Article
Biochemistry & Molecular Biology
Jeonghyeon Seo, Da Eun Lee, Seong Mi Kim, Eunjung Kim, Jin-Kyung Kim
Summary: The study found that LicA, a major active component of licorice, has anticancer activity against ovarian cancer cells. LicA inhibited cell viability and induced G2/M phase arrest in SKOV3 cells. LicA also induced apoptosis by increasing reactive oxygen species levels, reducing mitochondrial membrane potential, and promoting caspase activation and cytochrome c release. Furthermore, LicA reduced STAT3 protein levels and downstream signaling, suggesting its potential as an anti-cancer agent.
Article
Plant Sciences
Xueshuang Liu, Yue Xing, Mingyue Li, Zhihong Zhang, Jingying Wang, MyongHak Ri, Chenghua Jin, Guanghua Xu, Lianxun Piao, Honglan Jin, Hongxiang Zuo, Juan Ma, Xuejun Jin
Summary: Licochalcone A demonstrates anti-tumor activity by inhibiting PD-L1 expression and interfering with the interaction between p65 and Ras to regulate the immune response. It also inhibits cell proliferation, promotes cell apoptosis, and potentially suppresses tumor growth.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Luo-Wei Yuan, Xiao-Ming Jiang, Yu-Lian Xu, Mu-Yang Huang, Yu-Chi Chen, Wei-Bang Yu, Min-Xia Su, Zi-Han Ye, Xiuping Chen, Yitao Wang, Jin-Jian Lu
Summary: The study found that Licochalcone A can interfere with the expression of IFN-gamma-induced PD-L1 in lung cancer cells by inhibiting protein translation, especially through ROS generation, suggesting its potential for cancer immunotherapy.
Article
Oncology
Xiaoli Fan, Guoqiang Guan, Juan Wang, Meihua Jin, Liming Wang, Xiaoqun Duan
Summary: This study demonstrates that licochalcone A (LCA) has anticancer effects on lung squamous cell carcinoma (LSCC), inhibiting cell proliferation and inducing apoptosis. These effects are achieved through the inhibition of mitogen-activated protein kinase (MAPK) signaling pathways and the expression of F-box protein 5 (FBXO5).
Article
Biochemistry & Molecular Biology
Kyung-Ho Park, Sang Hoon Joo, Ji-Hye Seo, Jumi Kim, Goo Yoon, Young-Joo Jeon, Mee-Hyun Lee, Jung-Il Chae, Woo-Keun Kim, Jung-Hyun Shim
Summary: The study demonstrated that LCH inhibited the growth of skin cancer cells by inducing apoptosis and cell cycle arrest in the G1 phase. Additionally, LCH suppressed cell proliferation by modulating the JAK2/STAT3 signaling pathway.
BIOMOLECULES & THERAPEUTICS
(2022)
Article
Chemistry, Medicinal
Liqun Qu, Jianhui Wu, Yong Tang, Xiaoyun Yun, Hang Hong Lo, Lu Yu, Wenhua Li, Anguo Wu, Betty Yuen Kwan Law
Summary: The study found that Licochalcone B (LCB) has neuroprotective effects against oxidative stress-induced damage in neuronal cells. It reduces cell cytotoxicity and apoptosis, lowers the level of oxidative stress markers, and induces autophagy and signaling pathways to protect against damage.
Article
Biochemistry & Molecular Biology
Rong Liu, Guangxi Yang, Min Bao, Zhongmei Zhou, Xiaoyun Mao, Wenjing Liu, Xiaoyan Jiang, Di Zhu, Xinle Ren, Jian Huang, Ceshi Chen
Summary: This study identifies STAMBPL1 as a deubiquitinase of MKP-1 in breast cancer cells, which stabilizes MKP-1 protein by deubiquitination. Depletion of STAMBPL1 and MKP-1 increases breast cancer sensitivity to cisplatin and activates the JNK signaling pathway. These findings suggest that the STAMBPL1/MKP-1 axis could be a potential therapeutic target in breast cancer.
