The tubulin code at a glance

Graded Control of Microtubule Severing by Tubulin Glutamylation

(2016) Max L. Valenstein et al.   CELL

Dual Chromatin and Cytoskeletal Remodeling by SETD2

(2016) In Young Park et al.   CELL

A new mutation in TUBB1 associated with thrombocytopenia confirms that C-terminal part of β1-tubulin plays a role in microtubule assembly

(2016) M. Fiore et al.   CLINICAL GENETICS

The emerging role of the tubulin code: From the tubulin molecule to neuronal function and disease

(2016) Soumyananda Chakraborti et al.   Cytoskeleton

Mutations in Human Tubulin Proximal to the Kinesin-Binding Site Alter Dynamic Instability at Microtubule Plus- and Minus-Ends

(2016) Shih-Chieh Ti et al.   DEVELOPMENTAL CELL

Tyrosination of α‐tubulin controls the initiation of processive dynein–dynactin motility

(2016) Richard J McKenney et al.   EMBO JOURNAL

Structure and Dynamics of Single-isoform Recombinant Neuronal Human Tubulin

(2016) Annapurna Vemu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The structured core of human β tubulin confers isotype-specific polymerization properties

(2016) Melissa C. Pamula et al.   JOURNAL OF CELL BIOLOGY

Evidence for new C-terminally truncated variants of α- and β-tubulins

(2016) Chrystelle Aillaud et al.   MOLECULAR BIOLOGY OF THE CELL

The tubulin repertoire of Caenorhabditis elegans sensory neurons and its context‑dependent role in process outgrowth

(2016) Dean Lockhead et al.   MOLECULAR BIOLOGY OF THE CELL

Mutations in TUBB8 and Human Oocyte Meiotic Arrest

(2016) Ruizhi Feng et al.   NEW ENGLAND JOURNAL OF MEDICINE

2-(m-Azidobenzoyl)taxol binds differentially to distinct β-tubulin isotypes

(2016) Chia-Ping Huang Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of microtubule lumen entry for the α-tubulin acetyltransferase enzyme αTAT1

(2016) Courtney Coombes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Detyrosinated microtubules buckle and bear load in contracting cardiomyocytes

(2016) P. Robison et al.   SCIENCE

α-Tubulin Tyrosination and CLIP-170 Phosphorylation Regulate the Initiation of Dynein-Driven Transport in Neurons

(2016) Jeffrey J. Nirschl et al.   Cell Reports

Acetylated tubulin is essential for touch sensation in mice

(2016) Shane J Morley et al.   eLife

αTAT1 controls longitudinal spreading of acetylation marks from open microtubules extremities

(2016) Nathalie Ly et al.   Scientific Reports

Microtubule detyrosination guides chromosomes during mitosis

(2015) M. Barisic et al.   SCIENCE

Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle

(2015) Jaclyn P. Kerr et al.   Nature Communications

New HDAC6-mediated deacetylation sites of tubulin in the mouse brain identified by quantitative mass spectrometry

(2015) Ningning Liu et al.   Scientific Reports

A mutation uncouples the tubulin conformational and GTPase cycles, revealing allosteric control of microtubule dynamics

(2015) Elisabeth A Geyer et al.   eLife

Effects of α-Tubulin K40 Acetylation and Detyrosination on Kinesin-1 Motility in a Purified System

(2014) Neha Kaul et al.   BIOPHYSICAL JOURNAL

Insights into the Structure and Function of Ciliary and Flagellar Doublet Microtubules

(2014) Richard Linck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids

(2014) Olivia Tort et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of microtubule motors by tubulin isotypes and post-translational modifications

(2014) Minhajuddin Sirajuddin et al.   NATURE CELL BIOLOGY

Microtubules and Their Role in Cellular Stress in Cancer

(2014) Amelia L. Parker et al.   Frontiers in Oncology

TUBB1mutation disrupting microtubule assembly impairs proplatelet formation and results in congenital macrothrombocytopenia

(2013) Shinji Kunishima et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Overexpression, purification, and functional analysis of recombinant human tubulin dimer

(2013) Itsushi Minoura et al.   FEBS LETTERS

Structural basis of tubulin tyrosination by tubulin tyrosine ligase

(2013) Andrea E. Prota et al.   JOURNAL OF CELL BIOLOGY

Effects of tubulin acetylation and tubulin acetyltransferase binding on microtubule structure

(2013) Stuart C. Howes et al.   MOLECULAR BIOLOGY OF THE CELL

Transglutaminase and Polyamination of Tubulin: Posttranslational Modification for Stabilizing Axonal Microtubules

(2013) Yuyu Song et al.   NEURON

HDAC6 controls the kinetics of platelet activation

(2012) K. Sadoul et al.   BLOOD

Hematologic  -Tubulin VI Isoform Exhibits Genetic Variability That Influences Paclitaxel Toxicity

