Article
Psychiatry
Takeshi Inoue, Kohei Togashi, Jumpei Iwanami, Douglas W. Woods, Ryoichi Sakuta
Summary: This study assessed the preliminary efficacy, feasibility, and acceptability of remotely administered group comprehensive behavioral intervention for tics (RG-CBIT) in Japan. The results showed that RG-CBIT had satisfactory outcomes in reducing tic severity, as well as high attendance rates and favorable process measurement scores.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Wen Xu, Qiang Ding, Ying Zhao, Wenqing Jiang, Jingjing Han, Jinhua Sun
Summary: The objective of this study was to investigate the adaptability of Comprehensive Behavioral Intervention for Tics (CBIT) for a Chinese population, and to evaluate the efficacy of combined CBIT and pharmacotherapy (CBIT + PT) compared to CBIT or pharmacotherapy (PT) alone for reducing tics and improving the quality of life (QoL) in Chinese children with chronic tic disorders (CTD) and Tourette syndrome (TS). The results showed that CBIT was effective in reducing tic severity in Chinese children with tic disorders, but CBIT + PT may not be superior to CBIT alone in reducing tic severity and improving quality of life.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Valsamma Eapen, Rudi Crncec, Anna Xenia Pick, Owen Tsao, Richard Lai, Janette Lee, Paul F. Sowman
Summary: This study investigated the clinical effectiveness of Comprehensive Behavioural Intervention for Tics (CBIT) in reducing tic severity in patients with Gilles de la Tourette Syndrome (GTS), and explored the neurophysiological mechanisms associated with clinical change. The results demonstrated significant clinical improvements in tic severity with CBIT, and suggested a role for motor cortical Gamma-aminobutyric acid (GABA)-ergic inhibitory circuitry in the neurophysiological changes underlying CBIT treatment.
JOURNAL OF INTEGRATIVE NEUROSCIENCE
(2022)
Article
Clinical Neurology
Simon Morand-Beaulieu, Michael J. Crowley, Heidi Grantz, James F. Leckman, Lawrence Scahill, Denis G. Sukhodolsky
Summary: Comprehensive Behavioral Intervention for Tics (CBIT) is an effective treatment for Tourette syndrome (TS), but its underlying brain mechanisms are not well understood. This study found no association between EEG coherence during a Go/NoGo task and CBIT outcome, suggesting that the brain processes involved in motor response inhibition may not play a role in CBIT.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Psychology, Developmental
Noa Gur, Sharon Zimmerman-Brenner, Aviva Fattal-Valevski, Michael Rotstein, Tammy Pilowsky Peleg
Summary: There is increasing evidence suggesting that behavioral techniques, such as Comprehensive Behavioral Intervention for Tics (CBIT), are effective in managing tics in youth with Tourette syndrome and tics disorders (TDs). This study aimed to explore the contribution of CBIT to cognitive inhibition and emotion regulation beyond tic control. The findings revealed that following CBIT intervention, cognitive inhibition and cognitive reappraisal significantly increased. These results suggest that CBIT may have a broader impact on improving cognitive and emotional regulation abilities.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Review
Clinical Neurology
Jessica Frey, Irene A. Malaty
Summary: This article reviews the current treatments for Tourette syndrome (TS) and discusses emerging therapies. Recent studies have shown promising results in behavioral therapies, pharmacological treatments, and neuromodulation approaches. These new options may provide hope for future treatment of TS patients.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Julia Friedrich, Tina Rawish, Annet Bluschke, Christian Frings, Christian Beste, Alexander Muenchau
Summary: European clinical guidelines recommend the use of ERP and CBIT as first-line treatments for tic disorders. However, the neurophysiological mechanisms behind these behavioral interventions are poorly understood, which is crucial for tailoring interventions to individual patients.
Article
Psychology, Developmental
Lilach Rachamim, Sharon Zimmerman-Brenner, Osnat Rachamim, Hila Mualem, Netanel Zingboim, Michael Rotstein
Summary: This study evaluated the feasibility and potential effectiveness of an Internet-based, self-help CBIT program guided by parents with minimal therapist support delivered via telepsychotherapy. The results demonstrated significant improvement in tic disorders among youth using the ICBIT program, and the treatment was able to be delivered continuously during the COVID-19 pandemic.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2022)
Review
Multidisciplinary Sciences
Chih-Yi Chou, Julian Agin-Liebes, Sheng-Han Kuo
Summary: Tourette syndrome, the most prevalent hyperkinetic movement disorder in children, has remained largely obscure in terms of its pathomechanism. Recent studies have shed light on this condition, revealing a reduction in frontal cortical volume and long range connectivity to the frontal lobe from other parts of the brain. Several genes have also been associated with Tourette syndrome. Multidisciplinary treatment approaches, including behavioral and pharmacological therapy, are needed. Alternative therapies and new therapies tested in clinical trials show promising results.
