Fingolimod induces neuronal-specific gene expression with potential neuroprotective outcomes in maturing neuronal progenitor cells exposed to HIV

Apolipoprotein E4 Suppresses Neuronal-Specific Gene Expression in Maturing Neuronal Progenitor Cells Exposed to HIV

(2017) Rebeca Geffin et al.   Journal of Neuroimmune Pharmacology

Sphingosine-1-phosphate receptor therapies: Advances in clinical trials for CNS-related diseases

(2017) Sinead O'Sullivan et al.   NEUROPHARMACOLOGY

The multiple sclerosis drug fingolimod (FTY720) stimulates neuronal gene expression, axonal growth and regeneration

(2016) Sofia Anastasiadou et al.   EXPERIMENTAL NEUROLOGY

Oligodendrogliopathy in Multiple Sclerosis: Low Glycolytic Metabolic Rate Promotes Oligodendrocyte Survival

(2016) M. B. Rone et al.   JOURNAL OF NEUROSCIENCE

FTY720 Attenuates 6-OHDA-Associated Dopaminergic Degeneration in Cellular and Mouse Parkinsonian Models

(2016) Manru Ren et al.   NEUROCHEMICAL RESEARCH

Traumatic Brain Injury-Induced Neuronal Apoptosis is Reduced Through Modulation of PI3K and Autophagy Pathways in Mouse by FTY720

(2015) Li Zhang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Fingolimod induces neuroprotective factors in human astrocytes

(2015) Franziska S. Hoffmann et al.   Journal of Neuroinflammation

FTY720 attenuates excitotoxicity and neuroinflammation

(2015) Raffaela Cipriani et al.   Journal of Neuroinflammation

Sphingosine-1-Phosphate: Boon and Bane for the Brain

(2014) Gerhild van Echten-Deckert et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Safety and efficacy of fingolimod in patients with relapsing-remitting multiple sclerosis (FREEDOMS II): a double-blind, randomised, placebo-controlled, phase 3 trial

(2014) Peter A Calabresi et al.   LANCET NEUROLOGY

HIV and Aging: Effects on the Central Nervous System

(2014) Silvia Cañizares et al.   SEMINARS IN NEUROLOGY

Neurorestorative effect of FTY720 in a rat model of Alzheimer's disease: Comparison with Memantine

(2013) Fatemeh Hemmati et al.   BEHAVIOURAL BRAIN RESEARCH

Derivation of sensory neurons and neural crest stem cells from human neural progenitor hNP1

(2013) Xiufang Guo et al.   BIOMATERIALS

FTY720 (Fingolimod) Attenuates Beta-amyloid Peptide (Aβ42)-Induced Impairment of Spatial Learning and Memory in Rats

(2013) Masoumeh Asle-Rousta et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Apolipoprotein E-Dependent Differences in Innate Immune Responses of Maturing Human Neuroepithelial Progenitor Cells Exposed to HIV-1

(2013) Rebeca Geffin et al.   Journal of Neuroimmune Pharmacology

Fingolimod: Direct CNS effects of sphingosine 1-phosphate (S1P) receptor modulation and implications in multiple sclerosis therapy

(2013) Aran Groves et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

TGF-beta superfamily member activin A acts with BDNF and erythropoietin to improve survival of spiral ganglion neurons in vitro

(2013) Odett Kaiser et al.   NEUROPHARMACOLOGY

Fingolimod Phosphate Attenuates Oligomeric Amyloid β–Induced Neurotoxicity via Increased Brain-Derived Neurotrophic Factor Expression in Neurons

(2013) Yukiko Doi et al.   PLoS One

FTY720/Fingolimod, a Sphingosine Analogue, Reduces Amyloid-β Production in Neurons

(2013) Nobumasa Takasugi et al.   PLoS One

Cerebral β-amyloid deposition predicts HIV-associated neurocognitive disorders in APOE ε4 carriers

(2012) Virawudh Soontornniyomkij et al.   AIDS

The role and mechanism of action of activin A in neurite outgrowth of chicken embryonic dorsal root ganglia

(2012) L. Fang et al.   JOURNAL OF CELL SCIENCE

Depressed neurofilament expression associates with apolipoprotein E3/E4 genotype in maturing human fetal neurons exposed to HIV-1

(2012) Ricardo Martinez et al.   JOURNAL OF NEUROVIROLOGY

Fingolimod protects cultured cortical neurons against excitotoxic death

(2012) Luisa Di Menna et al.   PHARMACOLOGICAL RESEARCH

The National NeuroAIDS Tissue Consortium Brain Gene Array: Two Types of HIV-Associated Neurocognitive Impairment

(2012) Benjamin B. Gelman et al.   PLoS One

Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome

(2012) R. Deogracias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical Pharmacokinetics of Fingolimod

(2011) Olivier J. David et al.   CLINICAL PHARMACOKINETICS

Ion channels and ionotropic receptors in human embryonic stem cell derived neural progenitors

(2011) A. Young et al.   NEUROSCIENCE

Neurotoxicity of Human Immunodeficiency Virus-1: Viral Proteins and Axonal Transport

(2011) Italo Mocchetti et al.   NEUROTOXICITY RESEARCH

Significant Effects of Antiretroviral Therapy on Global Gene Expression in Brain Tissues of Patients with HIV-1-Associated Neurocognitive Disorders

(2011) Alejandra Borjabad et al.   PLoS Pathogens

The secretases: enzymes with therapeutic potential in Alzheimer disease

(2010) Bart De Strooper et al.   Nature Reviews Neurology

Cognition, glucose metabolism and amyloid burden in Alzheimer's disease

(2010) Ansgar J. Furst et al.   NEUROBIOLOGY OF AGING

Neurons under viral attack: Victims or warriors?

(2010) Swarupa Chakraborty et al.   NEUROCHEMISTRY INTERNATIONAL

A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis

(2010) Ludwig Kappos et al.   NEW ENGLAND JOURNAL OF MEDICINE

FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation

(2010) J. W. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosis

(2009) Bruce D Trapp et al.   LANCET NEUROLOGY

Phosphorylation by Sphingosine Kinase 2 is Essential for in vivo Potency of FTY720 Analogues

(2008) Klemens Högenauer et al.   ChemMedChem

Human neural progenitor cells derived from embryonic stem cells in feeder-free cultures

(2008) Sujoy K. Dhara et al.   DIFFERENTIATION