Biological function and histone recognition of family IV bromodomain-containing proteins

A Chemical Probe for the ATAD2 Bromodomain

(2016) Paul Bamborough et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mechanism of Histone H3K4me3 Recognition by the Plant Homeodomain of Inhibitor of Growth 3

(2016) Sophia Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Twenty Crystal Structures of Bromodomain and PHD Finger Containing Protein 1 (BRPF1)/Ligand Complexes Reveal Conserved Binding Motifs and Rare Interactions

(2016) Jian Zhu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains

(2016) Terry D. Crawford et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sensitivity and engineered resistance of myeloid leukemia cells to BRD9 inhibition

(2016) Anja F Hohmann et al.   Nature Chemical Biology

GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain

(2016) Paul Bamborough et al.   ACS Medicinal Chemistry Letters

LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor

(2015) Peter G. K. Clark et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2

(2015) Guillaume Poncet-Montange et al.   BIOCHEMICAL JOURNAL

ATAD2 is overexpressed in gastric cancer and serves as an independent poor prognostic biomarker

(2015) M.- J. Zhang et al.   Clinical & Translational Oncology

The Chromatin Regulator BRPF3 Preferentially Activates the HBO1 Acetyltransferase but Is Dispensable for Mouse Development and Survival

(2015) Kezhi Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-Based Optimization of Naphthyridones into Potent ATAD2 Bromodomain Inhibitors

(2015) Paul Bamborough et al.   JOURNAL OF MEDICINAL CHEMISTRY

9H-Purine Scaffold Reveals Induced-Fit Pocket Plasticity of the BRD9 Bromodomain

(2015) Sarah Picaud et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor

(2015) Wylie S. Palmer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Disrupting Acetyl-Lysine Recognition: Progress in the Development of Bromodomain Inhibitors

(2015) F. Anthony Romero et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bivalent interaction of the PZP domain of BRPF1 with the nucleosome impacts chromatin dynamics and acetylation

(2015) Brianna J. Klein et al.   NUCLEIC ACIDS RESEARCH

Oncogene ATAD2 promotes cell proliferation, invasion and migration in cervical cancer

(2015) LE ZHENG et al.   ONCOLOGY REPORTS

A Subset of Human Bromodomains Recognizes Butyryllysine and Crotonyllysine Histone Peptide Modifications

(2015) E. Megan Flynn et al.   STRUCTURE

ATAD2 Overexpression Identifies Colorectal Cancer Patients with Poor Prognosis and Drives Proliferation of Cancer Cells

(2015) Yang Luo et al.   Gastroenterology Research and Practice

Atad2 is a generalist facilitator of chromatin dynamics in embryonic stem cells

(2015) Yuichi Morozumi et al.   Journal of Molecular Cell Biology

JQ1 suppresses tumor growth through downregulating LDHA in ovarian cancer

(2015) Haifeng Qiu et al.   Oncotarget

ATAD2 overexpression links to enrichment of B-MYB-translational signatures and development of aggressive endometrial carcinoma

(2015) Camilla Krakstad et al.   Oncotarget

Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma

(2015) Sujatha Venataraman et al.   Oncotarget

ATAD2 is Highly Expressed in Ovarian Carcinomas and Indicates Poor Prognosis

(2014) Wei-Na Wan et al.   Asian Pacific Journal of Cancer Prevention

Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain

(2014) Mulu Y. Lubula et al.   FEBS LETTERS

The MOZ Histone Acetyltransferase in Epigenetic Signaling and Disease

(2014) Samuel Carlson et al.   JOURNAL OF CELLULAR PHYSIOLOGY

BRD7, a Tumor Suppressor, Interacts with p85α and Regulates PI3K Activity

(2014) Yu-Hsin Chiu et al.   MOLECULAR CELL

Targeting bromodomains: epigenetic readers of lysine acetylation

(2014) Panagis Filippakopoulos et al.   NATURE REVIEWS DRUG DISCOVERY

Bromodomains: pockets with therapeutic potential

(2014) Kostas A. Papavassiliou et al.   TRENDS IN MOLECULAR MEDICINE

1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain

(2014) Emmanuel H. Demont et al.   ACS Medicinal Chemistry Letters

Crystallization and preliminary X-ray diffraction analysis of the BRPF1 bromodomain in complex with its H2AK5ac and H4K12ac histone-peptide ligands

(2014) Mulu Y. Lubula et al.   Acta Crystallographica Section F-Structural Biology Communications

Malignant genome reprogramming by ATAD2

(2013) Fayçal Boussouar et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Exchange of associated factors directs a switch in HBO1 acetyltransferase histone tail specificity

(2013) M.-E. Lalonde et al.   GENES & DEVELOPMENT

Identification of driver genes in hepatocellular carcinoma by exome sequencing

(2013) Sean P. Cleary et al.   HEPATOLOGY

Molecular Insights into the Recognition of N-Terminal Histone Modifications by the BRPF1 Bromodomain

(2013) Amanda Poplawski et al.   JOURNAL OF MOLECULAR BIOLOGY

Integrated genomic characterization of endometrial carcinoma

(2013) Gad Getz et al.   NATURE

MYC, a downstream target of BRD-NUT, is necessary and sufficient for the blockade of differentiation in NUT midline carcinoma

(2013) A R Grayson et al.   ONCOGENE

Prognostic relevance of BRD7 expression in colorectal carcinoma

(2012) Wen-Jing Wu et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Druggability Analysis and Structural Classification of Bromodomain Acetyl-lysine Binding Sites

(2012) Lewis R. Vidler et al.   JOURNAL OF MEDICINAL CHEMISTRY

Direct Cooperation Between Androgen Receptor and E2F1 Reveals a Common Regulation Mechanism for Androgen-Responsive Genes in Prostate Cells

(2012) D. M. Altintas et al.   MOLECULAR ENDOCRINOLOGY

Comprehensive genomic characterization of squamous cell lung cancers

(2012)   NATURE

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

(2012) Christopher E Barbieri et al.   NATURE GENETICS

Developmental and androgenic regulation of chromatin regulators EZH2 and ANCCA/ATAD2 in the prostate Via MLL histone methylase complex

(2012) Zhijian Duan et al.   PROSTATE

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

(2011) Jake E. Delmore et al.   CELL

Toward Convergence of Experimental Studies and Theoretical Modeling of the Chromatin Fiber

(2011) Tamar Schlick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recognition of Unmodified Histone H3 by the First PHD Finger of Bromodomain-PHD Finger Protein 2 Provides Insights into the Regulation of Histone Acetyltransferases Monocytic Leukemic Zinc-finger Protein (MOZ) and MOZ-related factor (MORF)

(2011) Su Qin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery and Characterization of Small Molecule Inhibitors of the BET Family Bromodomains

(2011) Chun-wa Chung et al.   JOURNAL OF MEDICINAL CHEMISTRY

Prognosis of patients with t(8;16)(p11;p13) acute myeloid leukemia

(2011) Tanya Brown et al.   LEUKEMIA & LYMPHOMA

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

(2011) Mark A. Dawson et al.   NATURE

BRD7, a Subunit of SWI/SNF Complexes, Binds Directly to BRCA1 and Regulates BRCA1-Dependent Transcription

(2010) M. T. Harte et al.   CANCER RESEARCH

ANCCA/ATAD2 Overexpression Identifies Breast Cancer Patients with Poor Prognosis, Acting to Drive Proliferation and Survival of Triple-Negative Cells through Control of B-Myb and EZH2

(2010) E. V. Kalashnikova et al.   CANCER RESEARCH

ATAD2B is a phylogenetically conserved nuclear protein expressed during neuronal differentiation and tumorigenesis

(2010) Nathaniel T. Leachman et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Chromatin Loading of E2F-MLL Complex by Cancer-Associated Coregulator ANCCA via Reading a Specific Histone Mark

(2010) A. S. Revenko et al.   MOLECULAR AND CELLULAR BIOLOGY

Suppression of inflammation by a synthetic histone mimic

(2010) Edwige Nicodeme et al.   NATURE

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

BRD7 is a candidate tumour suppressor gene required for p53 function

(2010) Jarno Drost et al.   NATURE CELL BIOLOGY

Functional characterization of ATAD2 as a new cancer/testis factor and a predictor of poor prognosis in breast and lung cancers

(2010) C Caron et al.   ONCOGENE

Support of association between BRD1 and both schizophrenia and bipolar affective disorder

(2009) Mette Nyegaard et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Androgen-Induced Coactivator ANCCA Mediates Specific Androgen Receptor Signaling in Prostate Cancer

(2009) J. X. Zou et al.   CANCER RESEARCH

ATAD2 Is a Novel Cofactor for MYC, Overexpressed and Amplified in Aggressive Tumors

(2009) M. Ciro et al.   CANCER RESEARCH

Histone acetyltransferase Hbo1: Catalytic activity, cellular abundance, and links to primary cancers

(2009) Masayoshi Iizuka et al.   GENE

Gain at chromosomal region 5p15.33, containing TERT, is the most frequent genetic event in early stages of non-small cell lung cancer

(2008) Ji Un Kang et al.   CANCER GENETICS AND CYTOGENETICS

BRD7, a Novel PBAF-specific SWI/SNF Subunit, Is Required for Target Gene Activation and Repression in Embryonic Stem Cells

(2008) Matthias D. Kaeser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Architecture of Quartet MOZ/MORF Histone Acetyltransferase Complexes

(2008) M. Ullah et al.   MOLECULAR AND CELLULAR BIOLOGY

Integrative genomics analysis of chromosome 5p gain in cervical cancer reveals target over-expressed genes, including Drosha

(2008) Luigi Scotto et al.   Molecular Cancer

The AAA+ superfamily of functionally diverse proteins

(2008) Jamie Snider et al.   GENOME BIOLOGY