IFN-λ4 Attenuates Antiviral Responses by Enhancing Negative Regulation of IFN Signaling

Race or genetic makeup for hepatitis C virus treatment decisions?

(2017) Thomas R. O'Brien et al.   HEPATOLOGY

Interferon-λ Mediates Non-redundant Front-Line Antiviral Protection against Influenza Virus Infection without Compromising Host Fitness

(2017) Ioanna E. Galani et al.   IMMUNITY

IFN-λ3, not IFN-λ4, likely mediates IFNL3–IFNL4 haplotype–dependent hepatic inflammation and fibrosis

(2017) Mohammed Eslam et al.   NATURE GENETICS

Zinc is a potent and specific inhibitor of IFN-λ3 signalling

(2017) Scott A. Read et al.   Nature Communications

Cellular Mechanism for Impaired Hepatitis C Virus Clearance by Interferon Associated with IFNL3 Gene Polymorphisms Relates to Intrahepatic Interferon-λ Expression

(2016) Pauline Ferraris et al.   AMERICAN JOURNAL OF PATHOLOGY

Type III Interferons Produced by Human Placental Trophoblasts Confer Protection against Zika Virus Infection

(2016) Avraham Bayer et al.   Cell Host & Microbe

IFNλ is a potent anti‐influenza therapeutic without the inflammatory side effects of IFNα treatment

(2016) Sophia Davidson et al.   EMBO Molecular Medicine

Interferon lambda 4 expression is suppressed by the host during viral infection

(2016) MeeAe Hong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Comparative Functional Analysis of 12 Mammalian IFN-λ4 Orthologs

(2016) Ashley Paquin et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Achieving sustained virologic response after interferon-free hepatitis C virus treatment correlates with hepatic interferon gene expression changes independent of cirrhosis

(2016) E. G. Meissner et al.   JOURNAL OF VIRAL HEPATITIS

Prolonged activation of innate antiviral gene signature after childbirth is determined byIFNL3genotype

(2016) Aryn A. Price et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influence ofIFNL3andHLA-DPB1genotype on postpartum control of hepatitis C virus replication and T-cell recovery

(2016) Jonathan R. Honegger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptome analysis reveals a classical interferon signature induced by IFNλ4 in human primary cells

(2015) C Lauber et al.   GENES AND IMMUNITY

Interferon-λ: Immune Functions at Barrier Surfaces and Beyond

(2015) Helen M. Lazear et al.   IMMUNITY

Expression of Interferon Lambda 4 Is Associated with Reduced Proliferation and Increased Cell Death in Human Hepatic Cells

(2015) Olusegun O. Onabajo et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Genome-wide significant risk associations for mucinous ovarian carcinoma

(2015) Linda E Kelemen et al.   NATURE GENETICS

Interferon-λ and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection

(2015) Pedro P Hernández et al.   NATURE IMMUNOLOGY

Guarding the frontiers: the biology of type III interferons

(2015) Andreas Wack et al.   NATURE IMMUNOLOGY

Interferon-λ restricts West Nile virus neuroinvasion by tightening the blood-brain barrier

(2015) Helen M. Lazear et al.   Science Translational Medicine

Interferon-λ4 is a cell-autonomous type III interferon associated with pre-treatment hepatitis C virus burden

(2015) Yi-Fan Lu et al.   VIROLOGY

Interferon lambda inhibits dengue virus replication in epithelial cells

(2015) Helen K. Palma-Ocampo et al.   Virology Journal

Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease

(2015) Mohammed Eslam et al.   Nature Communications

Subversion of early innate antiviral responses during antibody-dependent enhancement of Dengue virus infection induces severe disease in immunocompetent mice

(2014) Vivian V. Costa et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Commensal microbes and interferon-  determine persistence of enteric murine norovirus infection

(2014) M. T. Baldridge et al.   SCIENCE

Interferon-  cures persistent murine norovirus infection in the absence of adaptive immunity

(2014) T. J. Nice et al.   SCIENCE

MiR-221 accentuates IFN׳s anti-HCV effect by downregulating SOCS1 and SOCS3

(2014) Gang Xu et al.   VIROLOGY

Reduced IFNλ4 activity is associated with improved HCV clearance and reduced expression of interferon-stimulated genes

