Trisubstituted Imidazoles with a Rigidized Hinge Binding Motif Act As Single Digit nM Inhibitors of Clinically Relevant EGFR L858R/T790M and L858R/T790M/C797S Mutants: An Example of Target Hopping

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Title
Trisubstituted Imidazoles with a Rigidized Hinge Binding Motif Act As Single Digit nM Inhibitors of Clinically Relevant EGFR L858R/T790M and L858R/T790M/C797S Mutants: An Example of Target Hopping
Authors
Keywords
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Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 60, Issue 11, Pages 4636-4656
Publisher
American Chemical Society (ACS)
Online
2017-05-09
DOI
10.1021/acs.jmedchem.7b00178

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