NFM Cross-Reactivity to MOG Does Not Expand a Critical Threshold Level of High-Affinity T Cells Necessary for Onset of Demyelinating Disease

In situexpansion of T cells that recognize distinct self-antigens sustains autoimmunity in the CNS

(2016) Abdulraouf Ramadan et al.   BRAIN

Myelin oligodendrocyte glycoprotein induces incomplete tolerance of CD4+ T cells specific for both a myelin and a neuronal self-antigen in mice

(2016) Liliana E. Lucca et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Thymus-Derived Regulatory T Cells Are Positively Selected on Natural Self-Antigen through Cognate Interactions of High Functional Avidity

(2016) Elisa Kieback et al.   IMMUNITY

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity

(2016) David K. Cole et al.   JOURNAL OF CLINICAL INVESTIGATION

Preferential Use of Public TCR during Autoimmune Encephalomyelitis

(2016) Yunqian Zhao et al.   JOURNAL OF IMMUNOLOGY

Low-affinity CD4+ T cells are major responders in the primary immune response

(2016) Ryan J. Martinez et al.   Nature Communications

An ImmunoChip study of multiple sclerosis risk in African Americans

(2015) Noriko Isobe et al.   BRAIN

T Cell Receptor Cross-Reactivity between Similar Foreign and Self Peptides Influences Naive Cell Population Size and Autoimmunity

(2015) Ryan W. Nelson et al.   IMMUNITY

CD4 + T Cell Tolerance to Tissue-Restricted Self Antigens Is Mediated by Antigen-Specific Regulatory T Cells Rather Than Deletion

(2015) Francois P. Legoux et al.   IMMUNITY

Clonal Deletion Prunes but Does Not Eliminate Self-Specific αβ CD8+ T Lymphocytes

(2015) Wong Yu et al.   IMMUNITY

Regulatory and T Effector Cells Have Overlapping Low to High Ranges in TCR Affinities for Self during Demyelinating Disease

(2015) Jennifer D. Hood et al.   JOURNAL OF IMMUNOLOGY

Force-Regulated In Situ TCR–Peptide-Bound MHC Class II Kinetics Determine Functions of CD4+T Cells

(2015) Jinsung Hong et al.   JOURNAL OF IMMUNOLOGY

Antigen Presentation, Autoantigens, and Immune Regulation in Multiple Sclerosis and Other Autoimmune Diseases

(2015) Christine Riedhammer et al.   Frontiers in Immunology

Deconstructing the Peptide-MHC Specificity of T Cell Recognition

(2014) Michael E. Birnbaum et al.   CELL

Accumulation of Dynamic Catch Bonds between TCR and Agonist Peptide-MHC Triggers T Cell Signaling

(2014) Baoyu Liu et al.   CELL

Structural basis for ineffective T-cell responses to MHC anchor residue-improved “heteroclitic” peptides

(2014) Florian Madura et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Loss of IFN-  Enables the Expansion of Autoreactive CD4+ T Cells to Induce Experimental Autoimmune Encephalomyelitis by a Nonencephalitogenic Myelin Variant Antigen

(2014) J. J. Sabatino et al.   JOURNAL OF IMMUNOLOGY

Retrogenic Modeling of Experimental Allergic Encephalomyelitis Associates T Cell Frequency but Not TCR Functional Affinity with Pathogenicity

(2014) R. Alli et al.   JOURNAL OF IMMUNOLOGY

MHC Variant Peptide-Mediated Anergy of Encephalitogenic T Cells Requires SHP-1

(2014) H. A. Wasserman et al.   JOURNAL OF IMMUNOLOGY

Bispecificity for Myelin and Neuronal Self-Antigens Is a Common Feature of CD4 T Cells in C57BL/6 Mice

(2014) Liliana E. Lucca et al.   JOURNAL OF IMMUNOLOGY

Progression of Relapsing-Remitting Demyelinating Disease Does Not Require Increased TCR Affinity or Epitope Spread

(2014) Anna E. Kersh et al.   JOURNAL OF IMMUNOLOGY

Cross-Reactivity of T Cells and Its Role in the Immune System

(2013) Galina Petrova et al.   CRITICAL REVIEWS IN IMMUNOLOGY

Virus-Specific CD4+ Memory-Phenotype T Cells Are Abundant in Unexposed Adults

(2013) Laura F. Su et al.   IMMUNITY

Crossreactivity of a human autoimmune TCR is dominated by a single TCR loop

(2013) Dhruv K. Sethi et al.   Nature Communications

Transcriptome sequencing of neonatal thymic epithelial cells

(2013) Charles St-Pierre et al.   Scientific Reports

Estimating the Diversity, Completeness, and Cross-Reactivity of the T Cell Repertoire

(2013) Veronika I. Zarnitsyna et al.   Frontiers in Immunology

Monitoring the Dynamics of T Cell Clonal Diversity Using Recombinant Peptide:MHC Technology

(2013) J. Lori Blanchfield et al.   Frontiers in Immunology

Self-reactive human CD4 T cell clones form unusual immunological synapses

(2012) David A. Schubert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Low 2-Dimensional CD4 T Cell Receptor Affinity for Myelin Sets in Motion Delayed Response Kinetics

(2012) Kristen M. Rosenthal et al.   PLoS One

The MHC, disease and selection

(2011) John Trowsdale   IMMUNOLOGY LETTERS

A Single Autoimmune T Cell Receptor Recognizes More Than a Million Different Peptides

(2011) Linda Wooldridge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High prevalence of low affinity peptide–MHC II tetramer–negative effectors during polyclonal CD4+T cell responses

(2011) Joseph J. Sabatino et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Discrete TCR Repertoires and CDR3 Features Distinguish Effector and Foxp3+ Regulatory T Lymphocytes in Myelin Oligodendrocyte Glycoprotein-Induced Experimental Allergic Encephalomyelitis

(2010) P. Nguyen et al.   JOURNAL OF IMMUNOLOGY

The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness

(2010) Jun Huang et al.   NATURE

Subtle Affinity-Enhancing Mutations in a Myelin Oligodendrocyte Glycoprotein-Specific TCR Alter Specificity and Generate New Self-Reactivity

(2009) A. Udyavar et al.   JOURNAL OF IMMUNOLOGY

Pathogenic MOG-reactive CD8+ T cells require MOG-reactive CD4+ T cells for sustained CNS inflammation during chronic EAE

(2009) Maria Bettini et al.   JOURNAL OF NEUROIMMUNOLOGY

Myelin-specific T cells also recognize neuronal autoantigen in a transgenic mouse model of multiple sclerosis

(2009) Gurumoorthy Krishnamoorthy et al.   NATURE MEDICINE

Tracking epitope-specific T cells

(2009) James J Moon et al.   Nature Protocols