Curcumin―The Paradigm of a Multi-Target Natural Compound with Applications in Cancer Prevention and Treatment

Elimination of Colon Cancer Stem-Like Cells by the Combination of Curcumin and FOLFOX

(2014) Yingjie Yu et al.   Translational Oncology

Mechanisms of microRNA deregulation in human cancer

(2011) Shan Deng et al.   CELL CYCLE

Curcumin analogues exhibit enhanced growth suppressive activity in human pancreatic cancer cells

(2010) Lauren Friedman et al.   ANTI-CANCER DRUGS

Androgen responsive and refractory prostate cancer cells exhibit distinct curcumin regulated transcriptome

(2010) Rajesh L. Thangapazham et al.   CANCER BIOLOGY & THERAPY

Phase I dose escalation trial of docetaxel plus curcumin in patients with advanced and metastatic breast cancer

(2010) Mathilde Bayet-Robert et al.   CANCER BIOLOGY & THERAPY

Gene Expression Profiling Related to Anti-inflammatory Properties of Curcumin in K562 Leukemia Cells

(2009) Marie-Helene Teiten et al.   Annals of the New York Academy of Sciences

Curcumin derivatives: Molecular basis of their anti-cancer activity

(2009) Valentina Basile et al.   BIOCHEMICAL PHARMACOLOGY

RETRACTED: Curcumin potentiates the antitumor effects of gemcitabine in an orthotopic model of human bladder cancer through suppression of proliferative and angiogenic biomarkers

(2009) Sheeja T. Tharakan et al.   BIOCHEMICAL PHARMACOLOGY

RETRACTED: Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo

(2009) Preetha Anand et al.   BIOCHEMICAL PHARMACOLOGY

Targeting critical steps of cancer metastasis and recurrence using telomerase template antagonists

(2009) Z. Gunnur Dikmen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Targeting the telosome: Therapeutic implications

(2009) Marco Folini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Anti- and pro-tumor functions of autophagy

(2009) Eugenia Morselli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Role and regulation of autophagy in cancer

(2009) Ning Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Curcumin, a Potential Inhibitor of Up-regulation of TNF-alpha and IL-6 Induced by Palmitate in 3T3-L1 Adipocytes through NF-kappaB and JNK Pathway

(2009) Shao-Ling WANG et al.   BIOMEDICAL AND ENVIRONMENTAL SCIENCES

Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies

(2009) Gamze Bora-Tatar et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, cytotoxic and combined cDDP activity of new stable curcumin derivatives

(2009) Erika Ferrari et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Curcumin Suppresses the Paclitaxel-Induced Nuclear Factor-κB in Breast Cancer Cells and Potentiates the Growth Inhibitory Effect of Paclitaxel in a Breast Cancer Nude Mice Model

(2009) Hee Joon Kang et al.   Breast Journal

Curcumin induces apoptosis-independent death in oesophageal cancer cells

(2009) G O'Sullivan-Coyne et al.   BRITISH JOURNAL OF CANCER

Curcumin Sensitizes Lung Cancer Cells to Cisplatin-Induced Apoptosis Through Superoxide Anion-Mediated Bcl-2 Degradation

(2009) Pithi Chanvorachote et al.   CANCER INVESTIGATION

Curcumin inhibits the migration and invasion of human A549 lung cancer cells through the inhibition of matrix metalloproteinase-2 and -9 and Vascular Endothelial Growth Factor (VEGF)

(2009) Song-Shei Lin et al.   CANCER LETTERS

Curcumin inhibits nuclear localization of telomerase by dissociating the Hsp90 co-chaperone p23 from hTERT

(2009) Ji Hoon Lee et al.   CANCER LETTERS

Curcumin Disrupts the Mammalian Target of Rapamycin-Raptor Complex

(2009) C. S. Beevers et al.   CANCER RESEARCH

New curcumin analogues exhibit enhanced growth-suppressive activity and inhibit AKT and signal transducer and activator of transcription 3 phosphorylation in breast and prostate cancer cells

(2009) Li Lin et al.   CANCER SCIENCE

Harnessing the fruits of nature for the development of multi-targeted cancer therapeutics

(2009) Fazlul H. Sarkar et al.   CANCER TREATMENT REVIEWS

Lung tumor promotion by curcumin

(2009) Stephanie T. Dance-Barnes et al.   CARCINOGENESIS

Cell-cycle inhibition and apoptosis induced by curcumin and cisplatin or oxaliplatin in human ovarian carcinoma cells

