Article
Dermatology
Qiuju Li, Xiuying Li, Wenyu Li, Runge Fan, Qing Ma, Xiaomei Luo, Huahui Jian, Xiaozhi Chen, Cunwei Cao, Wenjun Zheng
Summary: Cases of atopic dermatitis-like rash induced by IL-17A inhibitor secukinumab treatment have been reported in psoriasis patients. Abnormal expression of multiple immune and inflammatory factors suggests a shift from Th17 towards Th2 in SI-AD.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Immunology
Amalie W. Arildsen, Line F. Zachariassen, Lukasz Krych, Axel K. Hansen, Camilla H. F. Hansen
Summary: Microbial exposure during pregnancy and early postnatal stages plays a significant role in the development of dermatitis later in life, with delayed colonization leading to increased sensitivity and immunological responses. The maternal microbiota status during gestation does not affect the offspring's allergic immune response.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kyunghee Kim, Hyeju Kim, Gun Yong Sung
Summary: The study indicates that short-term use of I3LA for approximately one week can effectively suppress the progression of atopic dermatitis and impact the expression of major constituent proteins of the skin barrier.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Georgia Pappa, Dimitrios Sgouros, Konstantinos Theodoropoulos, Antonios Kanelleas, Evangelia Bozi, Stamatios Gregoriou, Konstantinos Krasagakis, Alexander C. Katoulis
Summary: Atopic dermatitis is a complex inflammatory skin disease with multiple underlying factors. Recent studies have highlighted the important roles of interleukins-4 and -13 in the pathogenesis of atopic dermatitis. Novel therapeutic approaches targeting Th2 cytokines and their pathways offer potential for optimizing the treatment of atopic dermatitis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Allergy
Rinkesh K. Gupta, Jacqueline Miller, Michael Croft
Summary: This study found that the TNF family cytokine TWEAK plays an important role in keratinocyte dysregulation and the pathogenesis of AD. Blocking TWEAK and IL-13 had similar therapeutic effects in treating AD. Therefore, neutralizing TWEAK could be a potential therapeutic option for treating AD.
Review
Pharmacology & Pharmacy
Vivi Nur Khalieda Mohd Kasim, Siti Mahirah Noble, Kong Yen Liew, Ji Wei Tan, Daud Ahmad Israf, Chau Ling Tham
Summary: This systematic review summarizes 103 articles on the use of orally and topically administered herbs and their active constituents in a murine model for the management of atopic dermatitis (AD). The majority of the studies showed that these herbs and their active constituents can suppress the immune response, improve the severity of AD lesions, and reduce IgE concentration and mast cell infiltration.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Xinyan Han, Ziyu Chen, Jinfeng Yuan, Gaorui Wang, Xiao Han, Hui Wu, Hailian Shi, Guixin Chou, Liu Yang, Xiaojun Wu
Summary: The study showed that Artemisia annua water extract (AWE) had a significant therapeutic effect on 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) in mice, possibly by inhibiting Th2 type inflammatory response.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Songwen Ren, You Gao, Luanjin Wang, Ce Qiu, Lingtao Yang, Li Li, Yueyue Xiao, Nengming Xiao, Lixin Liao, Zhenghong Zuo, Chunyan Yang, Chengyong He
Summary: The study demonstrated that Sacran could alleviate symptoms in AD mice, reduce skin inflammation induced by DNCB, potentially through inhibiting Th2 cell activation and decreasing IgE release.
