Article
Hematology
Fatemeh Shahneh, Alexandra Grill, Matthias Klein, Felix Frauhammer, Tobias Bopp, Katrin Schaefer, Verena K. Raker, Christian Becker
Summary: The cells and mechanisms involved in blood clot resorption are only partially known, with regulatory T cells playing a crucial role in regulating thrombolysis by controlling monocytes. The matricellular protein SPARC is shown to enhance monocyte activity and is crucial for blood clot resorption. Expanding Tregs within a therapeutic window can accelerate clot resorption.
Review
Immunology
Carsten Riether
Summary: Adult bone marrow hematopoietic stem cells (HSCs) maintain their function through interactions with regulatory T cells (Tregs). In leukemia, these regulatory mechanisms are disrupted, leading to compromised treatment outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Jin-Ming Yang, Yijie Ren, Anil Kumar, Xiaofang Xiong, Jugal Kishore Das, Hao-Yun Peng, Liqing Wang, Xingcong Ren, Yi Zhang, Cheng Ji, Yan Cheng, Li Zhang, Robert C. Alaniz, Paul de Figueiredo, Deyu Fang, Hongwei Zhou, Xiaoqi Liu, Jianlong Wang, Jianxun Song
Summary: This study shows that NAC1 plays a role in regulating the expression of FoxP3 in regulatory T cells, thereby affecting immune tolerance. NAC1-deficient mice display increased tolerance to autoimmunity and higher levels of immune-suppressive CD4(+) T-regs cells which exhibit enhanced metabolic profile and activity. These findings suggest that NAC1 destabilizes T-regs and suppresses tolerance induction, indicating its potential as a target for tolerogenic strategies in treating autoimmune disorders.
Article
Cell Biology
Anindita Roy, Guanlin Wang, Deena Iskander, Sorcha O'Byrne, Natalina Elliott, Jennifer O'Sullivan, Gemma Buck, Elisabeth F. Heuston, Wei Xiong Wen, Alba Rodriguez Meira, Peng Hua, Anastasios Karadimitris, Adam J. Mead, David M. Bodine, Irene Roberts, Bethan Psaila, Supat Thongjuea
Summary: Human hematopoiesis is a dynamic process that starts in utero 18-21 days post-conception, and understanding the site- and stage-specific variations is crucial for unraveling the origin of hematological disorders. The comparison of 57,489 HSPCs from 5 different tissues revealed significant transitions in cellular architecture and gene regulatory networks at different locations and developmental stages, with hematopoietic stem cells showing progression from cycling to quiescence during ontogeny. The dataset was also useful for understanding aberrant hematopoiesis in comparison to two cancers that present at distinct time points in postnatal life.
Article
Biochemical Research Methods
Wei Liu, Xingen Sun, Li Yang, Kaiwen Li, Yu Yang, Xiangzheng Fu
Summary: Accurately inferring gene regulatory networks is crucial for understanding pathogenesis and curing diseases. However, identifying redundant regulations remains a challenge in existing methods. In this study, we propose a network structure control method that specifies the specific forms and cooperation mode of both global and local topology. Experimental results demonstrate the unique advantages of our method in gene regulatory network inference.
BRIEFINGS IN BIOINFORMATICS
(2022)
Editorial Material
Biochemistry & Molecular Biology
Chrysothemis C. Brown, Rachel A. Gottschalk
Summary: The study in this issue of Cell highlights the importance of tightly regulating Treg-mediated immunosuppression to balance immunity and tissue protection. High-resolution imaging was used to define feedback circuits that quantitatively control local Treg expansion and function.
Article
Cardiac & Cardiovascular Systems
Fabienne Burger, Kapka Miteva, Daniela Baptista, Aline Roth, Rodrigo A. Fraga-Silva, Catherine Martel, Nikolaos Stergiopulos, Francois Mach, Karim J. Brandt
Summary: The study shows that follicular regulatory helper T cells (T-FR) can control regulatory B cell (B-REG) populations in mice models on a high-cholesterol diet, leading to the suppression of proatherogenic processes. This suggests that T-FR cells may have atheroprotective effects by modulating immune processes related to atherosclerosis.
CARDIOVASCULAR RESEARCH
(2021)
Article
Immunology
Weinian Liao, Chaonan Liu, Ke Yang, Jun Chen, Yiding Wu, Shuzhen Zhang, Kuan Yu, Lisha Wang, Li Ran, Mo Chen, Fang Chen, Yang Xu, Song Wang, Fengchao Wang, Qian Zhang, Jinghong Zhao, Lilin Ye, Changhong Du, Junping Wang
Summary: The accumulation of DNA mutations in aging hematopoietic stem cells (HSCs) increases the expression of MHCII on their surface, allowing them to be recognized by bone marrow regulatory T cells (Tregs). Tregs transfer cAMP to aged HSCs through gap junctions, promoting their survival and preventing apoptosis. Disrupting the interaction between HSCs and Tregs effectively prevents premature/physiological aging of HSCs.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Claudia Curci, Angela Picerno, Nada Chaoul, Alessandra Stasi, Giuseppe De Palma, Rossana Franzin, Paola Pontrelli, Giuseppe Castellano, Giovanni B. Pertosa, Luigi Macchia, Vito Francesco Di Lorenzo, Carlo Sabba, Anna Gallone, Loreto Gesualdo, Fabio Sallustio
Summary: Studies have shown that Adult Renal Stem/Progenitor Cells (ARPCs) can regulate immune responses by inducing Tregs and DN T cell modulation, which play a crucial role in maintaining immune tolerance and preventing autoimmunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Xiaofeng Wang, Fanyuan Yu, Ling Ye
Summary: Recent studies have shown that MSCs play a vital role in bone regeneration, including osteogenic differentiation and providing seed cells. However, factors like drug intake and body senescence can affect MSCs' functions in bone regeneration. Epigenetic regulation has received attention for its heritable nature and involvement in bone metabolism disorders. This review focuses on the effects of epigenetic regulation on osteogenic differentiation, proliferation, and cellular senescence in MSCs and its role in bone regeneration.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Immunology
Wen-wen Guo, Xiu-hua Su, Ming-yang Wang, Ming-zhe Han, Xiao-ming Feng, Er-lie Jiang
Summary: GVHD is a common and life-threatening complication after allo-HSCT, and Tregs play a crucial role in controlling GVHD by effectively preventing and treating it through their immunosuppressive properties without increasing the risk of infection and relapse.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Chunyu Pan, Yuyan Zhu, Meng Yu, Yongkang Zhao, Changsheng Zhang, Xizhe Zhang, Yang Yao
Summary: Utilizing network controllability theory, we identified a MYCN regulatory network with 79 genes and 129 interactions, and found 10 indispensable genes that could significantly alter the regulatory pathways of MYCN network. Through stability and correlation analysis, we identified EGFR as a potential drug target closely associated with MYCN.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Ioannis Sarropoulos, Mari Sepp, Robert Fromel, Kevin Leiss, Nils Trost, Evgeny Leushkin, Konstantin Okonechnikov, Piyush Joshi, Peter Giere, Lena M. Kutscher, Margarida Cardoso-Moreira, Stefan M. Pfister, Henrik Kaessmann
Summary: This study investigated the regulatory basis of mouse cerebellum development from early neurogenesis to adulthood using snATAC-seq profiles. The research revealed spatiotemporal heterogeneity among progenitor cells and gradual divergence in the regulatory programs of cerebellar neurons during differentiation. Comparison to vertebrate genomes showed a shared decrease in CRE conservation during development and differentiation, as well as differences in constraint between cell types. The study provides insights into mammalian organ development dynamics and evolutionary gene regulation in cerebellar cells.
Article
Cell Biology
Jemma Nicholls, Benjamin Cao, Laetitia Le Texier, Laura Yan Xiong, Christopher R. Hunter, Genesis Llanes, Ethan G. Aguliar, Wayne A. Schroder, Simon Phipps, Jason P. Lynch, Huimin Cao, Shen Y. Heazlewood, Brenda Williams, Andrew D. Clouston, Christian M. Nefzger, Jose M. Polo, Susan K. Nilsson, Bruce R. Blazar, Kelli P. A. MacDonald
Summary: BM-Treg and pTreg exhibit distinct characteristics, including differential expression of chemokine receptors, transcription factors, and cell cycle control genes. BM-Treg show unique properties and are functionally and phenotypically different from splenic Treg.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Haroon Shaikh, Joern Pezoldt, Zeinab Mokhtari, Juan Gamboa Vargas, Duc-Dung Le, Josefina Pena Mosca, Estibaliz Arellano Viera, Michael Ag Kern, Caroline Graf, Niklas Beyersdorf, Manfred B. Lutz, Angela Riedel, Maike Buettner-Herold, Alma Zernecke, Hermann Einsele, Antoine-Emmanuel Saliba, Burkhard Ludewig, Jochen Huehn, Andreas Beilhack
Summary: This study reveals the immunoprotective role of FRC niches in secondary lymphoid organs for regulating aGvHD and highlights the framework of cellular and molecular interactions that modulate CD4+ T cell alloimmunity.
Article
Hematology
Joakim S. Dahlin, Fiona K. Hamey, Blanca Pijuan-Sala, Mairi Shepherd, Winnie W. Y. Lau, Sonia Nestorowa, Caleb Weinreb, Samuel Wolock, Rebecca Hannah, Evangelia Diamanti, David G. Kent, Berthold Gottgens, Nicola K. Wilson
Article
Mathematical & Computational Biology
Steven Woodhouse, Nir Piterman, Christoph M. Wintersteiger, Berthold Goettgens, Jasmin Fisher
BMC SYSTEMS BIOLOGY
(2018)
Review
Hematology
Sam Watcham, Iwo Kucinski, Berthold Gottgens
Article
Cardiac & Cardiovascular Systems
Viktoria Kalna, Youwen Yang, Claire R. Peghaire, Karen Frudd, Rebecca Hannah, Aarti Shah, Lourdes Osuna Almagro, Joseph J. Boyle, Berthold Gottgens, Jorge Ferrer, Anna M. Randi, Graeme M. Birdsey
CIRCULATION RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Julio Sainz de Aja, Sergio Menchero, Isabel Rollan, Antonio Barral, Maria Tiana, Wajid Jawaid, Itziar Cossio, Alba Alvarez, Gonzalo Carreno-Tarragona, Claudio Badia-Careaga, Jennifer Nichols, Berthold Gottgens, Joan Isern, Miguel Manzanares
Article
Hematology
Clara Bueno, Fernando J. Calero-Nieto, Xiaonan Wang, Rafael Valdes-Mas, Francisco Gutierrez-Aguera, Heleia Roca-Ho, Veronica Ayllon, Pedro J. Real, David Arambilet, Lluis Espinosa, Raul Torres-Ruiz, Antonio Agraz-Doblas, Ignacio Varela, Jasper de Boer, Anna Bigas, Bertie Gottgens, Rolf Marschalek, Pablo Menendez
Article
Multidisciplinary Sciences
Blanca Pijuan-Sala, Jonathan A. Griffiths, Carolina Guibentif, Tom W. Hiscock, Wajid Jawaid, Fernando J. Calero-Nieto, Carla Mulas, Ximena Ibarra-Soria, Richard C. V. Tyser, Debbie Lee Lian Ho, Wolf Reik, Shankar Srinivas, Benjamin D. Simons, Jennifer Nichols, John C. Marioni, Berthold Gottgens
Article
Biology
Antonio Barral, Isabel Rollan, Hector Sanchez-Iranzo, Wajid Jawaid, Claudio Badia-Careaga, Sergio Menchero, Manuel J. Gomez, Carlos Torroja, Fatima Sanchez-Cabo, Berthold Gottgens, Miguel Manzanares, Julio Sainz de Aja
Review
Multidisciplinary Sciences
Jong-Eun Park, Laura Jardine, Berthold Gottgens, Sarah A. Teichmann, Muzlifah Haniffa
Article
Cell Biology
Luke T. G. Harland, Claire S. Simon, Anna D. Senft, Ita Costello, Lucas Greder, Ivan Imaz-Rosshandler, Berthold Gottgens, John C. Marioni, Elizabeth K. Bikoff, Catherine Porcher, Marella F. T. R. de Bruijn, Elizabeth J. Robertson
Summary: The study shows that the T-box transcription factor Eomes influences chromatin accessibility at SCL-bound enhancers in the extra-embryonic mesoderm, regulating erythropoiesis and Runx1 expression. Eomes governs the haemogenic competency of ExM and is essential for the normal development of haemogenic endothelium. The findings suggest that haemogenic competence is established earlier during embryonic development than previously thought, with Eomes playing a crucial role in the transcriptional hierarchy of early blood formation.
NATURE CELL BIOLOGY
(2021)
Article
Oncology
Xiaonan Wang, Carlotta Peticone, Ekaterini Kotsopoulou, Berthold Gottgens, Fernando J. Calero-Nieto
Summary: This study used single-cell transcriptomic analysis to characterize the molecular features of CAR T cell activation, revealing several subpopulations of cells in CAR products with reproducible cellular composition across donors. Targeted data interrogation also showed that a small proportion of antigen-responding CAR-expressing cells exhibited exhaustion signatures with known markers and previously unassociated genes.
Correction
Cell Biology
Luke T. G. Harland, Claire S. Simon, Anna D. Senft, Ita Costello, Lucas Greder, Ivan Imaz-Rosshandler, Berthold Gottgens, John C. Marioni, Elizabeth K. Bikoff, Catherine Porcher, Marella F. T. R. de Bruijn, Elizabeth J. Robertson
NATURE CELL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Daniel Prins, Hyun Jung Park, Sam Watcham, Juan Li, Michele Vacca, Hugo P. Bastos, Alexander Gerbaulet, Antonio Vidal-Puig, Berthold Gottgens, Anthony R. Green
Article
Biochemistry & Molecular Biology
Iwo Kucinski, Nicola K. Wilson, Rebecca Hannah, Sarah J. Kinston, Pierre Cauchy, Aurelie Lenaerts, Rudolf Grosschedl, Berthold Goettgens
Article
Biotechnology & Applied Microbiology
F. Alexander Wolf, Fiona K. Hamey, Mireya Plass, Jordi Solana, Joakim S. Dahlin, Berthold Gottgens, Nikolaus Rajewsky, Lukas Simon, Fabian J. Theis