Role of the fatty acid-binding protein 4 in heart failure and cardiovascular disease

Local Production of Fatty Acid–Binding Protein 4 in Epicardial/Perivascular Fat and Macrophages Is Linked to Coronary AtherosclerosisSignificance

(2016) Masato Furuhashi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Plasma Levels of Fatty Acid–Binding Protein 4, Retinol-Binding Protein 4, High-Molecular-Weight Adiponectin, and Cardiovascular Mortality Among Men With Type 2 DiabetesHighlights

(2016) Gang Liu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

No benefit from the obesity paradox for diabetic patients with heart failure

(2016) Elisabet Zamora et al.   EUROPEAN JOURNAL OF HEART FAILURE

Serum Levels of Adipocyte Fatty Acid–Binding Protein Are Independently Associated With Left Ventricular Mass and Myocardial Performance Index in Obstructive Sleep Apnea Syndrome

(2016) Mustafa Mücahit Balci et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Cardiomyocyte Overexpression of FABP4 Aggravates Pressure Overload-Induced Heart Hypertrophy

(2016) Ji Zhang et al.   PLoS One

Circulating FABP4 Is a Prognostic Biomarker in Patients With Acute Coronary Syndrome but Not in Asymptomatic IndividualsSignificance

(2015) Hans Reiser et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Deficiency of adipocyte fatty-acid-binding protein alleviates myocardial ischaemia/reperfusion injury and diabetes-induced cardiac dysfunction

(2015) Mi Zhou et al.   CLINICAL SCIENCE

Uncoupling Lipid Metabolism from Inflammation through Fatty Acid Binding Protein-Dependent Expression of UCP2

(2015) Hongliang Xu et al.   MOLECULAR AND CELLULAR BIOLOGY

The mAb against adipocyte fatty acid-binding protein 2E4 attenuates the inflammation in the mouse model of high-fat diet-induced obesity via toll-like receptor 4 pathway

(2015) Xiaoliang Miao et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Elevation of circulating fatty acid-binding protein 4 is independently associated with left ventricular diastolic dysfunction in a general population

(2014) Takahiro Fuseya et al.   Cardiovascular Diabetology

Executive Summary: Heart Disease and Stroke Statistics—2014 Update

(2014) Alan S. Go et al.   CIRCULATION

Cardiac steatosis in patients with dilated cardiomyopathy

(2014) Marit Granér et al.   HEART

Interaction of epoxyeicosatrienoic acids and adipocyte fatty acid-binding protein in the modulation of cardiomyocyte contractility

(2014) V Lamounier-Zepter et al.   INTERNATIONAL JOURNAL OF OBESITY

Discovery of FDA-Approved Drugs as Inhibitors of Fatty Acid Binding Protein 4 Using Molecular Docking Screening

(2014) Yan Wang et al.   Journal of Chemical Information and Modeling

Oligopeptide complex for targeted non-viral gene delivery to adipocytes

(2014) Young-Wook Won et al.   NATURE MATERIALS

FABP4 is secreted from adipocytes by adenyl cyclase-PKA- and guanylyl cyclase-PKG-dependent lipolytic mechanisms

(2014) Tomohiro Mita et al.   Obesity

Binding Modes of Three Inhibitors 8CA, F8A and I4A to A-FABP Studied Based on Molecular Dynamics Simulation

(2014) Jianzhong Chen et al.   PLoS One

Adipocyte fatty acid-binding protein levels are associated with left ventricular diastolic dysfunction in morbidly obese subjects

(2014) A Baessler et al.   Nutrition & Diabetes

Capillary Endothelial Fatty Acid Binding Proteins 4 and 5 Play a Critical Role in Fatty Acid Uptake in Heart and Skeletal Muscle

(2013) Tatsuya Iso et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Parallel evolution of circulating FABP4 and NT-proBNP in heart failure patients

(2013) Anna Cabré et al.   Cardiovascular Diabetology

Association between serum adipocyte fatty-acid binding protein concentrations, left ventricular function and myocardial perfusion abnormalities in patients with coronary artery disease

(2013) Chi-Lun Huang et al.   Cardiovascular Diabetology

Adipocyte Lipid Chaperone aP2 Is a Secreted Adipokine Regulating Hepatic Glucose Production

