Fingolimod induces neurogenesis in adult mouse hippocampus and improves contextual fear memory

The postnatal origin of adult neural stem cells and the effects of glucocorticoids on their genesis

(2015) Sylvia Ortega-Martínez et al.   BEHAVIOURAL BRAIN RESEARCH

Fingolimod increases brain-derived neurotrophic factor levels and ameliorates amyloid β-induced memory impairment

(2014) Kazuya Fukumoto et al.   BEHAVIOURAL BRAIN RESEARCH

Temporal dynamics of hippocampal neurogenesis in chronic neurodegeneration

(2014) Diego Gomez-Nicola et al.   BRAIN

Acute Neuroinflammation Impairs Context Discrimination Memory and Disrupts Pattern Separation Processes in Hippocampus

(2014) J. Czerniawski et al.   JOURNAL OF NEUROSCIENCE

Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory

(2014) Nitai C Hait et al.   NATURE NEUROSCIENCE

Prospective Identification and Purification of Quiescent Adult Neural Stem Cells from Their In Vivo Niche

(2014) Paolo Codega et al.   NEURON

Fingolimod for the treatment of neurological diseases—state of play and future perspectives

(2014) Robert Brunkhorst et al.   Frontiers in Cellular Neuroscience

Fingolimod affects gene expression profile associated with LPS-induced memory impairment

(2014) Rana Omidbakhsh et al.   EXPERIMENTAL BRAIN RESEARCH

FTY720 (Fingolimod) Attenuates Beta-amyloid Peptide (Aβ42)-Induced Impairment of Spatial Learning and Memory in Rats

(2013) Masoumeh Asle-Rousta et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Acute inflammation alters adult hippocampal neurogenesis in a multiple sclerosis mouse model

(2013) A. Giannakopoulou et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Fingolimod: Direct CNS effects of sphingosine 1-phosphate (S1P) receptor modulation and implications in multiple sclerosis therapy

(2013) Aran Groves et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Lysophospholipids and their receptors in the central nervous system

(2012) Ji Woong Choi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Neurogenesis and generalization: a new approach to stratify and treat anxiety disorders

(2012) Mazen A Kheirbek et al.   NATURE NEUROSCIENCE

Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome

(2012) R. Deogracias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation

(2011) Amar Sahay et al.   NATURE

Arrest of adult hippocampal neurogenesis in mice impairs single- but not multiple-trial contextual fear conditioning.

(2010) Michael R. Drew et al.   BEHAVIORAL NEUROSCIENCE

Modulation of adult hippocampal neurogenesis during myelin-directed autoimmune neuroinflammation

(2010) Petra Huehnchen et al.   GLIA

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?

(2010) Wei Deng et al.   NATURE REVIEWS NEUROSCIENCE

Aging of the subventricular zone neural stem cell niche: evidence for quiescence-associated changes between early and mid-adulthood

(2010) M. Bouab et al.   NEUROSCIENCE

Adult neurogenesis: integrating theories and separating functions

(2010) James B. Aimone et al.   TRENDS IN COGNITIVE SCIENCES

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

(2009) N. C. Hait et al.   SCIENCE

Neurogenesis in the chronic lesions of multiple sclerosis

(2008) Ansi Chang et al.   BRAIN

Regional hippocampal atrophy in multiple sclerosis

(2008) N. L. Sicotte et al.   BRAIN

Mechanisms and Functional Implications of Adult Neurogenesis

(2008) Chunmei Zhao et al.   CELL

Cognitive impairment in multiple sclerosis

(2008) Nancy D Chiaravalloti et al.   LANCET NEUROLOGY

FTY720 modulates human oligodendrocyte progenitor process extension and survival

(2007) Veronique E. Miron et al.   ANNALS OF NEUROLOGY