Applications of optogenetic and chemogenetic methods to seizure circuits: Where to go next?

Optogenetic Low-Frequency Stimulation of Specific Neuronal Populations Abates Ictogenesis

(2017) Zahra Shiri et al.   JOURNAL OF NEUROSCIENCE

A light- and calcium-gated transcription factor for imaging and manipulating activated neurons

(2017) Wenjing Wang et al.   NATURE BIOTECHNOLOGY

Bidirectional Control of Generalized Epilepsy Networks via Rapid Real-Time Switching of Firing Mode

(2017) Jordan M. Sorokin et al.   NEURON

Stellate cells drive maturation of the entorhinal-hippocampal circuit

(2017) Flavio Donato et al.   SCIENCE

Activation of specific neuronal networks leads to different seizure onset types

(2016) Zahra Shiri et al.   ANNALS OF NEUROLOGY

Cell-Specific Targeting of Genetically Encoded Tools for Neuroscience

(2016) Lucas Sjulson et al.   Annual Review of Genetics

Optogenetic Approaches for Controlling Seizure Activity

(2016) Jack K. Tung et al.   Brain Stimulation

Dopamine Neuron-Specific Optogenetic Stimulation in Rhesus Macaques

(2016) William R. Stauffer et al.   CELL

Chemogenetic silencing of the midline and intralaminar thalamus blocks amygdala-kindled seizures

(2016) Evan Wicker et al.   EXPERIMENTAL NEUROLOGY

DREADDs suppress seizure-like activity in a mouse model of pharmacoresistant epileptic brain tissue

(2016) N Avaliani et al.   GENE THERAPY

Target-selectivity of parvalbumin-positive interneurons in layer II of medial entorhinal cortex in normal and epileptic animals

(2016) Caren Armstrong et al.   HIPPOCAMPUS

Distinct Fos-Expressing Neuronal Ensembles in the Ventromedial Prefrontal Cortex Mediate Food Reward and Extinction Memories

(2016) Brandon L. Warren et al.   JOURNAL OF NEUROSCIENCE

Effects of Optogenetic Activation of Corticothalamic Terminals in the Motor Thalamus of Awake Monkeys

(2016) A. Galvan et al.   JOURNAL OF NEUROSCIENCE

Optogenetic study of networks in epilepsy

(2016) ManKin Choy et al.   JOURNAL OF NEUROSCIENCE RESEARCH

A thalamic input to the nucleus accumbens mediates opiate dependence

(2016) Yingjie Zhu et al.   NATURE

Biophysical constraints of optogenetic inhibition at presynaptic terminals

(2016) Mathias Mahn et al.   NATURE NEUROSCIENCE

Optogenetic activation of superior colliculus neurons suppresses seizures originating in diverse brain networks

(2016) Colin Soper et al.   NEUROBIOLOGY OF DISEASE

Cell-Targeted Optogenetics and Electrical Microstimulation Reveal the Primate Koniocellular Projection to Supra-granular Visual Cortex

(2016) Carsten Klein et al.   NEURON

The Rhesus Monkey Connectome Predicts Disrupted Functional Networks Resulting from Pharmacogenetic Inactivation of the Amygdala

(2016) David S. Grayson et al.   NEURON

DREADDs for Neuroscientists

(2016) Bryan L. Roth   NEURON

PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation

(2016) Yuji Nagai et al.   Nature Communications

Optogenetic dissection of ictal propagation in the hippocampal–entorhinal cortex structures

(2016) Yi Lu et al.   Nature Communications

Optogenetic control of human neurons in organotypic brain cultures

(2016) My Andersson et al.   Scientific Reports

A robust activity marking system for exploring active neuronal ensembles

(2016) Andreas T Sørensen et al.   eLife

The First Structure–Activity Relationship Studies for Designer Receptors Exclusively Activated by Designer Drugs

(2015) Xin Chen et al.   ACS Chemical Neuroscience

Cerebellar output controls generalized spike-and-wave discharge occurrence

(2015) Lieke Kros et al.   ANNALS OF NEUROLOGY

DREADDs (Designer Receptors Exclusively Activated by Designer Drugs): Chemogenetic Tools with Therapeutic Utility

(2015) Daniel J. Urban et al.   Annual Review of Pharmacology and Toxicology

Seizure reduction through interneuron-mediated entrainment using low frequency optical stimulation

(2015) Thomas P. Ladas et al.   EXPERIMENTAL NEUROLOGY

Selective activation of parvalbumin- or somatostatin-expressing interneurons triggers epileptic seizurelike activity in mouse medial entorhinal cortex

(2015) Latefa Yekhlef et al.   JOURNAL OF NEUROPHYSIOLOGY

Parvalbumin-Positive Inhibitory Interneurons Oppose Propagation But Favor Generation of Focal Epileptiform Activity

(2015) M. Sessolo et al.   JOURNAL OF NEUROSCIENCE

Monosynaptic Circuit Tracing with Glycoprotein-Deleted Rabies Viruses

(2015) E. M. Callaway et al.   JOURNAL OF NEUROSCIENCE

In vivoevaluation of the dentate gate theory in epilepsy

(2015) Esther Krook-Magnuson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Activating positive memory engrams suppresses depression-like behaviour

(2015) Steve Ramirez et al.   NATURE

Beyond the hammer and the scalpel: selective circuit control for the epilepsies

(2015) Esther Krook-Magnuson et al.   NATURE NEUROSCIENCE

Chemogenetic disconnection of monkey orbitofrontal and rhinal cortex reversibly disrupts reward value

(2015) Mark A G Eldridge et al.   NATURE NEUROSCIENCE

A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior

(2015) Eyal Vardy et al.   NEURON

Behavioral and Physiological Effects of a Novel Kappa-Opioid Receptor-Based DREADD in Rats

(2015) Nathan J Marchant et al.   NEUROPSYCHOPHARMACOLOGY

Elucidation of The Behavioral Program and Neuronal Network Encoded by Dorsal Raphe Serotonergic Neurons

(2015) Daniel J Urban et al.   NEUROPSYCHOPHARMACOLOGY

Optogenetic and pharmacological suppression of spatial clusters of face neurons reveal their causal role in face gender discrimination

(2015) Arash Afraz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The piriform, perirhinal, and entorhinal cortex in seizure generation

(2015) Marta S. Vismer et al.   Frontiers in Neural Circuits

Extratemporal lobe circuits in temporal lobe epilepsy

(2014) Edward H. Bertram   EPILEPSY & BEHAVIOR

Bidirectional switch of the valence associated with a hippocampal contextual memory engram

(2014) Roger L. Redondo et al.   NATURE

Independent optical excitation of distinct neural populations

(2014) Nathan C Klapoetke et al.   NATURE METHODS

Targeting cells with single vectors using multiple-feature Boolean logic

(2014) Lief E Fenno et al.   NATURE METHODS

Noninvasive optical inhibition with a red-shifted microbial rhodopsin

(2014) Amy S Chuong et al.   NATURE NEUROSCIENCE

Presynaptic long-term depression mediated by Gi/o-coupled receptors

(2014) Brady K. Atwood et al.   TRENDS IN NEUROSCIENCES

Chemical–genetic attenuation of focal neocortical seizures

(2014) Dennis Kätzel et al.   Nature Communications

An Engineered Glutamate-gated Chloride (GluCl) Channel for Sensitive, Consistent Neuronal Silencing by Ivermectin

(2013) Shawnalea J. Frazier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct extended amygdala circuits for divergent motivational states

(2013) Joshua H. Jennings et al.   NATURE

Distal connectivity causes summation and division across mouse visual cortex

(2013) Tatsuo K Sato et al.   NATURE NEUROSCIENCE

Closed-loop optogenetic intervention in mice

(2013) Caren Armstrong et al.   Nature Protocols

New technologies for examining the role of neuronal ensembles in drug addiction and fear

(2013) Fabio C. Cruz et al.   NATURE REVIEWS NEUROSCIENCE

Inception of a false memory by optogenetic manipulation of a hippocampal memory engram

(2013) X. Liu et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Creating a False Memory in the Hippocampus

(2013) S. Ramirez et al.   SCIENCE

On-demand optogenetic control of spontaneous seizures in temporal lobe epilepsy

(2013) Esther Krook-Magnuson et al.   Nature Communications

Neuronal circuits in epilepsy: Do they matter?

(2012) Edward H. Bertram   EXPERIMENTAL NEUROLOGY

Optogenetic stimulation of a hippocampal engram activates fear memory recall

(2012) Xu Liu et al.   NATURE

Closed-loop optogenetic control of thalamus as a tool for interrupting seizures after cortical injury

(2012) Jeanne T Paz et al.   NATURE NEUROSCIENCE

Optogenetic silencing strategies differ in their effects on inhibitory synaptic transmission

(2012) Joseph V Raimondo et al.   NATURE NEUROSCIENCE

Optogenetic Inactivation Modifies Monkey Visuomotor Behavior

(2012) James Cavanaugh et al.   NEURON

GPCR mediated regulation of synaptic transmission

(2012) Katherine M. Betke et al.   PROGRESS IN NEUROBIOLOGY

Optogenetic and Potassium Channel Gene Therapy in a Rodent Model of Focal Neocortical Epilepsy

(2012) R. C. Wykes et al.   Science Translational Medicine

Stereological analysis of the rat and monkey amygdala

(2011) Loïc J. Chareyron et al.   JOURNAL OF COMPARATIVE NEUROLOGY

A wirelessly powered and controlled device for optical neural control of freely-behaving animals

(2011) Christian T Wentz et al.   Journal of Neural Engineering

Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking

(2011) Garret D. Stuber et al.   NATURE

Neocortical excitation/inhibition balance in information processing and social dysfunction

(2011) Ofer Yizhar et al.   NATURE

Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins

(2011) Joanna Mattis et al.   NATURE METHODS

New Rabies Virus Variants for Monitoring and Manipulating Activity and Gene Expression in Defined Neural Circuits

(2011) Fumitaka Osakada et al.   NEURON

A simple head-mountable LED device for chronic stimulation of optogenetic molecules in freely moving mice

(2011) Youichi Iwai et al.   NEUROSCIENCE RESEARCH

Optogenetic tools for analyzing the neural circuits of behavior

(2011) Jacob G. Bernstein et al.   TRENDS IN COGNITIVE SCIENCES

Ultrafast optogenetic control

(2010) Lisa A Gunaydin et al.   NATURE NEUROSCIENCE

Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease

(2010) Christian Lüscher et al.   NATURE REVIEWS NEUROSCIENCE

Development of Spontaneous Recurrent Seizures after Kainate-Induced Status Epilepticus

(2009) P. A. Williams et al.   JOURNAL OF NEUROSCIENCE

Bi-stable neural state switches

(2009) André Berndt et al.   NATURE NEUROSCIENCE

Targeted disruption of cocaine-activated nucleus accumbens neurons prevents context-specific sensitization

(2009) Eisuke Koya et al.   NATURE NEUROSCIENCE

Remote Control of Neuronal Activity in Transgenic Mice Expressing Evolved G Protein-Coupled Receptors

(2009) Georgia M. Alexander et al.   NEURON

A chemical-genetic approach to study G protein regulation of β cell function in vivo

(2009) Jean-Marc Guettier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optogenetic control of epileptiform activity

(2009) J. Tonnesen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mapping seizure pathways in the temporal lobe

(2008) Dan C. McIntyre et al.   EPILEPSIA