IGF-binding proteins

IGFBP4 Is Required for Adipogenesis and Influences the Distribution of Adipose Depots

(2017) David E Maridas et al.   ENDOCRINOLOGY

IGFBP2 Produces Rapid-Acting and Long-Lasting Effects in Rat Models of Posttraumatic Stress Disorder via a Novel Mechanism Associated with Structural Plasticity

(2017) Jeffrey Burgdorf et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

IGFBP-4 regulates adult skeletal growth in a sex-specific manner

(2017) David E Maridas et al.   JOURNAL OF ENDOCRINOLOGY

Induction of Regulatory T Cells and Its Regulation with Insulin-like Growth Factor/Insulin-like Growth Factor Binding Protein-4 by Human Mesenchymal Stem Cells

(2017) Ippei Miyagawa et al.   JOURNAL OF IMMUNOLOGY

IGFBP3 Modulates Lung Tumorigenesis and Cell Growth through IGF1 Signaling

(2017) Yong Antican Wang et al.   MOLECULAR CANCER RESEARCH

Rare and low-frequency coding variants alter human adult height

(2017) Eirini Marouli et al.   NATURE

MicroRNA-34/449 targets IGFBP-3 and attenuates airway remodeling by suppressing Nur77-mediated autophagy

(2017) Huiming Yin et al.   Cell Death & Disease

Decreased expression of insulin-like growth factor binding protein 6 is associated with gastric adenocarcinoma prognosis

(2017) Changqing Zeng et al.   Oncology Letters

IGFBP2 plays an important role in heat shock protein 27-mediated cancer progression and metastasis

(2017) Chin-Sheng Hung et al.   Oncotarget

Human monocyte-derived dendritic cells exposed to hyperthermia show a distinct gene expression profile and selective upregulation of IGFBP6

(2017) Arcangelo Liso et al.   Oncotarget

Insulin-Like Growth Factor Binding Protein 6 in Rheumatoid Arthritis: A Possible Novel Chemotactic Factor?

(2017) Alessia Alunno et al.   Frontiers in Immunology

Opposing Roles of Wnt Inhibitors IGFBP-4 and Dkk1 in Cardiac Ischemia by Differential Targeting of LRP5/6 and β-cateninClinical Perspective

(2016) Da Wo et al.   CIRCULATION

Insulin-Like Growth Factor Binding Protein 1 Could Improve Glucose Regulation and Insulin Sensitivity Through Its RGD Domain

(2016) Natalie J. Haywood et al.   DIABETES

IGFBP1 increases β‐cell regeneration by promoting α‐ to β‐cell transdifferentiation

(2016) Jing Lu et al.   EMBO JOURNAL

Cross Talk Between Growth and Immunity: Coupling of the IGF Axis to Conserved Cytokine Pathways in Rainbow Trout

(2016) Abdullah Alzaid et al.   ENDOCRINOLOGY

Suppression of IGF binding protein-3 by palmitate promotes hepatic inflammatory responses

(2016) Hae-Ki Min et al.   FASEB JOURNAL

Early hypermethylation of hepaticIgfbp2results in its reduced expression preceding fatty liver in mice

(2016) Anne Kammel et al.   HUMAN MOLECULAR GENETICS

IRS-1 Functions as a Molecular Scaffold to Coordinate IGF-I/IGFBP-2 Signaling During Osteoblast Differentiation

(2016) Gang Xi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

IGFBP-3 inhibits Wnt signaling in metastatic melanoma cells

(2016) Antimo Naspi et al.   MOLECULAR CARCINOGENESIS

The Expression of IGFBP6 after Spinal Cord Injury: Implications for Neuronal Apoptosis

(2016) Song Wang et al.   NEUROCHEMICAL RESEARCH

Preoperative serum levels of insulin-like growth factor-binding protein 2 predict prognosis of gastric cancer patients

