Novel TCR-Mediated Mechanisms of Notch Activation and Signaling

Notch in T Cell Differentiation: All Things Considered

(2015) Derk Amsen et al.   TRENDS IN IMMUNOLOGY

A Voltage-Gated Calcium Channel Regulates Lysosomal Fusion with Endosomes and Autophagosomes and Is Required for Neuronal Homeostasis

(2015) Xuejun Tian et al.   PLOS BIOLOGY

In vivo TCR Signaling in CD4+ T Cells Imprints a Cell-Intrinsic, Transient Low-Motility Pattern Independent of Chemokine Receptor Expression Levels, or Microtubular Network, Integrin, and Protein Kinase C Activity

(2015) Markus Ackerknecht et al.   Frontiers in Immunology

Ikaros Regulates Notch Target Gene Expression in Developing Thymocytes

(2014) S. Chari et al.   JOURNAL OF IMMUNOLOGY

NOTCH ligands JAG1 and JAG2 as critical pro-survival factors in childhood medulloblastoma

(2014) Giulio Fiaschetti et al.   Acta Neuropathologica Communications

Activation of the Notch1 Stem Cell Signaling Pathway during Routine Cell Line Subculture

(2014) Wenyu Liu et al.   Frontiers in Oncology

Notch Simultaneously Orchestrates Multiple Helper T Cell Programs Independently of Cytokine Signals

(2013) Will Bailis et al.   IMMUNITY

Distinct TCR signaling pathways drive proliferation and cytokine production in T cells

(2013) Clifford S Guy et al.   NATURE IMMUNOLOGY

Protein kinase C, an elusive therapeutic target?

(2012) Daria Mochly-Rosen et al.   NATURE REVIEWS DRUG DISCOVERY

Notch signaling: simplicity in design, versatility in function

(2011) E. R. Andersson et al.   DEVELOPMENT

Shedding of the Mer Tyrosine Kinase Receptor Is Mediated by ADAM17 Protein through a Pathway Involving Reactive Oxygen Species, Protein Kinase Cδ, and p38 Mitogen-activated Protein Kinase (MAPK)

(2011) Edward Thorp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PKCα and PKCδ Regulate ADAM17-Mediated Ectodomain Shedding of Heparin Binding-EGF through Separate Pathways

(2011) Marie Kveiborg et al.   PLoS One

Real-Time Imaging of Notch Activation with a Luciferase Complementation-Based Reporter

(2011) M. X. G. Ilagan et al.   Science Signaling

Ion flux and the function of endosomes and lysosomes: pH is just the start

(2010) Cameron C. Scott et al.   BIOESSAYS

Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model

(2010) Jason T. Yustein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein kinase C: poised to signal

(2009) Alexandra C. Newton   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

T Cell Activation

(2009) Jennifer E. Smith-Garvin et al.   Annual Review of Immunology

Origin and evolution of the Notch signalling pathway: an overview from eukaryotic genomes

(2009) Eve Gazave et al.   BMC EVOLUTIONARY BIOLOGY

PKC inhibitors: potential in T cell-dependent immune diseases

(2009) Gottfried Baier et al.   CURRENT OPINION IN CELL BIOLOGY

Metalloprotease ADAM10 Is Required for Notch1 Site 2 Cleavage

(2009) Geert van Tetering et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Potent Protein Kinase C-Selective Inhibitor AEB071 (Sotrastaurin) Represents a New Class of Immunosuppressive Agents Affecting Early T-Cell Activation

(2009) J.-P. Evenou et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Selective Use of ADAM10 and ADAM17 in Activation of Notch1 Signaling

(2009) E. C. Bozkulak et al.   MOLECULAR AND CELLULAR BIOLOGY

The nuts and bolts of AGC protein kinases

(2009) Laura R. Pearce et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL

(2008) W. R. Gordon et al.   BLOOD

Drosophila HOPS and AP-3 Complex Genes Are Required for a Deltex-Regulated Activation of Notch in the Endosomal Trafficking Pathway

(2008) Marian Wilkin et al.   DEVELOPMENTAL CELL

Integrated Regulation of Toll-like Receptor Responses by Notch and Interferon-γ Pathways

(2008) Xiaoyu Hu et al.   IMMUNITY

Endosomal entry regulates Notch receptor activation inDrosophila melanogaster

(2008) Thomas Vaccari et al.   JOURNAL OF CELL BIOLOGY