Article
Pharmacology & Pharmacy
Serah Kimani, Suparna Chakraborty, Ikponmwosa Irene, Jo de la Mare, Adrienne Edkins, Andre du Toit, Ben Loos, Angelique Blanckenberg, Annick Van Niekerk, Leticia Costa-Lotufo, K. N. ArulJothi, Selwyn Mapolie, Sharon Prince
Summary: The study investigated the anti-cancer activity of a palladium complex, BTC2, in human breast cancer cells, demonstrating its selectivity, inhibition of cancer cell migration, and suppression of cancer stem cell activity. BTC2 also induced DNA double strand breaks, triggered cell cycle arrests, and activated multiple cell death pathways, showing promising anti-breast cancer activity both in vitro and in vivo.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sylvain Lefort, Amal El-Naggar, Susanna Tan, Shane Colborne, Gian Luca Negri, Davide Pellacani, Martin Hirst, Barry Gusterson, Gregg B. Morin, Poul H. Sorensen, Connie J. Eaves
Summary: The role of YB-1 in newly arising human breast cancers and established cell lines was investigated, showing that YB-1 regulation affects tumor formation and metastasis. Experimental results suggest a close correlation between the expression levels of YB-1, HIF1α, and G3BP1, all of which are involved in the development of breast cancer.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Environmental Sciences
Chang-Fang Chiu, Shih-Jiuan Chiu, Li-Yuan Bai, Chia-Hsien Feng, Jing-Lan Hu, Wei-Yu Lin, Hao-Yu Huang, Jing-Ru Weng
Summary: The study showed that JBIR-100 could inhibit proliferation and induce apoptosis in breast cancer cells by modulating the Akt/NF-kappa B signaling pathway and Bcl-2 family members. Additionally, JBIR-100 also inhibited autophagy in MCF-7 cells.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Multidisciplinary Sciences
Emma Grant, Fatma Bucklain, Lucy E. Ginn, Peter C. Laity, Barbara C. Ciani, Helen C. Bryant
Summary: This study developed in vitro models that mimic the stiffness of normal and cancerous breast tissue, and found that breast cancer cells showed resistance to gemcitabine at higher stiffness. The study also revealed that the use of selective progesterone receptor modulators could reduce resistance to gemcitabine.
Article
Oncology
Dhanir Tailor, Catherine C. Going, Angel Resendez, Vineet Kumar, Dhanya K. Nambiar, Yang Li, Arpit Dheeraj, Edward Lewis LaGory, Ali Ghoochani, Alisha M. Birk, Tanya Stoyanova, Jiangbin Ye, Amato J. Giaccia, Quynh-Thu Le, Rana P. Singh, George W. Sledge, Sharon J. Pitteri, Sanjay Malhotra
Summary: A novel AMPK activator (SU212) has been developed to selectively induce oxidative phosphorylation and decrease glycolysis in TNBC cells, without affecting normal cells. SU212 activates AMPK independently of energy stress and irrespective of glycaemic/insulin state, leading to mitotic phase arrest and apoptosis in TNBC cells. In vivo, SU212 inhibits tumour growth, cancer progression and metastasis.