Article
Psychology, Clinical
Douglas W. Woods, Michael B. Himle, Jordan T. Stiede, Brandon X. Pitts
Summary: Over the past decade, behavioral interventions have gained recognition as effective first-line therapies for individuals with tic disorders. This article provides a theoretical framework for understanding the application of these interventions for treating tics and describes the three primary interventions with strong empirical support. It summarizes research on the efficacy and delivery formats of these interventions and discusses possible mechanisms of change and future research areas.
ANNUAL REVIEW OF CLINICAL PSYCHOLOGY
(2023)
Article
Psychology, Clinical
Erica Greenberg, Caroline Albright, Margaret Hall, Susanne Hoeppner, Sarah Miller, Alyssa Farley, Michelle Silverman, Valerie Braddick, Susan Sprich, Sabine Wilhelm
Summary: This study evaluated the feasibility, acceptability, and preliminary efficacy of a modified comprehensive behavioral intervention for tics (MCBIT) therapy for youths with chronic tic disorders (CTDs), attention-deficit hyperactivity disorder (ADHD), and associated psychosocial impairment. The results showed that MCBIT treatment is feasible and acceptable for youths with CTD and ADHD, and is similarly well tolerated relative to traditional comprehensive behavioral intervention for tics (CBIT). However, there were no significant differences between MCBIT and CBIT in terms of treatment outcomes. The study recommends further investigation of novel behavioral approaches that can target tics and related conditions simultaneously and successfully.
Article
Psychology, Clinical
Steffen Moritz, Danielle Penney, Stella Schmotz
Summary: This study examines the usefulness of decoupling, a behavioral self-help treatment, in a patient with Tourette syndrome. The results show that decoupling is effective in reducing eye tics, but not effective for other symptoms. The study suggests that decoupling can be considered as an alternative treatment when habit reversal training is not feasible.
BEHAVIOURAL AND COGNITIVE PSYCHOTHERAPY
(2023)
Article
Neurosciences
Xuanzi Zhou, Zhaoying Liao, Yi Li, Nanqing Wang, Nong Xiao
Summary: This retrospective study analyzed 126 children diagnosed with Tourette syndrome (TS) at Children's Hospital of Chongqing Medical University from 2019 to 2021. The treatment included tiapride (n = 60) and topiramate (n = 66). The results showed that both tiapride and topiramate significantly reduced tic severity scores, with topiramate showing better results. Furthermore, medication led to significant reduction in five subscores of CPRS in TS patients. However, there was no significant difference in CBCL scores after treatment in both tiapride and topiramate groups.
Article
Geriatrics & Gerontology
Martha L. Bruce, Renee Pepin, C. Nathan Marti, CourtneyJ. Stevens, Namkee G. Choi
Summary: The study showed that the positive impact of tailored behavioral activation on social connectedness was maintained over 1 year, although to a lesser degree, when delivered by lay counselors using tele-videoconferencing. The intervention's scalability and potential reach were suggested by factors such as recruitment through home delivered meals programs and the increasing commonality of care delivery by tele-videoconferencing. The 1-year outcomes indicate that brief behavioral activation delivered by tele-videoconferencing can have a lasting impact on social connectedness.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Psychology, Multidisciplinary
Morten Bekk, Karete J. Meland, Erna Moen, Liv I. Nostvik, Anne-Line Gausdal, Benjamin Hummelen
Summary: This pilot study investigated the effectiveness of group-based CBIT for adults with Tourette syndrome and chronic tic disorders, and found that it can significantly reduce tic severity and impairment, as well as improve tic-related quality of life.
SCANDINAVIAN JOURNAL OF PSYCHOLOGY
(2023)
Article
Psychology, Developmental
Soren Kuitunen-Paul, Anna Eichler, Melina Wiedmann, Lukas A. Basedow, Veit Roessner, Yulia Golub
Summary: Both self-reports and parental reports are important in the treatment of substance use disorders in adolescents. Parental reports are more accurate in assessing externalizing problems, while no differences were found in internalizing problems.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Psychiatry
Judith T. Mack, Nicole Wolff, Gregor Kohls, Andreas Becker, Sanna Stroth, Luise Poustka, Inge Kamp-Becker, Veit Roessner
Summary: This study examined the pathological link between autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) using the Autism Diagnostic Observation Schedule (ADOS Module 3) and the Autism Diagnostic Interview-Revised (ADI-R). The results showed that in the presence of both ASD and ADHD, there is an additive model of symptomatology across areas of communication, social interaction, and stereotyped behaviors and restricted interests. This suggests that the phenotypic overlap of ASD and ADHD may be less complicated than suspected, at least in terms of ASD symptomatology, and that ASD symptomatology can be well measured with diagnostic instruments.
Article
Neurosciences
Maria Bretzke, Nora C. Vetter, Gregor Kohls, Hannes Wahl, Veit Roessner, Michael M. Plichta, Judith Buse
Summary: This study investigates the role of uncertainty in loss processing and avoidance. The results show slower response times in adolescents compared to adults when it comes to avoiding loss, and adults show higher brain activation during the anticipation of potential monetary loss compared to adolescents.
COGNITIVE NEUROSCIENCE
(2023)
Article
Clinical Neurology
Davide Martino, Tammy Hedderly, Tara Murphy, Kirsten R. Mueller-Vahl, Russell C. Dale, Donald L. Gilbert, Renata Rizzo, Andreas Hartmann, Peter Nagy, Mathieu Anheim, Tamsin Owen, Osman Malik, Morvwen Duncan, Isobel Heyman, Holan Liang, Andrew McWilliams, Shauna O'Dwyer, Carolin Fremer, Natalia Szejko, Velda X. Han, Kasia Kozlowska, Tamara M. Pringsheim
Summary: There has been a significant increase in adolescents and young adults seeking urgent help for functional tic-like behaviors (FTLBs) between 2019 and 2022. An international collaborative group collected retrospective data to better understand this spectrum and its clinical differences from primary tic disorders. The study findings suggest that social media exposure may be a relevant contributing factor to FTLBs.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Carolin Fremer, Natalia Szejko, Anna Pisarenko, Martina Haas, Luise Laudenbach, Claudia Wegener, Kirsten R. Mueller-Vahl
Summary: Since 2019, there has been a global increase in patients exhibiting functional Tourette-like behaviors (FTB), which is believed to be caused by exposure to tic-related content on social media. This paper introduces the concept of mass social media-induced illness (MSMI) as a new type of mass sociogenic illness (MSI). The study compares clinical characteristics of patients diagnosed with MSMI-FTB and Tourette syndrome/chronic tic disorders (TS/CTD) to distinguish between the two. The main findings include a higher age at onset, a higher rate of females, a higher rate of obscene and socially inappropriate symptoms, a lower rate of comorbid ADHD, and a lower rate of OCD/OCB among patients with MSMI-FTB.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Psychiatry
Kirsten R. Mueller-Vahl, Anna Pisarenko, Natalia Szejko, Martina Haas, Carolin Fremer, Ewgeni Jakubovski, Richard Musil, Alexander Muenchau, Irene Neuner, Daniel Huys, Ludger Tebartz van Elst, Christoph Schroeder, Rieke Ringlstetter, Armin Koch, Eva Beate Jenz, Anika Grosshennig
Summary: Preliminary data suggest that cannabis-based medicines might be a promising new treatment for patients with Tourette syndrome (TS)/chronic tic disorders (CTD) resulting in an improvement of tics, comorbidities, and quality of life. This study aimed to examine efficacy and safety of the cannabis extract nabiximols in adults with TS/CTD. Secondary analyses revealed trends for improvements of tics, depression, and quality of life, and subgroup analyses suggested that certain subgroups may benefit better from treatment with cannabis-based medication.
PSYCHIATRY RESEARCH
(2023)
Article
Psychiatry
Pritesh Jain, Tyne Miller-Fleming, Apostolia R. Topaloudi, Dongmei K. Yu, Petros Drineas, Marianthi Georgitsi, Zhiyu Yang, Renata Rizzo, Kirsten R. Mueller-Vahl, Zeynep A. Tumer, Nanette Mol Debes, Andreas S. Hartmann, Christel E. Depienne, Yulia S. Worbe, Pablo Mir, Danielle C. Cath, Dorret Boomsma, Veit Roessner, Tomasz Wolanczyk, Piotr Janik, Natalia Szejko, Cezary Zekanowski, Csaba Barta, Zsofia Nemoda, Zsanett Tarnok, Joseph D. Buxbaum, Dorothy Grice, Jeffrey Glennon, Hreinn Stefansson, Bastian Hengerer, Noa Benaroya-Milshtein, Francesco Cardona, Tammy Hedderly, Isobel Heyman, Chaim Huyser, Astrid Morer, Norbert Mueller, Alexander Munchau, Kerstin J. Plessen, Cesare Porcelli, Susanne Walitza, Anette Schrag, Davide Martino, Andrea Dietrich, Carol A. Mathews, Jeremiah M. Scharf, Pieter J. Hoekstra, Lea K. Davis, Peristera Paschou
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Clinical Neurology
Valerie Brandt, Jana Essing, Ewgeni Jakubovski, Kirsten Mueller-Vahl
Summary: This study investigated the presence of premonitory urges (PU) in tic disorders. The results showed a significant association between tic severity and urge severity, with 85% of urge-related tics followed by relief. ADHD, depression, female gender, and older age increased the likelihood of experiencing PU, while more obsessive-compulsive symptoms and younger age were associated with higher urge intensities. PU, complex vocal tics, ADHD, OCD, anxiety, and depression were related to lower quality of life.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Rica Riechmann, Ewgeni Jakubovski, Jana Essing, Martina Haas, Christopher G. Goetz, Glenn T. Stebbins, Kirsten R. Mueller-Vahl
Summary: Researchers have made improvements to the MRVS rating scale by shortening the recording time to 5 minutes and comparing it with the YGTSS-TTS. The results show that reducing the recording time does not significantly affect the assessment results, and the revised rating method has higher correlation with the YGTSS-TTS.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Pharmacology & Pharmacy
Sebastian Haeckl, Armin Koch, Florian Lasch
Summary: Pre-specification of the primary analysis model is essential to control the type-I-error rate in clinical trials, but the specified mixed models for repeated measures (MMRM) are often poorly defined. This investigation aims to quantify the inflation of the type-I-error rate caused by ambiguous model specifications. Simulated data from a clinical trial were analyzed using different MMRM clusters compatible with imprecise pre-specification. The results show a significant inflation of the type-I-error rate, indicating the importance of precise MMRM specifications in generating confirmatory evidence.
PHARMACEUTICAL STATISTICS
(2023)
Article
Clinical Neurology
Ronja Weiblen, Carina Robert, Pauline Petereit, Marcus Heldmann, Thomas F. Muente, Alexander Muenchau, Kirsten Mueller-Vahl, Ulrike M. Kraemer
Summary: Persons with Tourette syndrome exhibit altered social behaviors, such as echophenomena and increased personal distress in emotional situations. A study was conducted to test the hypothesis of an overactive mirror neuron system in Tourette syndrome by examining echophenomena and empathy for pain in participants with Tourette syndrome and matched controls. The results showed that the Tourette syndrome group had significantly more echophenomena but no differences in empathic abilities compared to controls. Additionally, the Tourette syndrome group exhibited reduced neural differentiation between painful and neutral stimuli. This suggests that there may be altered processing of others' emotional states in Tourette syndrome, but the hypothesis of an overactive mirror neuron system could not be supported.
BRAIN COMMUNICATIONS
(2023)
Article
Clinical Neurology
Kirsten R. Mueller-Vahl, Anna Pisarenko, Carolin Fremer, Martina Haas, Ewgeni Jakubovski, Natalia Szejko
Summary: This study presents the first large sample of patients with Tourette syndrome and functional tic-like behaviors (FTB), aiming to raise awareness of this clinical presentation and guide differentiation between the two. The study found that FTB is a common comorbidity in Tourette syndrome, with specific clinical features such as complex movements, vocalizations, and psychological stress. Therefore, FTB should be ruled out before classifying a patient as treatment-resistant Tourette syndrome.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Letter
Clinical Neurology
Kirsten R. Mueller-Vahl, Rica Riechmann, Ewgeni Jakubovski, Jana Essing, Martina Haas, Glenn T. Stebbins, Christopher G. Goetz
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Sport Sciences
Sven Haufe, Hedwig Theda Boeck, Sebastian Haeckl, Johanna Boyen, Momme Kueck, Clara Catharina van Rhee, Johann-Matthias Graf von der Schulenburg, Jan Zeidler, Torben Schmidt, Heiko Johannsen, Dennis Holzwart, Armin Koch, Uwe Tegtbur
Summary: This study aimed to evaluate the physical activity levels and usage characteristics of e-bikers and conventional cyclists in real-world conditions. The results showed that conventional cyclists were more likely to reach the World Health Organization's target for physical activity compared to e-bikers. Additionally, e-bikers had a higher risk of traffic accidents when controlled for cycling time and frequency.
BMJ OPEN SPORT & EXERCISE MEDICINE
(2022)
Article
Psychology, Developmental
Juliana Hoefer, Falk Hoffmann, Michael Doerks, Inge Kamp-Becker, Charlotte Kuepper, Luise Poustka, Stefan Roepke, Veit Roessner, Sanna Stroth, Nicole Wolff, Christian J. Bachmann
Summary: The study found that the annual health costs related to ASD are comparable to those of schizophrenia, and female patients incur higher costs, calling for further research.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2022)
