Sterol methyltransferase a target for anti-amoeba therapy: towards transition state analog and suicide substrate drug design

Azole Antifungal Agents To Treat the Human Pathogens Acanthamoeba castellanii and Acanthamoeba polyphaga through Inhibition of Sterol 14α-Demethylase (CYP51)

(2015) David C. Lamb et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Fluorinated Sterols Are Suicide Inhibitors of Ergosterol Biosynthesis and Growth in Trypanosoma brucei

(2015) David J. Leaver et al.   CHEMISTRY & BIOLOGY

Characterization, mutagenesis and mechanistic analysis of an ancient algal sterol C24-methyltransferase: Implications for understanding sterol evolution in the green lineage

(2015) Brad A. Haubrich et al.   PHYTOCHEMISTRY

Discovery of an ergosterol-signaling factor that regulatesTrypanosoma bruceigrowth

(2014) Brad A. Haubrich et al.   JOURNAL OF LIPID RESEARCH

Genome profiling of sterol synthesis shows convergent evolution in parasites and guides chemotherapeutic attack

(2014) Matthias A. Fügi et al.   JOURNAL OF LIPID RESEARCH

Motility and more: the flagellum of Trypanosoma brucei

(2014) Gerasimos Langousis et al.   NATURE REVIEWS MICROBIOLOGY

Discovery of Anthelmintic Drug Targets and Drugs Using Chokepoints in Nematode Metabolic Pathways

(2013) Christina M. Taylor et al.   PLoS Pathogens

Evolutionarily conserved Δ25(27)-olefin ergosterol biosynthesis pathway in the algaChlamydomonas reinhardtii

(2012) Matthew B. Miller et al.   JOURNAL OF LIPID RESEARCH

Novel sterol metabolic network ofTrypanosoma bruceiprocyclic and bloodstream forms

(2011) Craigen R. Nes et al.   BIOCHEMICAL JOURNAL

Purification, characterization and inhibition of sterol C24-methyltransferase from Candida albicans

(2010) Kulothungan Ganapathy et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Cloning, mechanistic and functional analysis of a fungal sterol C24-methyltransferase implicated in brassicasterol biosynthesis

(2010) Maristela Pereira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Successful Treatment of Chronic Stromal Acanthamoeba Keratitis With Oral Voriconazole Monotherapy

(2010) Elmer Y Tu et al.   CORNEA

Acanthamoeba Keratitis: Diagnosis and Treatment Update 2009

(2009) John K.G. Dart et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Cloning, functional expression and phylogenetic analysis of plant sterol 24C-methyltransferases involved in sitosterol biosynthesis

(2009) Anjanasree K. Neelakandan et al.   PHYTOCHEMISTRY

Molecular probing of the Saccharomyces cerevisiae sterol 24-C methyltransferase reveals multiple amino acid residues involved with C2-transfer activity

(2008) Kulothungan Ganapathy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Photoaffinity Labeling and Mutational Analysis of 24-C-Sterol Methyltransferase Defines the AdoMet Binding Site

(2008) Pruthvi Jayasimha et al.   LIPIDS