Effects of FTY720 on brain neurogenic niches in vitro and after kainic acid-induced injury

The sphingosine-1-phosphate analogue, FTY-720, promotes the proliferation of embryonic neural stem cells, enhances hippocampal neurogenesis and learning and memory abilities in adult mice

(2016) Yili Sun et al.   BRITISH JOURNAL OF PHARMACOLOGY

Adenosine A1 receptor inhibits postnatal neurogenesis and sustains astrogliogenesis from the subventricular zone

(2016) Monica Benito-Muñoz et al.   GLIA

Insights into the Biology and Therapeutic Applications of Neural Stem Cells

(2016) Lachlan Harris et al.   Stem Cells International

Sphingosine-1-Phosphate Receptor Antagonism Enhances Proliferation and Migration of Engrafted Neural Progenitor Cells in a Model of Viral-Induced Demyelination

(2015) Caroline A. Blanc et al.   AMERICAN JOURNAL OF PATHOLOGY

Neuronal Hyperactivity Accelerates Depletion of Neural Stem Cells and Impairs Hippocampal Neurogenesis

(2015) Amanda Sierra et al.   Cell Stem Cell

Fingolimod induces neuroprotective factors in human astrocytes

(2015) Franziska S. Hoffmann et al.   Journal of Neuroinflammation

FTY720 attenuates excitotoxicity and neuroinflammation

(2015) Raffaela Cipriani et al.   Journal of Neuroinflammation

Fingolimod treatment promotes proliferation and differentiation of oligodendrocyte progenitor cells in mice with experimental autoimmune encephalomyelitis

(2015) Jing Zhang et al.   NEUROBIOLOGY OF DISEASE

Enhanced remyelination following lysolecithin-induced demyelination in mice under treatment with fingolimod (FTY720)

(2015) A. Yazdi et al.   NEUROSCIENCE

Epileptogenesis following Kainic Acid-Induced Status Epilepticus in Cyclin D2 Knock-Out Mice with Diminished Adult Neurogenesis

(2015) Ilona Kondratiuk et al.   PLoS One

Fingolimod induces neurogenesis in adult mouse hippocampus and improves contextual fear memory

(2015) P Efstathopoulos et al.   Translational Psychiatry

Role of p38MAPK in S1P receptor-mediated differentiation of human oligodendrocyte progenitors

(2014) Qiao Ling Cui et al.   GLIA

Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory

(2014) Nitai C Hait et al.   NATURE NEUROSCIENCE

Reconceptualizing Adult Neurogenesis: Role for Sphingosine-1-Phosphate and Fibroblast Growth Factor-1 in Co-Ordinating Astrocyte-Neuronal Precursor Interactions

(2013) George Anderson et al.   CNS & Neurological Disorders-Drug Targets

The kainic acid model of temporal lobe epilepsy

(2013) Maxime Lévesque et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

FTY720, sphingosine 1-phosphate receptor modulator, selectively radioprotects hippocampal neural stem cells

(2012) Alexander M. Stessin et al.   NEUROSCIENCE LETTERS

Fingolimod protects cultured cortical neurons against excitotoxic death

(2012) Luisa Di Menna et al.   PHARMACOLOGICAL RESEARCH

Fingolimod (FTY720) inhibits neuroinflammation and attenuates spontaneous convulsions in lithium-pilocarpine induced status epilepticus in rat model

(2012) Fei Gao et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome

(2012) R. Deogracias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oligodendrocyte differentiation from adult multipotent stem cells is modulated by glutamate

(2012) F Cavaliere et al.   Cell Death & Disease

Neural Stem Cell Grafting Counteracts Hippocampal Injury-Mediated Impairments in Mood, Memory, and Neurogenesis

(2012) Bharathi Hattiangady et al.   Stem Cells Translational Medicine

Neurodegenerative disease and adult neurogenesis

(2011) Beate Winner et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Glutamate and ATP signalling in white matter pathology

(2011) Carlos Matute   JOURNAL OF ANATOMY

Heterogeneous Integration of Adult-Generated Granule Cells into the Epileptic Brain

(2011) B. L. Murphy et al.   JOURNAL OF NEUROSCIENCE

NG2-glia as Multipotent Neural Stem Cells: Fact or Fantasy?

(2011) William D. Richardson et al.   NEURON

Fingolimod (FTY720) Enhances Remyelination Following Demyelination of Organotypic Cerebellar Slices

(2010) Veronique E. Miron et al.   AMERICAN JOURNAL OF PATHOLOGY

CNS-Resident Glial Progenitor/Stem Cells Produce Schwann Cells as well as Oligodendrocytes during Repair of CNS Demyelination

(2010) Malgorzata Zawadzka et al.   Cell Stem Cell

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

There is More to a Lipid than just Being a Fat: Sphingolipid-Guided Differentiation of Oligodendroglial Lineage from Embryonic Stem Cells

(2010) Erhard Bieberich   NEUROCHEMICAL RESEARCH

Mechanisms and Functional Implications of Adult Neurogenesis

(2008) Chunmei Zhao et al.   CELL

Structural changes for adult-born dentate granule cells after status epilepticus

(2008) Lee A. Shapiro et al.   EPILEPSIA

Hippocampal neurogenesis and neural stem cells in temporal lobe epilepsy

(2008) Ramkumar Kuruba et al.   EPILEPSY & BEHAVIOR

Status epilepticus during old age is not associated with enhanced hippocampal neurogenesis

(2008) Muddanna S. Rao et al.   HIPPOCAMPUS

Central nervous system-directed effects of FTY720 (fingolimod)

(2008) Veronique E. Miron et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Remyelination in the CNS: from biology to therapy

(2008) Robin J. M. Franklin et al.   NATURE REVIEWS NEUROSCIENCE

FTY720 modulates human oligodendrocyte progenitor process extension and survival

(2007) Veronique E. Miron et al.   ANNALS OF NEUROLOGY

Region-specific differentiation of embryonic stem cell-derived neural progenitor transplants into the adult mouse hippocampus following seizures

(2007) Joseph E. Carpentino et al.   JOURNAL OF NEUROSCIENCE RESEARCH