Review
Biochemistry & Molecular Biology
Futaba Inoue, Kenbun Sone, Yusuke Toyohara, Yu Takahashi, Asako Kukita, Aki Hara, Ayumi Taguchi, Michihiro Tanikawa, Tetsushi Tsuruga, Yutaka Osuga
Summary: Epigenetic changes play a crucial role in endometrial cancer, including DNA methylation and histone modification. There are currently inhibitors targeting epigenetic regulators in preclinical studies and clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Saikat Bhattacharya, Divya Reddy, Ning Zhang, Hua Li, Jerry L. L. Workman
Summary: The methyltransferase SETD2 plays a crucial role in regulating transcription, splicing, and other processes through the deposition of the H3K36me3 histone mark. Its stability is controlled by proteasome-mediated degradation to maintain low levels. Excessive SETD2 leads to upregulation of cell cycle-associated pathways, resulting in increased cell proliferation and migration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Oncology
Richard Sean Lee, Kirti Sad, Dorelle V. Fawwal, Jennifer Marie Spangle
Summary: Breast cancer is a frequent and deadly disease in women, with histone-modifying enzymes playing a role in treatment response and patient outcomes. Epigenetic changes to chromatin affect the tumor environment and can be targeted for breast cancer treatment. Understanding these mechanisms may improve therapeutic interventions and patient outcomes.
Article
Psychiatry
Anil Srivastava, Oluwagbenga Dada, Jessica Qian, Nzaar Al-Chalabi, Ali Bani Fatemi, Philip Gerretsen, Ariel Graff, Vincenzo De Luca
Summary: Schizophrenia is a chronic psychotic disorder that significantly impacts behavior, thought, and cognition, with possible contributions from both genetic and epigenetic factors. Current research focuses on DNA methylation, histone modification, and non-coding RNA, offering potential new avenues for diagnosis and treatment of schizophrenia. Limitations in current knowledge and potential future research directions are also discussed.
PSYCHIATRY RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Rachel J. Kehrberg, Namita Bhyravbhatla, Surinder K. Batra, Sushil Kumar
Summary: Cancer-associated fibroblasts (CAFs), a significant component of the tumor microenvironment (TME), contribute to cancer progression through the secretion of extracellular matrix (ECM), growth factors, and metabolites. It is now well recognized that CAFs are a heterogenous population with ablation experiments leading to reduced tumor growth and single-cell RNA sequencing demonstrating CAF subgroups. CAFs lack genetic mutations yet substantially differ from their normal stromal precursors.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Review
Plant Sciences
Rocio Nunez-Vazquez, Benedicte Desvoyes, Crisanto Gutierrez
Summary: Plants have developed various mechanisms to adapt to abiotic stresses, which involve transcriptional regulation and chromatin modifications. Understanding and manipulating these regulatory networks are crucial for enhancing crop resilience and performance against stress.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Neurosciences
Jean Lud Cadet, Subramaniam Jayanthi
Summary: This review discusses the evidence of methamphetamine exposure causing changes in epigenetic modifications and the correlations between these changes and behavioral alterations. Studies on rats have shown associations between prolonged methamphetamine self-administration with compulsive drug-taking and abstinent phenotypes, as well as increased DNA hydroxymethylation and mRNA expression in genes encoding potassium channels in the nucleus accumbens. Further research is needed to understand how pharmacological or genetic manipulations of epigenetic alterations and potassium channel expression can affect methamphetamine-taking behaviors and relapse after long periods of abstinence.
CURRENT NEUROPHARMACOLOGY
(2021)
Review
Oncology
Jiaxin Liu, Jia-nan Li, Hongyu Wu, Panpan Liu
Summary: Epigenetic regulation plays a crucial role in lymphoma development and is closely associated with various malignancies. Understanding these epigenetic mechanisms can guide the development of clinical treatments.
FRONTIERS IN ONCOLOGY
(2022)
Review
Pharmacology & Pharmacy
Chaithanya Ganji, Batoul Farran
Summary: This review focuses on dysregulated genes associated with epigenetic mechanisms in pancreatic cancer progression and resistance, as well as current clinical trials for epigenetic drugs. Combining epigenetic drugs with targeted therapies might represent a promising approach for treating pancreatic cancer.
DRUG DISCOVERY TODAY
(2022)
Review
Biochemistry & Molecular Biology
Hirotomo Takatsuka, Atsushi Shibata, Masaaki Umeda
Summary: Plant DNA is vulnerable to environmental stressors, and chromatin plays a crucial role in protecting DNA by altering its structure. Changes in chromatin modifications, regulation of gene expression, and the physical barrier function of condensed chromatin are key mechanisms for plants to maintain genome integrity under genotoxic stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Werner Giehl Glanzner, Mariana Priotto de Macedo, Karina Gutierrez, Vilceu Bordignon
Summary: Animal cloning has been successful in over 20 mammalian species using SCNT, with pigs being the leading species. The importance of pig cloning lies in its relevance to food production and biomedical applications. Despite recognized progress, the overall efficiency of SCNT in pigs remains low. New strategies for chromatin and epigenetic reprogramming may revolutionize pig cloning.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Eleni Skourti, Paraminder Dhillon
Summary: This Special Issue of The FEBS Journal, Cancer Epigenetics, features a collection of review articles that focus on the functions of a broad spectrum of epigenetic modulators in cancer. The topics explored in these articles range from the roles of transposable elements and chromatin architecture in cancer, to the effects of altered epigenetics on transcription and advanced cancer cell phenotypes. The potential of epigenetics for targeted cancer therapeutics is also discussed.
Review
Biochemistry & Molecular Biology
Farzin Zobdeh, Ivan I. Eremenko, Mikail A. Akan, Vadim V. Tarasov, Vladimir N. Chubarev, Helgi B. Schioeth, Jessica Mwinyi
Summary: Migraine is a complex neurological disorder and current drug treatments have limited success rates. Understanding the epigenetic changes associated with migraine may help to improve treatment strategies and identify new therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Rodrigo Villasenor, Tuncay Baubec
Summary: Nucleosomes are basic structures used to package genetic information, subject to diverse chemical modifications. These modifications serve as interaction hubs for nuclear proteins, ensuring correct deposition to the genome. The regulation of chromatin marks relies on coordinated activities of writer, eraser, and reader enzymes, often depending on complex multicomponent regulatory circuits.
CURRENT OPINION IN CELL BIOLOGY
(2021)
Review
Plant Sciences
Justin Su, Zhujun Yao, Yixuan Wu, Joohyun Lee, Jeeyon Jeong
Summary: This article mainly introduces the latest understanding of chromatin-based regulation of iron homeostasis in plants, highlighting recent studies in Arabidopsis and rice. Understanding iron homeostasis in plants is crucial as it is relevant to fundamental biological questions, agriculture, biofortification, and human health.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Multidisciplinary Sciences
Natalia Sacilotto, Josefa Castillo, Angela L. Riffo-Campos, Juana M. Flores, Olivia Hibbitt, Richard Wade-Martins, Carlos Lopez, M. Isabel Rodrigo, Luis Franco, Gerardo Lopez-Rodas
Article
Immunology
Juan Sandoval, Javier Pereda, Salvador Perez, Isabela Finamor, Azahara Vallet-Sanchez, Jose Luis Rodriguez, Luis Franco, Juan Sastre, Gerardo Lopez-Rodas
JOURNAL OF IMMUNOLOGY
(2016)
Article
Oncology
Angela L. Riffo-Campos, Josefa Castillo, Azahara Vallet-Sanchez, Guillermo Ayala, Andres Cervantes, Gerardo Lopez-Rodas, Luis Franco
Article
Biochemistry & Molecular Biology
J. Sandoval, J. Pereda, J. L. Rodriguez, J. Escobar, J. Hidalgo, L. A. B. Joosten, L. Franco, J. Sastre, G. Lopez-Rodas
CELLULAR AND MOLECULAR LIFE SCIENCES
(2010)
Article
Biochemistry & Molecular Biology
Gema Tur, Elena I. Georgieva, Andres Gagete, Gerardo Lopez-Rodas, Jose L. Rodriguez, Luis Franco
CELLULAR AND MOLECULAR LIFE SCIENCES
(2010)
Article
Biochemistry & Molecular Biology
Angela L. Riffo-Campos, Josefa Castillo, Gema Tur, Paula Gonzalez-Figueroa, Elena I. Georgieva, Jose L. Rodriguez, Gerardo Lopez-Rodas, M. Isabel Rodrigo, Luis Franco
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Plant Sciences
Andres P. Gagete, Luis Franco, M. Isabel Rodrigo
Article
Multidisciplinary Sciences
Natalia Sacilotto, Antonio Espert, Josefa Castillo, Luis Franco, Gerardo Lopez-Rodas
Article
Multidisciplinary Sciences
Desamparados Roda, Josefa Castillo, Marcelino Telechea-Fernandez, Anabel Gil, Gerardo Lopez-Rodas, Luis Franco, Patricia Gonzalez-Rodriguez, Susana Rosello, J. Alejandro Perez-Fidalgo, Elena R. Garcia-Trevijano, Andres Cervantes, Rosa Zaragoza
Article
Multidisciplinary Sciences
Francisco Gimeno-Valiente, Angela L. Riffo-Campos, Azahara Vallet-Sanchez, Sofia Siscar-Lewin, Valentina Gambardella, Noelia Tarazona, Andres Cervantes, Luis Franco, Josefa Castillo, Gerardo Lopez-Rodas
SCIENTIFIC REPORTS
(2019)
Article
Multidisciplinary Sciences
F. Gimeno-Valiente, A. L. Riffo-Campos, G. Ayala, N. Tarazona, V Gambardella, F. M. Rodriguez, M. Huerta, C. Martinez-Ciarpaglini, J. Monton-Bueno, S. Rosello, D. Roda, A. Cervantes, L. Franco, G. Lopez-Rodas, J. Castillo
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Sergio Rius-Perez, Salvador Perez, Isabel Torres-Cuevas, Pablo Marti-Andres, Raquel Talens-Visconti, Alberto Paradela, Laura Guerrero, Luis Franco, Gerardo Lopez-Rodas, Luis Torres, Fernando Corrales, Juan Sastre
Article
Pharmacology & Pharmacy
Francisco J. Lopez-Iranzo, Ana M. Lopez-Rodas, Luis Franco, Gerardo Lopez-Rodas
CURRENT PHARMACEUTICAL DESIGN
(2020)
Article
Oncology
Francisco Gimeno-Valiente, Angela L. Riffo-Campos, Luis Torres, Noelia Tarazona, Valentina Gambardella, Andres Cervantes, Gerardo Lopez-Rodas, Luis Franco, Josefa Castillo
Summary: The ZNF518B gene, up-regulated in colorectal cancer, is involved in cell dissemination and metastasis. It interacts with histone methyltransferases G9A and EZH2, impacting the activity of many genes. The ratio of different mRNA isoforms of ZNF518B is related to disease relapse, and its involvement in recruiting enzymes and depositing epigenetic marks on genes highlights the importance of epigenetic changes in cancer development.