The regulation of pre- and post-maturational plasticity of mammalian islet cell mass

Human  -Cell Proliferation and Intracellular Signaling Part 2: Still Driving in the Dark Without a Road Map

(2014) E. Bernal-Mizrachi et al.   DIABETES

Targeting the pancreatic β-cell to treat diabetes

(2014) Amedeo Vetere et al.   NATURE REVIEWS DRUG DISCOVERY

Islet β cell mass in diabetes and how it relates to function, birth, and death

(2013) Gordon C. Weir et al.   Annals of the New York Academy of Sciences

RETRACTED: Betatrophin: A Hormone that Controls Pancreatic β Cell Proliferation

(2013) Peng Yi et al.   CELL

New Opportunities: Harnessing Induced Pluripotency for Discovery in Diabetes and Metabolism

(2013) Adrian Kee Keong Teo et al.   Cell Metabolism

Argonaute2 Mediates Compensatory Expansion of the Pancreatic β Cell

(2013) Sudhir G. Tattikota et al.   Cell Metabolism

Adult Duct-Lining Cells Can Reprogram into β-like Cells Able to Counter Repeated Cycles of Toxin-Induced Diabetes

(2013) Keith Al-Hasani et al.   DEVELOPMENTAL CELL

Epidermal Growth Factor Receptor Signaling Promotes Pancreatic  -Cell Proliferation in Response to Nutrient Excess in Rats Through mTOR and FOXM1

(2013) B. Zarrouki et al.   DIABETES

Marked Expansion of Exocrine and Endocrine Pancreas With Incretin Therapy in Humans With Increased Exocrine Pancreas Dysplasia and the Potential for Glucagon-Producing Neuroendocrine Tumors

(2013) A. E. Butler et al.   DIABETES

Insulin Resistance Alters Islet Morphology in Nondiabetic Humans

(2013) T. Mezza et al.   DIABETES

X-Box Binding Protein 1 Is Essential for Insulin Regulation of Pancreatic  -Cell Function

(2013) M. Akiyama et al.   DIABETES

Incretin Action in the Pancreas: Potential Promise, Possible Perils, and Pathological Pitfalls

(2013) D. J. Drucker   DIABETES

Systemic Regulation of the Age-Related Decline of Pancreatic β-Cell Replication

(2013) Seth J. Salpeter et al.   DIABETES

Identification of particular groups of microRNAs that positively or negatively impact on beta cell function in obese models of type 2 diabetes

(2013) Valeria Nesca et al.   DIABETOLOGIA

Pancreatic α-Cell Specific Deletion of Mouse Arx Leads to α-Cell Identity Loss

(2013) Crystal L. Wilcox et al.   PLoS One

Liver-Derived Systemic Factors Drive β Cell Hyperplasia in Insulin-Resistant States

(2013) Abdelfattah El Ouaamari et al.   Cell Reports

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

A VGF-Derived Peptide Attenuates Development of Type 2 Diabetes via Enhancement of Islet β-Cell Survival and Function

(2012) Samuel B. Stephens et al.   Cell Metabolism

The Human GLP-1 Analog Liraglutide and the Pancreas

(2012) Niels C.B. Nyborg et al.   DIABETES

MicroRNA-7 Regulates the mTOR Pathway and Proliferation in Adult Pancreatic  -Cells

(2012) Y. Wang et al.   DIABETES

Human  -Cell Proliferation and Intracellular Signaling: Driving in the Dark Without a Road Map

(2012) R. N. Kulkarni et al.   DIABETES

Liver-Specific Disruption of the Murine Glucagon Receptor Produces  -Cell Hyperplasia: Evidence for a Circulating  -Cell Growth Factor

(2012) C. Longuet et al.   DIABETES

 -Cell Mass and Turnover in Humans: Effects of obesity and aging

(2012) Y. Saisho et al.   DIABETES CARE

Studies in rodents with the dipeptidyl peptidase-4 inhibitor vildagliptin to evaluate possible drug-induced pancreatic histological changes that are predictive of pancreatitis and cancer development in man

(2012) S. J. Busch et al.   DIABETES OBESITY & METABOLISM

Emerging roles of non-coding RNAs in pancreatic β-cell function and dysfunction

(2012) C. Guay et al.   DIABETES OBESITY & METABOLISM

Lactogens protect rodent and human beta cells against glucolipotoxicity-induced cell death through Janus kinase‐2 (JAK2)/signal transducer and activator of transcription-5 (STAT5) signalling

(2012) N. Guthalu Kondegowda et al.   DIABETOLOGIA

The ghrelin gene products and exendin-4 promote survival of human pancreatic islet endothelial cells in hyperglycaemic conditions, through phosphoinositide 3-kinase/Akt, extracellular signal-related kinase (ERK)1/2 and cAMP/protein kinase A (PKA) signalling pathways

(2012) E. Favaro et al.   DIABETOLOGIA

Chronic DPP-IV inhibition with PKF-275-055 attenuates inflammation and improves gene expressions responsible for insulin secretion in streptozotocin induced diabetic rats

(2012) Atul Sureshrao Akarte et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Impact of obesity severity and duration on pancreatic β- and α-cell dynamics in normoglycemic non-human primates

(2012) R Guardado-Mendoza et al.   INTERNATIONAL JOURNAL OF OBESITY

Formation of a Human β-Cell Population within Pancreatic Islets Is Set Early in Life

(2012) Brigid E. Gregg et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

MicroRNAs contribute to compensatory β cell expansion during pregnancy and obesity

