Licochalcone A inhibits proliferation and promotes apoptosis of colon cancer cell by targeting programmed cell death-ligand 1 via the NF-κB and Ras/Raf/MEK pathways

Glycyrrhiza glabra (Licorice) root extract attenuates doxorubicin-induced cardiotoxicity via alleviating oxidative stress and stabilising the cardiac health in H9c2 cardiomyocytes

(2020) Shishir Upadhyay et al.   JOURNAL OF ETHNOPHARMACOLOGY

Convallatoxin promotes apoptosis and inhibits proliferation and angiogenesis through crosstalk between JAK2/STAT3 (T705) and mTOR/STAT3 (S727) signaling pathways in colorectal cancer

(2020) Zhi Hong Zhang et al.   PHYTOMEDICINE

Panaxadiol inhibits programmed cell death-ligand 1 expression and tumour proliferation via hypoxia-inducible factor (HIF)-1α and STAT3 in human colon cancer cells

(2020) Zhe Wang et al.   PHARMACOLOGICAL RESEARCH

Curcumol inhibits the expression of programmed cell death-ligand 1 through crosstalk between hypoxia-inducible factor-1α and STAT3 (T705) signaling pathways in hepatic cancer

(2020) Hong Xiang Zuo et al.   JOURNAL OF ETHNOPHARMACOLOGY

Cirsilineol inhibits proliferation of lung squamous cell carcinoma by inducing ROS mediated apoptosis

(2020) Gauri Pathak et al.   FOOD AND CHEMICAL TOXICOLOGY

Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape

(2019) Xianjie Jiang et al.   Molecular Cancer

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Stromal PD-1 / PD-L1 expression predicts outcome in colon cancer patients

(2018) Jacqueline Wyss et al.   Clinical Colorectal Cancer

Fraxinellone has anticancer activity in vivo by inhibiting programmed cell death-ligand 1 expression by reducing hypoxia-inducible factor-1α and STAT3

(2018) Yue Xing et al.   PHARMACOLOGICAL RESEARCH

Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA

(2017) Matthew A. Coelho et al.   IMMUNITY

Folic acid-functionalized polyethylenimine superparamagnetic iron oxide nanoparticles as theranostic agents for magnetic resonance imaging and PD-L1 siRNA delivery for gastric cancer

(2017) Xin Luo et al.   International Journal of Nanomedicine

Antioxidative and anticancer properties of Licochalcone A from licorice

(2017) Xiangrong Chen et al.   JOURNAL OF ETHNOPHARMACOLOGY

Imperatorin efficiently blocks TNF-α-mediated activation of ROS/PI3K/Akt/NF-κB pathway

(2017) Ke Si Wang et al.   ONCOLOGY REPORTS

Chelidonine inhibits TNF-α-induced inflammation by suppressing the NF-κB pathways in HCT116 cells

(2017) Zhi Hong Zhang et al.   PHYTOTHERAPY RESEARCH

Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality

(2017) Mayumi Kitagawa et al.   Nature Communications

The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function

(2017) Lixin Wan et al.   Cancer Discovery

Deubiquitination and Stabilization of PD-L1 by CSN5

(2016) Seung-Oe Lim et al.   CANCER CELL

Apicobasal polarity and Ras/Raf/MEK/ERK signalling in cancer

(2016) Juan Peng et al.   GUT

Dihydromyricetin suppresses TNF-α-induced NF-κB activation and target gene expression

(2016) Nina Tang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

NF-κB Regulates PD-1 Expression in Macrophages

(2015) Alexander P. R. Bally et al.   JOURNAL OF IMMUNOLOGY

Stamping out RAF and MEK1/2 to inhibit the ERK1/2 pathway: an emerging threat to anticancer therapy

(2015) R Mandal et al.   ONCOGENE

The Pharmacological Activities of Licorice

(2015) Rui Yang et al.   PLANTA MEDICA

Inhibition of human cytochrome P450 enzymes by licochalcone A, a naturally occurring constituent of licorice

(2015) Wei He et al.   TOXICOLOGY IN VITRO

The anticancer immune response of anti-PD-1/PD-L1 and the genetic determinants of response to anti-PD-1/PD-L1 antibodies in cancer patients

(2015) Xinbing Sui et al.   Oncotarget

EML4-ALK enhances programmed cell death-ligand 1 expression in pulmonary adenocarcinoma via hypoxia-inducible factor (HIF)-1α and STAT3

(2015) Jaemoon Koh et al.   OncoImmunology

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

(2014) Muhammad Zaeem Noman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ocular albinism type 1-induced melanoma cell migration is mediated through the RAS/RAF/MEK/ERK signaling pathway

(2014) JUN BAI et al.   Molecular Medicine Reports

Targeting RAS–ERK signalling in cancer: promises and challenges

(2014) Ahmed A. Samatar et al.   NATURE REVIEWS DRUG DISCOVERY

MEK and the inhibitors: from bench to bedside

(2013) Akintunde Akinleye et al.   Journal of Hematology & Oncology

Up-Regulation of PD-L1, IDO, and Tregs in the Melanoma Tumor Microenvironment Is Driven by CD8+ T Cells

(2013) S. Spranger et al.   Science Translational Medicine

Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors

(2013) E. A. Akbay et al.   Cancer Discovery

Chemical analysis of the Chinese herbal medicine Gan-Cao (licorice)

(2008) Qingying Zhang et al.   JOURNAL OF CHROMATOGRAPHY A

Review of Pharmacological Effects ofGlycyrrhiza sp. and its Bioactive Compounds

(2008) Marjan Nassiri Asl et al.   PHYTOTHERAPY RESEARCH