Mechanisms and rates of nucleation of amyloid fibrils

Alzheimer's Disease and the Amyloid-β Peptide

(2017) M. Paul Murphy et al.   JOURNAL OF ALZHEIMERS DISEASE

Kinetics of spontaneous filament nucleation via oligomers: Insights from theory and simulation

(2016) Anđela Šarić et al.   JOURNAL OF CHEMICAL PHYSICS

Atomic Resolution Structure of Monomorphic Aβ42 Amyloid Fibrils

(2016) Michael T. Colvin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Atomic-resolution structure of a disease-relevant Aβ(1–42) amyloid fibril

(2016) Marielle Aulikki Wälti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

On the lag phase in amyloid fibril formation

(2015) Paolo Arosio et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

The inverted free energy landscape of an intrinsically disordered peptide by simulations and experiments

(2015) Daniele Granata et al.   Scientific Reports

Role of filament annealing in the kinetics and thermodynamics of nucleated polymerization

(2014) Thomas C. T. Michaels et al.   JOURNAL OF CHEMICAL PHYSICS

Nucleation-conversion-polymerization reactions of biological macromolecules with prenucleation clusters

(2014) Gonzalo A. Garcia et al.   PHYSICAL REVIEW E

Crucial role of nonspecific interactions in amyloid nucleation

(2014) Anđela Šarić et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides

(2014) Georg Meisl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Seven competing ways to recover the Michaelis–Menten equation reveal the alternative approaches to steady state modeling

(2013) Denis Michel et al.   JOURNAL OF MATHEMATICAL CHEMISTRY

Energy interactions in amyloid-like fibrils from NNQQNY

(2013) Inmaculada García Cuesta et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Proliferation of amyloid- 42 aggregates occurs through a secondary nucleation mechanism

(2013) S. I. A. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Detailed Analysis of the Energy Barriers for Amyloid Fibril Growth

(2012) Alexander K. Buell et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein

(2012) Nunilo Cremades et al.   CELL

From Macroscopic Measurements to Microscopic Mechanisms of Protein Aggregation

(2012) Samuel I.A. Cohen et al.   JOURNAL OF MOLECULAR BIOLOGY

Two-Step Nucleation of Amyloid Fibrils: Omnipresent or Not?

(2012) Stefan Auer et al.   JOURNAL OF MOLECULAR BIOLOGY

Twisting Transition between Crystalline and Fibrillar Phases of Aggregated Peptides

(2012) Tuomas P. J. Knowles et al.   PHYSICAL REVIEW LETTERS

Toxic fibrillar oligomers of amyloid-  have cross-  structure

(2012) J. C. Stroud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Connecting Macroscopic Observables and Microscopic Assembly Events in Amyloid Formation Using Coarse Grained Simulations

(2012) Noah S. Bieler et al.   PLoS Computational Biology

Assessing the contribution of heterogeneous distributions of oligomers to aggregation mechanisms of polyglutamine peptides

(2011) Andreas Vitalis et al.   BIOPHYSICAL CHEMISTRY

Nature of the Amyloid-β Monomer and the Monomer-Oligomer Equilibrium

(2011) Suman Nag et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments

(2011) Samuel I. A. Cohen et al.   JOURNAL OF CHEMICAL PHYSICS

Amyloid-β forms fibrils by nucleated conformational conversion of oligomers

(2011) Jiyong Lee et al.   Nature Chemical Biology

Atomic-Scale Simulations Confirm that Soluble β-Sheet-Rich Peptide Self-Assemblies Provide Amyloid Mimics Presenting Similar Conformational Properties

(2010) Xiang Yu et al.   BIOPHYSICAL JOURNAL

Probing the Nucleus Model for Oligomer Formation during Insulin Amyloid Fibrillogenesis

(2010) Leonard F. Pease et al.   BIOPHYSICAL JOURNAL

Mysterious oligomerization of the amyloidogenic proteins

(2010) Vladimir N. Uversky   FEBS Journal

Progressive accumulation of amyloid-β oligomers in Alzheimer’s disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins

(2010) Emiley Pham et al.   FEBS Journal

Amyloid oligomers: formation and toxicity of Aβ oligomers

(2010) Masafumi Sakono et al.   FEBS Journal

Nucleation of amyloid fibrils

(2010) Dimo Kashchiev et al.   JOURNAL OF CHEMICAL PHYSICS

Elucidation of Amyloid β-Protein Oligomerization Mechanisms: Discrete Molecular Dynamics Study

(2010) B. Urbanc et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ion mobility–mass spectrometry reveals a conformational conversion from random assembly to β-sheet in amyloid fibril formation

(2010) Christian Bleiholder et al.   Nature Chemistry

Frequency Factors in a Landscape Model of Filamentous Protein Aggregation

(2010) Alexander K. Buell et al.   PHYSICAL REVIEW LETTERS

A molecular dynamics study of the early stages of amyloid-β(1-42) oligomerization: The role of lipid membranes

(2010) Charles H. Davis et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Characterization of Oligomeric Species on the Aggregation Pathway of Human Lysozyme

(2009) Erica Frare et al.   JOURNAL OF MOLECULAR BIOLOGY

Interprotofilament interactions between Alzheimer's A 1-42 peptides in amyloid fibrils revealed by cryoEM

(2009) R. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Analytical Solution to the Kinetics of Breakable Filament Assembly

(2009) T. P. J. Knowles et al.   SCIENCE

Real-time analysis of amyloid fibril formation of α-synuclein using a fibrillation-state-specific fluorescent probe of JC-1

(2008) Jung-Ho Lee et al.   BIOCHEMICAL JOURNAL

Amyloid load in Parkinson's disease dementia and Lewy body dementia measured with [11C]PIB positron emission tomography

(2008) P Edison et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Amyloid   Oligomers (A 1-42 Globulomer) Suppress Spontaneous Synaptic Activity by Inhibition of P/Q-Type Calcium Currents

(2008) V. Nimmrich et al.   JOURNAL OF NEUROSCIENCE

Amyloid formation by globular proteins under native conditions

(2008) Fabrizio Chiti et al.   Nature Chemical Biology

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Molecular structural basis for polymorphism in Alzheimer's  -amyloid fibrils

(2008) A. K. Paravastu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Generic Mechanism of Emergence of Amyloid Protofilaments from Disordered Oligomeric Aggregates

(2008) Stefan Auer et al.   PLoS Computational Biology