(2016) Hoon Hur et al.   Oncotarget

Phosphorylated IGFBP-1 as a non-invasive predictor of liver fat in NAFLD

(2016) Elina M. Petäjä et al.   Scientific Reports

Activated Factor X Induces Endothelial Cell Senescence Through IGFBP-5

(2016) Fumihiro Sanada et al.   Scientific Reports

The C-terminus of IGFBP-5 suppresses tumor growth by inhibiting angiogenesis

(2016) Jae Ryoung Hwang et al.   Scientific Reports

The RGD sequence present in IGFBP-2 is required for reduced glucose clearance after oral glucose administration in female transgenic mice

(2015) Anja Reyer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Insulin-like growth factor binding-protein-3 (IGFBP–3)

(2015) Michael B. Ranke   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Physiology and pathophysiology of IGFBP-1 and IGFBP-2 – Consensus and dissent on metabolic control and malignant potential

(2015) Andreas Hoeflich et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

A Liver-Bone Endocrine Relay by IGFBP1 Promotes Osteoclastogenesis and Mediates FGF21-Induced Bone Resorption

(2015) Xunde Wang et al.   Cell Metabolism

IGFBP-2: The dark horse in metabolism and cancer

(2015) V.C. Russo et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Nuclear actions of insulin-like growth factor binding protein-3

(2015) Robert C. Baxter   GENE

IGFBP-2/PTEN: A critical interaction for tumours and for general physiology?

(2015) Li Zeng et al.   GROWTH HORMONE & IGF RESEARCH

The Coordinate Cellular Response to Insulin-like Growth Factor-I (IGF-I) and Insulin-like Growth Factor-binding Protein-2 (IGFBP-2) Is Regulated through Vimentin Binding to Receptor Tyrosine Phosphatase β (RPTPβ)

(2015) Xinchun Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Paternally Inherited IGF2 Mutation and Growth Restriction

(2015) Matthias Begemann et al.   NEW ENGLAND JOURNAL OF MEDICINE

The transcribed-ultraconserved regions in prostate and gastric cancer: DNA hypermethylation and microRNA-associated regulation

(2015) K Goto et al.   ONCOGENE

IGFBP2 potentiates nuclear EGFR–STAT3 signaling

(2015) C Y Chua et al.   ONCOGENE

Insulin-like growth factor-independent insulin-like growth factor binding protein 3 promotes cell migration and lymph node metastasis of oral squamous cell carcinoma cells by requirement of integrin β1

(2015) Yi-Chen Yen et al.   Oncotarget

Epigenetic regulation of insulin-like growth factor binding protein-3 (IGFBP-3) in cancer

(2015) Claire M Perks et al.   Journal of Cell Communication and Signaling

The role and regulation of IGFBP-1 phosphorylation in fetal growth restriction

(2015) Madhulika B. Gupta   Journal of Cell Communication and Signaling

IGFBP-5 Promotes Fibrosis Independently of Its Translocation to the Nucleus and Its Interaction with Nucleolin and IGF

(2015) Yunyun Su et al.   PLoS One

IGFBP-4 Anti-Angiogenic and Anti-Tumorigenic Effects Are Associated with Anti-Cathepsin B Activity

(2015) María J Moreno et al.   NEOPLASIA

Inhibition of tumor-associated αvβ3 integrin regulates the angiogenic switch by enhancing expression of IGFBP-4 leading to reduced melanoma growth and angiogenesis in vivo

(2014) Liangru W. Contois et al.   ANGIOGENESIS

Genome-wide association and functional studies identify a role forIGFBP3in hip osteoarthritis

(2014) Daniel S Evans et al.   ANNALS OF THE RHEUMATIC DISEASES

An Essential Mesenchymal Function for miR-143/145 in Intestinal Epithelial Regeneration

(2014) Raghu R. Chivukula et al.   CELL

MicroRNA-21 Promotes Glioblastoma Tumorigenesis by Down-regulating Insulin-like Growth Factor-binding Protein-3 (IGFBP3)

(2014) Chuan He Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin-Like Growth Factor Binding Protein 4 Enhances Cardiomyocytes Induction in Murine-Induced Pluripotent Stem Cells

(2014) Yuanyuan Xue et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The Insulin-Like Growth Factor System in Obesity, Insulin Resistance and Type 2 Diabetes Mellitus

(2014) Moira Lewitt et al.   Journal of Clinical Medicine

Rescue of silenced UCHL1 and IGFBP4 expression suppresses clonogenicity of giant cell tumor-derived stromal cells

(2013) Jörg Fellenberg et al.   CANCER LETTERS

Hyperglycaemia-induced chemoresistance of prostate cancer cells due to IGFBP2

(2013) K M Biernacka et al.   ENDOCRINE-RELATED CANCER

IGF2 and cancer

(2013) Callum Livingstone   ENDOCRINE-RELATED CANCER

Prohibitin-2 Binding Modulates Insulin-like Growth Factor-binding Protein-6 (IGFBP-6)-induced Rhabdomyosarcoma Cell Migration

(2013) Ping Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IGFBP-2 nuclear translocation is mediated by a functional NLS sequence and is essential for its pro-tumorigenic actions in cancer cells

(2013) W J Azar et al.   ONCOGENE

Insulin-Like Growth Factor Binding Proteins Increase Intracellular Calcium Levels in Two Different Cell Lines

(2013) Danielle Seurin et al.   PLoS One

Insulin-like growth factor binding proteins 4 and 7 released by senescent cells promote premature senescence in mesenchymal stem cells

(2013) V Severino et al.   Cell Death & Disease

Abstract 5154: Serotonin signaling as a novel target of tumor angiogenesis

(2012) Ali Zamani et al.   CANCER RESEARCH

Insulin-like growth factor-binding protein-6 and cancer

(2012) Leon A. Bach et al.   CLINICAL SCIENCE

IGFBP5 induces cell adhesion, increases cell survival and inhibits cell migration in MCF-7 human breast cancer cells

(2012) A. Sureshbabu et al.   JOURNAL OF CELL SCIENCE

The role of insulin-like growth factor binding protein-3 in the breast cancer cell response to DNA-damaging agents

(2012) M Z Lin et al.   ONCOGENE

IGFBP-3 binds GRP78, stimulates autophagy and promotes the survival of breast cancer cells exposed to adverse microenvironments

(2012) S Grkovic et al.   ONCOGENE

Insulin-like growth factor-binding protein 2-driven glioma progression is prevented by blocking a clinically significant integrin, integrin-linked kinase, and NF- B network

(2012) K. M. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acid-labile subunit (ALS) deficiency

(2011) Horacio M. Domené et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Insulin-like growth factor-binding protein-5 (IGFBP-5) inhibits TNF-α-induced NF-κB activity by binding to TNFR1

(2011) Jae Ryoung Hwang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

IGF binding protein 2 supports the survival and cycling of hematopoietic stem cells

(2011) H. Huynh et al.   BLOOD

Wnt Signaling Exerts an Antiproliferative Effect on Adult Cardiac Progenitor Cells Through IGFBP3

(2011) Angelos Oikonomopoulos et al.   CIRCULATION RESEARCH

Evolution of the Insulin-Like Growth Factor Binding Protein (IGFBP) Family

(2011) Daniel Ocampo Daza et al.   ENDOCRINOLOGY

IGF binding protein-6 expression in vascular endothelial cells is induced by hypoxia and plays a negative role in tumor angiogenesis

(2011) Chunyang Zhang et al.   INTERNATIONAL JOURNAL OF CANCER

Insulin-like Growth Factor Binding Protein-4 Differentially Inhibits Growth Factor-induced Angiogenesis

