Clinical implications of genome-wide DNA methylation studies in acute myeloid leukemia

Impact of Global and Gene-Specific DNA Methylation in de Novo or Relapsed Acute Myeloid Leukemia Patients Treated with Decitabine

(2016) Li-Ying Zhang et al.   Asian Pacific Journal of Cancer Prevention

The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia

(2016) D. A. Arber et al.   BLOOD

Update on rational targeted therapy in AML

(2016) Danielle Shafer et al.   BLOOD REVIEWS

Saturation analysis for whole-genome bisulfite sequencing data

(2016) Emanuele Libertini et al.   NATURE BIOTECHNOLOGY

Quantitative comparison of DNA methylation assays for biomarker development and clinical applications

(2016) Christoph Bock et al.   NATURE BIOTECHNOLOGY

Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia

(2016) Sheng Li et al.   NATURE MEDICINE

Genomic Classification and Prognosis in Acute Myeloid Leukemia

(2016) Elli Papaemmanuil et al.   NEW ENGLAND JOURNAL OF MEDICINE

The European Medicines Agency Review of Decitabine (Dacogen) for the Treatment of Adult Patients With Acute Myeloid Leukemia: Summary of the Scientific Assessment of the Committee for Medicinal Products for Human Use

(2016) Maria Nieto et al.   ONCOLOGIST

Validation of a DNA methylation microarray for 850,000 CpG sites of the human genome enriched in enhancer sequences

(2016) Sebastian Moran et al.   Epigenomics

Information recovery from low coverage whole-genome bisulfite sequencing

(2016) Emanuele Libertini et al.   Nature Communications

eFORGE: A Tool for Identifying Cell Type-Specific Signal in Epigenomic Data

(2016) Charles E. Breeze et al.   Cell Reports

The International Human Epigenome Consortium Data Portal

(2016) David Bujold et al.   Cell Systems

The BLUEPRINT Data Analysis Portal

(2016) José María Fernández et al.   Cell Systems

Presence of isocitrate dehydrogenase mutations may predict clinical response to hypomethylating agents in patients with acute myeloid leukemia

(2015) Ashkan Emadi et al.   AMERICAN JOURNAL OF HEMATOLOGY

Azacitidine in AML: a treatment option?

(2015) G. Huls   BLOOD

International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with >30% blasts

(2015) H. Dombret et al.   BLOOD

Epigenetics and approaches to targeted epigenetic therapy in acute myeloid leukemia

(2015) B. J. Wouters et al.   BLOOD

Integration of gene expression and DNA-methylation profiles improves molecular subtype classification in acute myeloid leukemia

(2015) Erdogan Taskesen et al.   BMC BIOINFORMATICS

Mutational Cooperativity Linked to Combinatorial Epigenetic Gain of Function in Acute Myeloid Leukemia

(2015) Alan H. Shih et al.   CANCER CELL

Molecular Pathways: IDH2 Mutations--Co-opting Cellular Metabolism for Malignant Transformation

(2015) E. M. Stein   CLINICAL CANCER RESEARCH

The diagnostic and clinical impact of genetics and epigenetics in acute myeloid leukemia

(2015) R. S. Ohgami et al.   International Journal of Laboratory Hematology

PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia

(2015) Christopher B. Cole et al.   JOURNAL OF CLINICAL INVESTIGATION

Specific molecular signatures predict decitabine response in chronic myelomonocytic leukemia

(2015) Kristen Meldi et al.   JOURNAL OF CLINICAL INVESTIGATION

The Hedgehog pathway as targetable vulnerability with 5-azacytidine in myelodysplastic syndrome and acute myeloid leukemia

(2015) Raoul Tibes et al.   Journal of Hematology & Oncology

Azacytidine sensitizes acute myeloid leukemia cells to arsenic trioxide by up-regulating the arsenic transporter aquaglyceroporin 9

(2015) David Chau et al.   Journal of Hematology & Oncology

DNA methyltransferase 1 functions through C/ebpa to maintain hematopoietic stem and progenitor cells in zebrafish

(2015) Xiaohui Liu et al.   Journal of Hematology & Oncology

Model-based adaptive phase I trial design of post-transplant decitabine maintenance in myelodysplastic syndrome

(2015) Seunghoon Han et al.   Journal of Hematology & Oncology

Epigenetic therapy restores normal hematopoiesis in a zebrafish model of NUP98–HOXA9-induced myeloid disease

(2015) A P Deveau et al.   LEUKEMIA

AML1/ETO cooperates with HIF1α to promote leukemogenesis through DNMT3a transactivation

(2015) X N Gao et al.   LEUKEMIA

Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

Acute Myeloid Leukemia

(2015) Hartmut Döhner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clustering of Cancer Cell Lines Using A Promoter- Targeted Liquid Hybridization Capture-Based Bisulfite Sequencing Approach

(2015) Fei Gao et al.   TECHNOLOGY IN CANCER RESEARCH & TREATMENT

Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants

(2015) Fiona Allum et al.   Nature Communications

Validation of DNA Methylation to Predict Outcome in Acute Myeloid Leukemia by Use of xMELP

(2014) G. B. W. Wertheim et al.   CLINICAL CHEMISTRY

Differential methylation in CN-AML preferentially targets non-CGI regions and is dictated byDNMT3Amutational status and associated with predominant hypomethylation of HOX genes

(2014) Ying Qu et al.   Epigenetics

Epigenetic inactivation ofDAPK1,p14ARF,mir-34aand-34b/cin acute promyelocytic leukaemia

(2014) Ho Yin Ng et al.   JOURNAL OF CLINICAL PATHOLOGY

CBFB-MYH11 hypomethylation signature and PBX3 differential methylation revealed by targeted bisulfite sequencing in patients with acute myeloid leukemia

(2014) Hana Hájková et al.   Journal of Hematology & Oncology

Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

(2014) Liran I. Shlush et al.   NATURE

The Diagnostic Value of DNA Methylation in Leukemia: A Systematic Review and Meta-Analysis

(2014) Danjie Jiang et al.   PLoS One

IDH1 Inhibitor Shows Promising Early Results

(2014)   Cancer Discovery

Epigenetics Meets Genetics in Acute Myeloid Leukemia: Clinical Impact of a Novel Seven-Gene Score

(2013) Guido Marcucci et al.   JOURNAL OF CLINICAL ONCOLOGY

Epigenetic changes: a common theme in acute myelogenous leukemogenesis

(2013) Soraya E Gutierrez et al.   Journal of Hematology & Oncology

Microsphere-Based Multiplex Analysis of DNA Methylation in Acute Myeloid Leukemia

(2013) Gerald B.W. Wertheim et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Impact of molecular mutations on treatment response to DNMT inhibitors in myelodysplasia and related neoplasms

(2013) F Traina et al.   LEUKEMIA

Origins of aberrant DNA methylation in acute myeloid leukemia

(2013) T Schoofs et al.   LEUKEMIA

DNA methylation: roles in mammalian development

(2013) Zachary D. Smith et al.   NATURE REVIEWS GENETICS

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

DNA Methyltransferases in Hematologic Malignancies

(2013) Keqin Kathy Li et al.   SEMINARS IN HEMATOLOGY

Mining cancer methylomes: prospects and challenges

(2013) Clare Stirzaker et al.   TRENDS IN GENETICS

Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia

(2012) A. F. T. Ribeiro et al.   BLOOD

DNA methylation changes are a late event in acute promyelocytic leukemia and coincide with loss of transcription factor binding

(2012) T. Schoofs et al.   BLOOD

The Origin and Evolution of Mutations in Acute Myeloid Leukemia

(2012) John S. Welch et al.   CELL

Current treatment of acute myeloid leukemia

(2012) Gail J. Roboz   CURRENT OPINION IN ONCOLOGY

Azacitidine

(2012) Gillian M. Keating   DRUGS

TET2 Mutations in Acute Myeloid Leukemia (AML): Results From a Comprehensive Genetic and Clinical Analysis of the AML Study Group

(2012) Verena I. Gaidzik et al.   JOURNAL OF CLINICAL ONCOLOGY

MeDIP coupled with a promoter tiling array as a platform to investigate global DNA methylation patterns in AML cells

(2012) Arzu Yalcin et al.   LEUKEMIA RESEARCH

Functions of DNA methylation: islands, start sites, gene bodies and beyond

(2012) Peter A. Jones   NATURE REVIEWS GENETICS

Base-Pair Resolution DNA Methylation Sequencing Reveals Profoundly Divergent Epigenetic Landscapes in Acute Myeloid Leukemia

(2012) Altuna Akalin et al.   PLoS Genetics

Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia

(2011) Y. Shen et al.   BLOOD

Prognostic DNA methylation patterns in cytogenetically normal acute myeloid leukemia are predefined by stem cell chromatin marks

(2011) S. Deneberg et al.   BLOOD

Genome-wide functions of PML–RARα in acute promyelocytic leukaemia

(2011) S Saeed et al.   BRITISH JOURNAL OF CANCER

High density DNA methylation array with single CpG site resolution

(2011) Marina Bibikova et al.   GENOMICS

Dnmt3a is essential for hematopoietic stem cell differentiation

(2011) Grant A Challen et al.   NATURE GENETICS

Evaluation of the Infinium Methylation 450K technology

(2011) Sarah Dedeurwaerder et al.   Epigenomics

Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value

(2010) S. Abbas et al.   BLOOD

Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials

(2010) D. Grimwade et al.   BLOOD

Genome-wide analysis of aberrant methylation in human breast cancer cells using methyl-DNA immunoprecipitation combined with high-throughput sequencing

(2010) Yoshinao Ruike et al.   BMC GENOMICS

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

(2010) Maria E. Figueroa et al.   CANCER CELL

DNA Methylation Signatures Identify Biologically Distinct Subtypes in Acute Myeloid Leukemia

(2010) Maria E. Figueroa et al.   CANCER CELL

PML-RARα/RXR Alters the Epigenetic Landscape in Acute Promyelocytic Leukemia

(2010) Joost H.A. Martens et al.   CANCER CELL

Gene-specific and global methylation patterns predict outcome in patients with acute myeloid leukemia

(2010) S Deneberg et al.   LEUKEMIA

DNMT3AMutations in Acute Myeloid Leukemia

(2010) Timothy J. Ley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Quantitative DNA methylation predicts survival in adult acute myeloid leukemia

(2009) L. Bullinger et al.   BLOOD

Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet

(2009) H. Dohner et al.   BLOOD

MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation

(2009) M. E. Figueroa et al.   BLOOD

Identification of acquired copy number alterations and uniparental disomies in cytogenetically normal acute myeloid leukemia using high-resolution single-nucleotide polymorphism analysis

(2009) L Bullinger et al.   LEUKEMIA

Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome

(2009) Elaine R. Mardis et al.   NEW ENGLAND JOURNAL OF MEDICINE