IL-1β Induces Pathologically Activated Osteoclasts Bearing Extremely High Levels of Resorbing Activity: A Possible Pathological Subpopulation of Osteoclasts, Accompanied by Suppressed Expression of Kindlin-3 and Talin-1

Real-time intravital imaging of pH variation associated with osteoclast activity

(2016) Hiroki Maeda et al.   Nature Chemical Biology

Tissue biology perspective on macrophages

(2016) Yasutaka Okabe et al.   NATURE IMMUNOLOGY

Mechanisms that lead to the regulation of NLRP3 inflammasome expression and activation in human dental pulp fibroblasts

(2015) Ansheng Zhang et al.   MOLECULAR IMMUNOLOGY

Mechanisms of Bone Resorption in Periodontitis

(2015) Stefan A. Hienz et al.   Journal of Immunology Research

The Great Beauty of the osteoclast

(2014) Alfredo Cappariello et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Interleukin-1β promotes the LC3-mediated secretory function of osteoclast precursors by stimulating the Ca2+-dependent activation of ERK

(2014) Yeon-Ho Chung et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Increased RANKL-mediated osteoclastogenesis by interleukin-1β and endoplasmic reticulum stress

(2014) Eun-Gyeong Lee et al.   JOINT BONE SPINE

Porphyromonas gingivalis-derived Lysine Gingipain Enhances Osteoclast Differentiation Induced by Tumor Necrosis Factor-α and Interleukin-1β but Suppresses That by Interleukin-17A

(2014) Tomohito Akiyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Absence of Dap12 and the αvβ3 integrin causes severe osteopetrosis

(2014) Wei Zou et al.   JOURNAL OF CELL BIOLOGY

Bone- and Cartilage-Protective Effects of a Monoclonal Antibody Against Colony-Stimulating Factor 1 Receptor in Experimental Arthritis

(2014) Myew-Ling Toh et al.   Arthritis & Rheumatology

Mechanisms of talin-dependent integrin signaling and crosstalk

(2013) Mitali Das et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Tissue-resident macrophages

(2013) Luke C Davies et al.   NATURE IMMUNOLOGY

How Cytokine Networks Fuel Inflammation: Toward a cytokine-based disease taxonomy

(2013) Georg Schett et al.   NATURE MEDICINE

Inflammatory monocytes and Fc  receptor IV on osteoclasts are critical for bone destruction during inflammatory arthritis in mice

(2013) M. Seeling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2

(2012) Uta Praekelt et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor function

(2012) Julia F. Charles et al.   JOURNAL OF CLINICAL INVESTIGATION

Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment

(2012) Georg Schett et al.   Nature Reviews Rheumatology

New insights into osteoclastogenic signaling mechanisms

(2012) Tomoki Nakashima et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Kindlin-3–mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorption

(2011) Sarah Schmidt et al.   JOURNAL OF CELL BIOLOGY

Cutting Edge: The Murine High-Affinity IgG Receptor Fc RIV Is Sufficient for Autoantibody-Induced Arthritis

(2011) D. A. Mancardi et al.   JOURNAL OF IMMUNOLOGY

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

IL-1β induces ER stress in a JNK dependent manner that determines cell death in human pancreatic epithelial MIA PaCa-2 cells

(2010) Gaurav Verma et al.   APOPTOSIS

Neutrophils in a mouse model of autoantibody-mediated arthritis: Critical producers of Fc receptor γ, the receptor for C5a, and lymphocyte function−associated antigen 1

(2010) Paul A. Monach et al.   ARTHRITIS AND RHEUMATISM

Kindlins in FERM adhesion

(2010) N. L. Malinin et al.   BLOOD

Integrins and bone metastasis: Integrating tumor cell and stromal cell interactions

(2010) Jochen G. Schneider et al.   BONE

Direct Inhibition of Human RANK+ Osteoclast Precursors Identifies a Homeostatic Function of IL-1 

(2010) B. Lee et al.   JOURNAL OF IMMUNOLOGY

Fc RIV deletion reveals its central role for IgG2a and IgG2b activity in vivo

(2010) F. Nimmerjahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-1 is essential for systemic inflammatory bone loss

(2009) K Polzer et al.   ANNALS OF THE RHEUMATIC DISEASES

A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans

(2009) Nikolay L Malinin et al.   NATURE MEDICINE

The Kindlin protein family: new members to the club of focal adhesion proteins

(2009) Alexander Meves et al.   TRENDS IN CELL BIOLOGY

Selective molecular imaging of viable cancer cells with pH-activatable fluorescence probes

(2008) Yasuteru Urano et al.   NATURE MEDICINE