BRITISH JOURNAL OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Yun-yun Zhang, Pan-pan Feng, Hong-fei Wang, Heng Zhang, Tao Liang, Xiao-shan Hao, Feng-ze Wang, Hong-rong Fei
Summary: The study found that licochalcone B (LCB), a compound from the root of Glycyrrhiza uralensis Fisch., inhibited proliferation and induced apoptosis in hepatocellular carcinoma (HCC) cells. LCB also enhanced sensitivity to TNF-related apoptosis-inducing ligand (TRAIL) through modulation of signaling pathways. This suggests that combination therapy with LCB and TRAIL could be an alternative treatment strategy for HCC.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Cell Biology
Jing Zhang, Christina Trojel-Hansen, Jianghuang Wang, Zili Zhang, Xing Wang, Yuhui Qiao, Huike Jiao, Mickael Michaud, Oliver Kepp, Marja Jäättelä, Guido Kroemer, Qing Zhong
Summary: An experimental inducer of TNF-independent necrosis, NC1, kills human cancer cells in a non-apoptotic, necrotic manner. The cell death induced by NC1 is not inhibited by apoptosis-related pathways, but depends on reactive oxygen species (ROS) production by mitochondria and elimination of mitochondrial DNA. These findings suggest that inducing regulated necrosis may be a promising approach for anticancer therapy.
CELL DEATH & DISEASE
(2023)
Review
Cell Biology
Matthew L. Winder, Kirsteen J. Campbell
Summary: MCL-1, a pro-survival member of the BCL-2 family, has emerged as an attractive target in breast cancer due to its potential to restore apoptosis and enhance the efficacy of conventional therapies.
Article
Biochemistry & Molecular Biology
Ah-Won Kwak, Seung-Sik Cho, Goo Yoon, Ha-Na Oh, Mee-Hyun Lee, Jung-Il Chae, Jung-Hyun Shim
CELL BIOCHEMISTRY AND BIOPHYSICS
(2020)
Article
Biochemistry & Molecular Biology
Ha-Na Oh, Mee-Hyun Lee, Eunae Kim, Ah-Won Kwak, Goo Yoon, Seung-Sik Cho, Kangdong Liu, Jung-Il Chae, Jung-Hyun Shim
Article
Biochemistry & Molecular Biology
Ah-Won Kwak, Goo Yoon, Mee-Hyun Lee, Seung-Sik Cho, Jung-Hyun Shim, Jung-Il Chae
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Ah-Won Kwak, Mee-Hyun Lee, Goo Yoon, Seung-Sik Cho, Joon-Seok Choi, Jung-Il Chae, Jung-Hyun Shim
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Sun-Young Hwang, Jung-Il Chae, Ah-Won Kwak, Mee-Hyun Lee, Jung-Hyun Shim
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Shakya Rajina, Woo Jean Kim, Jung-Hyun Shim, Kyung-Soo Chun, Sang Hoon Joo, Hwa Kyoung Shin, Seo-Yeon Lee, Joon-Seok Choi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Plant Sciences
Ha-Na Oh, Ah-Won Kwak, Mee-Hyun Lee, Eunae Kim, Goo Yoon, Seung-Sik Cho, Kangdong Liu, Jung-Il Chae, Jung-Hyun Shim
Summary: The study investigated the mechanism of PPT-induced apoptosis in NSCLC cells, revealing that the inhibition of c-MET kinase activity played a crucial role in PPT-induced cell death.
Article
Pharmacology & Pharmacy
Hyesook Lee, Da Hye Kim, Hyun Hwangbo, So Young Kim, Seon Yeong Ji, Min Yeong Kim, Jung-Hyun Shim, Sun-Hee Leem, Jin Won Hyun, Gi-Young Kim, Yung Hyun Choi
Summary: The study showed that spermidine eye drops have protective effects against particulate matter2.5-induced dry eye symptoms by stabilizing the tear film and suppressing inflammation, and may partially improve retinal function and lipid metabolism disorder.
Article
Biotechnology & Applied Microbiology
Ji-Hye Seo, Young-Joo Jeon
Summary: This study aimed to establish an effective novel therapeutic cellular source from human embryonic stem cells (hESCs) and investigate its molecular expression profile. The results indicated that the derived mesenchymal stem cells have high proliferative capacity, potentially interact with the Wnt/beta-catenin pathway, and offer higher therapeutic potential.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Food Science & Technology
So Young Kim, Hee-Jae Cha, Hyun Hwangbo, Cheol Park, Hyesook Lee, Kyoung Seob Song, Jung-Hyun Shim, Jeong Sook Noh, Heui-Soo Kim, Bae-Jin Lee, Suhkmann Kim, Gi-Young Kim, You-Jin Jeon, Yung Hyun Choi
Summary: The study demonstrated that fermented extract of sea tangle (FST) could protect MC3T3-E1 cells from H2O2-induced damage by maintaining mitochondrial function, eliminating ROS, and activating the Nrf2/HO-1 antioxidant pathway.
