Patient-derived xenografts as tools in pharmaceutical development

Abstract 5031: A humanized mouse model for translational assessment of targeted immune checkpoint blockade

(2015) Gilson Baia et al.   CANCER RESEARCH

Zebrafish: A New Companion for Translational Research in Oncology

(2015) J. Barriuso et al.   CLINICAL CANCER RESEARCH

ITOC2 – 005. Humanized mouse models for preclinical testing of antitumour immune therapy

(2015) Wulf-Goldenberg Annika et al.   EUROPEAN JOURNAL OF CANCER

ExpandedRAS: Refining the Patient Population

(2015) Chloe E. Atreya et al.   JOURNAL OF CLINICAL ONCOLOGY

Clinical Utility of Patient-Derived Xenografts to Determine Biomarkers of Prognosis and Map Resistance Pathways inEGFR-Mutant Lung Adenocarcinoma

(2015) Erin L. Stewart et al.   JOURNAL OF CLINICAL ONCOLOGY

High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response

(2015) Hui Gao et al.   NATURE MEDICINE

XactMice: humanizing mouse bone marrow enables microenvironment reconstitution in a patient-derived xenograft model of head and neck cancer

(2015) J J Morton et al.   ONCOGENE

Establishment of a Patient-Derived Orthotopic Xenograft (PDOX) Model of HER-2-Positive Cervical Cancer Expressing the Clinical Metastatic Pattern

(2015) Yukihiko Hiroshima et al.   PLoS One

Correlation between tumor engraftment in patient-derived xenograft models and clinical outcomes in colorectal cancer patients

(2015) Bo Young Oh et al.   Oncotarget

An Advanced Preclinical Mouse Model for Acute Myeloid Leukemia Using Patients' Cells of Various Genetic Subgroups and In Vivo Bioluminescence Imaging

(2015) Binje Vick et al.   PLoS One

OKT3 prevents xenogeneic GVHD and allows reliable xenograft initiation from unfractionated human hematopoietic tissues

(2014) M. Wunderlich et al.   BLOOD

Patient-derived xenografts for individualized care in advanced sarcoma

(2014) Justin Stebbing et al.   CANCER

Tumorgrafts asIn VivoSurrogates for Women with Ovarian Cancer

(2014) S. John Weroha et al.   CLINICAL CANCER RESEARCH

Integrated Next-Generation Sequencing and Avatar Mouse Models for Personalized Cancer Treatment

(2014) E. Garralda et al.   CLINICAL CANCER RESEARCH

Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution

(2014) Peter Eirew et al.   NATURE

Development and function of human innate immune cells in a humanized mouse model

(2014) Anthony Rongvaux et al.   NATURE BIOTECHNOLOGY

Patient-derived models of acquired resistance can identify effective drug combinations for cancer

(2014) Adam S. Crystal et al.   SCIENCE

Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research

(2014) M. Hidalgo et al.   Cancer Discovery

Transcriptional dissection of pancreatic tumors engrafted in mice

(2014) Raquel Martinez-Garcia et al.   Genome Medicine

A Renewable Tissue Resource of Phenotypically Stable, Biologically and Ethnically Diverse, Patient-Derived Human Breast Cancer Xenograft Models

(2013) X. Zhang et al.   CANCER RESEARCH

Patient-Derived Tumor Xenografts: Transforming Clinical Samples into Mouse Models

(2013) D. Siolas et al.   CANCER RESEARCH

Proteomic Characterization of Breast Cancer Xenografts Identifies Early and Late Bevacizumab-Induced Responses and Predicts Effective Drug Combinations

(2013) E. M. Lindholm et al.   CLINICAL CANCER RESEARCH

Establishment of a Human Allergy Model Using Human IL-3/GM-CSF-Transgenic NOG Mice

(2013) R. Ito et al.   JOURNAL OF IMMUNOLOGY

A patient tumor transplant model of squamous cell cancer identifies PI3K inhibitors as candidate therapeutics in defined molecular bins

(2013) Stephen B. Keysar et al.   Molecular Oncology

Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine

(2013) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Niche-Dependent Gene Expression Profile of Intratumoral Heterogeneous Ovarian Cancer Stem Cell Populations

(2013) Sagi Abelson et al.   PLoS One

Lurbinectedin (PM01183), a New DNA Minor Groove Binder, Inhibits Growth of Orthotopic Primary Graft of Cisplatin-Resistant Epithelial Ovarian Cancer

(2012) A. Vidal et al.   CLINICAL CANCER RESEARCH

Inhibition of MEK and PI3K/mTOR Suppresses Tumor Growth but Does Not Cause Tumor Regression in Patient-Derived Xenografts of RAS-Mutant Colorectal Carcinomas

(2012) G. Migliardi et al.   CLINICAL CANCER RESEARCH

Characterization of a Large Panel of Patient-Derived Tumor Xenografts Representing the Clinical Heterogeneity of Human Colorectal Cancer

(2012) S. Julien et al.   CLINICAL CANCER RESEARCH

Tumor heterogeneity and its implication for drug delivery

(2012) Tracy A. Denison et al.   JOURNAL OF CONTROLLED RELEASE

Patient-derived tumour xenografts as models for oncology drug development

(2012) John J. Tentler et al.   Nature Reviews Clinical Oncology

Variable Clonal Repopulation Dynamics Influence Chemotherapy Response in Colorectal Cancer

(2012) A. Kreso et al.   SCIENCE

A Model for Personalized in Vivo Analysis of Human Immune Responsiveness

(2012) H. Kalscheuer et al.   Science Translational Medicine

ROCK Inhibitor and Feeder Cells Induce the Conditional Reprogramming of Epithelial Cells

(2011) Xuefeng Liu et al.   AMERICAN JOURNAL OF PATHOLOGY

Tumor Engraftment in Nude Mice and Enrichment in Stroma- Related Gene Pathways Predict Poor Survival and Resistance to Gemcitabine in Patients with Pancreatic Cancer

(2011) I. Garrido-Laguna et al.   CLINICAL CANCER RESEARCH

Gemcitabine Plusnab-Paclitaxel Is an Active Regimen in Patients With Advanced Pancreatic Cancer: A Phase I/II Trial

(2011) Daniel D. Von Hoff et al.   JOURNAL OF CLINICAL ONCOLOGY

Prioritizing Phase I Treatment Options Through Preclinical Testing on Personalized Tumorgraft

(2011) M. Pia Morelli et al.   JOURNAL OF CLINICAL ONCOLOGY

A Pilot Clinical Study of Treatment Guided by Personalized Tumorgrafts in Patients with Advanced Cancer

(2011) M. Hidalgo et al.   MOLECULAR CANCER THERAPEUTICS

Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes

(2011) Yoko S DeRose et al.   NATURE MEDICINE

A Molecularly Annotated Platform of Patient-Derived Xenografts ("Xenopatients") Identifies HER2 as an Effective Therapeutic Target in Cetuximab-Resistant Colorectal Cancer

(2011) A. Bertotti et al.   Cancer Discovery

Integrated preclinical and clinical development of mTOR inhibitors in pancreatic cancer

(2010) I Garrido-Laguna et al.   BRITISH JOURNAL OF CANCER

Patient-Derived First Generation Xenografts of Non-Small Cell Lung Cancers: Promising Tools for Predicting Drug Responses for Personalized Chemotherapy

(2010) X. Dong et al.   CLINICAL CANCER RESEARCH

The Ability to Form Primary Tumor Xenografts Is Predictive of Increased Risk of Disease Recurrence in Early-Stage Non-Small Cell Lung Cancer

(2010) T. John et al.   CLINICAL CANCER RESEARCH

Personalizing Cancer Treatment in the Age of Global Genomic Analyses: PALB2 Gene Mutations and the Response to DNA Damaging Agents in Pancreatic Cancer

(2010) M. C. Villarroel et al.   MOLECULAR CANCER THERAPEUTICS

Translating cancer research into targeted therapeutics

(2010) J. S. de Bono et al.   NATURE

Genome remodelling in a basal-like breast cancer metastasis and xenograft

(2010) Li Ding et al.   NATURE

Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r null humanized mice

(2010) L. D. Shultz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Primary Xenograft Model of Small-Cell Lung Cancer Reveals Irreversible Changes in Gene Expression Imposed by Culture In vitro

(2009) V. C. Daniel et al.   CANCER RESEARCH

Molecular profiling and characterization of luminal-like and basal-like in vivo breast cancer xenograft models

(2009) Anna Bergamaschi et al.   Molecular Oncology

Coordinated Epidermal Growth Factor Receptor Pathway Gene Overexpression Predicts Epidermal Growth Factor Receptor Inhibitor Sensitivity in Pancreatic Cancer

(2008) A. Jimeno et al.   CANCER RESEARCH

Establishment of Patient-Derived Non-Small Cell Lung Cancer Xenografts as Models for the Identification of Predictive Biomarkers

(2008) I. Fichtner et al.   CLINICAL CANCER RESEARCH

Direct In Vivo Xenograft Tumor Model for Predicting Chemotherapeutic Drug Response in Cancer Patients

(2008) B Rubio-Viqueira et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Denosumab, a Fully Human Monoclonal Antibody to RANKL, Inhibits Bone Resorption and Increases BMD in Knock-In Mice That Express Chimeric (Murine/Human) RANKL*

(2008) Paul J Kostenuik et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Differential transplantability of human endothelial cells in colorectal cancer and renal cell carcinoma primary xenografts

(2008) Laura Sanz et al.   LABORATORY INVESTIGATION

Establishment and characterization ofin vivohuman tumor models in the NOD/SCID/γcnullmouse

(2008) Etsuko Fujii et al.   PATHOLOGY INTERNATIONAL