Unconventional role of voltage-gated proton channels (VSOP/Hv1) in regulation of microglial ROS production

Deficiency in the voltage-gated proton channel Hv1 increases M2 polarization of microglia and attenuates brain damage from photothrombotic ischemic stroke

(2016) Dai-Shi Tian et al.   JOURNAL OF NEUROCHEMISTRY

Microglial brain region−dependent diversity and selective regional sensitivities to aging

(2016) Kathleen Grabert et al.   NATURE NEUROSCIENCE

The voltage-gated proton channel Hv1/VSOP inhibits neutrophil granule release

(2015) Yoshifumi Okochi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Microglial Hv1 proton channel promotes cuprizone-induced demyelination through oxidative damage

(2015) Junli Liu et al.   JOURNAL OF NEUROCHEMISTRY

Microglia in action: how aging and injury can change the brain’s guardians

(2015) Athanasios Lourbopoulos et al.   Frontiers in Cellular Neuroscience

Microglial K+channel expression in young adult and aged mice

(2014) Tom Schilling et al.   GLIA

Hv1 proton channels differentially regulate the pH of neutrophil and macrophage phagosomes by sustaining the production of phagosomal ROS that inhibit the delivery of vacuolar ATPases

(2014) Antoun El Chemaly et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Aging causes exacerbated ischemic brain injury and failure of sevoflurane post-conditioning: Role of B-cell lymphoma-2

(2014) P. Dong et al.   NEUROSCIENCE

Proton channel HVCN1 is required for effector functions of mouse eosinophils

(2013) Xiang Zhu et al.   BMC IMMUNOLOGY

Microglia release ATP by exocytosis

(2013) Yoshio Imura et al.   GLIA

The microglial sensome revealed by direct RNA sequencing

(2013) Suzanne E Hickman et al.   NATURE NEUROSCIENCE

Voltage-Gated Proton Channels: Molecular Biology, Physiology, and Pathophysiology of the HV Family

(2013) Thomas E. DeCoursey   PHYSIOLOGICAL REVIEWS

Biological markers of oxidative stress: Applications to cardiovascular research and practice

(2013) Edwin Ho et al.   Redox Biology

Autoimmune disorder phenotypes inHvcn1-deficient mice

(2012) Mari Sasaki et al.   BIOCHEMICAL JOURNAL

The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke

(2012) Long-Jun Wu et al.   NATURE NEUROSCIENCE

Age-dependent neuroinflammatory responses and deficits in long-term potentiation in the hippocampus during systemic inflammation

(2012) X. Liu et al.   NEUROSCIENCE

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Effects of F/G-actin ratio and actin turn-over rate on NADPH oxidase activity in microglia

(2010) Izabela Rasmussen et al.   BMC IMMUNOLOGY

Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling

(2010) Mirkka Koivusalo et al.   JOURNAL OF CELL BIOLOGY

HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species

(2010) Melania Capasso et al.   NATURE IMMUNOLOGY

Molecular and Functional Characterization of Hv1 Proton Channel in Human Granulocytes

(2010) Gábor L. Petheő et al.   PLoS One

Voltage-gated proton channel is expressed on phagosomes

(2009) Yoshifumi Okochi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Plasminogen activator inhibitor type 1 derived peptide, EEIIMD, diminishes cortical infarct but fails to improve neurological function in aged rats following middle cerebral artery occlusion

(2009) Zhenjun Tan et al.   BRAIN RESEARCH

VSOP/Hv1 proton channels sustain calcium entry, neutrophil migration, and superoxide production by limiting cell depolarization and acidification

(2009) Antoun El Chemaly et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burst

(2009) I. S. Ramsey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Update of the Stroke Therapy Academic Industry Roundtable Preclinical Recommendations

(2009) Marc Fisher et al.   STROKE

Charge compensation for NADPH oxidase activity in microglia in rat brain slices does not involve a proton current

(2008) Anna De Simoni et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Cofilin is a pH sensor for actin free barbed end formation: role of phosphoinositide binding

(2008) Christian Frantz et al.   JOURNAL OF CELL BIOLOGY

Early disruptions of the blood–brain barrier may contribute to exacerbated neuronal damage and prolonged functional recovery following stroke in aged rats

(2007) Vincent A. DiNapoli et al.   NEUROBIOLOGY OF AGING