(2012) Cécile Jacovetti et al.   JOURNAL OF CLINICAL INVESTIGATION

The ontogeny of the endocrine pancreas in the fetal/newborn baboon

(2012) Amy R Quinn et al.   JOURNAL OF ENDOCRINOLOGY

Control of Pancreatic β Cell Regeneration by Glucose Metabolism

(2011) Shay Porat et al.   Cell Metabolism

Nkx2.2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression

(2011) Teresa L. Mastracci et al.   DEVELOPMENTAL BIOLOGY

Growth factor signalling in the regulation of α-cell fate

(2011) D. Kawamori et al.   DIABETES OBESITY & METABOLISM

Recombinant human prolactin promotes human beta cell survival via inhibition of extrinsic and intrinsic apoptosis pathways

(2011) L. F. Terra et al.   DIABETOLOGIA

Dual elimination of the glucagon and GLP-1 receptors in mice reveals plasticity in the incretin axis

(2011) Safina Ali et al.   JOURNAL OF CLINICAL INVESTIGATION

Type 2 diabetes across generations: from pathophysiology to prevention and management

(2011) Christopher J Nolan et al.   LANCET

Long-term recovery of β-cell function after partial pancreatectomy in humans

(2011) Bjoern A. Menge et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Insulin and Glucagon Regulate Pancreatic α-Cell Proliferation

(2011) Zhuo Liu et al.   PLoS One

Differential Glucose-Regulation of MicroRNAs in Pancreatic Islets of Non-Obese Type 2 Diabetes Model Goto-Kakizaki Rat

(2011) Jonathan Lou S. Esguerra et al.   PLoS One

Cell cycle control of β-cell replication in the prenatal and postnatal human pancreas

(2010) Christina U. Köhler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Gastrointestinal hormones and the regulation of β-cell mass

(2010) Jeremy A. Lavine et al.   Annals of the New York Academy of Sciences

Regenerating pancreatic β-cells: plasticity of adult pancreatic cells and the feasibility of in-vivo neogenesis

(2010) Kirstine Juhl et al.   Current Opinion in Organ Transplantation

Causes and cures for endoplasmic reticulum stress in lipotoxic β-cell dysfunction

(2010) M. Cnop et al.   DIABETES OBESITY & METABOLISM

Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic beta cell dysfunction and apoptosis

(2010) F. Allagnat et al.   DIABETOLOGIA

Differences between amyloid toxicity in alpha and beta cells in human and mouse islets and the role of caspase-3

(2010) E. Law et al.   DIABETOLOGIA

The glucagon-producing alpha cell: an electrophysiologically exceptional cell

(2010) M. Braun et al.   DIABETOLOGIA

α Cell–Specific Men1 Ablation Triggers the Transdifferentiation of Glucagon-Expressing Cells and Insulinoma Development

(2010) Jieli Lu et al.   GASTROENTEROLOGY

Significant Human β-Cell Turnover Is Limited to the First Three Decades of Life as Determined byin VivoThymidine Analog Incorporation and Radiocarbon Dating

(2010) S. Perl et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

A GIP Receptor Agonist Exhibits β-Cell Anti-Apoptotic Actions in Rat Models of Diabetes Resulting in Improved β-Cell Function and Glycemic Control

(2010) Scott B. Widenmaier et al.   PLoS One

The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into α and Subsequently β Cells

(2009) Patrick Collombat et al.   CELL

Insulin Signaling in α Cells Modulates Glucagon Secretion In Vivo

(2009) Dan Kawamori et al.   Cell Metabolism

Age-Dependent Decline in  -Cell Proliferation Restricts the Capacity of  -Cell Regeneration in Mice

(2009) S.-I. Tschen et al.   DIABETES

Exogenous Glucose-Dependent Insulinotropic Polypeptide Worsens Post prandial Hyperglycemia in T ype 2 Diabetes

(2009) C. W. Chia et al.   DIABETES

The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation

(2009) M. Cnop et al.   DIABETOLOGIA

β-cell development and turnover during prenatal life in humans

(2009) Juris J Meier et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Bmi-1 regulates the Ink4a/Arf locus to control pancreatic  -cell proliferation

(2009) S. Dhawan et al.   GENES & DEVELOPMENT

Polycomb protein Ezh2 regulates pancreatic  -cell Ink4a/Arf expression and regeneration in diabetes mellitus

(2009) H. Chen et al.   GENES & DEVELOPMENT

Insulin Signaling Regulates Mitochondrial Function in Pancreatic β-Cells

(2009) Siming Liu et al.   PLoS One

miR-375 maintains normal pancreatic  - and  -cell mass

(2009) M. N. Poy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pancreatic islet amyloidosis,  -cell apoptosis, and  -cell proliferation are determinants of islet remodeling in type-2 diabetic baboons

(2009) R. Guardado-Mendoza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

β Cells Can Be Generated from Endogenous Progenitors in Injured Adult Mouse Pancreas

(2008) Xiaobo Xu et al.   CELL

 -Cell Proliferation, but Not Neogenesis, Following 60% Partial Pancreatectomy Is Impaired in the Absence of FoxM1

(2008) A. Ackermann Misfeldt et al.   DIABETES

Inhibition of Foxo1 Protects Pancreatic Islet  -Cells Against Fatty Acid and Endoplasmic Reticulum Stress-Induced Apoptosis

(2008) S. C. Martinez et al.   DIABETES

 -Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of  -Cell Mass in Humans

(2008) J. J. Meier et al.   DIABETES

Impaired islet turnover in human donor pancreata with aging

(2008) Christina Reers et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Protein Restriction during Pregnancy Induces Hypertension and Impairs Endothelium-Dependent Vascular Function in Adult Female Offspring

(2008) Kunju Sathishkumar et al.   JOURNAL OF VASCULAR RESEARCH

Interleukin-6 regulates pancreatic  -cell mass expansion

(2008) H. Ellingsgaard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA