Irisin, an exercise-induced myokine as a metabolic regulator: an updated narrative review

Muscle and bone, two interconnected tissues

(2015) Camille Tagliaferri et al.   AGEING RESEARCH REVIEWS

Irisin is associated with osteoporotic fractures independently of bone mineral density, body composition or daily physical activity

(2015) Andrea Palermo et al.   CLINICAL ENDOCRINOLOGY

High circulating irisin levels are associated with insulin resistance and vascular atherosclerosis in a cohort of nondiabetic adult subjects

(2014) G. Sesti et al.   ACTA DIABETOLOGICA

Irisin and FGF21 Are Cold-Induced Endocrine Activators of Brown Fat Function in Humans

(2014) Paul Lee et al.   Cell Metabolism

Identification, Cloning, and Functional Analysis of the TATA-Less Mouse FNDC5 Promoter During Neural Differentiation

(2014) Tahere Seifi et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Metabolic Syndrome and Hypertension: Regular Exercise as Part of Lifestyle Management

(2014) Daniel T. Lackland et al.   CURRENT HYPERTENSION REPORTS

Implication of Circulating Irisin Levels with Brown Adipose Tissue and Sarcopenia in Humans

(2014) Hae Yoon Choi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Browning of white fat: does irisin play a role in humans?

(2014) Manuela Elsen et al.   JOURNAL OF ENDOCRINOLOGY

Metabolic Syndrome and Its Factors Affect Cognitive Function in Chronic Schizophrenia Complicated by Metabolic Syndrome

(2014) Chenhu Li et al.   JOURNAL OF NERVOUS AND MENTAL DISEASE

Exercise-induced changes in basal ganglia volume and cognition in older adults

(2014) C. Niemann et al.   NEUROSCIENCE

Circulating irisin is associated with osteoporotic fractures in postmenopausal women with low bone mass but is not affected by either teriparatide or denosumab treatment for 3 months

(2014) A. D. Anastasilakis et al.   OSTEOPOROSIS INTERNATIONAL

Decreased saliva/serum irisin concentrations in the acute myocardial infarction promising for being a new candidate biomarker for diagnosis of this pathology

(2014) Suna Aydin et al.   PEPTIDES

High-Intensity Exercise Causes Greater Irisin Response Compared with Low-Intensity Exercise under Similar Energy Consumption

(2014) Yoshifumi Tsuchiya et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Irisin Enhances Osteoblast DifferentiationIn Vitro

(2014) Graziana Colaianni et al.   International Journal of Endocrinology

Higher baseline irisin concentrations are associated with greater reductions in glycemia and insulinemia after weight loss in obese subjects

(2014) P Lopez-Legarrea et al.   Nutrition & Diabetes

Irisin and exercise training in humans – Results from a randomized controlled training trial

(2013) Anne Hecksteden et al.   BMC Medicine

RETRACTED: Betatrophin: A Hormone that Controls Pancreatic β Cell Proliferation

(2013) Peng Yi et al.   CELL

BDNF (I)rising from Exercise

(2013) Baoji Xu   Cell Metabolism

Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway

(2013) Christiane D. Wrann et al.   Cell Metabolism

Banting Lecture 2012: Regulation of Adipogenesis: Toward New Therapeutics for Metabolic Disease

(2013) B. M. Spiegelman   DIABETES

Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling

(2013) Y. Zhang et al.   DIABETES

Serum irisin levels in new-onset type 2 diabetes

(2013) Yeon-Kyung Choi et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

White, Brown, Beige/Brite: Different Adipose Cells for Different Functions?

(2013) Marta Giralt et al.   ENDOCRINOLOGY

The effects of acute and chronic exercise on PGC-1α, irisin and browning of subcutaneous adipose tissue in humans

(2013) Frode Norheim et al.   FEBS Journal

The Structure of Irisin Reveals a Novel Intersubunit β-Sheet Fibronectin Type III (FNIII) Dimer

(2013) Maria A. Schumacher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Irisin Is Expressed and Produced by Human Muscle and Adipose Tissue in Association With Obesity and Insulin Resistance

(2013) José María Moreno-Navarrete et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Lower circulating irisin is associated with type 2 diabetes mellitus

(2013) Jian-Jun Liu et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Irisin in obesity and type 2 diabetes

(2013) Kurt Højlund et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Are skeletal muscleFNDC5gene expression and irisin release regulated by exercise and related to health?

(2013) Satu Pekkala et al.   JOURNAL OF PHYSIOLOGY-LONDON

Effects of obesity, diabetes and exercise onFndc5gene expression and irisin release in human skeletal muscle and adipose tissue:in vivoandin vitrostudies

(2013) Timea Kurdiova et al.   JOURNAL OF PHYSIOLOGY-LONDON

Saturated fatty acid palmitate-induced insulin resistance is accompanied with myotube loss and the impaired expression of health benefit myokine genes in C2C12 myotubes

(2013) Ming Yang et al.   Lipids in Health and Disease

Brown and beige fat: development, function and therapeutic potential

(2013) Matthew Harms et al.   NATURE MEDICINE

Adipose tissue browning and metabolic health

(2013) Alexander Bartelt et al.   Nature Reviews Endocrinology

Irisin-immunoreactivity in neural and non-neural cells of the rodent

(2013) S.L. Dun et al.   NEUROSCIENCE

FNDC5/Irisin Is Not Only a Myokine but Also an Adipokine

(2013) Arturo Roca-Rivada et al.   PLoS One

Evidence against a Beneficial Effect of Irisin in Humans

(2013) Silja Raschke et al.   PLoS One

The p38–PGC-1α–irisin–betatrophin axis

(2013) Fabian Sanchis-Gomar et al.   Adipocyte

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

Irisin, Turning Up the Heat

(2012) Francesc Villarroya   Cell Metabolism

Expression of the Irisin Precursor FNDC5 in Skeletal Muscle Correlates With Aerobic Exercise Performance in Patients With Heart Failure

(2012) Stewart H. Lecker et al.   Circulation-Heart Failure

The adipose organ at a glance

(2012) S. Cinti   Disease Models & Mechanisms

From white to brown fat through the PGC-1 -dependent myokine irisin: implications for diabetes and obesity

(2012) J. I. Castillo-Quan   Disease Models & Mechanisms

FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise

(2012) Joo Young Huh et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Is irisin a human exercise gene?

(2012) James A. Timmons et al.   NATURE

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Exercise hormone fights metabolic disease

(2012) Sarah Crunkhorn   NATURE REVIEWS DRUG DISCOVERY

Muscles, exercise and obesity: skeletal muscle as a secretory organ

(2012) Bente K. Pedersen et al.   Nature Reviews Endocrinology

Fndc5 knockdown significantly decreased neural differentiation rate of mouse embryonic stem cells

(2012) M.-S. Hashemi et al.   NEUROSCIENCE

Involvement of PGC-1α in the formation and maintenance of neuronal dendritic spines

(2012) Aiwu Cheng et al.   Nature Communications

Diet, physical exercise and cognitive behavioral training as a combined workplace based intervention to reduce body weight and increase physical capacity in health care workers - a randomized controlled trial

(2011) Jeanette R Christensen et al.   BMC PUBLIC HEALTH

Physical activity, adiponectin, and cardiovascular structure and function

(2011) Michaela Kozakova et al.   HEART AND VESSELS

PGC-1α at the intersection of bioenergetics regulation and neuron function: From Huntington's disease to Parkinson's disease and beyond

(2011) Taiji Tsunemi et al.   PROGRESS IN NEUROBIOLOGY

Hippocampal Plasticity in Response to Exercise in Schizophrenia

(2010) Frank-Gerald Pajonk et al.   ARCHIVES OF GENERAL PSYCHIATRY

Physical Activity and Cognitive Function in Alzheimer Disease

(2009) James A. Mortimer   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Chronic Peroxisome Proliferator-activated Receptor γ (PPARγ) Activation of Epididymally Derived White Adipocyte Cultures Reveals a Population of Thermogenically Competent, UCP1-containing Adipocytes Molecularly Distinct from Classic Brown Adipocytes

(2009) Natasa Petrovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Association Between Physical Activity in Leisure Time and Leukocyte Telomere Length

(2008) Lynn F. Cherkas   ARCHIVES OF INTERNAL MEDICINE

Aerobic exercise effects on cognitive and neural plasticity in older adults

(2008) K I Erickson et al.   BRITISH JOURNAL OF SPORTS MEDICINE

PRDM16 controls a brown fat/skeletal muscle switch

(2008) Patrick Seale et al.   NATURE