Article
Clinical Neurology
Tamara Pringsheim, Christos Ganos, Christelle Nilles, Andrea E. E. Cavanna, Donald L. L. Gilbert, Erica Greenberg, Andreas Hartmann, Tammy Hedderly, Isobel Heyman, Holan Liang, Irene Malaty, Osman Malik, Nanette Mol Debes, Kirsten Muller Vahl, Alexander Munchau, Tara Murphy, Peter Nagy, Tamsin Owen, Renata Rizzo, Liselotte Skov, Jeremy Stern, Natalia Szejko, Yulia Worbe, Davide Martino
Summary: In 2020, there was a significant increase in referrals for young people with rapid onset of severe tic-like behaviors. A working group was formed to develop clinical criteria for the diagnosis of functional tic-like behaviors (FTLBs) to aid in recognition and diagnosis by healthcare professionals.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Theresa Paulus, Tobias Baeumer, Julius Verrel, Anne Weissbach, Veit Roessner, Christian Beste, Alexander Muenchau
Summary: TLBs after social media exposure have distinct clinical features compared to Tourette's syndrome, including abrupt symptom onset, lack of spontaneous symptom fluctuations, symptom deterioration in the presence of others, and predominantly complex movements involving trunk/extremities, suggesting that these phenomena are categorically different conditions.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Jose Fidel Baizabal-Carvallo, Marlene Alonso-Juarez, Joseph Jankovic
Summary: Tics are rapid, recurrent, non-rhythmic movements or emitted sounds. This study compared tics associated with Tourette syndrome (TS) and secondary tic disorders (STD). It found that patients with TS had a younger age at onset, more severe and complex tics, and involvement of cranial-cervical muscles. Simple phonic tics showed the highest diagnostic accuracy for TS, but there was overlap in tic types and comorbidities between TS and STD patients.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Clinical Neurology
Stephanie Cernera, Leena Pramanik, Zachary Boogaart, Jackson N. Cagle, Julieth Gomez, Katie Moore, Ka Loong Kelvin Au, Michael S. Okun, Aysegul Gunduz, Wissam Deeb
Summary: This study aimed to develop a sensor-based paradigm to detect and classify tics in Tourette syndrome. The results demonstrate that wearable sensors can capture physiological differences between tic and voluntary movements and are comparable to expert consensus. This has significant implications for individualizing and improving care for people with TS.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Pediatrics
Adriana Prato, Federica Saia, Maria Chiara Milana, Miriam Scerbo, Rita Barone, Renata Rizzo
Summary: This study explores the characteristics and course of newly diagnosed functional tic-like behaviors. It was found that there was an increase in functional tic-like behaviors in vulnerable children and adolescents after social media exposure during the COVID-19 pandemic. The results showed significant variations in the severity of tics and anxiety symptoms among patients with functional tic-like behaviors.
FRONTIERS IN PEDIATRICS
(2023)
Article
Clinical Neurology
Melanie J. Firestone, Stacy Holzbauer, Christine Conelea, Richard Danila, Kirk Smith, Rebecca H. Bitsko, Susan M. Klammer, Stefan Gingerich, Ruth Lynfield
Summary: On October 15, 2021, the Minnesota Department of Health initiated an investigation into a cluster of students in a school displaying tic-like behaviors believed to be linked to recent COVID-19. Through interviews and questionnaires, it was discovered that eight female students aged 15-17 had tic-like behaviors lasting more than 24 hours. These behaviors were found to be associated with underlying mental health issues rather than the immediate effects of COVID-19. This study emphasizes the importance of understanding functional tic-like behaviors and adolescent mental health.
FRONTIERS IN NEUROLOGY
(2023)
Article
Psychology, Developmental
Sharon Zimmerman-Brenner, Tammy Pilowsky-Peleg, Lilach Rachamim, Amit Ben-Zvi, Noa Gur, Tara Murphy, Aviva Fattal-Valevski, Michael Rotstein
Summary: Exposure and response prevention (ERP), habit reversal training (HRT), and comprehensive behavioral intervention for tics (CBIT) are effective in reducing tic severity. Group-CBIT shows superior efficacy in reducing motor tic severity compared to group-EIT at a 3-month follow-up, with gains maintained over time.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2022)
Review
Psychology, Developmental
Natalia Szejko, Sally Robinson, Andreas Hartmann, Christos Ganos, Nanette M. Debes, Liselotte Skov, Martina Haas, Renata Rizzo, Jeremy Stern, Alexander Munchau, Virginie Czernecki, Andrea Dietrich, Tara L. Murphy, Davide Martino, Zsanett Tarnok, Tammy Hedderly, Kirsten R. Muller-Vahl, Danielle C. Cath
Summary: This article presents an updated version 2.0 of European clinical guidelines for Tourette syndrome and other tic disorders, focusing on assessment. The guidelines were developed through thorough literature screening, national guidelines supplementation, and expert discussions within ESSTS. Diagnostic changes between DSM-IV and DSM-5 classifications, recommendations for rating scales, and new information on differential diagnoses are highlighted. Additionally, a recent survey among ESSTS members on assessment in TS is discussed.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2022)
Article
Medicine, General & Internal
Martina Haas, Ewgeni Jakubovski, Katja Kunert, Carolin Fremer, Nadine Buddensiek, Sebastian Haeckl, Martina Lenz-Ziegenbein, Richard Musil, Veit Roessner, Alexander Muenchau, Irene Neuner, Armin Koch, Kirsten Mueller-Vahl
Summary: Comprehensive Behavioral Intervention for Tics (CBIT) is a first-line therapy for tics, but its availability is limited due to a lack of qualified therapists. This study suggests that internet-delivered, therapist-independent CBIT intervention (iCBIT) is superior to placebo in treating tics, and the treatment effects of iCBIT even increase over time.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Behavioral Sciences
Lina Schubert, Julius Verrel, Amelie Behm, Tobias Baeumer, Christian Beste, Alexander Muenchau
Summary: The study found that associations between urges and tics in patients with Gilles de la Tourette syndrome are complex and heterogeneous, with some individuals not showing the expected positive correlation, and even displaying negative associations. While most patients demonstrated a positive relationship between urges and tics, there were substantial inter-individual differences in these associations.
Review
Psychology, Developmental
Kirsten R. Mueller-Vahl, Natalia Szejko, Cara Verdellen, Veit Roessner, Pieter J. Hoekstra, Andreas Hartmann, Danielle C. Cath
Summary: The European Society for the Study of Tourette syndrome (ESSTS) has updated the first European Guidelines for Tourette syndrome, covering assessment, psychological interventions, pharmacological treatment, and deep brain stimulation. Over the past decade, there has been a significant shift towards non-pharmacological treatments in the assessment and treatment of tics.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2022)
Review
Psychology, Developmental
Veit Roessner, Heike Eichele, Jeremy S. Stern, Liselotte Skov, Renata Rizzo, Nanette Mol Debes, Peter Nagy, Andrea E. Cavanna, Cristiano Termine, Christos Ganos, Alexander Muenchau, Natalia Szejko, Danielle Cath, Kirsten R. Mueller-Vahl, Cara Verdellen, Andreas Hartmann, Aribert Rothenberger, Pieter J. Hoekstra, Kerstin J. Plessen
Summary: The first European guidelines for Tourette Syndrome (TS) were published in 2011 by the European Society for the Study of Tourette Syndrome (ESSTS). The updated part on pharmacological treatment emphasizes the importance of psychoeducation and behavioral approaches as first-line treatments. Pharmacological treatment, particularly with dopamine blocking agents like aripiprazole, is indicated in some patients, especially when behavioral approaches are not effective or feasible. Treatment should be individualized based on the patient's needs, preferences, and co-existing conditions.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2022)
Review
Medicine, General & Internal
Irene A. Malaty, Seonaid Anderson, Shannon M. Bennett, Cathy L. Budman, Barbara J. Coffey, Keith A. Coffman, Erica Greenberg, Joseph F. McGuire, Kirsten R. Mueller-Vahl, Michael S. Okun, Julio Quezada, Amy Robichaux-Viehoever, Kevin J. Black
Summary: A global phenomenon characterized by sudden onset and rapid escalation of tics and tic-like movements and phonations has emerged in the past 3 years. It has been observed not only in youth known to have tics or Tourette syndrome, but also in those with no prior history of tics.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Psychiatry
Ashruta Narapareddy, Michelle R. Eckland, Heather R. Riordan, Carissa J. Cascio, David A. Isaacs
Summary: This study compared interoceptive sensibility between adults with chronic tic disorders (CTDs) and healthy controls, finding that it is associated with sex and obsessive-compulsive symptoms but not CTD diagnosis. Furthermore, increased general body awareness is associated with greater severity of premonitory urges.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Psychiatry
Kareem Khan, Chris Hollis, Tara Murphy, Charlotte L. Hall
Summary: The rapid expansion of access to and engagement with digital technology has transformed the potential for remote delivery of evidence-based digital health interventions. This article presents a critical synthesis of recent advances in digitally delivered therapy for tics, highlighting the clinical and cost-effectiveness, as well as the acceptability, of these interventions. The findings support the clinical utility of these interventions, showing promise for reducing tic severity in both children and adults.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Chemistry, Applied
Chia-Lin Lee, Chien-Ming Wang, Hung-Rong Yen, Ying-Chyi Song, Chao-Jung Chen
Summary: A new indazole alkaloid, indigodole E (1), was isolated from Qing Dai, a traditional Chinese medicine. Its chemical structure was determined using various spectroscopic techniques. The compound was found to significantly inhibit the production and gene expression of IL-17A without causing cytotoxicity towards specific cells. These findings suggest that indigodole E (1) may contribute to the anti-IL-17A activity of Qing Dai.
NATURAL PRODUCT RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Ying-Chyi Song, Chuan-Teng Liu, Hui-Ju Lee, Hung-Rong Yen
Summary: The study found that cordycepin treatment can prevent the occurrence of multiple sclerosis (MS) by inhibiting the activation and migration of dendritic cells, and can alleviate the progression of the disease by reducing neuroinflammation. This provides new insights for the development of treatments for MS.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Immunology
Chiung-Hui Liu, Bo-Shiou Lin, Mei-Yao Wu, Ying-Chyi Song, Tao-Wei Ke, Yu-Lun Chou, Chuan-Teng Liu, Chia-Hsin Lin, Vedran Radojcic, Charles Drake, Hung-Rong Yen
Summary: The IL-4/AKT/Eomes/Trat1 axis promotes the transformation of Tc17 cells into therapeutic cytotoxic effectors. IL-4 priming can be used as a cell therapy engineering strategy to enhance anti-tumor responses.
Article
Immunology
Chuan-Teng Liu, Ying-Chyi Song, Tsai-Chen Wu, Ko-Chieh Shiung, I-Hsuan Chen, Tung-Ti Chang, Shinn-Jye Liang, Hung-Rong Yen
Summary: Studies have found that Pterostilbene (PS) can treat asthma by modulating T cell immunity and improving symptoms by inhibiting the accumulation of Th2 cells and eosinophils. PS inhibits the production of IL-4 by downregulating mTOR, GATA3, and histone acetylation. Moreover, PS attenuates HDM-induced asthma by inhibiting the Glut1/mTOR/GATA3 axis.
Article
Pediatrics
Wan-Yu Lai, David J. Kay, Chang-Ching Wei, Fen-Wei Huang, Kai-Li Liang, Hung-Rong Yen
Summary: This study translated the SN-5 questionnaire into traditional Chinese and evaluated its validity and reliability. The results showed that the traditional Chinese version of SN-5 is reliable and valid for measuring sinonasal-related quality of life in children in Chinese-speaking countries.
PEDIATRICS AND NEONATOLOGY
(2022)
Article
Immunology
Chia-Yu Huang, Ching-Chan Lin, Ching-Yun Hsieh, Chen-Yuan Lin, Tzu-Ting Chen, Pei-Ching Wu, Dung-Huan Liu, Sio-Ian Tou, Hung-Rong Yen
Summary: This study investigated the willingness, attitudes, awareness, and knowledge of COVID-19 vaccination among elderly individuals in Taiwan. The results showed that a significant proportion of the elderly population was willing to receive COVID-19 vaccines. Older individuals who needed to visit outpatient departments and had concerns about the safety of the vaccines were less likely to accept them. Factors such as understanding the risk of infection, effectiveness of the vaccines, willingness to protect others, and perceived safety were associated with vaccine acceptance. The study highlights the importance of these factors for policymakers and medical staff in developing vaccination plans during the COVID-19 pandemic.
Review
Integrative & Complementary Medicine
Gil Ton, Chia-Hui Lin, Wen-Chao Ho, Wan-Yu Lai, Hung-Rong Yen, Yu-Chen Lee
Summary: The study shows that laser acupuncture therapy has a significant improvement in treating nocturnal enuresis. However, the quality of evidence available in the literature is relatively low, and more rigorous and higher-quality trials are needed to further investigate this treatment modality.
MEDICAL ACUPUNCTURE
(2022)
Review
Cell Biology
Chia-Yu Huang, Peter Karl Mayer, Mei-Yao Wu, Dung-Huan Liu, Pei-Ching Wu, Hung-Rong Yen
Summary: This systematic review and meta-analysis demonstrated that Tai Chi exercise can improve physical performance in elderly individuals with sarcopenia and frailty, including the 30-second chair stand test, the Timed up and go test, number of falls, and fear of falling. However, there was no significant difference in muscle mass, grip strength, gait speed, or Short Physical Performance Battery score between the Tai Chi and control groups.
AGEING RESEARCH REVIEWS
(2022)
Article
Medicine, Research & Experimental
Chuan-Teng Liu, Jui-Hung Jimmy Yen, Dennis A. Brown, Ying-Chyi Song, Mei-Yun Chu, Yu-Hsiang Hung, Yi-Huan Tang, Po-Yuan Wu, Hung-Rong Yen Abckl
Summary: Targeting Nrf2 with D3T may alleviate psoriasis symptoms by reducing hyperkeratosis and scaling, inhibiting IL-17A-secreting γδ T cells in IMQ-induced psoriatic mice.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Oncology
Ming-Cheng Huang, Sheng-Chi Chang, Wen-Ling Liao, Tao-Wei Ke, Ai-Lin Lee, Hwei-Ming Wang, Che-Pin Chang, Hung-Rong Yen, Hen-Hong Chang, William Tzu-Liang Chen
Summary: This article reports on the efficacy of acupuncture in preventing chemotherapy-induced peripheral neuropathy in patients with colorectal cancer. The results suggest that acupuncture may have a neuroprotective effect on chemotherapy-induced peripheral neuropathy in patients with colorectal cancer.
Article
Integrative & Complementary Medicine
Chia-Yu Huang, Mei-Yao Wu, Ming-Cheng Huang, Teng-Shun Yu, Hung-Rong Yen
Summary: This study investigated the association between acupuncture therapy and the development of pressure ulcers in patients with dementia. The results showed a reduced incidence of pressure ulcers in patients who received acupuncture therapy. This finding provides important insights for further research.
INTEGRATIVE MEDICINE RESEARCH
(2023)
Article
Medicine, General & Internal
Hou-Hsun Liao, Hanoch Livneh, Miao-Chiu Lin, Ming-Chi Lu, Ning-Sheng Lai, Hung-Rong Yen, Tzung-Yi Tsai
Summary: This study aimed to compare the risk of primary Sjogren's Syndrome (SS) in patients with rheumatoid arthritis (RA) who used Chinese herbal medicine (CHM) versus those who did not. The results showed that CHM use was associated with a lower risk of SS.
MEDICINA-LITHUANIA
(2023)
Article
Oncology
Ming-Cheng Huang, Sheng-Chi Chang, Wen-Ling Liao, Tao-Wei Ke, Ai-Lin Lee, Hwei-Ming Wang, Che-Pin Chang, Hung-Rong Yen, Hen-Hong Chang, William Tzu-Liang Chen
Summary: This study investigated the efficacy of acupuncture in preventing chemotherapy-induced peripheral neuropathy (CIPN) in patients with colorectal cancer (CRC). The results showed that prophylactic acupuncture may exert neuroprotective effects on mechanical or tactile touch thresholds and this protectiveness persists at 6 months' follow-up.
Article
Oncology
Ying-Chyi Song, Cheng-Chieh Kuo, Chuan-Teng Liu, Tsai-Chen Wu, Yi-Ting Kuo, Hung-Rong Yen
Summary: This study aimed to investigate the anticancer effects of tanshinone IIA (TAIIA) and its combination with an autophagy inhibitor on acute myeloid leukemia (AML) cells. The results showed that TAIIA induced apoptosis and inhibited tumor cell growth through multiple signaling pathways, including oxidative stress. The combination of TAIIA and the autophagy inhibitor enhanced the apoptotic effects. These findings provide a theoretical basis for the clinical therapy of AML with TAIIA and autophagy inhibitors.
INTEGRATIVE CANCER THERAPIES
(2022)
Article
Integrative & Complementary Medicine
Chia-Yu Huang, Mei-Yao Wu, Ming-Cheng Huang, Greg Zimmerman, Liang-Yo Yang, Cheng-Li Lin, Sio-Ian Tou, Hung-Rong Yen
Summary: This study investigates the association between acupuncture therapy and the risk of fracture in patients with osteoarthritis (OA). The results show that patients who received acupuncture therapy have a lower incidence of fracture, and this association is independent of sex, comorbidities, drug use, and surgical experiences.
JOURNAL OF INTEGRATIVE AND COMPLEMENTARY MEDICINE
(2022)
