TCR Signaling and CD28/CTLA-4 Signaling Cooperatively Modulate T Regulatory Cell Homeostasis

An essential role for the IL-2 receptor in Treg cell function

(2016) Takatoshi Chinen et al.   NATURE IMMUNOLOGY

Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity

(2015) Alison M. Paterson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulatory T Cells Require TCR Signaling for Their Suppressive Function

(2015) Amanda M. Schmidt et al.   JOURNAL OF IMMUNOLOGY

Confusing signals: Recent progress in CTLA-4 biology

(2015) Lucy S.K. Walker et al.   TRENDS IN IMMUNOLOGY

Continuous T Cell Receptor Signals Maintain a Functional Regulatory T Cell Pool

(2014) J. Christoph Vahl et al.   IMMUNITY

CTLA4 Expression Is an Indicator and Regulator of Steady-State CD4+FoxP3+ T Cell Homeostasis

(2014) A. L. Tang et al.   JOURNAL OF IMMUNOLOGY

TCR Signaling Events Are Required for Maintaining CD4 Regulatory T Cell Numbers and Suppressive Capacities in the Periphery

(2014) Arnaud Delpoux et al.   JOURNAL OF IMMUNOLOGY

Continuous requirement for the TCR in regulatory T cell function

(2014) Andrew G Levine et al.   NATURE IMMUNOLOGY

Inflammation-induced repression of chromatin bound by the transcription factor Foxp3 in regulatory T cells

(2014) Aaron Arvey et al.   NATURE IMMUNOLOGY

An obligate cell-intrinsic function for CD28 in Tregs

(2013) Ruan Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Fcγ receptors enable anticancer action of proapoptotic and immune-modulatory antibodies

(2013) Jeong M. Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma

(2013) Tyler R. Simpson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets

(2013) Kate S. Smigiel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Highly self-reactive naive CD4 T cells are prone to differentiate into regulatory T cells

(2013) Bruno Martin et al.   Nature Communications

Basis of CTLA-4 function in regulatory and conventional CD4+ T cells

(2012) X. Tai et al.   BLOOD

Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4

(2011) O. S. Qureshi et al.   SCIENCE

Memory Phenotype CD4 T Cells Undergoing Rapid, Nonburst-Like, Cytokine-Driven Proliferation Can Be Distinguished from Antigen-Experienced Memory Cells

(2011) Souheil-Antoine Younes et al.   PLOS BIOLOGY

CD4+regulatory T cells require CTLA-4 for the maintenance of systemic tolerance

(2009) Randall H. Friedline et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti–CTLA-4 antibodies

(2009) Karl S. Peggs et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CTLA4 blockade expands FoxP3+ regulatory and activated effector CD4+ T cells in a dose-dependent fashion

(2008) B. Kavanagh et al.   BLOOD

Homeostasis of Naive and Memory T Cells

(2008) Charles D. Surh et al.   IMMUNITY

CTLA-4 Control over Foxp3+ Regulatory T Cell Function

(2008) K. Wing et al.   SCIENCE