(2012) L. J. Leandro-Garcia et al.   CANCER RESEARCH

Posttranslational Acetylation of α-Tubulin Constrains Protofilament Number in Native Microtubules

(2012) Juan G. Cueva et al.   CURRENT BIOLOGY

Genetically Separable Functions of the MEC-17 Tubulin Acetyltransferase Affect Microtubule Organization

(2012) Irini Topalidou et al.   CURRENT BIOLOGY

Panobinostat (LBH589)-induced acetylation of tubulin impairs megakaryocyte maturation and platelet formation

(2012) Camelia Iancu-Rubin et al.   EXPERIMENTAL HEMATOLOGY

Tubulin Acetylation Alone Does Not Affect Kinesin-1 Velocity and Run Length In Vitro

(2012) Wilhelm J. Walter et al.   PLoS One

The Tubulin Deglutamylase CCPP-1 Regulates the Function and Stability of Sensory Cilia in C. elegans

(2011) Robert O'Hagan et al.   CURRENT BIOLOGY

Phenotypic spectrum of the tubulin-related disorders and functional implications of disease-causing mutations

(2011) Max A Tischfield et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Tubulin Tyrosine Ligase-like Genesttll3andttll6Maintain Zebrafish Cilia Structure and Motility

(2011) Narendra Pathak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytosolic Carboxypeptidase 1 Is Involved in Processing α- and β-Tubulin

(2011) Iryna Berezniuk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions

(2011) Carsten Janke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Family of Protein-Deglutamylating Enzymes Associated with Neurodegeneration

(2010) Krzysztof Rogowski et al.   CELL

Human TUBB3 Mutations Perturb Microtubule Dynamics, Kinesin Interactions, and Axon Guidance

(2010) Max A. Tischfield et al.   CELL

Tubulin Glutamylation Regulates Ciliary Motility by Altering Inner Dynein Arm Activity

(2010) Swati Suryavanshi et al.   CURRENT BIOLOGY

Tubulin Polyglutamylation Regulates Axonemal Motility by Modulating Activities of Inner-Arm Dyneins

(2010) Tomohiro Kubo et al.   CURRENT BIOLOGY

Disease-associated mutations in TUBA1A result in a spectrum of defects in the tubulin folding and heterodimer assembly pathway

(2010) Guoling Tian et al.   HUMAN MOLECULAR GENETICS

Identification of Tubulin Deglutamylase amongCaenorhabditis elegansand Mammalian Cytosolic Carboxypeptidases (CCPs)

(2010) Yoshishige Kimura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tubulin polyglutamylation stimulates spastin-mediated microtubule severing

(2010) Benjamin Lacroix et al.   JOURNAL OF CELL BIOLOGY

A novel acetylation of β-tubulin by San modulates microtubule polymerization via down-regulating tubulin incorporation

(2010) Chih-Wen Chu et al.   MOLECULAR BIOLOGY OF THE CELL

MEC-17 is an α-tubulin acetyltransferase

(2010) Jyothi S. Akella et al.   NATURE

The major  -tubulin K40 acetyltransferase  TAT1 promotes rapid ciliogenesis and efficient mechanosensation

(2010) T. Shida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolutionary Divergence of Enzymatic Mechanisms for Posttranslational Polyglycylation

(2009) Krzysztof Rogowski et al.   CELL

TTLL3 Is a Tubulin Glycine Ligase that Regulates the Assembly of Cilia

(2009) Dorota Wloga et al.   DEVELOPMENTAL CELL

Motor-dependent microtubule disassembly driven by tubulin tyrosination

(2009) Leticia Peris et al.   JOURNAL OF CELL BIOLOGY

Tubulin tyrosination navigates the kinesin-1 motor domain to axons

(2009) Yoshiyuki Konishi et al.   NATURE NEUROSCIENCE

Tubulin Tyrosination Is Required for the Proper Organization and Pathfinding of the Growth Cone

(2009) Séverine Marcos et al.   PLoS One

Synaptic activation modifies microtubules underlying transport of postsynaptic cargo

(2009) C. Maas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Mutation of the  1-tubulin gene associated with congenital macrothrombocytopenia affecting microtubule assembly

(2008) S. Kunishima et al.   BLOOD

Axoneme β-Tubulin Sequence Determines Attachment of Outer Dynein Arms

(2008) Elizabeth C. Raff et al.   CURRENT BIOLOGY

CLIP-170 tracks growing microtubule ends by dynamically recognizing composite EB1/tubulin-binding sites

(2008) Peter Bieling et al.   JOURNAL OF CELL BIOLOGY

Differential trafficking of Kif5c on tyrosinated and detyrosinated microtubules in live cells

(2008) S. Dunn et al.   JOURNAL OF CELL SCIENCE

A Pachygyria-causing α-Tubulin Mutation Results in Inefficient Cycling with CCT and a Deficient Interaction with TBCB

(2008) Guoling Tian et al.   MOLECULAR BIOLOGY OF THE CELL