(2011) Liangru W. Contois et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IGF binding protein 3 exerts its ligand-independent action by antagonizing BMP in zebrafish embryos

(2011) Y. Zhong et al.   JOURNAL OF CELL SCIENCE

A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells

(2011) Kim J. Png et al.   NATURE

IGFBP2 promotes glioma tumor stem cell expansion and survival

(2010) David Hsieh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Antidiabetic Effects of IGFBP2, a Leptin-Regulated Gene

(2010) Kristina Hedbacker et al.   Cell Metabolism

Insulin-like growth factor binding protein-6 (IGFBP-6) interacts with DNA-end binding protein Ku80 to regulate cell fate

(2010) Cristiana Iosef et al.   CELLULAR SIGNALLING

IGFBP-6 plays a role as an oncosuppressor gene in NPC pathogenesis through regulating EGR-1 expression

(2010) Yuan-Sung Kuo et al.   JOURNAL OF PATHOLOGY

Insulin-like growth factor binding protein-4 gene silencing in lung adenocarcinomas

(2010) Hanako Sato et al.   PATHOLOGY INTERNATIONAL

The Fibrotic Phenotype Induced by IGFBP-5 Is Regulated by MAPK Activation and Egr-1-Dependent and -Independent Mechanisms

(2009) Hidekata Yasuoka et al.   AMERICAN JOURNAL OF PATHOLOGY

Molecular and functional characterization of two distinct IGF binding protein-6 genes in zebrafish

(2009) Xianlei Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease

(2009) Antonino Belfiore et al.   ENDOCRINE REVIEWS

Identification of genes epigenetically silenced by CpG methylation in human gastric carcinoma

(2009) Chang Do Jee et al.   EUROPEAN JOURNAL OF CANCER

IGF-independent effects of insulin-like growth factor binding protein-5 (Igfbp5) in vivo

(2009) Gyanendra Tripathi et al.   FASEB JOURNAL

Potentiation of Growth Factor Signaling by Insulin-like Growth Factor-binding Protein-3 in Breast Epithelial Cells Requires Sphingosine Kinase Activity

(2009) Janet L. Martin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IGFBP3 polymorphisms and risk of cancer: a meta-analysis

(2009) Li Li et al.   MOLECULAR BIOLOGY REPORTS

Keeping IGF-II under control: Lessons from the IGF-II–IGF2R crystal structure

(2009) James Brown et al.   TRENDS IN BIOCHEMICAL SCIENCES

IGF-dependent and IGF-independent actions of IGF-binding protein-1 and -2: implications for metabolic homeostasis

(2009) Stephen B. Wheatcroft et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Insulin-like growth factor-binding protein-5 (IGFBP-5) acts as a tumor suppressor by inhibiting angiogenesis

(2008) Seung Bae Rho et al.   CARCINOGENESIS

Gender-Specific Changes in Bone Turnover and Skeletal Architecture inIgfbp-2-Null Mice

(2008) V. E. DeMambro et al.   ENDOCRINOLOGY

Hypoxia and Leucine Deprivation Induce Human Insulin-Like Growth Factor Binding Protein-1 Hyperphosphorylation and Increase Its Biological Activity

(2008) Maxim D. Seferovic et al.   ENDOCRINOLOGY

Insulin-Like Growth Factor (IGF) Binding Protein-4 Is Both a Positive and Negative Regulator of IGF Activityin Vivo

(2008) Yun Ning et al.   MOLECULAR ENDOCRINOLOGY

IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis

(2008) Weidong Zhu et al.   NATURE

IGF binding protein alterations on periplaque oligodendrocytes in multiple sclerosis: Implications for remyelination

(2008) Nadine Wilczak et al.   NEUROCHEMISTRY INTERNATIONAL

A Functional Nuclear Localization Signal in Insulin-Like Growth Factor Binding Protein-6 Mediates Its Nuclear Import

(2007) Cristiana Iosef et al.   ENDOCRINOLOGY