Article
Clinical Neurology
Song Li, Zhengzhi Wu, Weidong Le
Summary: In Western medicine, dementia affects cognition, mental health, and physical abilities, while Traditional Chinese Medicine explains it from the perspectives of brain dystrophy, Spleen-Kidney weakness, Blood stasis, and Phlegm stagnation. Ancient Chinese physicians believed that dementia manifests not only as cognitive symptoms but also as psychiatric disorders and sleep disturbance, offering various treatment methods.
ALZHEIMERS & DEMENTIA
(2021)
Article
Pharmacology & Pharmacy
Chien-Chen Huang, Yu-Cih Yang, Iona MacDonald, Ching-Yuan Lai, Cheng-Hao Tu, Yi-Hung Chen
Summary: The study in Taiwan found that chemotherapy is a risk factor for stroke in cancer patients, but the use of traditional Chinese medicine can significantly reduce this risk and decrease the mortality rate associated with chemotherapy.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Xue Bai, Meng Zhang
Summary: Research has shown that traditional Chinese medicine has a clinical impact on vascular dementia, improving patients' cognitive function and quality of life. The pharmacological mechanisms of TCM for VD treatment include targeting the kidneys, eliminating turbidity, and promoting blood circulation, indicating promising prospects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Xinyue Liu, Jinying Liu, Bangze Fu, Ruzhen Chen, Jianzhou Jiang, He Chen, Runa Li, Lin Xing, Liying Yuan, Xuetai Chen, Jing Zhang, Honglei Li, Shuzhen Guo, Feifei Guo, Jiachen Guo, Yuan Liu, Yaning Qi, Biyue Yu, Feng Xu, Dong Li, Zhongyang Liu
Summary: The study developed a database that collects blood constituents of TCM prescriptions and herbs, providing a resource for understanding the molecular mechanism of TCMs and discovering new TCM-derived drugs based on blood constituents.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Review
Pharmacology & Pharmacy
Pengyu Tao, Wenxin Xu, Simeng Gu, Haiyan Shi, Qian Wang, Yuzhen Xu
Summary: Dementia is a syndrome that impairs learning and memory, and there is currently no effective therapy. Traditional Chinese medicine has shown potential in treating dementia, with the ability to improve memory and cognitive dysfunctions. It has fewer adverse effects and lower costs compared to prescription drugs.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Kuan-Yu Chen, Ming- Cheng Huang, Cheng-Li Lin, Yu-Chen Lee, Mei-Yao Wu, Hung-Rong Yen
Summary: Acupuncture treatment in patients with depression is associated with a decreased risk of dementia, particularly vascular dementia and Alzheimer's disease. This real-world evidence supports the use of acupuncture in clinical practice to reduce the risk of dementia in depression patients.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Review
Pharmacology & Pharmacy
Pengyu Tao, Jing Ji, Simeng Gu, Qian Wang, Yuzhen Xu
Summary: This article summarizes the potential and mechanisms of herbal medicine in the treatment of dementia. It highlights the regulatory effect of herbal extracts on autophagy, as well as their effects in reducing oxidative stress, inhibiting inflammation, and neurotoxicity.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Integrative & Complementary Medicine
Li-Jen Tsai, Chi-Hsiang Chung, Chien-Jung Lin, Sheng-Chiang Su, Feng-Chih Kuo, Jhih-Syuan Liu, Kuan-Chan Chen, Li-Ju Ho, Chih-Chun Kuo, Chun-Yung Chang, Ming-Hsun Lin, Nain-Feng Chu, Chien-Hsing Lee, Chang-Hsun Hsieh, Yi-Jen Hung, Po-Shiuan Hsieh, Fu-Huang Lin, Chieh-Hua Lu, Wu-Chien Chien
Summary: This study aimed to investigate the potential of traditional Chinese medicine (TCM) in the management of diabetic patients with carcinoma in situ (CIS). By comparing nearly 7,000 diabetic patients receiving TCM therapy with a control group of over 38,000 patients, it was found that TCM therapy was associated with lower hospitalization and mortality rates in diabetic patients with CIS. These findings suggest that the application of TCM may help alleviate the burden on national medical resources.
INTEGRATIVE MEDICINE RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Liu-Xia Zhang, Jie Dong, Hui Wei, Shao-Hua Shi, Ai-Ping Lu, Gui-Ming Deng, Dong-Sheng Cao
Summary: Traditional Chinese Medicine (TCM) has a long history in treating various diseases, and TCM ingredient databases are becoming increasingly important in the modernization of TCM. However, existing databases lack simplification functions for extracting key ingredients and lack quality control and standardization. To address these issues, a high-quality and standardized Traditional Chinese Medicine Simplified Integrated Database (TCMSID) was developed, providing abundant data sources and analysis platforms to promote the modernization and internationalization of TCM.
JOURNAL OF CHEMINFORMATICS
(2022)
Review
Plant Sciences
Si-min Qi, Jing-tian Zhang, Hong-yan Zhu, Zi Wang, Wei Li
Summary: Glaucoma is the second most common blindness in the world, affecting the life quality of patients. Traditional Chinese Medicines (TCM) have become an important content in ophthalmology, characterized by more targets and lower toxicity. This review presents an overview of glaucoma pathogenesis and therapeutic effects of TCM, as well as the application of acupuncture.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Medical Informatics
Yidi Cui, Bo Gao, Lihong Liu, Jing Liu, Yan Zhu
Summary: The research team constructed a large-scale intelligent retrieval system AMFormulaS using ontology, which efficiently retrieves and analyzes information on traditional Chinese medicine formulas and decoction pieces, providing support for scientific research and new drug development.
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2021)
Article
Computer Science, Hardware & Architecture
Shiwen Zheng, Shicheng Zheng
Summary: With global aging, the incidence of cerebrovascular diseases caused by cognitive impairment and dementia may increase. The cognitive syndrome related to Vascular Involvement of Cognitive and Dementia (VCID) begins regardless of vascular factors, progressing to Vascular Dementia (VaD). Recent studies suggest that dysfunctional Neurovascular Function (NVU) can lead to neurodegenerative diseases.
MICROPROCESSORS AND MICROSYSTEMS
(2021)
Article
Neurosciences
Cheng-Yu Tseng, Pei-Shan Hsu, Chang-Ti Lee, Hui-Fen Huang, Chou-Chin Lan, Tsung-Han Hsieh, Guan-Ting Liu, Chan-Yen Kuo, Ming-Chieh Wang, Po-Chun Hsieh
Summary: The integration of acupuncture and traditional Chinese herbal medicine with conventional rehabilitation has been found to significantly improve functional recovery in stroke patients, particularly those with poor activities of daily living (ADL).
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Plant Sciences
Shun-Ku Lin, Pin-Hsuan Wang, Ching-Hsuan Huang, Yu-Hsien Kuo, Jung-Nien Lai, James Cheng-Chung Wei
Summary: The study results suggest that traditional Chinese medicine is associated with a lower risk of dementia in patients with major depression.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Yu-Min Cho, Ka-Kit Hui, Wuu-Tsun Perng, Yu-Hsun Wang, James Cheng-Chung Wei
Summary: This study showed that adjuvant Chinese herbal medicine (CHM) might be associated with a lower risk of joint replacement in osteoarthritis (OA) patients, especially among younger users. However, this benefit was not observed in older OA patients. CHM therapy could be considered for OA patients to reduce the need for joint replacement.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Chemistry, Applied
Chia-Lin Lee, Chien-Ming Wang, Hung-Rong Yen, Ying-Chyi Song, Chao-Jung Chen
Summary: A new indazole alkaloid, indigodole E (1), was isolated from Qing Dai, a traditional Chinese medicine. Its chemical structure was determined using various spectroscopic techniques. The compound was found to significantly inhibit the production and gene expression of IL-17A without causing cytotoxicity towards specific cells. These findings suggest that indigodole E (1) may contribute to the anti-IL-17A activity of Qing Dai.
NATURAL PRODUCT RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Ying-Chyi Song, Chuan-Teng Liu, Hui-Ju Lee, Hung-Rong Yen
Summary: The study found that cordycepin treatment can prevent the occurrence of multiple sclerosis (MS) by inhibiting the activation and migration of dendritic cells, and can alleviate the progression of the disease by reducing neuroinflammation. This provides new insights for the development of treatments for MS.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Immunology
Chiung-Hui Liu, Bo-Shiou Lin, Mei-Yao Wu, Ying-Chyi Song, Tao-Wei Ke, Yu-Lun Chou, Chuan-Teng Liu, Chia-Hsin Lin, Vedran Radojcic, Charles Drake, Hung-Rong Yen
Summary: The IL-4/AKT/Eomes/Trat1 axis promotes the transformation of Tc17 cells into therapeutic cytotoxic effectors. IL-4 priming can be used as a cell therapy engineering strategy to enhance anti-tumor responses.
Article
Immunology
Chuan-Teng Liu, Ying-Chyi Song, Tsai-Chen Wu, Ko-Chieh Shiung, I-Hsuan Chen, Tung-Ti Chang, Shinn-Jye Liang, Hung-Rong Yen
Summary: Studies have found that Pterostilbene (PS) can treat asthma by modulating T cell immunity and improving symptoms by inhibiting the accumulation of Th2 cells and eosinophils. PS inhibits the production of IL-4 by downregulating mTOR, GATA3, and histone acetylation. Moreover, PS attenuates HDM-induced asthma by inhibiting the Glut1/mTOR/GATA3 axis.
Article
Medicine, Research & Experimental
Chuan-Teng Liu, Jui-Hung Jimmy Yen, Dennis A. Brown, Ying-Chyi Song, Mei-Yun Chu, Yu-Hsiang Hung, Yi-Huan Tang, Po-Yuan Wu, Hung-Rong Yen Abckl
Summary: Targeting Nrf2 with D3T may alleviate psoriasis symptoms by reducing hyperkeratosis and scaling, inhibiting IL-17A-secreting γδ T cells in IMQ-induced psoriatic mice.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Oncology
Ming-Cheng Huang, Sheng-Chi Chang, Wen-Ling Liao, Tao-Wei Ke, Ai-Lin Lee, Hwei-Ming Wang, Che-Pin Chang, Hung-Rong Yen, Hen-Hong Chang, William Tzu-Liang Chen
Summary: This article reports on the efficacy of acupuncture in preventing chemotherapy-induced peripheral neuropathy in patients with colorectal cancer. The results suggest that acupuncture may have a neuroprotective effect on chemotherapy-induced peripheral neuropathy in patients with colorectal cancer.
Article
Medicine, General & Internal
Hou-Hsun Liao, Hanoch Livneh, Miao-Chiu Lin, Ming-Chi Lu, Ning-Sheng Lai, Hung-Rong Yen, Tzung-Yi Tsai
Summary: This study aimed to compare the risk of primary Sjogren's Syndrome (SS) in patients with rheumatoid arthritis (RA) who used Chinese herbal medicine (CHM) versus those who did not. The results showed that CHM use was associated with a lower risk of SS.
MEDICINA-LITHUANIA
(2023)
Article
Oncology
Ming-Cheng Huang, Sheng-Chi Chang, Wen-Ling Liao, Tao-Wei Ke, Ai-Lin Lee, Hwei-Ming Wang, Che-Pin Chang, Hung-Rong Yen, Hen-Hong Chang, William Tzu-Liang Chen
Summary: This study investigated the efficacy of acupuncture in preventing chemotherapy-induced peripheral neuropathy (CIPN) in patients with colorectal cancer (CRC). The results showed that prophylactic acupuncture may exert neuroprotective effects on mechanical or tactile touch thresholds and this protectiveness persists at 6 months' follow-up.
Article
Oncology
Ying-Chyi Song, Cheng-Chieh Kuo, Chuan-Teng Liu, Tsai-Chen Wu, Yi-Ting Kuo, Hung-Rong Yen
Summary: This study aimed to investigate the anticancer effects of tanshinone IIA (TAIIA) and its combination with an autophagy inhibitor on acute myeloid leukemia (AML) cells. The results showed that TAIIA induced apoptosis and inhibited tumor cell growth through multiple signaling pathways, including oxidative stress. The combination of TAIIA and the autophagy inhibitor enhanced the apoptotic effects. These findings provide a theoretical basis for the clinical therapy of AML with TAIIA and autophagy inhibitors.
INTEGRATIVE CANCER THERAPIES
(2022)
Article
Integrative & Complementary Medicine
Chia-Yu Huang, Mei-Yao Wu, Ming-Cheng Huang, Greg Zimmerman, Liang-Yo Yang, Cheng-Li Lin, Sio-Ian Tou, Hung-Rong Yen
Summary: This study investigates the association between acupuncture therapy and the risk of fracture in patients with osteoarthritis (OA). The results show that patients who received acupuncture therapy have a lower incidence of fracture, and this association is independent of sex, comorbidities, drug use, and surgical experiences.
JOURNAL OF INTEGRATIVE AND COMPLEMENTARY MEDICINE
(2022)