Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease

Cyst expansion and regression in a mouse model of polycystic kidney disease

(2013) Hester Happé et al.   KIDNEY INTERNATIONAL

Neutrophil recruitment is inhibited by nicotinamide in experimental pleurisy in mice

(2012) Raphael G. Ferreira et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Protective effects of nicotinamide against acetaminophen-induced acute liver injury

(2012) Youdan Shi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Sirt-1 Is Required for the Inhibition of Apoptosis and Inflammatory Responses in Human Tenocytes

(2012) Franziska Busch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nicotinamide Blocks Proliferation and Induces Apoptosis of Chronic Lymphocytic Leukemia Cells through Activation of the p53/miR-34a/SIRT1 Tumor Suppressor Network

(2011) V. Audrito et al.   CANCER RESEARCH

Sirtuins, Aging, and Medicine

(2011) Leonard Guarente   NEW ENGLAND JOURNAL OF MEDICINE

Activation of Sirt1 by Resveratrol Inhibits TNF-α Induced Inflammation in Fibroblasts

(2011) Xiaoxia Zhu et al.   PLoS One

Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis

(2011) V. Takiar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Involvement of the p65/RelA subunit of NF-κB in TNF-α-induced SIRT1 expression in vascular smooth muscle cells

(2010) Hui-Na Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Epigenetics and autosomal dominant polycystic kidney disease

(2010) Xiaogang Li   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Kidney-specific Overexpression of Sirt1 Protects against Acute Kidney Injury by Retaining Peroxisome Function

(2010) Kazuhiro Hasegawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetylation of Rb by PCAF is required for nuclear localization and keratinocyte differentiation

(2010) A. Pickard et al.   JOURNAL OF CELL SCIENCE

Sirtuins and Their Relevance to the Kidney

(2010) C.-M. Hao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Diagnosis and management of childhood polycystic kidney disease

(2010) William E. Sweeney et al.   PEDIATRIC NEPHROLOGY

A c-Myc–SIRT1 feedback loop regulates cell growth and transformation

(2009) Jian Yuan et al.   JOURNAL OF CELL BIOLOGY

Recent progress in the biology and physiology of sirtuins

(2009) Toren Finkel et al.   NATURE

Nicotinamide Prevents NAD+ Depletion and Protects Neurons Against Excitotoxicity and Cerebral Ischemia: NAD+ Consumption by SIRT1 may Endanger Energetically Compromised Neurons

(2009) Dong Liu et al.   NEUROMOLECULAR MEDICINE

Sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression

(2008) Kazuhiro Hasegawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Acetylation Is Indispensable for p53 Activation

(2008) Yi Tang et al.   CELL

Mammalian Target of Rapamycin and Caspase Inhibitors in Polycystic Kidney Disease

(2008) C. L. Edelstein   Clinical Journal of the American Society of Nephrology

Loss of polycystin-1 causes centrosome amplification and genomic instability

(2008) Lorenzo Battini et al.   HUMAN MOLECULAR GENETICS

Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1

(2008) Sekiya Shibazaki et al.   HUMAN MOLECULAR GENETICS

Nicotinamide Restores Cognition in Alzheimer's Disease Transgenic Mice via a Mechanism Involving Sirtuin Inhibition and Selective Reduction of Thr231-Phosphotau

(2008) K. N. Green et al.   JOURNAL OF NEUROSCIENCE

Triptolide Reduces Cystogenesis in a Model of ADPKD

(2008) S. J. Leuenroth et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Neutrophil gelatinase-associated lipocalin suppresses cyst growth by Pkd1 null cells in vitro and in vivo

(2008) Feng Wei et al.   KIDNEY INTERNATIONAL

A tumor necrosis factor-α–mediated pathway promoting autosomal dominant polycystic kidney disease

(2008) Xiaogang Li et al.   NATURE MEDICINE