Article
Chemistry, Medicinal
Ah-Won Kwak, Jin-Young Lee, Seung-On Lee, Ji-hye Seo, Jin Woo Park, Yung Hyun Choi, Seung-Sik Cho, Goo Yoon, Mee-Hyun Lee, Jung-Hyun Shim
Summary: This study elucidates the molecular mechanism of Ech-induced apoptosis in both oxaliplatin-sensitive and -resistant CRC cells, showing that Ech exhibits anticancer activity by inducing ROS-mediated apoptosis through the JNK/p38 MAPK signaling pathway.
PHYTOTHERAPY RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Sultan Pulat, Laxman Subedi, Prashant Pandey, Suresh R. Bhosle, Jae-Seoun Hur, Jung-Hyun Shim, Seung-Sik Cho, Ki-Taek Kim, Hyung-Ho Ha, Hangun Kim, Jin Woo Park
Summary: Atraric acid (AA) is a phenolic compound derived from Stereocaulon japonicum and has anti-androgen properties, making it a viable alternative for treating alopecia. A new topical formulation, AA-TF#15, was designed using a solvent mixture system and showed significantly higher skin flux and dermal drug deposition compared to AA in ethanol. Furthermore, AA-TF#15 demonstrated the ability to activate keratinocytes and human dermal papilla cell proliferation, leading to increased hair regrowth compared to minoxidil and oral finasteride treatments.
Article
Engineering, Chemical
Seung-Yub Song, Dae-Hun Park, Sung-Ho Lee, Chul-Yung Choi, Jung-Hyun Shim, Goo Yoon, Jin-Woo Park, Min-Suk Bae, Seung-Sik Cho
Summary: Chamaecyparis obtusa (Siebold & Zucc.) Endl. (Cupressaceae) is found to contain antimicrobial substances, with thujopsene and pinene as common markers. The essential oil of C. obtusa has disinfectant effects, as demonstrated by its ability to remove airborne microorganisms in indoor spaces. This study suggests that C. obtusa essential oil can effectively reduce contamination by infectious microorganisms in confined spaces.
Article
Biochemistry & Molecular Biology
Ah-Won Kwak, Woo-Keun Kim, Seung-On Lee, Goo Yoon, Seung-Sik Cho, Ki-Taek Kim, Mee-Hyun Lee, Yung Hyun Choi, Jin-Young Lee, Jin Woo Park, Jung-Hyun Shim
Summary: This study aims to investigate the antitumor potential and molecular mechanism of Licochalcone B (LCB) in human colorectal cancer cells. The results demonstrate that LCB has a potential therapeutic effect against colorectal cancer cells through the ROS-mediated JNK/p38 MAPK signaling pathway, making it a promising anticancer therapeutic and prophylactic agent.
Article
Biochemistry & Molecular Biology
Cheol Park, Hee-Jae Cha, Hyun Hwangbo, Seon Yeong Ji, Da Hye Kim, Min Yeong Kim, EunJin Bang, Su Hyun Hong, Sung Ok Kim, Soon-Jeong Jeong, Hyesook Lee, Sung-Kwon Moon, Jung-Hyun Shim, Gi-Young Kim, Suengmok Cho, Yung Hyun Choi
Summary: Phloroglucinol, a polyphenolic compound, has potent antioxidant activity in mouse myoblasts and may have therapeutic benefits for oxidative-stress-mediated muscle disease by activating Nrf2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)