(2009) M. Montopoli et al.   CELL PROLIFERATION

Potent growth suppressive activity of curcumin in human breast cancer cells: Modulation of Wnt/β-catenin signaling

(2009) Chandra P. Prasad et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Curcumin Inhibits Prosurvival Pathways in Chronic Lymphocytic Leukemia B Cells and May Overcome Their Stromal Protection in Combination with EGCG

(2009) A. K. Ghosh et al.   CLINICAL CANCER RESEARCH

Targeting Inflammatory Pathways for Prevention and Therapy of Cancer: Short-Term Friend, Long-Term Foe

(2009) B. B. Aggarwal et al.   CLINICAL CANCER RESEARCH

MicroRNAs and cancer epigenetics: a macrorevolution

(2009) Veronica Davalos et al.   CURRENT OPINION IN ONCOLOGY

Inflammation and cancer: how friendly is the relationship for cancer patients?

(2009) Bharat B Aggarwal et al.   CURRENT OPINION IN PHARMACOLOGY

Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer

(2009) J. Shaikh et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Epigenetics and cancer treatment

(2009) Lasse Sommer Kristensen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Curcuminoid-phospholipid complex induces apoptosis in mammary epithelial cells by STAT-3 signaling

(2009) Laura Starvaggi Cucuzza et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer

(2009) Tetsuya Mitsudomi et al.   FEBS Journal

Liposome encapsulation of curcumin and resveratrol in combination reduces prostate cancer incidence in PTEN knockout mice

(2009) Narayanan K. Narayanan et al.   INTERNATIONAL JOURNAL OF CANCER

Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model

(2009) Ajaikumar B. Kunnumakkara et al.   INTERNATIONAL JOURNAL OF CANCER

The dark side of curcumin

(2009) Estefanía Burgos-Morón et al.   INTERNATIONAL JOURNAL OF CANCER

Curcumin Modulates the Radiosensitivity of Colorectal Cancer Cells by Suppressing Constitutive and Inducible NF-κB Activity

(2009) Santosh K. Sandur et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Mechanisms for the activity of heterocyclic cyclohexanone curcumin derivatives in estrogen receptor negative human breast cancer cell lines

(2009) Tiffany J. Somers-Edgar et al.   INVESTIGATIONAL NEW DRUGS

Antitumor activity of natural compounds, curcumin and PKF118-310, as Wnt/β-catenin antagonists against human osteosarcoma cells

(2009) Pay-Chin Leow et al.   INVESTIGATIONAL NEW DRUGS

Novel Artemisinin and Curcumin Micellar Formulations: Drug Solubility Studies by NMR Spectroscopy

(2009) Silvia Lapenna et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Epigenetics, miRNAs, and human cancer: a new chapter in human gene regulation

(2009) Nicola Valeri et al.   MAMMALIAN GENOME

Cell cycle inhibition and apoptosis induced by curcumin in Ewing sarcoma cell line SK-NEP-1

(2009) Mansher Singh et al.   MEDICAL ONCOLOGY

Curcumin reduces the expression of Bcl-2 by upregulating miR-15a and miR-16 in MCF-7 cells

(2009) Jie Yang et al.   MEDICAL ONCOLOGY

Molecular mechanism of curcumin induced cytotoxicity in human cervical carcinoma cells

(2009) Mayank Singh et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Curcumin modulates eukaryotic initiation factors in human lung adenocarcinoma epithelial cells

(2009) Lixia Chen et al.   MOLECULAR BIOLOGY REPORTS

Hepatocyte Nuclear Factor-4-Independent Synthesis of Coagulation Factor VII in Breast Cancer Cells and Its Inhibition by Targeting Selective Histone Acetyltransferases

(2009) S. Koizume et al.   MOLECULAR CANCER RESEARCH

Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model

(2009) B. Sung et al.   MOLECULAR CANCER THERAPEUTICS

Curcumin induces proapoptotic effects against human melanoma cells and modulates the cellular response to immunotherapeutic cytokines

(2009) M. A. Bill et al.   MOLECULAR CANCER THERAPEUTICS

Curcumin Synergizes With Resveratrol to Inhibit Colon Cancer

(2009) Adhip P. N. Majumdar et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

The microRNA network and tumor metastasis

(2009) H Zhang et al.   ONCOGENE

Fluorocurcumins as Cyclooxygenase-2 Inhibitor: Molecular Docking, Pharmacokinetics and Tissue Distribution in Mice

(2009) Subhash Padhye et al.   PHARMACEUTICAL RESEARCH

Curcumin inhibits cell proliferation of MDA-MB-231 and BT-483 breast cancer cells mediated by down-regulation of NFκB, cyclinD and MMP-1 transcription

(2009) Q. Liu et al.   PHYTOMEDICINE

Curcumin in clinical practice: myth or reality?

(2009) Cesare Mancuso et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Natural derivatives of curcumin attenuate the Wnt/β-catenin pathway through down-regulation of the transcriptional coactivator p300

(2008) Min-Jung Ryu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells

(2008) Simone Reuter et al.   BIOCHEMICAL PHARMACOLOGY

Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature

(2008) Preetha Anand et al.   BIOCHEMICAL PHARMACOLOGY

Curcumin is a potent DNA hypomethylation agent

(2008) Zhongfa Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator

(2008) Y. Jiao et al.   BLOOD

Effects of curcumin on bladder cancer cells and development of urothelial tumors in a rat bladder carcinogenesis model

(2008) Binqiang Tian et al.   CANCER LETTERS

Curcumin Inhibits the Proteasome Activity in Human Colon Cancer Cells In vitro and In vivo

(2008) V. Milacic et al.   CANCER RESEARCH

Apoptosis and non-apoptotic deaths in cancer development and treatment response

(2008) Elza C. de Bruin et al.   CANCER TREATMENT REVIEWS

Curcumin: From ancient medicine to current clinical trials

(2008) H. Hatcher et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Phase II Trial of Curcumin in Patients with Advanced Pancreatic Cancer

(2008) N. Dhillon et al.   CLINICAL CANCER RESEARCH

Natural Compounds with Proteasome Inhibitory Activity for Cancer Prevention and Treatment

(2008) H. Yang et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Resistance against novel anticancer metal compounds: Differences and similarities

(2008) P HEFFETER et al.   DRUG RESISTANCE UPDATES

Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-κB and STAT3 pathways in Hodgkin's lymphoma cells

(2008) Gerardo G. Mackenzie et al.   INTERNATIONAL JOURNAL OF CANCER

Curcumin sensitizes TRAIL-resistant xenografts: molecular mechanisms of apoptosis, metastasis and angiogenesis

(2008) Sharmila Shankar et al.   Molecular Cancer

Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cells

(2008) M. Sun et al.   MOLECULAR CANCER THERAPEUTICS

Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism

(2008) S. Yu et al.   MOLECULAR CANCER THERAPEUTICS

Metabolism of curcumin and induction of mitotic catastrophe in human cancer cells

(2008) Julia S. Dempe et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Inhibition of I B Kinase-Nuclear Factor- B Signaling Pathway by 3,5-Bis(2-flurobenzylidene)piperidin-4-one (EF24), a Novel Monoketone Analog of Curcumin

(2008) A. L. Kasinski et al.   MOLECULAR PHARMACOLOGY

The Chemopreventive Agent Curcumin Is a Potent Radiosensitizer of Human Cervical Tumor Cells via Increased Reactive Oxygen Species Production and Overactivation of the Mitogen-Activated Protein Kinase Pathway

(2008) P. Javvadi et al.   MOLECULAR PHARMACOLOGY

Prevention and Treatment of Pancreatic Cancer by Curcumin in Combination With Omega-3 Fatty Acids

(2008) Malisetty V. Swamy et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Evidence for dietary regulation of microRNA expression in cancer cells

(2008) Cindy D Davis et al.   NUTRITION REVIEWS

Therapeutic Efficacy of Curcumin/TRAIL Combination Regimen for Hormone-Refractory Prostate Cancer

(2008) Tanja Andrzejewski et al.   ONCOLOGY RESEARCH

Anti-cancer and anti-angiogenic effects of curcumin and tetrahydrocurcumin on implanted hepatocellular carcinoma in nude mice

(2008) Pornprom Yoysungnoen et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Curcumin as “Curecumin”: From kitchen to clinic

(2007) Ajay Goel et al.   BIOCHEMICAL PHARMACOLOGY

Curcumin down-regulates the multidrug-resistance mdr1b gene by inhibiting the PI3K/Akt/NFκB pathway

(2007) Byeong Hyeok Choi et al.   CANCER LETTERS