(2014) Ewa Terczyńska-Dyla et al.   Nature Communications

Interferon lambda 4 signals via the IFNλ receptor to regulate antiviral activity against HCV and coronaviruses

(2013) Ole J Hamming et al.   EMBO JOURNAL

Kinetic differences in the induction of interferon stimulated genes by interferon-α and interleukin 28B are altered by infection with hepatitis C virus

(2013) Nikolaus Jilg et al.   HEPATOLOGY

Dynamic expression profiling of type I and type III interferon-stimulated hepatocytes reveals a stable hierarchy of gene expression

(2013) Christopher R. Bolen et al.   HEPATOLOGY

IFNL4-ΔG Genotype Is Associated With Slower Viral Clearance in Hepatitis C, Genotype-1 Patients Treated With Sofosbuvir and Ribavirin

(2013) Eric G. Meissner et al.   JOURNAL OF INFECTIOUS DISEASES

Association of the IFNL4-ΔG Allele With Impaired Spontaneous Clearance of Hepatitis C Virus

(2013) Peter V. Aka et al.   JOURNAL OF INFECTIOUS DISEASES

A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus

(2013) Ludmila Prokunina-Olsson et al.   NATURE GENETICS

Interferon-λ4 (IFNL4) Transcript Expression in Human Liver Tissue Samples

(2013) Ahmad Amanzada et al.   PLoS One

SOCS1 abrogates IFN’s antiviral effect on hepatitis C virus replication

(2012) Run-Xuan Shao et al.   ANTIVIRAL RESEARCH

Hepatic Cell–Type Specific Gene Expression Better Predicts HCV Treatment Outcome Than IL28B Genotype

(2012) Ian McGilvray et al.   GASTROENTEROLOGY

HCV Infection Induces a Unique Hepatic Innate Immune Response Associated With Robust Production of Type III Interferons

(2012) Emmanuel Thomas et al.   GASTROENTEROLOGY

HCV RNA levels in a multiethnic cohort of injection drug users: Human genetic, viral and demographic associations

(2012) Lorenzo Uccellini et al.   HEPATOLOGY

Overview. Type I interferons as primers, activators and inhibitors of innate and adaptive immune responses

(2012) Paul J Hertzog   IMMUNOLOGY AND CELL BIOLOGY

Activation of Type III Interferon Genes by Pathogenic Bacteria in Infected Epithelial Cells and Mouse Placenta

(2012) Hélène Bierne et al.   PLoS One

Hepatitis C virus induces interferon-λ and interferon-stimulated genes in primary liver cultures

(2011) Svetlana Marukian et al.   HEPATOLOGY

Suppressor of Cytokine Signaling (SOCS) 1 Inhibits Type I Interferon (IFN) Signaling via the Interferon α Receptor (IFNAR1)-associated Tyrosine Kinase Tyk2

(2011) Rebecca A. R. Piganis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

USP18-Based Negative Feedback Control Is Induced by Type I and Type III Interferons and Specifically Inactivates Interferon α Response

(2011) Véronique François-Newton et al.   PLoS One

Genetic Variation in IL28B Is Associated With Chronic Hepatitis C and Treatment Failure: A Genome-Wide Association Study

(2010) Andri Rauch et al.   GASTROENTEROLOGY

Interferon-Induced Gene Expression Is a Stronger Predictor of Treatment Response Than IL28B Genotype in Patients With Hepatitis C

(2010) Michael T. Dill et al.   GASTROENTEROLOGY

Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance

(2009) Dongliang Ge et al.   NATURE

Genetic variation in IL28B and spontaneous clearance of hepatitis C virus

(2009) David L. Thomas et al.   NATURE

IL28B is associated with response to chronic hepatitis C interferon-α and ribavirin therapy

(2009) Vijayaprakash Suppiah et al.   NATURE GENETICS

Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C

(2009) Yasuhito Tanaka et al.   NATURE GENETICS

Human interferon-λ3 is a potent member of the type III interferon family

(2008) C Dellgren et al.   GENES AND IMMUNITY

SOCS regulation of the JAK/STAT signalling pathway

(2008) Ben A. Croker et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY