarization

(2014) Zixue Jin et al.   Cell Metabolism

Biological agents in management of osteoporosis

(2014) Sri Harsha Tella et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Conditional Disruption of the Prolyl Hydroxylase Domain-Containing Protein 2 (Phd2) Gene Defines Its Key Role in Skeletal Development

(2014) Shaohong Cheng et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Prolyl-4-hydroxylase domain 3 (PHD3) is a critical terminator for cell survival of macrophages under stress conditions

(2014) Lija Swain et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Integrating Phosphoproteome and Transcriptome Reveals New Determinants of Macrophage Multinucleation

(2014) Maxime Rotival et al.   MOLECULAR & CELLULAR PROTEOMICS

Angiopoietin-Like 4 Is Over-Expressed in Rheumatoid Arthritis Patients: Association with Pathological Bone Resorption

(2014) Catherine Swales et al.   PLoS One

Dimethyloxalylglycine Prevents Bone Loss in Ovariectomized C57BL/6J Mice through Enhanced Angiogenesis and Osteogenesis

(2014) Jia Peng et al.   PLoS One

The role of peripheral nerve fibers and their neurotransmitters in cartilage and bone physiology and pathophysiology

(2014) Susanne Grässel   ARTHRITIS RESEARCH & THERAPY

Prolyl Hydroxylase Inhibitors Protect from the Bone Loss in Ovariectomy Rats by Increasing Bone Vascularity

(2013) Xiaodong Liu et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

MicroRNA-124 Suppresses the Transactivation of Nuclear Factor of Activated T Cells by Targeting Multiple Genes and Inhibits the Proliferation of Pulmonary Artery Smooth Muscle Cells

(2013) Kang Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic regulation of osteoclast differentiation and function

(2013) Yoriko Indo et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Differential regulation of HIF-mediated pathways increases mitochondrial metabolism and ATP production in hypoxic osteoclasts

(2013) Karl J Morten et al.   JOURNAL OF PATHOLOGY

HIF1  is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosis

(2013) Y. Miyauchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GNAS1 and PHD2 Short-interfering RNA Support Bone Regeneration in Vitro and in an in Vivo Sheep Model

(2012) Carmen N. Ríos et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

New bone formation in a true bone ceramic scaffold loaded with desferrioxamine in the treatment of segmental bone defect: a preliminary study

(2012) Weibin Zhang et al.   JOURNAL OF ORTHOPAEDIC SCIENCE

Effects of cobalt and chromium ions at clinically equivalent concentrations after metal-on-metal hip replacement on human osteoblasts and osteoclasts: Implications for skeletal health

(2011) Rebecca E. Andrews et al.   BONE

Role of 2-methoxyestradiol as inhibitor of arthritis and osteoporosis in a model of postmenopausal rheumatoid arthritis

(2011) Alexandra Stubelius et al.   CLINICAL IMMUNOLOGY

Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice

(2011) Sarah R. Walmsley et al.   JOURNAL OF CLINICAL INVESTIGATION

Increasing Vascularity to Improve Healing of a Segmental Defect of the Rat Femur

(2011) Rena Stewart et al.   JOURNAL OF ORTHOPAEDIC TRAUMA

2-Methoxyestradiol Analogue ENMD-1198 Reduces Breast Cancer-Induced Osteolysis and Tumor Burden Both In Vitro and In Vivo

(2011) T. J. A. Snoeks et al.   MOLECULAR CANCER THERAPEUTICS

Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis

(2011) Yukiji Takeda et al.   NATURE

Acidosis, hypoxia and bone

(2010) Timothy R. Arnett   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Hypoxia stimulates osteoclast formation from human peripheral blood

(2010) Jennifer C. Utting et al.   CELL BIOCHEMISTRY AND FUNCTION

Hypoxia-inducible factor regulates osteoclast-mediated bone resorption: role of angiopoietin-like 4

(2010) Helen J. Knowles et al.   FASEB JOURNAL

Inhibition of osteoclastogenesis by prolyl hydroxylase inhibitor dimethyloxallyl glycine

(2010) Andrew J. Leger et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Disease modifying and antiangiogenic activity of 2-Methoxyestradiol in a murine model of rheumatoid arthritis

(2009) Stacy M Plum et al.   BMC MUSCULOSKELETAL DISORDERS

Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

(2009) Massimiliano Mazzone et al.   CELL

Hypoxia-inducible factors 1α and 2α exert both distinct and overlapping functions in long bone development

(2009) Stacy H. Shomento et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Prolyl hydroxylase inhibitors increase neoangiogenesis and callus formation following femur fracture in mice

(2009) Xing Shen et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Acute hypoxia and osteoclast activity: a balance between enhanced resorption and increased apoptosis

(2009) Helen J Knowles et al.   JOURNAL OF PATHOLOGY

Effects of soluble cobalt and cobalt incorporated into calcium phosphate layers on osteoclast differentiation and activation

(2008) Somying Patntirapong et al.   BIOMATERIALS

Hypoxia-inducible factor is expressed in giant cell tumour of bone and mediates paracrine effects of hypoxia on monocyte–osteoclast differentiation via induction of VEGF

(2008) HJ Knowles et al.   JOURNAL OF PATHOLOGY

Abnormal Sympathoadrenal Development and Systemic Hypotension in PHD3-/- Mice

(2008) T. Bishop et al.   MOLECULAR AND CELLULAR BIOLOGY

Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia

(2008) Aline Bozec et al.   NATURE

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

(2008) Julián Aragonés et al.   NATURE GENETICS

Activation of the hypoxia-inducible factor-1  pathway accelerates bone regeneration

(2008) C. Wan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA