Regulating osteogenesis and adipogenesis in adipose-derived stem cells by controlling underlying substrate stiffness

The fabrication of biomimetic biphasic CAN-PAC hydrogel with a seamless interfacial layer applied in osteochondral defect repair

(2017) Jinfeng Liao et al.   Bone Research

Softening Substrates Promote Chondrocytes Phenotype via RhoA/ROCK Pathway

(2016) Tao Zhang et al.   ACS Applied Materials & Interfaces

PCL-PEG-PCL film promotes cartilage regeneration in vivo

(2016) Na Fu et al.   CELL PROLIFERATION

Effects of low oxygen tension on gene profile of soluble growth factors in co-cultured adipose-derived stromal cells and chondrocytes

(2016) Sirong Shi et al.   CELL PROLIFERATION

Primordial germ cell-like cells derived from canine adipose mesenchymal stem cells

(2016) Yudong Wei et al.   CELL PROLIFERATION

Substrate Stress-Relaxation Regulates Scaffold Remodeling and Bone Formation In Vivo

(2016) Max Darnell et al.   Advanced Healthcare Materials

Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) Based Electrospun 3D Scaffolds for Delivery of Autogeneic Chondrocytes and Adipose-Derived Stem Cells: Evaluation of Cartilage Defects in Rabbit

(2015) Guo Li et al.   Journal of Biomedical Nanotechnology

Gene expression modulation in TGF-β3-mediated rabbit bone marrow stem cells using electrospun scaffolds of various stiffness

(2015) Qianping Guo et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Matrix Stiffness and Nanoscale Spatial Organization of Cell-Adhesive Ligands Direct Stem Cell Fate

(2015) Kai Ye et al.   NANO LETTERS

Hydrogels with tunable stress relaxation regulate stem cell fate and activity

(2015) Ovijit Chaudhuri et al.   NATURE MATERIALS

Substrate stress relaxation regulates cell spreading

(2015) Ovijit Chaudhuri et al.   Nature Communications

Extracellular Stiffness Modulates the Expression of Functional Proteins and Growth Factors in Endothelial Cells

(2015) Lívia Santos et al.   Advanced Healthcare Materials

Compressive Stress Induces Dephosphorylation of the Myosin Regulatory Light Chain via RhoA Phosphorylation by the Adenylyl Cyclase/Protein Kinase A Signaling Pathway

(2015) Kenji Takemoto et al.   PLoS One

Substrate Stiffness Together with Soluble Factors Affects Chondrocyte Mechanoresponses

(2014) Cheng Chen et al.   ACS Applied Materials & Interfaces

Three-Dimensional Printing of Elastomeric, Cellular Architectures with Negative Stiffness

(2014) Eric B. Duoss et al.   ADVANCED FUNCTIONAL MATERIALS

The combined effects of matrix stiffness and growth factor immobilization on the bioactivity and differentiation capabilities of adipose-derived stem cells

(2014) Jessica M. Banks et al.   BIOMATERIALS

Matrix elasticity, replicative senescence and DNA methylation patterns of mesenchymal stem cells

(2014) Anne Schellenberg et al.   BIOMATERIALS

Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium

(2014) Ovijit Chaudhuri et al.   NATURE MATERIALS

Interplay of matrix stiffness and protein tethering in stem cell differentiation

(2014) Jessica H. Wen et al.   NATURE MATERIALS

Fabrication and Characterization of Heparin-Grafted Poly-l-lactic acid–Chitosan Core–Shell Nanofibers Scaffold for Vascular Gasket

(2013) Ting Wang et al.   ACS Applied Materials & Interfaces

Rigidity-Patterned Polyelectrolyte Films to Control Myoblast Cell Adhesion and Spatial Organization

(2013) Claire Monge et al.   ADVANCED FUNCTIONAL MATERIALS

Directing stem cell fate on hydrogel substrates by controlling cell geometry, matrix mechanics and adhesion ligand composition

(2013) Junmin Lee et al.   BIOMATERIALS

Stimulation of adipogenesis of adult adipose-derived stem cells using substrates that mimic the stiffness of adipose tissue

(2013) D. Adam Young et al.   BIOMATERIALS

A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors

(2013) Mariaceleste Aragona et al.   CELL

Effects of matrix elasticity and cell density on human mesenchymal stem cells differentiation

(2013) Ruyue Xue et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Forcing Stem Cells to Behave: A Biophysical Perspective of the Cellular Microenvironment

(2012) Yubing Sun et al.   Annual Review of Biophysics

Extracellular-matrix tethering regulates stem-cell fate

(2012) Britta Trappmann et al.   NATURE MATERIALS

Insights into the Role of Focal Adhesion Modulation in Myogenic Differentiation of Human Mesenchymal Stem Cells

(2012) Haiyang Yu et al.   STEM CELLS AND DEVELOPMENT

Stiffening hydrogels to probe short- and long-term cellular responses to dynamic mechanics

(2012) Murat Guvendiren et al.   Nature Communications

Artificial extracellular matrices composed of collagen I and sulfated hyaluronan with adsorbed transforming growth factor β1 promote collagen synthesis of human mesenchymal stromal cells

(2011) Ute Hempel et al.   Acta Biomaterialia

Soft matrix supports osteogenic differentiation of human dental follicle cells

(2011) Sandra Viale-Bouroncle et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The influence of elasticity and surface roughness on myogenic and osteogenic-differentiation of cells on silk-elastin biomaterials

(2011) Xiao Hu et al.   BIOMATERIALS

The effect of matrix stiffness on the differentiation of mesenchymal stem cells in response to TGF-β

(2011) Jennifer S. Park et al.   BIOMATERIALS

Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth

(2011) Michael S. Samuel et al.   CANCER CELL

Chondrocyte redifferentiation in 3D: The effect of adhesion site density and substrate elasticity

(2011) Elena Schuh et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

General functionalization route for cell adhesion on non-wetting surfaces

(2010) Sook Hee Ku et al.   BIOMATERIALS

An Updated Overview on Wnt Signaling Pathways

(2010) Tata Purushothama Rao et al.   CIRCULATION RESEARCH

Vinculin, an adapter protein in control of cell adhesion signalling

(2010) Alex Carisey et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Increased mechanosensitivity of cells cultured on nanotopographies

(2010) Joshua D. Salvi et al.   JOURNAL OF BIOMECHANICS

Matrix stiffness regulation of integrin-mediated mechanotransduction during osteogenic differentiation of human mesenchymal stem cells

(2010) Yu-Ru V Shih et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The effect of matrix stiffness on mesenchymal stem cell differentiation in a 3D thixotropic gel

(2009) Y. Shona Pek et al.   BIOMATERIALS

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Ultrathin and Stable Active Layer of Dense Composite Membrane Enabled by Poly(dopamine)

(2009) Ben Li et al.   LANGMUIR

Extracellular matrix as a biological scaffold material: Structure and function

(2008) S BADYLAK et al.   Acta Biomaterialia

Directing osteogenic and myogenic differentiation of MSCs: interplay of stiffness and adhesive ligand presentation

(2008) Andrew S. Rowlands et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Rho kinase-dependent CCL20 induced by dynamic compression of human chondrocytes

(2008) Dominik R. Haudenschild et al.   ARTHRITIS AND RHEUMATISM

Wnt–β-catenin signaling

(2008) Ken M. Cadigan   CURRENT BIOLOGY

Engineering cartilage tissue

(2007) Cindy Chung et al.   ADVANCED DRUG DELIVERY REVIEWS