Prolylcarboxypeptidase deficiency is associated with increased blood pressure, glomerular lesions, and cardiac dysfunction independent of altered circulating and cardiac angiotensin II

Prolyl carboxypeptidase purified from human placenta: its characterization and identification as an apelin-cleaving enzyme

(2016) Kaat Kehoe et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Plasma and Kidney Angiotensin Peptides: Importance of the Aminopeptidase A/Angiotensin III Axis

(2015) Jan Wysocki et al.   AMERICAN JOURNAL OF HYPERTENSION

Combined Angiotensin Receptor Modulation in the Management of Cardio-Metabolic Disorders

(2015) Ludovit Paulis et al.   DRUGS

Angiotensins and the Heart

(2015) Jan Wysocki et al.   HYPERTENSION

Loss of Prolyl Carboxypeptidase in Two-Kidney, One-Clip Goldblatt Hypertensive Mice

(2015) Nadja Grobe et al.   PLoS One

Angiotensin-Converting Enzyme 2–Independent Action of Presumed Angiotensin-Converting Enzyme 2 Activators

(2014) Philipp K. Haber et al.   HYPERTENSION

Prolyl Carboxypeptidase Activity Decline Correlates with Severity and Short-Term Outcome in Acute Ischemic Stroke

(2014) Kaat Kehoe et al.   NEUROCHEMICAL RESEARCH

Deficient prolylcarboxypeptidase gene and protein expression in left ventricles of spontaneously hypertensive rats (SHR)

(2014) Rossana Anderson Marangoni et al.   PEPTIDES

Overexpression of Renin in the Collecting Duct Causes Elevated Blood Pressure

(2013) Nirupama Ramkumar et al.   AMERICAN JOURNAL OF HYPERTENSION

Identification of prolyl carboxypeptidase as an alternative enzyme for processing of renal angiotensin II using mass spectrometry

(2013) Nadja Grobe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Prolylcarboxypeptidase promotes angiogenesis and vascular repair

(2013) G. N. Adams et al.   BLOOD

Proteome-derived Peptide Libraries to Study the Substrate Specificity Profiles of Carboxypeptidases

(2013) Sebastian Tanco et al.   MOLECULAR & CELLULAR PROTEOMICS

Deletion of prolyl carboxypeptidase attenuates the metabolic effects of diet-induced obesity

(2012) Jin Kwon Jeong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Comparison of Velocity Vector Imaging Echocardiography With Magnetic Resonance Imaging in Mouse Models of Cardiomyopathy

(2012) Salman Azam et al.   Circulation-Cardiovascular Imaging

Plasma Prolylcarboxypeptidase (Angiotensinase C) Is Increased in Obesity and Diabetes Mellitus and Related to Cardiovascular Dysfunction

(2012) S. Xu et al.   CLINICAL CHEMISTRY

Murine Recombinant Angiotensin-Converting Enzyme 2

(2012) Minghao Ye et al.   HYPERTENSION

Global identification of peptidase specificity by multiplex substrate profiling

(2012) Anthony J O'Donoghue et al.   NATURE METHODS

Murine prolylcarboxypeptidase depletion induces vascular dysfunction with hypertension and faster arterial thrombosis

(2011) G. N. Adams et al.   BLOOD

Molecular mechanisms of left ventricular hypertrophy (LVH) in systemic hypertension (SH)—possible therapeutic perspectives

(2011) Federico Cacciapuoti   Journal of the American Society of Hypertension

Highly selective hydrolysis of kinins by recombinant prolylcarboxypeptidase

(2010) S.M. Chajkowski et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Prolylcarboxypeptidase Regulates Proliferation, Autophagy, and Resistance to 4-Hydroxytamoxifen-induced Cytotoxicity in Estrogen Receptor-positive Breast Cancer Cells

(2010) Lei Duan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design and Synthesis of Prolylcarboxypeptidase (PrCP) Inhibitors To Validate PrCP As A Potential Target for Obesity

(2010) Changyou Zhou et al.   JOURNAL OF MEDICINAL CHEMISTRY

BTBR Ob/Ob Mutant Mice Model Progressive Diabetic Nephropathy

(2010) K. L. Hudkins et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Peptidomic profiling of human cerebrospinal fluid identifies YPRPIHPA as a novel substrate for prolylcarboxypeptidase

(2010) Xuemei Zhao et al.   PROTEOMICS

Structural definition and substrate specificity of the S28 protease family: the crystal structure of human prolylcarboxypeptidase

(2010) Stephen M Soisson et al.   BMC STRUCTURAL BIOLOGY

Angiotensin-converting enzyme 2 gene targeting studies in mice: mixed messages

(2008) Susan B. Gurley et al.   EXPERIMENTAL PHYSIOLOGY

Modulation of Blood Pressure by Central Melanocortinergic Pathways

(2008) Jerry R. Greenfield et al.   NEW ENGLAND JOURNAL OF MEDICINE