Suppression of Toll-like receptor-mediated innate immune responses at the ocular surface by the membrane-associated mucins MUC1 and MUC16

MUC1 Regulates Epithelial Inflammation and Apoptosis by PolyI:C through Inhibition of Toll/IL-1 Receptor-Domain–Containing Adapter-Inducing IFN-β (TRIF) Recruitment to Toll-like Receptor 3

(2014) Kosuke Kato et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Upregulation of Toll-like receptor 5 expression in the conjunctival epithelium of various human ocular surface diseases

(2014) Keiko Yamada et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

MUC16: molecular analysis and its functional implications in benign and malignant conditions

(2014) Dhanya Haridas et al.   FASEB JOURNAL

TLR2 Regulates Gap Junction Intercellular Communication in Airway Cells

(2014) F. J. Martin et al.   JOURNAL OF IMMUNOLOGY

Comparison of the Transmembrane Mucins MUC1 and MUC16 in Epithelial Barrier Function

(2014) Ilene K. Gipson et al.   PLoS One

Spdef Null Mice Lack Conjunctival Goblet Cells and Provide a Model of Dry Eye

(2013) Christina K. Marko et al.   AMERICAN JOURNAL OF PATHOLOGY

CA125/MUC16 interacts with Src family kinases, and over-expression of its C-terminal fragment in human epithelial cancer cells reduces cell–cell adhesion

(2013) Kaoru Akita et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Toll-Like Receptor Expression and Induction of Type I and Type III Interferons in Primary Airway Epithelial Cells

(2013) I. Ioannidis et al.   JOURNAL OF VIROLOGY

Membrane-Tethered MUC1 Mucin Is Phosphorylated by Epidermal Growth Factor Receptor in Airway Epithelial Cells and Associates with TLR5 To Inhibit Recruitment of MyD88

(2012) K. Kato et al.   JOURNAL OF IMMUNOLOGY

Identification of an atypical zinc metalloproteinase, ZmpC, from an epidemic conjunctivitis-causing strain of Streptococcus pneumoniae

(2012) Balaraj B. Menon et al.   MICROBIAL PATHOGENESIS

MUC1 and MUC13 differentially regulate epithelial inflammation in response to inflammatory and infectious stimuli

(2012) Y H Sheng et al.   Mucosal Immunology

A Metalloproteinase Secreted by Streptococcus pneumoniae Removes Membrane Mucin MUC16 from the Epithelial Glycocalyx Barrier

(2012) Bharathi Govindarajan et al.   PLoS One

Toll-like receptor activation modulates antimicrobial peptide expression by ocular surface cells

(2011) Rachel L. Redfern et al.   EXPERIMENTAL EYE RESEARCH

Toll-like receptors as targets for immune disorders

(2011) Brian Keogh et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Membrane-tethered mucins have multiple functions on the ocular surface

(2010) Bharathi Govindarajan et al.   EXPERIMENTAL EYE RESEARCH

Toll-like receptors in ocular surface disease

(2010) Rachel L. Redfern et al.   EXPERIMENTAL EYE RESEARCH

Muc1 Cell Surface Mucin Attenuates Epithelial Inflammation in Response to a Common Mucosal Pathogen

(2010) Wei Guang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human TLRs 10 and 1 Share Common Mechanisms of Innate Immune Sensing but Not Signaling

(2010) Y. Guan et al.   JOURNAL OF IMMUNOLOGY

Membrane-bound mucins: the mechanistic basis for alterations in the growth and survival of cancer cells

(2010) S Bafna et al.   ONCOGENE

Tyrosine Kinases and Inflammatory Signalling

(2009) Theresa Page et al.   CURRENT MOLECULAR MEDICINE

Association of Cell Surface Mucins with Galectin-3 Contributes to the Ocular Surface Epithelial Barrier

(2009) Pablo Argüeso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deletion of the Mucin-Like Molecule Muc1 Enhances Dendritic Cell Activation in Response to Toll-Like Receptor Ligands

(2009) Marc A. Williams et al.   Journal of Innate Immunity

Mucin-interacting proteins: from function to therapeutics

(2009) Shantibhusan Senapati et al.   TRENDS IN BIOCHEMICAL SCIENCES

MUC1 Limits Helicobacter pylori Infection both by Steric Hindrance and by Acting as a Releasable Decoy

(2009) Sara K. Lindén et al.   PLoS Pathogens

MUC1 Mucin

(2008) K. Chul Kim et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

MUC16 expression during embryogenesis, in adult tissues, and ovarian cancer in the mouse

(2008) Ying Wang et al.   DIFFERENTIATION

MUC1 Mucin Is a Negative Regulator of Toll-Like Receptor Signaling

(2007) Keiko Ueno et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Structure and Function of the Cell Surface (Tethered) Mucins

(2007) Christine L. Hattrup et al.   Annual Review of Physiology