Review
Immunology
Celina Dubin, Ester Del Duca, Emma Guttman-Yassky
Summary: Atopic dermatitis is a common inflammatory skin disease with a complex pathophysiology involving immune dysregulation and barrier defects. The IL-4, IL-13, and IL-31 pathways play key roles in the disease's pathogenesis, and novel therapeutics targeting these pathways are being developed for potential treatments.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2021)
Article
Food Science & Technology
Rong Wang, Haruyo Nakajima-Adachi, Yimei Wang, Yingyu Zhou, Wenting Gu, Erika Hiraide, Mamiko Morinaga, Ryogo Nakagawa, Shotaro Nakamura, Tomohiro Takano, Xuyang Li, Mayumi Saeki, Osamu Kaminuma, Takachika Hiroi, Kenji Uchida, Hidemasa Motoshima, Masaru Tanokura, Takuya Miyakawa, Satoshi Hachimura
Summary: Lactococcus lactis subsp. cremoris YRC3780 isolated from kefir has anti-allergic effects in humans. The oral administration of L. cremoris YRC3780 enhanced IFN-gamma and IL-12 production, inhibited IL-4 production, and attenuated symptoms in an atopic dermatitis mouse model by regulating cytokine expression.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biochemistry & Molecular Biology
Sung Won Lee, Hyun Jung Park, Jungmin Jeon, Yun Hoo Park, Tae-Cheol Kim, Sung Ho Jeon, Rho Hyun Seong, Luc Van Kaer, Seokmann Hong
Summary: The overexpression of SRG3 has been shown to accelerate the development of AD in mice, leading to increased clinical severity and immune cell infiltration in skin lesions. This enhanced pathogenesis is linked to the expansion of IL-4-producing cells and suppression of Treg cells, suggesting that modulation of SRG3 function may be a potential therapeutic option for controlling AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Lu Yu, Qishan Xu, Ping Wang, Jialiang Luo, Zhuojun Zheng, Jia Zhou, Liyun Zhang, Ledong Sun, Daming Zuo
Summary: Atopic dermatitis (AD) is a severe inflammatory skin disease, and this study found that intestinal microbiome disorders and changes in the immune microenvironment are associated with AD. The researchers demonstrated that oral administration of a natural dietary lignan called secoisolariciresinol-diglycoside (SDG) significantly reduced serum IgE levels, limited skin inflammation, and decreased Th2 immune responses in AD mice. Furthermore, the study showed that the bacterial metabolite enterolactone (ENL), which is derived from SDG, suppressed IL-4 production via the JAK-STAT6 signaling pathway. These findings suggest that SDG and ENL may have potential as therapeutic candidates for AD treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Chun-Wen Chan, Hung-Wen Chen, Yu-Wen Wang, Chia- Lin, Ya-Hui Chuang
Summary: This study found that the Th17 cell-derived cytokine IL-21 plays a role in the pathogenesis of PBC, exacerbating liver inflammation and fibrosis and increasing the numbers and effector activities of CD8+ T cells.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2023)
Review
Cell Biology
Alicja Mesjasz, Magdalena Trzeciak, Jolanta Glen, Marta Jaskulak
Summary: Interleukin 37 is a member of the IL-1 cytokine family with anti-inflammatory and immunosuppressive effects. It acts both extracellularly and intracellularly, and is linked to IL-18 and regulates Th2 inflammation in atopic dermatitis.
Article
Pharmacology & Pharmacy
Jaemoo Chun, So Min Lee, You Mee Ahn, Min-Gyung Baek, Hana Yi, Sarah Shin, Jeeyoun Jung
Summary: The study found that Sihocheonggan-Tang (SHCGT) can alleviate AD-like symptoms induced by 2,4-dinitrochlorobenzene (DNCB) in mice by modulating the gut microbiome and increasing short-chain fatty acid levels. This suggests that SHCGT may have therapeutic potential for patients with AD.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Tomoyuki Shimazu, Mai Suzuki, Ryo Takasaki, Asuka Besshi, Yuna Suzuki, Yoichiro Iwakura
Summary: This study investigated the relationship between lactic acid bacteria (LAB) and innate immune receptors. The researchers found that C-type lectin receptors (CLRs) are involved in the immune-stimulating function of LAB. The interaction between LAB and CLRs can reduce the levels of certain cytokines and is only observed in heat-killed LAB. These findings contribute to a better understanding of the immunomodulatory effects of LAB.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Infectious Diseases
Takamitsu Ohnishi, Shinichi Watanabe, Tetsuya Matsumoto, Hiroshi Yotsuyanagi, Junko Sato, Intestu Kobayashi, Shin Iinuma, Takashi Nagayama, Shuichiro Shibuya, Natsuki Ogawa, Ken Iozumi, Yasuyuki Nakajima, Yukiko Kurikawa, Motoko Kobayashi, Koma Matsuo, Hideyuki Ishikawa, Tadamichi Shimizu, Kiyohiro Tsutsui, Tatsuyoshi Kawamura, Ryuhei Okuyama, Mariko Seishima, Yoichi Akita, Chikatoshi Kasugai, Katsuaki Yano, Yasuhiko Tamada, Kimihiko Mizutani, Kenji Kabashima, Nanako Yamada, Masami Ikeda
Summary: The present study compared trends in antimicrobial resistance patterns in pathogens isolated from skin and soft-tissue infections (SSTIs) in Japan with those of a nationwide survey conducted in 2013. The prevalence of methicillin-resistant Staphylococcus aureus (MRSA) did not differ significantly between the present study and the 2013 survey. However, the prevalence of methicillin-resistant coagulase-negative staphylococci (MRCNS) was higher in the present study compared to the 2013 survey. The susceptibility profiles of MRSA and MRCNS to various antibiotics were not significantly different between the two surveys. Continuous monitoring is important for guiding the appropriate treatment of SSTIs.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2023)
Letter
Dermatology
Takayoshi Komatsu-Fujii, Corrine Sison de Jesus, Takashi Nomura, Kenji Kabashima
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Hidehisa Saeki, Masashi Akiyama, Masatoshi Abe, Atsuyuki Igarashi, Shinichi Imafuku, Yukihiro Ohya, Norito Katoh, Hideto Kameda, Kenji Kabashima, Yuichiro Tsunemi, Michihiro Hide, Mamitaro Ohtsuki
Summary: This guidance provides information on the use of oral JAK inhibitors for the treatment of atopic dermatitis. It explains the role of oral JAK inhibitors in inhibiting the signal transduction of cytokines involved in the pathogenesis of atopic dermatitis. It also highlights the authorized oral JAK inhibitors for atopic dermatitis in Japan and emphasizes the importance of considering disease factors, treatment factors, and patient backgrounds in the selection of treatment options.
JOURNAL OF DERMATOLOGY
(2023)
Review
Dermatology
R. Bissonnette, L. F. Eichenfield, E. Simpson, D. Thaci, K. Kabashima, J. P. Thyssen, E. Guttman-Yassky, F. P. Nunes, M. Gamalo, F. Ahmad, M. Kuligowski, K. Sun, C. Pipper, A. W. Christensen, P. D'Angelo, M. Milutinovic, A. Guettner, J. I. Silverberg
Summary: Despite the lack of guidelines for analyzing clinical trial data in atopic dermatitis (AD), using the estimand framework can help standardize the analysis and incorporate intercurrent events. Intercurrent events, such as rescue therapy and sleep deprivation, frequently occur in AD trials and their inconsistent handling limits result interpretation. Applying the estimand framework, as guided by the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH), can improve AD trial design and analysis by providing more reflective and informative results for clinicians to make treatment selection.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Medicine, General & Internal
Emma Guttman-Yassky, Eric L. Simpson, Kristian Reich, Kenji Kabashima, Ken Igawa, Tetsuya Suzuki, Hirotaka Mano, Takeshi Matsui, Ehsanollah Esfandiari, Masutaka Furue
Summary: This study evaluated the efficacy and safety of the anti-OX40 antibody rocatinlimab in patients with moderate-to-severe atopic dermatitis. The results showed significant reductions in EASI score at week 16 in patients receiving rocatinlimab compared to placebo. The treatment led to progressive improvements in atopic dermatitis, which were maintained in most patients after treatment discontinuation, and it was well tolerated.
Article
Toxicology
Takashi Ashino, Yuki Nakamura, Hirokazu Ohtaki, Yoichiro Iwakura, Satoshi Numazawa
Summary: In the study of polymicrobial sepsis, pro-inflammatory cytokines play a vital role in regulating hepatic drug transporter expression. The research found that both CLP and LPS can reduce the expression of drug transporters, but IL-6 is the major factor in the downregulation of hepatic multidrug transporters caused by polymicrobial sepsis.