(2013) Haiming Cao et al.   Cell Metabolism

Fatty acid binding protein 4 predicts left ventricular mass and longitudinal function in overweight and obese women

(2013) Stefan Engeli et al.   HEART

The annual global economic burden of heart failure

(2013) Christopher Cook et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Body Mass Index and Mortality in Acutely Decompensated Heart Failure Across the World

(2013) Ravi Shah et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Risk of Myocardial Infarction and Heart Failure Among Metabolically Healthy But Obese Individuals

(2013) Bjørn Mørkedal et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Circulating Levels of Fatty Acid-Binding Protein Family and Metabolic Phenotype in the General Population

(2013) Shutaro Ishimura et al.   PLoS One

Peroxisome Proliferator‐Activated Receptor‐γ in Capillary Endothelia Promotes Fatty Acid Uptake by Heart During Long‐Term Fasting

(2013) Kosaku Goto et al.   Journal of the American Heart Association

Elevated Circulating Adipocyte‐Fatty Acid Binding Protein Levels Predict Incident Cardiovascular Events in a Community‐Based Cohort: A 12‐Year Prospective Study

(2013) Wing Sun Chow et al.   Journal of the American Heart Association

Circulating Adipocyte Fatty Acid-Binding Protein Levels and Cardiovascular Morbidity and Mortality in Patients With Coronary Heart Disease

(2012) Maximilian von Eynatten et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Increased expression of fatty acid binding protein 4 and leptin in resident macrophages characterises atherosclerotic plaque rupture

(2012) K. Lee et al.   ATHEROSCLEROSIS

Circulating adipocyte fatty acid-binding protein levels are independently associated with heart failure

(2012) Mingya Liu et al.   CLINICAL SCIENCE

Fatty acid-binding protein 4 and incident heart failure: the Cardiovascular Health Study

(2012) Luc Djoussé et al.   EUROPEAN JOURNAL OF HEART FAILURE

Design, synthesis and biological evaluation of thiazole- and indole-based derivatives for the treatment of type II diabetes

(2012) Qinyuan Xu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cardiometabolic Correlates and Heritability of Fetuin-A, Retinol-Binding Protein 4, and Fatty-Acid Binding Protein 4 in the Framingham Heart Study

(2012) Bernhard M. Kaess et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

New aromatic substituted pyrazoles as selective inhibitors of human adipocyte fatty acid-binding protein

(2011) Xiujie Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Association of increased plasma adipocyte fatty acid-binding protein with coronary artery disease in non-elderly men

(2011) Masayuki Doi et al.   Cardiovascular Diabetology

Ectopic Fat Depots and Cardiovascular Disease

(2011) Kathryn A. Britton et al.   CIRCULATION

Small-molecule inhibitors of FABP4/5 ameliorate dyslipidemia but not insulin resistance in mice with diet-induced obesity

(2011) Hong Lan et al.   JOURNAL OF LIPID RESEARCH

Increased Heart Failure Risk in Normal-Weight People With Metabolic Syndrome Compared With Metabolically Healthy Obese Individuals

(2011) Christina Voulgari et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Receptor Mediated Elevation in FABP4 Levels by Advanced Glycation End Products Induces Cholesterol and Triacylglycerol Accumulation in THP-1 Macrophages

(2011) Xiao Qun Wang et al.   LIPIDS

Serum adipocyte fatty acid-binding protein associated with ischemic stroke and early death

(2011) A. W. K. Tso et al.   NEUROLOGY

Adiponectin in outpatients with coronary artery disease: Independent predictors and relationship with heart failure

(2011) S. Baldasseroni et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Serum Levels of Adipocyte Fatty Acid-Binding Protein Are Associated with the Severity of Coronary Artery Disease in Chinese Women

(2011) Yuqian Bao et al.   PLoS One

Fatty Acid Binding Protein 4 Is Associated with Carotid Atherosclerosis and Outcome in Patients with Acute Ischemic Stroke

(2011) Sverre Holm et al.   PLoS One

New insights into insulin resistance in the diabetic heart

(2011) Susan Gray et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Relation of Plasma Fatty Acid Binding Proteins 4 and 5 With the Metabolic Syndrome, Inflammation and Coronary Calcium in Patients With Type-2 Diabetes Mellitus

(2010) Roshanak Bagheri et al.   AMERICAN JOURNAL OF CARDIOLOGY

Serum adipocyte fatty acid-binding protein is independently associated with coronary atherosclerotic burden measured by intravascular ultrasound

(2010) Toru Miyoshi et al.   ATHEROSCLEROSIS

Chronic administration of BMS309403 improves endothelial function in apolipoprotein E-deficient mice and in cultured human endothelial cells

(2010) Mary YK Lee et al.   BRITISH JOURNAL OF PHARMACOLOGY

Joint Effects of Physical Activity, Body Mass Index, Waist Circumference, and Waist-to-Hip Ratio on the Risk of Heart Failure

(2010) Gang Hu et al.   CIRCULATION

Adipocyte fatty acid binding protein in atherosclerotic plaques is associated with local vulnerability and is predictive for the occurrence of adverse cardiovascular events

(2010) Wouter Peeters et al.   EUROPEAN HEART JOURNAL

Adipocyte Fatty Acid-binding Protein Modulates Inflammatory Responses in Macrophages through a Positive Feedback Loop Involving c-Jun NH2-terminal Kinases and Activator Protein-1

(2010) Xiaoyan Hui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of fatty acid-binding protein 4/aP2 is correlated with plaque instability in carotid atherosclerosis

(2010) H. E. Agardh et al.   JOURNAL OF INTERNAL MEDICINE

Myocardial Fatty Acid Metabolism in Health and Disease

(2010) Gary D. Lopaschuk et al.   PHYSIOLOGICAL REVIEWS

Influence of age on the management of heart failure: Findings from Get With the Guidelines–Heart Failure (GWTG-HF)

(2009) Daniel E. Forman et al.   AMERICAN HEART JOURNAL

The metabolic syndrome predicts incident congestive heart failure: A 20-year follow-up study of elderly finns

(2009) Jianjun Wang et al.   ATHEROSCLEROSIS

N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte fatty-acid binding protein (A-FABP) inhibitors

(2009) Tjeerd Barf et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Heart Disease and Stroke Statistics—2010 Update

(2009) et al.   CIRCULATION

Adipocyte Fatty Acid–Binding Protein Suppresses Cardiomyocyte Contraction

(2009) Valéria Lamounier-Zepter et al.   CIRCULATION RESEARCH

Albumin as Fatty Acid Transporter

(2009) Ger J. van der Vusse   Drug Metabolism and Pharmacokinetics

Fatty acid binding protein 4 is a target of VEGF and a regulator of cell proliferation in endothelial cells

(2009) Harun Elmasri et al.   FASEB JOURNAL

Identification and Characterization of a Small Molecule Inhibitor of Fatty Acid Binding Proteins

(2009) Ann V. Hertzel et al.   JOURNAL OF MEDICINAL CHEMISTRY

N-Terminal Pro–B-Type Natriuretic Peptide-Guided Treatment for Chronic Heart Failure

(2009) John G. Lainchbury et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

2009 Focused Update Incorporated Into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults

(2009) Sharon Ann Hunt et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Obesity and Cardiovascular Disease

(2009) Carl J. Lavie et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Body mass index and mortality in heart failure: A meta-analysis

(2008) Antigone Oreopoulos et al.   AMERICAN HEART JOURNAL

Heart Failure Incidence and Survival (from the Atherosclerosis Risk in Communities Study)

(2008) Laura R. Loehr et al.   AMERICAN JOURNAL OF CARDIOLOGY

Presence of fatty-acid-binding protein 4 expression in human epicardial adipose tissue in metabolic syndrome

(2008) Burcak Vural et al.   CARDIOVASCULAR PATHOLOGY

Body Mass Index and Vigorous Physical Activity and the Risk of Heart Failure Among Men

(2008) Satish Kenchaiah et al.   CIRCULATION

The association of serum adipocyte fatty acid-binding protein with coronary artery disease in Korean adults

(2008) E J Rhee et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Novel Metabolic Risk Factors for Incident Heart Failure and Their Relationship With Obesity

(2008) Hossein Bahrami et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets

(2008) Masato Furuhashi et al.   NATURE REVIEWS DRUG DISCOVERY