Acamprosate in a mouse model of fragile X syndrome: modulation of spontaneous cortical activity, ERK1/2 activation, locomotor behavior, and anxiety

Selective Disruption of Metabotropic Glutamate Receptor 5-Homer Interactions Mimics Phenotypes of Fragile X Syndrome in Mice

(2016) W. Guo et al.   JOURNAL OF NEUROSCIENCE

Neuron class-specific requirements for Fragile X Mental Retardation Protein in critical period development of calcium signaling in learning and memory circuitry

(2016) Caleb A. Doll et al.   NEUROBIOLOGY OF DISEASE

Does Acamprosate Really Produce its Anti-Relapse Effects via Calcium? No Support from the PREDICT Study in Human Alcoholics

(2016) Karl Mann et al.   NEUROPSYCHOPHARMACOLOGY

Reply to: Does acamprosate really produce its anti-relapse effects via calcium? No support from the PREDICT study in human alcoholics

(2016) Rainer Spanagel et al.   NEUROPSYCHOPHARMACOLOGY

Analyzing dendritic spine pathology in Alzheimer’s disease: problems and opportunities

(2015) Mario M. Dorostkar et al.   ACTA NEUROPATHOLOGICA

ERK1 and ERK2 present functional redundancy in tetrapods despite higher evolution rate of ERK1

(2015) Roser Buscà et al.   BMC EVOLUTIONARY BIOLOGY

Fragile X mice have robust mGluR5-dependent alterations of social behaviour in the Automated Tube Test

(2015) C.E.F. de Esch et al.   NEUROBIOLOGY OF DISEASE

NNZ-2566, a Novel Analog of (1–3) IGF-1, as a Potential Therapeutic Agent for Fragile X Syndrome

(2015) Robert M. J. Deacon et al.   NEUROMOLECULAR MEDICINE

Abnormal neuronal morphology and neurochemistry in the auditory brainstem of Fmr1 knockout rats

(2015) K. Ruby et al.   NEUROSCIENCE

Behavioral analysis of male and female Fmr1 knockout mice on C57BL/6 background

(2014) Qi Ding et al.   BEHAVIOURAL BRAIN RESEARCH

Impact of acamprosate on plasma amyloid-β precursor protein in youth: A pilot analysis in fragile X syndrome-associated and idiopathic autism spectrum disorder suggests a pharmacodynamic protein marker

(2014) Craig A. Erickson et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Acamprosate: An Alcoholism Treatment That May Not Be What We Thought

(2014) Markus Heilig   NEUROPSYCHOPHARMACOLOGY

Regulation of ERK1/2 mitogen-activated protein kinase by NMDA-receptor-induced seizure activity in cortical slices

(2013) Yoko Yamagata et al.   BRAIN RESEARCH

Altered auditory processing in a mouse model of fragile X syndrome

(2013) Sarah Rotschafer et al.   BRAIN RESEARCH

Impaired Critical Period Plasticity in Primary Auditory Cortex of Fragile X Model Mice

(2013) H. Kim et al.   JOURNAL OF NEUROSCIENCE

Acamprosate Produces Its Anti-Relapse Effects Via Calcium

(2013) Rainer Spanagel et al.   NEUROPSYCHOPHARMACOLOGY

The influence of ionotropic and metabotropic glutamate receptor ligands on anxiety-like effect of amphetamine withdrawal in rats

(2013) D. Koltunowska et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Impact of acamprosate on behavior and brain-derived neurotrophic factor: an open-label study in youth with fragile X syndrome

(2013) Craig A. Erickson et al.   PSYCHOPHARMACOLOGY

Hyperactivity, perseveration and increased responding during attentional rule acquisition in the Fragile X mouse model

(2013) Ioannis Kramvis et al.   Frontiers in Behavioral Neuroscience

Activation of the extracellular signal-regulated kinase pathway contributes to the behavioral deficit of fragile x-syndrome

(2012) Xinglong Wang et al.   JOURNAL OF NEUROCHEMISTRY

Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome

(2012) Jennifer A Ronesi et al.   NATURE NEUROSCIENCE

Chronic Pharmacological mGlu5 Inhibition Corrects Fragile X in Adult Mice

(2012) Aubin Michalon et al.   NEURON

Ethanol withdrawal-induced brain metabolites and the pharmacological effects of acamprosate in mice lacking ENT1

(2012) David J. Hinton et al.   NEUROPHARMACOLOGY

Potential opposite roles of the extracellular signal-regulated kinase (ERK) pathway in autism spectrum and bipolar disorders

(2012) Hans O. Kalkman   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Involvement of mGlu5 and NMDA receptors in the antidepressant-like effect of acamprosate in the tail suspension test

(2012) Agnieszka Pałucha-Poniewiera et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Genetic reduction of group 1 metabotropic glutamate receptors alters select behaviors in a mouse model for fragile X syndrome

(2011) Alexia M. Thomas et al.   BEHAVIOURAL BRAIN RESEARCH

A novel target for Huntington's disease: ERK at the crossroads of signaling

(2011) László Bodai et al.   BIOESSAYS

Retracted: Upregulation of Ras/Raf/ERK1/2 signaling and ERK5 in the brain of autistic subjects

