CD27-Mediated Regulatory T Cell Depletion and Effector T Cell Costimulation Both Contribute to Antitumor Efficacy
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
CD27-Mediated Regulatory T Cell Depletion and Effector T Cell Costimulation Both Contribute to Antitumor Efficacy
Authors
Keywords
-
Journal
JOURNAL OF IMMUNOLOGY
Volume 199, Issue 12, Pages 4110-4123
Publisher
The American Association of Immunologists
Online
2017-11-07
DOI
10.4049/jimmunol.1700606
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Safety and Activity of Varlilumab, a Novel and First-in-Class Agonist Anti-CD27 Antibody, in Patients With Advanced Solid Tumors
- (2017) Howard A. Burris et al. JOURNAL OF CLINICAL ONCOLOGY
- CD27 Agonism Plus PD-1 Blockade Recapitulates CD4+ T-cell Help in Therapeutic Anticancer Vaccination
- (2016) T. Ahrends et al. CANCER RESEARCH
- Inherited CD70 deficiency in humans reveals a critical role for the CD70–CD27 pathway in immunity to Epstein-Barr virus infection
- (2016) Kazushi Izawa et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Combined immunodeficiency and Epstein-Barr virus–induced B cell malignancy in humans with inherited CD70 deficiency
- (2016) Hassan Abolhassani et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Novel mutations in TNFRSF7/CD27: Clinical, immunologic, and genetic characterization of human CD27 deficiency
- (2015) Omar K. Alkhairy et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Combination cancer immunotherapy and new immunomodulatory targets
- (2015) Kathleen M. Mahoney et al. NATURE REVIEWS DRUG DISCOVERY
- PD-1 Blockade with Nivolumab in Relapsed or Refractory Hodgkin's Lymphoma
- (2015) Stephen M. Ansell et al. NEW ENGLAND JOURNAL OF MEDICINE
- OX40 engagement depletes intratumoral Tregs via activating FcγRs, leading to antitumor efficacy
- (2014) Yannick Bulliard et al. IMMUNOLOGY AND CELL BIOLOGY
- Dual Function of CD70 in Viral Infection: Modulator of Early Cytokine Responses and Activator of Adaptive Responses
- (2014) Atef Allam et al. JOURNAL OF IMMUNOLOGY
- Agonistic CD40 Antibodies and Cancer Therapy
- (2013) R. H. Vonderheide et al. CLINICAL CANCER RESEARCH
- Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies
- (2013) Yannick Bulliard et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma
- (2013) Tyler R. Simpson et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Epithelial and dendritic cells in the thymic medulla promote CD4+Foxp3+regulatory T cell development via the CD27–CD70 pathway
- (2013) Jonathan M. Coquet et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Agonist Anti-Human CD27 Monoclonal Antibody Induces T Cell Activation and Tumor Immunity in Human CD27-Transgenic Mice
- (2013) L.-Z. He et al. JOURNAL OF IMMUNOLOGY
- CD27-CD70 Costimulation Controls T Cell Immunity during Acute and Persistent Cytomegalovirus Infection
- (2013) S. P. M. Welten et al. JOURNAL OF VIROLOGY
- Nivolumab plus Ipilimumab in Advanced Melanoma
- (2013) Jedd D. Wolchok et al. NEW ENGLAND JOURNAL OF MEDICINE
- CD27 Signaling Increases the Frequency of Regulatory T Cells and Promotes Tumor Growth
- (2012) C. Claus et al. CANCER RESEARCH
- Development of a Human Monoclonal Antibody for Potential Therapy of CD27-Expressing Lymphoma and Leukemia
- (2012) L. A. Vitale et al. CLINICAL CANCER RESEARCH
- Combined immunodeficiency with life-threatening EBV-associated lymphoproliferative disorder in patients lacking functional CD27
- (2012) E. Salzer et al. HAEMATOLOGICA
- CD70-Driven Costimulation Induces Survival or Fas-Mediated Apoptosis of T Cells Depending on Antigenic Load
- (2012) F. M. Wensveen et al. JOURNAL OF IMMUNOLOGY
- CD27 Stimulation Promotes the Frequency of IL-7 Receptor-Expressing Memory Precursors and Prevents IL-12-Mediated Loss of CD8+ T Cell Memory in the Absence of CD4+ T Cell Help
- (2012) H. Dong et al. JOURNAL OF IMMUNOLOGY
- Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer
- (2012) Julie R. Brahmer et al. NEW ENGLAND JOURNAL OF MEDICINE
- Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer
- (2012) Suzanne L. Topalian et al. NEW ENGLAND JOURNAL OF MEDICINE
- CD27 deficiency is associated with combined immunodeficiency and persistent symptomatic EBV viremia
- (2011) Joris M. van Montfrans et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Interaction with Fc RIIB Is Critical for the Agonistic Activity of Anti-CD40 Monoclonal Antibody
- (2011) A. L. White et al. JOURNAL OF IMMUNOLOGY
- CD70 Is Selectively Expressed on Th1 but Not on Th2 Cells and Is Required for Th1-Type Immune Responses
- (2011) Tatsuyoshi Kawamura et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Opposing Effects of CD70 Costimulation during Acute and Chronic Lymphocytic Choriomeningitis Virus Infection of Mice
- (2011) P. Penaloza-MacMaster et al. JOURNAL OF VIROLOGY
- Inhibitory Fc Receptor Engagement Drives Adjuvant and Anti-Tumor Activities of Agonistic CD40 Antibodies
- (2011) F. Li et al. SCIENCE
- Anti-tumor effects of depleting and non-depleting anti-CD27 monoclonal antibodies in immune-competent mice
- (2010) Tamami Sakanishi et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Continuous CD27 triggeringin vivostrongly reduces NK cell numbers
- (2010) Veerle De Colvenaer et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Control of Established Melanoma by CD27 Stimulation Is Associated With Enhanced Effector Function and Persistence, and Reduced PD-1 Expression of Tumor Infiltrating CD8+ T Cells
- (2010) Drew J. Roberts et al. JOURNAL OF IMMUNOTHERAPY
- Improved Survival with Ipilimumab in Patients with Metastatic Melanoma
- (2010) F. Stephen Hodi et al. NEW ENGLAND JOURNAL OF MEDICINE
- Costimulatory ligand CD70 allows induction of CD8+ T-cell immunity by immature dendritic cells in a vaccination setting
- (2009) A. M. Keller et al. BLOOD
- Protective CD8 T Cell Memory Is Impaired during Chronic CD70-Driven Costimulation
- (2009) K. P. J. M. van Gisbergen et al. JOURNAL OF IMMUNOLOGY
- Soluble CD70: a novel immunotherapeutic agent for experimental glioblastoma
- (2009) James Miller et al. JOURNAL OF NEUROSURGERY
- Enhanced formation and survival of CD4+CD25hiFoxp3+T-cells in chronic lymphocytic leukemia
- (2009) Margot Jak et al. LEUKEMIA & LYMPHOMA
- Expression of Costimulatory Ligand CD70 on Steady-State Dendritic Cells Breaks CD8+ T Cell Tolerance and Permits Effective Immunity
- (2008) Anna M. Keller et al. IMMUNITY
- OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection
- (2008) Silvia Piconese et al. JOURNAL OF EXPERIMENTAL MEDICINE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More