TOXICOLOGY LETTERS
(2023)
Article
Dermatology
Amy S. Paller, Jonathan I. Silverberg, Michael J. Cork, Emma Guttman-Yassky, Benjamin Lockshin, Alan D. Irvine, Moon Bum Kim, Kenji Kabashima, Zhen Chen, Yufang Lu, Ashish Bansal, Ana B. Rossi, Arsalan Shabbir
Summary: This study assessed the efficacy and safety of dupilumab in patients with severe erythrodermic atopic dermatitis (AD). The results showed that dupilumab significantly improved AD signs and symptoms, including affected body surface area, Eczema Area and Severity Index (EASI) score, and Pruritus Numerical Rating Scale (PP-NRS) score. The treatment also led to reductions in serum biomarker levels.
Correction
Oncology
Chunyan Yu, Xiulong Niu, Yongrui Du, Yan Chen, Xiaomei Liu, Lingling Xu, Yoichiro Iwakura, Xiaoxia Ma, Yan Li, Zhi Yao, Weimin Deng
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Immunology
Takashi Ashino, Yuki Nakamura, Hirokazu Ohtaki, Yoichiro Iwakura, Satoshi Numazawa
Summary: Sepsis affects drug metabolism and the expression of cytochrome P450s. The study shows that cecal ligation and puncture (CLP) induces the expression of proinflammatory cytokines and leads to decreased survival in IL-6(-/-) mice. CLP also downregulates the expression of Cyp2c and Cyp3a11 genes, but this effect is abolished by IL-6 depletion.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Takehisa Nakanishi, Shohei Iida, Junko Maruyama, Hayato Urushima, Masako Ichishi, Yoshiaki Matsushima, Kento Mizutani, Yuichi Nakayama, Kyoko Sugioka, Mai Nishimura, Ai Umaoka, Yoichiro Iwakura, Makoto Kondo, Koji Habe, Daisuke Tsuruta, Osamu Yamamoto, Yasutomo Imai, Keiichi Yamanaka
Summary: The skin is a major immune organ that produces inflammatory cytokines in response to stimuli, leading to systemic inflammation. Inflammatory skin diseases like psoriasis and atopic dermatitis can cause vascular disorders like arteriosclerosis. However, the mechanism of arteriosclerosis in dermatitis and the role of cytokines are not fully understood. This study investigates the pathophysiology of arteriosclerosis and treatment options for inflammatory skin conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dermatology
Kenji Kabashima, Takayo Matsumura, Hiroshi Komazaki, Makoto Kawashima
Summary: This study investigated the impact of nemolizumab on the quality of life in patients with atopic dermatitis. The results showed that nemolizumab treatment improved sleep quality, interpersonal relationships, and work activities.
DERMATOLOGY AND THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Azusa Saika, Prabha Tiwari, Takahiro Nagatake, Eri Node, Koji Hosomi, Tetsuya Honda, Kenji Kabashima, Jun Kunisawa
Summary: Mead acid can suppress retinol-induced irritant contact dermatitis and prevent keratinocyte hyperproliferation and the expression of neutrophil chemoattractants through the PPAR-alpha pathway.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Review
Immunology
Toshiaki Kogame, Gyohei Egawa, Kenji Kabashima
Summary: Recent studies have shown that Janus kinase (JAK) plays a crucial role in signal transduction for inflammatory diseases like atopic dermatitis (AD). Clinical trials using JAK inhibitors and biologic reagents have been successful in treating AD, indicating the efficacy of molecular-based therapies. However, there are concerns about the safety of JAK inhibitors, including severe heart disease. This article provides an overview of the molecular mechanisms of AD and discusses JAK-related biology as a target for AD treatment.
IMMUNOLOGICAL MEDICINE
(2023)
Article
Dermatology
Hitomi Nakaizumi, Naotomo Kambe, Hiroyuki Irie, Yo Kaku, Masakazu Fujimoto, Hajime Yoshifuji, Yasuhiro Kazuma, Kazumoto Katagiri, Takuro Kanekura, Kenji Kabashima
Summary: Schnitzler syndrome (SchS) is a rare autoinflammatory disease characterized by bone pain, recurrent fever, and other symptoms. A key feature of the syndrome is the presence of a persistent urticarial-like rash. Histopathological data suggests that neutrophilic epitheliotropism, or the tendency of neutrophils to infiltrate and affect epithelial tissue, can be a useful marker for diagnosing SchS and differentiating it from conventional urticaria. Understanding this characteristic is crucial for early diagnosis and appropriate treatment.
JOURNAL OF DERMATOLOGY
(2023)