Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in demyelinating disease

In vitro and ex vivo models of multiple sclerosis

(2016) Martin Madill et al.   DRUG DISCOVERY TODAY

Peripheral and central neuronal ATF3 precedes CD4+ T-cell infiltration in EAE

(2016) Noémie Frezel et al.   EXPERIMENTAL NEUROLOGY

The crucial role of Erk2 in demyelinating inflammation in the central nervous system

(2016) Rentaro Okazaki et al.   Journal of Neuroinflammation

Lack of ceramide synthase 2 suppresses the development of experimental autoimmune encephalomyelitis by impairing the migratory capacity of neutrophils

(2015) Julia Barthelmes et al.   BRAIN BEHAVIOR AND IMMUNITY

Exacerbation of experimental autoimmune encephalomyelitis in ceramide synthase 6 knockout mice is associated with enhanced activation/migration of neutrophils

(2015) Max Eberle et al.   IMMUNOLOGY AND CELL BIOLOGY

Pathological mechanisms in progressive multiple sclerosis

(2015) Don H Mahad et al.   LANCET NEUROLOGY

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

Microglial NLRP3 inflammasome activation mediates IL-1β-related inflammation in prefrontal cortex of depressive rats

(2014) Ying Pan et al.   BRAIN BEHAVIOR AND IMMUNITY

Cyclic phosphatidic acid treatment suppress cuprizone-induced demyelination and motor dysfunction in mice

(2014) Shinji Yamamoto et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neither T-helper type 2 nor Foxp3+ regulatory T cells are necessary for therapeutic benefit of atorvastatin in treatment of central nervous system autoimmunity

(2014) Martin S Weber et al.   Journal of Neuroinflammation

Prostaglandin F2α FP receptor inhibitor reduces demyelination and motor dysfunction in a cuprizone-induced multiple sclerosis mouse model

(2014) K. Iwasa et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Role of mitochondria ROS generation in ethanol-induced NLRP3 inflammasome activation and cell death in astroglial cells

(2014) Silvia Alfonso-Loeches et al.   Frontiers in Cellular Neuroscience

NAD+ protects against EAE by regulating CD4+ T-cell differentiation

(2014) Stefan G. Tullius et al.   Nature Communications

A functional role of NMDA receptor in regulating the differentiation of oligodendrocyte precursor cells and remyelination

(2013) Cui Li et al.   GLIA

The Classification of Microglial Activation Phenotypes on Neurodegeneration and Regeneration in Alzheimer’s Disease Brain

(2012) Megan M. Varnum et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Neurodegeneration and Neuroprotection in Multiple Sclerosis

(2012) Martin Stangel   CURRENT PHARMACEUTICAL DESIGN

IL-17-Induced Act1-Mediated Signaling Is Critical for Cuprizone-Induced Demyelination

(2012) Z. Kang et al.   JOURNAL OF NEUROSCIENCE

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Protection of Neuroblastoma Neuro2A Cells from Hypoxia-Induced Apoptosis by Cyclic Phosphatidic Acid (cPA)

(2012) Mari Gotoh et al.   PLoS One

Synthesis of enantiopure 2-carba-cyclic phosphatidic acid and effects of its chirality on biological functions

(2011) Emi Nozaki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Antinociceptive Effect of Cyclic Phosphatidic Acid and Its Derivative on Animal Models of Acute and Chronic Pain

(2011) Yasutaka Kakiuchi et al.   Molecular Pain

Inhibition of 5-lipoxygenase activity in mice during cuprizone-induced demyelination attenuates neuroinflammation, motor dysfunction and axonal damage

(2011) K. Yoshikawa et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

The role of antigen presenting cells in multiple sclerosis

(2010) Emily M.L. Chastain et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Demyelination versus remyelination in progressive multiple sclerosis

(2010) Stephan Bramow et al.   BRAIN

Effects of cyclic phosphatidic acid on delayed neuronal death following transient ischemia in rat hippocampal CA1

(2010) Mari Gotoh et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neuroprotective effect of modified Wu-Zi-Yan-Zong granule, a traditional Chinese herbal medicine, on CoCl2-induced PC12 cells

(2010) Ke-Wu Zeng et al.   JOURNAL OF ETHNOPHARMACOLOGY

Activated Microglia Mediate Axoglial Disruption That Contributes to Axonal Injury in Multiple Sclerosis

(2010) Owain W. Howell et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The Inflammasome Sensor, NLRP3, Regulates CNS Inflammation and Demyelination via Caspase-1 and Interleukin-18

(2010) S. Jha et al.   JOURNAL OF NEUROSCIENCE

17β-estradiol protects male mice from cuprizone-induced demyelination and oligodendrocyte loss

(2010) Lorelei C. Taylor et al.   NEUROBIOLOGY OF DISEASE

Role of microglia in neurotrauma

(2010) David J. Loane et al.   Neurotherapeutics

The cuprizone animal model: new insights into an old story

(2009) Markus Kipp et al.   ACTA NEUROPATHOLOGICA

Cuprizone induces similar demyelination in male and female C57BL/6 mice and results in disruption of the estrous cycle

(2009) Lorelei C. Taylor et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The cuprizone model for demyelination

(2008) Ø. Torkildsen et al.   ACTA NEUROLOGICA SCANDINAVICA

Mitochondrial defects in acute multiple sclerosis lesions

(2008) Don Mahad et al.   BRAIN

Selenium protects the hypoxia induced apoptosis in neuroblastoma cells through upregulation of Bcl-2

(2008) S.K.S. Sarada et al.   BRAIN RESEARCH