(2011) K. Yang et al.   GENES BRAIN AND BEHAVIOR

Altered Neocortical Rhythmic Activity States in Fmr1 KO Mice Are Due to Enhanced mGluR5 Signaling and Involve Changes in Excitatory Circuitry

(2011) S. A. Hays et al.   JOURNAL OF NEUROSCIENCE

ERK2 Contributes to the Control of Social Behaviors in Mice

(2011) Y. Satoh et al.   JOURNAL OF NEUROSCIENCE

Lithium reverses increased rates of cerebral protein synthesis in a mouse model of fragile X syndrome

(2011) Zhong-Hua Liu et al.   NEUROBIOLOGY OF DISEASE

Acamprosate Calcium as Augmentation Therapy for Anxiety Disorders

(2010) Thomas L Schwartz et al.   ANNALS OF PHARMACOTHERAPY

Open-label riluzole in fragile X syndrome

(2010) Craig A. Erickson et al.   BRAIN RESEARCH

Lithium ameliorates phenotypic deficits in a mouse model of fragile X syndrome

(2010) Zhong-Hua Liu et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Inhibitory Modulation of Cortical Up States

(2010) Maria V. Sanchez-Vives et al.   JOURNAL OF NEUROPHYSIOLOGY

Defective GABAergic Neurotransmission and Pharmacological Rescue of Neuronal Hyperexcitability in the Amygdala in a Mouse Model of Fragile X Syndrome

(2010) J. L. Olmos-Serrano et al.   JOURNAL OF NEUROSCIENCE

The fragile X mental retardation protein developmentally regulates the strength and fidelity of calcium signaling in Drosophila mushroom body neurons

(2010) Charles R. Tessier et al.   NEUROBIOLOGY OF DISEASE

Early continuous inhibition of group 1 mGlu signaling partially rescues dendritic spine abnormalities in the Fmr1 knockout mouse model for fragile X syndrome

(2010) Tao Su et al.   PSYCHOPHARMACOLOGY

Targeted mutations in the Na,K-ATPase alpha 2 isoform confer ouabain resistance and result in abnormal behavior in mice

(2010) Tori L. Schaefer et al.   SYNAPSE

Ca2+/Calmodulin-dependent Protein Kinase IV Links Group I Metabotropic Glutamate Receptors to Fragile X Mental Retardation Protein in Cingulate Cortex

(2009) Hansen Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MAP'ing CNS Development and Cognition: An ERKsome Process

(2009) Ivy S. Samuels et al.   NEURON

Rapid Neocortical Dynamics: Cellular and Network Mechanisms

(2009) Bilal Haider et al.   NEURON

Mouse plasmacytoma-expressed transcript 1 knock out induced 5-HT disruption results in a lack of cognitive deficits and an anxiety phenotype complicated by hypoactivity and defensiveness

(2009) T.L. Schaefer et al.   NEUROSCIENCE

Association and Mutation Analyses of 16p11.2 Autism Candidate Genes

(2009) Ravinesh A. Kumar et al.   PLoS One

Acamprosate and naltrexone treatment effects on ethanol and sucrose seeking and intake in ethanol-dependent and nondependent rats

(2009) Cristine L. Czachowski et al.   PSYCHOPHARMACOLOGY

A microdialysis study of extracellular levels of acamprosate and naltrexone in the rat brain following acute and repeated administration

(2008) Costanza Burattini et al.   ADDICTION BIOLOGY

Early-phase ERK activation as a biomarker for metabolic status in fragile X syndrome

(2008) Ning Weng et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Prepulse inhibition in fragile X syndrome: Feasibility, reliability, and implications for treatment

(2008) David Hessl et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Expression of the GABAergic system in animal models for fragile X syndrome and fragile X associated tremor/ataxia syndrome (FXTAS)

(2008) Charlotte D'Hulst et al.   BRAIN RESEARCH

Neurofibromin Regulation of ERK Signaling Modulates GABA Release and Learning

(2008) Yijun Cui et al.   CELL

Fragile X syndrome

(2008) Kathryn B Garber et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Open-Label Treatment Trial of Lithium to Target the Underlying Defect in Fragile X Syndrome

(2008) Elizabeth Berry-Kravis et al.   JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS

Imbalance of Neocortical Excitation and Inhibition and Altered UP States Reflect Network Hyperexcitability in the Mouse Model of Fragile X Syndrome

(2008) Jay R. Gibson et al.   JOURNAL OF NEUROPHYSIOLOGY

Deletion of ERK2 Mitogen-Activated Protein Kinase Identifies Its Key Roles in Cortical Neurogenesis and Cognitive Function

(2008) I. S. Samuels et al.   JOURNAL OF NEUROSCIENCE

Advances in the Treatment of Fragile X Syndrome

(2008) R. J. Hagerman et al.   PEDIATRICS

Aberrant early-phase ERK inactivation impedes neuronal function in fragile X syndrome

(2008) S. H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA