On One Leg: Trehalose Monoesters Activate Macrophages in a Mincle-Dependent Manner

The Macrophage-Inducible C-Type Lectin, Mincle, Is an Essential Component of the Innate Immune Response to Candida albicans

(2014) C. A. Wells et al.   JOURNAL OF IMMUNOLOGY

Recent Mechanistic Insights on Glycoconjugate Vaccines and Future Perspectives

(2013) Francesco Berti et al.   ACS Chemical Biology

Identification of Distinct Ligands for the C-type Lectin Receptors Mincle and Dectin-2 in the Pathogenic Fungus Malassezia

(2013) Tetsuaki Ishikawa et al.   Cell Host & Microbe

C-type Lectin MCL Is an FcRγ-Coupled Receptor that Mediates the Adjuvanticity of Mycobacterial Cord Factor

(2013) Yasunobu Miyake et al.   IMMUNITY

The Dectin-2 family of C-type lectin-like receptors: an update

(2013) Bernhard Kerscher et al.   INTERNATIONAL IMMUNOLOGY

Mechanism for Recognition of an Unusual Mycobacterial Glycolipid by the Macrophage Receptor Mincle

(2013) Hadar Feinberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cord Factor and Peptidoglycan Recapitulate the Th17-Promoting Adjuvant Activity of Mycobacteria through Mincle/CARD9 Signaling and the Inflammasome

(2013) K. Shenderov et al.   JOURNAL OF IMMUNOLOGY

The Mincle-Activating Adjuvant TDB Induces MyD88-Dependent Th1 and Th17 Responses through IL-1R Signaling

(2013) Christiane Desel et al.   PLoS One

Structural analysis for glycolipid recognition by the C-type lectins Mincle and MCL

(2013) A. Furukawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis of a maradolipid without using protecting groups

(2013) René Csuk et al.   TETRAHEDRON LETTERS

Recognition of the mycobacterial cord factor by Mincle: relevance for granuloma formation and resistance to tuberculosis

(2013) Roland Lang   Frontiers in Immunology

Mincle polarizes human monocyte and neutrophil responses to Candida albicans

(2012) Dipti Vijayan et al.   IMMUNOLOGY AND CELL BIOLOGY

Direct Synthesis of Maradolipids and Other Trehalose 6-Monoesters and 6,6′-Diesters

(2012) Nawal K. Paul et al.   JOURNAL OF ORGANIC CHEMISTRY

Development of a benzophenone and alkyne functionalised trehalose probe to study trehalose dimycolate binding proteins

(2012) Ashna A. Khan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Neutrophils Promote Mycobacterial Trehalose Dimycolate-Induced Lung Inflammation via the Mincle Pathway

(2012) Wook-Bin Lee et al.   PLoS Pathogens

Restoration of Pattern Recognition Receptor Costimulation to Treat Chromoblastomycosis, a Chronic Fungal Infection of the Skin

(2011) Maria da Glória Sousa et al.   Cell Host & Microbe

Long-Chain Lipids Are Required for the Innate Immune Recognition of Trehalose Diesters by Macrophages

(2011) Ashna A. Khan et al.   CHEMBIOCHEM

First in humans: A new molecularly defined vaccine shows excellent safety and strong induction of long-livedMycobacterium tuberculosis-specific Th1-cell like responses

(2011) Tom H. M. Ottenhoff et al.   Human vaccines & immunotherapeutics

Targeting Syk-Card9-activating C-type lectin receptors by vaccine adjuvants: Findings, implications and open questions

(2011) Roland Lang et al.   IMMUNOBIOLOGY

Syk-coupled C-type lectins in immunity

(2011) Ann M. Kerrigan et al.   TRENDS IN IMMUNOLOGY

Synthesis, characterization and assessment of suitability of trehalose fatty acid esters as alternatives for polysorbates in protein formulation

(2010) L. Schiefelbein et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Survey of immune-related, mannose/fucose-binding C-type lectin receptors reveals widely divergent sugar-binding specificities

(2010) R. T. Lee et al.   GLYCOBIOLOGY

Cutting Edge: Mincle Is Essential for Recognition and Adjuvanticity of the Mycobacterial Cord Factor and its Synthetic Analog Trehalose-Dibehenate

(2010) H. Schoenen et al.   JOURNAL OF IMMUNOLOGY

New vaccines for tuberculosis

(2010) Stefan HE Kaufmann et al.   LANCET

Interleukin-17 Is Required for T Helper 1 Cell Immunity and Host Resistance to the Intracellular Pathogen Francisella tularensis

(2009) Yinyao Lin et al.   IMMUNITY

Precarious Balance: Th17 Cells in Host Defense

(2009) A. Peck et al.   INFECTION AND IMMUNITY

Adjuvanticity of a synthetic cord factor analogue for subunitMycobacterium tuberculosisvaccination requires FcRγ–Syk–Card9–dependent innate immune activation

(2009) Kerstin Werninghaus et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mincle is a long sought receptor for mycobacterial cord factor

(2009) Isamu Matsunaga et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle

(2009) Eri Ishikawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

C-type lectin Mincle is an activating receptor for pathogenic fungus,Malassezia

(2009) Sho Yamasaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The first unique synthetic mycobacterial cord factors

(2009) Juma’a R. Al Dulayymi et al.   TETRAHEDRON LETTERS

MARCO, TLR2, and CD14 Are Required for Macrophage Cytokine Responses to Mycobacterial Trehalose Dimycolate and Mycobacterium tuberculosis

(2009) Dawn M. E. Bowdish et al.   PLoS Pathogens

Dectin-1 synergizes with TLR2 and TLR4 for cytokine production in human primary monocytes and macrophages

(2008) Gerben Ferwerda et al.   CELLULAR MICROBIOLOGY

Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome

(2008) Joshua D. Milner et al.   NATURE

Mincle is an ITAM-coupled activating receptor that senses damaged cells

(2008) Sho Yamasaki et al.   NATURE IMMUNOLOGY